{"title":"Transradial Percutaneous Coronary Intervention and Patient Risk: A New Radial Paradox?","authors":"Ryan A Watson, Ajar Kochar, Pinak B Shah","doi":"10.1161/CIRCINTERVENTIONS.121.010890","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.121.010890","url":null,"abstract":"","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010890"},"PeriodicalIF":5.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39177485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Julien Ternacle, Karim Al-Azizi, Molly Szerlip, Srinivasa Potluri, Mohanad Hamandi, Philipp Blanke, Jonathon Leipsic, Abdellaziz Dahou, Erwan Salaun, Flavien Vincent, Erin Rogers, Maria C Alu, Michael Lu, Xiao Yu, Vinod H Thourani, Rebecca T Hahn, Martin B Leon, Philippe Pibarot, Michael J Mack
{"title":"Impact of Predilation During Transcatheter Aortic Valve Replacement: Insights From the PARTNER 3 Trial.","authors":"Julien Ternacle, Karim Al-Azizi, Molly Szerlip, Srinivasa Potluri, Mohanad Hamandi, Philipp Blanke, Jonathon Leipsic, Abdellaziz Dahou, Erwan Salaun, Flavien Vincent, Erin Rogers, Maria C Alu, Michael Lu, Xiao Yu, Vinod H Thourani, Rebecca T Hahn, Martin B Leon, Philippe Pibarot, Michael J Mack","doi":"10.1161/CIRCINTERVENTIONS.120.010336","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.120.010336","url":null,"abstract":"<p><p>[Figure: see text].</p>","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010336"},"PeriodicalIF":5.6,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39243215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Suzanne V Arnold, George Petrossian, Michael J Reardon, Neal S Kleiman, Steven J Yakubov, Kaijun Wang, James Hermiller, J Kevin Harrison, G Michael Deeb, Jian Huang, David J Cohen
{"title":"Five-Year Clinical and Quality of Life Outcomes From the CoreValve US Pivotal Extreme Risk Trial.","authors":"Suzanne V Arnold, George Petrossian, Michael J Reardon, Neal S Kleiman, Steven J Yakubov, Kaijun Wang, James Hermiller, J Kevin Harrison, G Michael Deeb, Jian Huang, David J Cohen","doi":"10.1161/CIRCINTERVENTIONS.120.010258","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.120.010258","url":null,"abstract":"<p><strong>Background: </strong>Older adults with comorbidities who are at extreme risk for surgical aortic valve replacement may be appropriate candidates for transcatheter aortic valve replacement (TAVR). We present the 5-year clinical, echocardiographic, and health status outcomes of such patients treated with CoreValve self-expanding supra-annular TAVR.</p><p><strong>Methods: </strong>The CoreValve US Extreme Risk Pivotal Trial was a prospective, nonrandomized, single-arm clinical trial of TAVR at 41 sites in the United States. The primary outcome was all-cause mortality or major stroke. Secondary outcomes included echocardiographic parameters and patient-reported health status, assessed with the Kansas City Cardiomyopathy Questionnaire.</p><p><strong>Results: </strong>Between February 2011 and August 2012, 639 patients with severe aortic stenosis at extreme surgical risk underwent attempted TAVR (mean age 82.8±8.4 years, 53% women, mean Society of Thoracic Surgeons Predicted Risk of Mortality 10.4±5.6%, 77% iliofemoral access). The 5-year Kaplan-Meier rate of death or major stroke was 72.6% ([95% CI, 68.4%–76.7%]; death 71.6%, major stroke 11.5%), with no significant differences according to access site. Among patients who survived 5 years, mean transvalvular gradient was 7.5±5.9 mm Hg, and 3.1% had moderate or severe aortic regurgitation. Health status measures improved significantly by 1 month after TAVR through 1 year (mean change in Kansas City Cardiomyopathy Questionnaire–Overall Summary score 24.8 points [95% CI, 22.4–27.2]). Beyond 1 year, the Kansas City Cardiomyopathy Questionnaire–Overall Summary score decreased gradually but remained significantly improved from pre-TAVR through 5 years of follow-up among surviving patients (mean change from baseline, 14.3 points [95% CI, 10.7–17.9]).</p><p><strong>Conclusions: </strong>Patients with severe aortic stenosis at extreme surgical risk who are treated with self-expanding supra-annular TAVR have high 5-year mortality. However, the short-term benefits of TAVR in terms of valve hemodynamics and quality of life are mostly preserved among surviving patients at 5 years, thereby supporting the continued use of TAVR in these challenging patients.</p><p><strong>Registration: </strong>https://www.clinicaltrials.gov; Unique identifier: NCT01240902.</p>","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010258"},"PeriodicalIF":5.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39064161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Stephanie C El Hajj, Takumi Toya, Takayuki Warisawa, John Nan, Bradley R Lewis, Christopher M Cook, Christopher Rajkumar, James P Howard, Henry Seligman, Yousif Ahmad, Shunichi Doi, Akihiro Nakajima, Masafumi Nakayama, Sonoka Goto, Rafael Vera-Urquiza, Takao Sato, Yuetsu Kikuta, Yoshiaki Kawase, Hidetaka Nishina, Sunao Nakamura, Hitoshi Matsuo, Javier Escaned, Yoshihiro J Akashi, Justin E Davies, Amir Lerman
{"title":"Correlation of Intravascular Ultrasound and Instantaneous Wave-Free Ratio in Patients With Intermediate Left Main Coronary Artery Disease.","authors":"Stephanie C El Hajj, Takumi Toya, Takayuki Warisawa, John Nan, Bradley R Lewis, Christopher M Cook, Christopher Rajkumar, James P Howard, Henry Seligman, Yousif Ahmad, Shunichi Doi, Akihiro Nakajima, Masafumi Nakayama, Sonoka Goto, Rafael Vera-Urquiza, Takao Sato, Yuetsu Kikuta, Yoshiaki Kawase, Hidetaka Nishina, Sunao Nakamura, Hitoshi Matsuo, Javier Escaned, Yoshihiro J Akashi, Justin E Davies, Amir Lerman","doi":"10.1161/CIRCINTERVENTIONS.120.009830","DOIUrl":"10.1161/CIRCINTERVENTIONS.120.009830","url":null,"abstract":"<p><strong>Background: </strong>There is great degree of interobserver variability in the visual angiographic assessment of left main coronary disease (LMCD). Fractional flow reserve and intravascular ultrasound are often used in this setting. The use of instantaneous wave-free ratio (iFR) for evaluation of LMCD has not been well studied. The aim of this study is to evaluate the use of iFR in the assessment of angiographically intermediate LMCD.</p><p><strong>Methods: </strong>This is an international multicenter retrospective observational study of patients who underwent both iFR and intravascular ultrasound evaluation for angiographically intermediate LMCD. An independent core laboratory performed blinded off-line analysis of all intravascular ultrasound data. A minimum lumen area of 6 mm2 was used as the cutoff for significant disease.</p><p><strong>Results: </strong>One hundred twenty-five patients (mean age, 68.4±9.5 years, 84.8% male) were included in this analysis. Receiver operating curve analysis showed that an iFR of ≤0.89 identified minimum lumen area <6 mm2 with an area under the curve of 0.77 (77% sensitivity, 66% specificity; P<0.0001). Among the 69 patients without ostial left anterior descending artery or left circumflex artery disease, receiver operating curve analysis showed that an iFR of ≤0.89 identified minimum lumen area <6 mm2 with an area under the curve of 0.84 (70% sensitivity, 84% specificity; P<0.0001). The correlation was not significantly different when the body surface area was considered.</p><p><strong>Conclusions: </strong>In this study, in patients with intermediate LMCD, iFR of ≤0.89 correlates with intravascular ultrasound minimum lumen area <6 mm2 regardless of body surface area. The current study supports the use of iFR for the evaluation of intermediate LMCD.</p>","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e009830"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8206001/pdf/nihms-1700236.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39064165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Long-Term Outcomes of the Coarctation of the Aorta Stent Trials.","authors":"Ralf J Holzer, Kimberlee Gauvreau, Kerry McEnaney, Hanano Watanabe, Richard Ringel","doi":"10.1161/CIRCINTERVENTIONS.120.010308","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.120.010308","url":null,"abstract":"<p><strong>Background: </strong>Long-term outcome data of stent-implantation for coarctation of the aorta are limited. We report up to 5 years of postimplant follow-up in patients enrolled into the COAST (Coarctation of the Aorta Stent Trial) and the COAST II trial (Covered Cheatham-Platinum Stents for Prevention or Treatment of Aortic Wall Injury Associated With Coarctation of the Aorta), evaluating the bare and Covered Cheatham-Platinum Stents for the treatment of coarctation of the aorta and associated aortic wall injury.</p><p><strong>Methods: </strong>Data was prospectively collected during the 2 multi-center studies, enrolling 248 patients (COAST: n=121, COAST II: n=127). Late follow-up data (48–60 month) was compared with immediate (1 month) and early (12 months) follow-up.</p><p><strong>Results: </strong>There was a notable decrease in the use of antihypertensive medication, from 53% at immediate, to 42% at early, and 29% at late follow-up. The cumulative incidence of stent fractures was 0% immediately, 2.9% at early, and 24.4% at late follow-up. Independent predictors for stent fractures at late follow-up were age <18 years, male sex, minimum stent diameter ≥12 mm, and use of bare metal stent. The cumulative incidence of reintervention was 1.6% at immediate, 5.1% at early, and 21.3% at late follow-up. Independent predictors for reinterventions at late follow-up were age <18 years, post implantation systolic arm-leg blood pressure gradient ≥10 mm Hg, minimum stent diameter at implantation <12 mm, and initial coarctation minimum diameter <6 mm. There were 13 patients with aortic aneurysms, with a cumulative incidence of 6.3% at late follow-up.</p><p><strong>Conclusions: </strong>Coarctation stenting is effective at maintaining obstruction relief up to 60 months postimplant with reduction in the number of patients requiring antihypertensive medication. However, an increase in-stent fractures and reinterventions were observed between medium and long-term follow-up. Covered stents appear to confer some protection from the development of stent fractures but do not provide complete protection from late aneurysm formation.</p><p><strong>Registration: </strong>URL: https://www.clinicaltrials.gov; Unique identifiers: NCT00552812 and NCT01278303.</p>","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010308"},"PeriodicalIF":5.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39021296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The COAST Is Not Clear: Late Aneurysms and Fractures.","authors":"Gregory T Adamson, Kyong-Jin Lee","doi":"10.1161/CIRCINTERVENTIONS.121.010886","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.121.010886","url":null,"abstract":"","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010886"},"PeriodicalIF":5.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39021295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Repeat Transcatheter Aortic Valve Implantation: All That Glitters Is Not Gold…Yet.","authors":"Marco Barbanti, Giuliano Costa","doi":"10.1161/CIRCINTERVENTIONS.121.010884","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.121.010884","url":null,"abstract":"","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010884"},"PeriodicalIF":5.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39064159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Imaging and Physiology Get Along in the Left Main Coronary Artey Disease: The Case for Intravascular Ultrasound and Instantaneous Wave-Free Ratio.","authors":"Jose M de la Torre Hernandez","doi":"10.1161/CIRCINTERVENTIONS.121.010887","DOIUrl":"https://doi.org/10.1161/CIRCINTERVENTIONS.121.010887","url":null,"abstract":"","PeriodicalId":516631,"journal":{"name":"Circulation. Cardiovascular interventions","volume":" ","pages":"e010887"},"PeriodicalIF":5.6,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39064160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}