IJTLD OPEN最新文献_第4页

Assessing for comorbidities, determinants and disability during TB treatment 在结核病治疗期间评估合并症、决定因素和残疾情况

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0441

K. Viney, A. Baddeley, E. Jaramillo, M. Calvi, A. Carlqvist, F. Mavhunga

引用次数: 0

A social enterprise model for TB detection and treatment through the private sector in Pakistan 巴基斯坦通过私营部门开展结核病检测和治疗的社会企业模式

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0376

S. M. A. Zaidi, W. Z. Jamal, U. Ibrahim, S. Khowaja, A. J. Khan, J. Creswell

{"title":"A social enterprise model for TB detection and treatment through the private sector in Pakistan","authors":"S. M. A. Zaidi, W. Z. Jamal, U. Ibrahim, S. Khowaja, A. J. Khan, J. Creswell","doi":"10.5588/ijtldopen.23.0376","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0376","url":null,"abstract":"BACKGROUNDExisting models to increase TB case notifications from the private sector in Pakistan are financially unsustainable and have achieved modest success due to limited coverage.OBJECTIVETo\u0000 evaluate the impact of a social enterprise model (SEM) intervention on TB case detection in Karachi, Pakistan, and to assess its financial sustainability.METHODSPurpose-built centres were established within the private sector that integrated\u0000 TB screening, diagnostics and treatment and operated 12 hours per day with convenient locations to improve access. TB services were offered free of cost, and revenue generation took place through user fees from other diagnostics. Private providers with a focus on the informal sector were engaged\u0000 through community workers to generate screening referrals.RESULTSOverall 171,488 people were screened and 18,683 cases were notified, including 197 individuals with drug-resistant TB. Annual TB notifications in Karachi increased from 18,105\u0000 in 2014 to a maximum of 25,840 (40% increase). The proportion of cases in Karachi notified by the centres grew to 27% in 2020. Commercial revenue reached USD288,065 and enabled operating cost recovery of 15%. Average cost per TB case notified was USD203.CONCLUSIONThe\u0000 SEM intervention contributed a large proportion of notifications in Karachi and achieved modest cost recovery.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140467482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB 评估用于诊断儿童肺结核的胸部 X 光片解读短期培训课程

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0484

B. F. Melingui, E. Leroy-Terquem, M. Palmer, J-V. Taguebue, A. P. Wachinou, J. Gaudelus, A. Salomao, D. Bunnet, T. C. Eap, L. Borand, C. Chabala, C. Khosa, R. Moh, J. Mwanga-Amumpere, M. T. Eang, I. Manhiça, A. Mustapha, S. Beneteau, L. Falzon, J. Seddon, L. Berteloot, E. Wobudeya, O. Marcy, M. Bonnet, P. Y. Norval

{"title":"Evaluation of a short training course of chest X-ray interpretation for the diagnosis of paediatric TB","authors":"B. F. Melingui, E. Leroy-Terquem, M. Palmer, J-V. Taguebue, A. P. Wachinou, J. Gaudelus, A. Salomao, D. Bunnet, T. C. Eap, L. Borand, C. Chabala, C. Khosa, R. Moh, J. Mwanga-Amumpere, M. T. Eang, I. Manhiça, A. Mustapha, S. Beneteau, L. Falzon, J. Seddon, L. Berteloot, E. Wobudeya, O. Marcy, M. Bonnet, P. Y. Norval","doi":"10.5588/ijtldopen.23.0484","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0484","url":null,"abstract":"BACKGROUNDChest X-ray (CXR) interpretation is challenging for the diagnosis of paediatric TB. We assessed the performance of a three half-day CXR training module for healthcare workers (HCWs) at low healthcare levels in six high TB incidence\u0000 countries.METHODSWithin the TB-Speed Decentralization Study, we developed a three half-day training course to identify normal CXR, CXR of good quality and identify six TB-suggestive features. We performed a pre–post training assessment\u0000 on a pre-defined set of 20 CXR readings. We compared the proportion of correctly interpreted CXRs and the median reading score before and after the training using the McNemar test and a linear mixed model.RESULTSOf 191 HCWs, 43 (23%) were\u0000 physicians, 103 (54%) nurses, 18 (9.4%) radiology technicians and 12 (6.3%) other professionals. Of 2,840 CXRs with both assessment, respectively 1,843 (64.9%) and 2,277 (80.2%) were correctly interpreted during pre-training and post-training (P < 0.001). The median reading score\u0000 improved significantly from 13/20 to 16/20 after the training, after adjusting by country, facility and profession (adjusted β = 3.31, 95% CI 2.44–4.47).CONCLUSIONDespite some limitations of the course assessment that did not\u0000 include abnormal non-TB suggestive CXR, study findings suggest that a short CXR training course could improve HCWs’ interpretation skills in diagnosing paediatric TB.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140469052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A call to invest in post-TB lung disease to halt TB transmission in communities 呼吁对结核病后肺部疾病进行投资，以阻止结核病在社区的传播

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0397

P. Mbelele, F. J. Mtei, F. Thobias, K. S. Msaji, L. Løchting, L. M. Subi, D. Bwana, R. M. Kisonga, P. Neema, P. Howlett, M. Drage, S. Heysell, S. G. Mpagama

引用次数: 0

Acceptability of levofloxacin dispersible and non-dispersible tablet formulations in children receiving TB preventive treatment 接受结核病预防治疗的儿童对左氧氟沙星分散片和非分散片制剂的接受度

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0462

D. Wademan, H. R. Draper, S. Purchase, M. Palmer, A. Hesseling, L. E. van der Laan, A. Garcia-Prats

{"title":"Acceptability of levofloxacin dispersible and non-dispersible tablet formulations in children receiving TB preventive treatment","authors":"D. Wademan, H. R. Draper, S. Purchase, M. Palmer, A. Hesseling, L. E. van der Laan, A. Garcia-Prats","doi":"10.5588/ijtldopen.23.0462","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0462","url":null,"abstract":"BACKGROUNDWe evaluated the palatability and acceptability of a 100 mg dispersible and a non-dispersible 250 mg levofloxacin (LVX) tablet formulation in children.METHODSPerform was a randomised,\u0000 open-label, cross-over trial of the relative bioavailability of LVX dispersible vs. crushed non-dispersible tablets in children aged <6 years routinely receiving TB preventive treatment. Children and caregivers completed Likert- and ranking-type measures on the acceptability of both formulations.\u0000 We used summary, comparative and ranking statistics to characterise formulation acceptability.RESULTSA total of 25 children were enrolled (median age: 2.6 years, IQR 1.6–4.0). Caregivers reported frequent challenges with preventive\u0000 therapy in routine care prior to study entry, including taste of tablets (n = 14, 56%), vomiting/spitting out medicines (n = 11, 44%), and children refusing medicines (n = 10, 40%). Caregivers reported that the dispersible formulation was easier for their child to take\u0000 than the non-dispersible formulation (P = 0.0253). Mean ranks for caregiver’s formulation preferences (dispersible tablets: 1.48, SD ±0.71; non-dispersible tablets: 2.12, SD ±0.67; routinely available formulations: 2.40 SD ±0.82) differed significantly (Friedman’s\u0000 F 11.120; P < 0.0038); post-hoc testing showed dispersible tablets were preferred over non-dispersible (P = 0.018) and routinely available LVX formulations (P < 0.001).CONCLUSIONSThe dispersible LVX 100\u0000 mg tablet formulation was preferred and should be prioritised for integration into routine care.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139965832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preference for daily (1HP) vs. weekly (3HP) isoniazid-rifapentine among people living with HIV in Uganda 乌干达艾滋病毒感染者对每日（1HP）与每周（3HP）服用异烟肼-利福喷丁的偏好

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0283

A. Musinguzi, H. E. Aschmann, J. Kadota, J. Nakimuli, F. Welishe, J. Kakeeto, C. Namale, L. Akello, A. Nakitende, C. Berger, A. Katamba, J. Tumuhamye, N. Kiwanuka, D. Dowdy, A. Cattamanchi, F. Semitala

{"title":"Preference for daily (1HP) vs. weekly (3HP) isoniazid-rifapentine among people living with HIV in Uganda","authors":"A. Musinguzi, H. E. Aschmann, J. Kadota, J. Nakimuli, F. Welishe, J. Kakeeto, C. Namale, L. Akello, A. Nakitende, C. Berger, A. Katamba, J. Tumuhamye, N. Kiwanuka, D. Dowdy, A. Cattamanchi, F. Semitala","doi":"10.5588/ijtldopen.23.0283","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0283","url":null,"abstract":"BACKGROUNDBoth 1 month of daily (1HP) and 3 months of weekly (3HP) isoniazid-rifapentine are recommended as short-course regimens for TB prevention among people living with HIV (PLHIV). We aimed to assess acceptability and preferences for 1HP\u0000 vs. 3HP among PLHIV.METHODSIn a cross-sectional survey among PLHIV at an HIV clinic in Kampala, Uganda, participants were randomly assigned to a hypothetical scenario of receiving 1HP or 3HP. Participants rated their level of perceived\u0000 intention and confidence to complete treatment using a 0–10 Likert scale, and chose between 1HP and 3HP.RESULTSAmong 429 respondents (median age: 43 years, 71% female, median time on ART: 10 years), intention and confidence were rated\u0000 high for both regimens. Intention to complete treatment was rated at least 7/10 by 92% (189/206 randomized to 1HP) and 93% (207/223 randomized to 3HP). Respectively 86% (178/206) and 93% (208/223) expressed high confidence to complete treatment. Overall, 81% (348/429) preferred 3HP over 1HP.CONCLUSIONSBoth\u0000 1HP and 3HP were highly acceptable regimens, with 3HP preferred by most PLHIV. Weekly, rather than daily, dosing appears preferable to shorter duration of treatment, which should inform scale-up and further development of short-course regimens for TB prevention.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140464151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying ‘timeliness’ to the screening and prevention of TB in household contacts of pulmonary TB patients 将 "及时性 "用于肺结核患者家庭接触者的结核病筛查和预防

IJTLD OPEN Pub Date : 2024-02-01 DOI: 10.5588/ijtldopen.23.0615

A. Harries, D. Nair, P. Thekkur, R. Ananthakrishnan, R. Thiagesan, J. M. Chakaya, I. Mbithi, B. Jamil, R. Fatima, M. Khogali, R. Zachariah, S. Berger, S. Satyanarayana, A. M. V. Kumar, A. Bochner, A. McClelland

引用次数: 0

Characteristics of TPT initiation and completion among people living with HIV 艾滋病毒感染者开始和完成 TPT 的特点

IJTLD OPEN Pub Date : 2024-01-01 DOI: 10.5588/ijtldopen.23.0194

L. Gunde, A. Wang, D. Payne, S. O'Connor, A. Kabaghe, N. Kalata, A. Maida, D. Kayira, V. Buie, L. Tauzi, A. Sankhani, A. Thawani, E. Rambik, A. Ahimbisibwe, T. Maphosa, K. Kudiabor, R. Nyirenda, J. Mpunga, K. Mbendera, P. Nyasulu, F. Kayigamba, M. Farahani, A.C. Voetsch, K. Brown, A. Jahn, B. Girma, K. Mirkovic, MPHIA Survey Team

{"title":"Characteristics of TPT initiation and completion among people living with HIV","authors":"L. Gunde, A. Wang, D. Payne, S. O'Connor, A. Kabaghe, N. Kalata, A. Maida, D. Kayira, V. Buie, L. Tauzi, A. Sankhani, A. Thawani, E. Rambik, A. Ahimbisibwe, T. Maphosa, K. Kudiabor, R. Nyirenda, J. Mpunga, K. Mbendera, P. Nyasulu, F. Kayigamba, M. Farahani, A.C. Voetsch, K. Brown, A. Jahn, B. Girma, K. Mirkovic, MPHIA Survey Team","doi":"10.5588/ijtldopen.23.0194","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0194","url":null,"abstract":"BACKGROUND: TB preventive treatment (TPT) reduces morbidity and mortality among people living with HIV (PLHIV). Despite the successful scale-up of TPT in Malawi, monitoring and evaluation have been suboptimal. We utilized the Malawi Population-Based HIV Impact Assessment (MPHIA) 2020‐2021\u0000 survey data to estimate TPT uptake and completion among self-reported HIVpositive persons.METHODS: We estimated the proportion of HIV-positive respondents who had ever undergone TPT, and determined the percentage of those currently on TPT who had completed more than 6 months of treatment.\u0000 Bivariate and multivariable logistic regression were performed to calculate the odds ratios for factors associated with evertaking TPT. All variables were self-reported, and the analysis was weighted and accounted for in the survey design.RESULTS: Of the HIV+ respondents, 38.8%\u0000 (95% CI 36.4‐41.3) had ever taken TPT. The adjusted odds of ever taking TPT were 8.0 and 5.2 times as high in the Central and Southern regions, respectively, compared to the Northern region; 1.9 times higher among those in the highest wealth quintile, and 2.1 times higher for those\u0000 on antiretroviral therapy >10 years. Of those currently taking TPT, 56.2% completed >6 months of TPT.CONCLUSION: These results suggest low TPT uptake and >6 months’ completion rates among self-reported HIV+ persons. Initiatives to create demand and strengthen\u0000 adherence would improve TPT uptake.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140516875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

More is needed to end TB: commentary on the United Nations High-Level Meeting on TB 消除结核病需要更多努力：联合国结核病问题高级别会议评述

IJTLD OPEN Pub Date : 2024-01-01 DOI: 10.5588/ijtldopen.23.0576

G. B. Migliori, V. Bhatia, L. D'Ambrosio, M.C.B. Raviglione, S. Rijal

引用次数: 1

Screening of household contacts for TB infection in Cote d'Ivoire 在科特迪瓦对家庭接触者进行结核病感染筛查

IJTLD OPEN Pub Date : 2024-01-01 DOI: 10.5588/ijtldopen.23.0342

R.K. N’Guessan, D.A.B. Orsot, J. Ahui Brou, N.K. Bamba, M.E. Tchoutedjem Mefo, A.S. Bakayoko

{"title":"Screening of household contacts for TB infection in Cote d'Ivoire","authors":"R.K. N’Guessan, D.A.B. Orsot, J. Ahui Brou, N.K. Bamba, M.E. Tchoutedjem Mefo, A.S. Bakayoko","doi":"10.5588/ijtldopen.23.0342","DOIUrl":"https://doi.org/10.5588/ijtldopen.23.0342","url":null,"abstract":"SETTING: Côte d'Ivoire is a country with a high incidence of TB. The control of TB infection is focused on high-risk patients but has limited implementation.OBJECTIVE: Cost-benefit analysis of TB infection (TBI) screening of household contacts in Côte d'Ivoire to evaluate\u0000 economic implications of the implementation of interferon-gamma release assays (IGRAs) and the tuberculin skin test (TST).DESIGN: We compared the effectiveness of QuantiFERON-TB Gold Plus (QuantiFERON) with the TST using an economic model previously evaluated in medium TB incidence settings.\u0000 Principal outcomes relating to TBI screening, as well as the lifetime costs and benefits of the patient cohort, were captured using a decision tree, followed by a Markov model.RESULTS: QuantiFERON proved to be both more effective and less costly than TST. Compared to QuantiFERON, TST use\u0000 leads to an approximate 33% increase in the lifetime risk of developing active TB.CONCLUSIONS: For household contacts of active TB cases in Côte d'Ivoire, QuantiFERON is cost-effective when compared with TST. R shiny interactive interface enables model customisation for different\u0000 scenarios, settings, risk groups and TBI screening methods. Further research should be conducted in similar settings to generalise the results.","PeriodicalId":516613,"journal":{"name":"IJTLD OPEN","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140526516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1