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Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter Pylori 具有粘液穿透功能的含铜金属有机框架可多效清除粘膜定植的幽门螺旋杆菌
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0358
Chunxi Shu, Wei Zhang, Yiwei Zhang, Yu Li, Xinbo Xu, Yanan Zhou, Yue Zhang, Qin Zhong, Cong He, Yin Zhu, Xiaolei Wang
{"title":"Copper-Bearing Metal-Organic Framework with Mucus-Penetrating Function for the Multi-Effective Clearance of Mucosal Colonized Helicobacter Pylori","authors":"Chunxi Shu, Wei Zhang, Yiwei Zhang, Yu Li, Xinbo Xu, Yanan Zhou, Yue Zhang, Qin Zhong, Cong He, Yin Zhu, Xiaolei Wang","doi":"10.34133/research.0358","DOIUrl":"https://doi.org/10.34133/research.0358","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140742221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Temporal quasi-phase matching assists robust acoustic adiabatic passage 时间准相位匹配有助于稳健的声绝热通过
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0362
Klaas Bergmann
{"title":"Temporal quasi-phase matching assists robust acoustic adiabatic passage","authors":"Klaas Bergmann","doi":"10.34133/research.0362","DOIUrl":"https://doi.org/10.34133/research.0362","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions 运动与免疫疗法之间的相互影响：当前认识与未来方向
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0360
Jiwei Liu, Weici Liu, Yuan Wan, Wenjun Mao
{"title":"Crosstalk between Exercise and Immunotherapy: Current Understanding and Future Directions","authors":"Jiwei Liu, Weici Liu, Yuan Wan, Wenjun Mao","doi":"10.34133/research.0360","DOIUrl":"https://doi.org/10.34133/research.0360","url":null,"abstract":"Accumulated evidence highlights that exercise can modulate multiple cytokines, influencing transcriptional pathways, and reprogramming certain metabolic processes, ultimately promoting antitumor immunity and enhancing the efficacy of immune checkpoint inhibitors in cancer patients. Exploring the mechanisms behind this will, for one thing, help us uncover key factors and pathways in exercise-assisted cancer immunotherapy, offering more possibilities for future treatment methods. For another, it will support the development of more personalized and effective exercise prescriptions, thereby improving the prognosis of cancer patients.","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FM-FCN: a neural network with filtering modules for accurate vital signs extraction FM-FCN：用于准确提取生命体征的带过滤模块的神经网络
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0361
Fangfang Zhu, Qichao Niu, Xiang Li, Qi Zhao, Honghong Su, Jianwei Shuai
{"title":"FM-FCN: a neural network with filtering modules for accurate vital signs extraction","authors":"Fangfang Zhu, Qichao Niu, Xiang Li, Qi Zhao, Honghong Su, Jianwei Shuai","doi":"10.34133/research.0361","DOIUrl":"https://doi.org/10.34133/research.0361","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity 糖尿病通过训练免疫力促使中性粒细胞形成中性粒细胞胞外捕获器
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0365
Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, J. Bae, I. Lee, Jae-Han Jeon, Chang-Won Hong
{"title":"Diabetes Primes Neutrophils for Neutrophil Extracellular Trap Formation through Trained Immunity","authors":"Sanjeeb Shrestha, Yu-Bin Lee, Hoyul Lee, Yeon-Kyung Choi, Bo-Yoon Park, Mi-Jin Kim, Young-Jin Youn, Sun-Hwa Kim, Soo-Jung Jung, Dong-Keun Song, Hee Kyung Jin, J. Bae, I. Lee, Jae-Han Jeon, Chang-Won Hong","doi":"10.34133/research.0365","DOIUrl":"https://doi.org/10.34133/research.0365","url":null,"abstract":"Neutrophils are primed for neutrophil extracellular trap (NET) formation during diabetes, and excessive NET formation from primed neutrophils compromises wound healing in patients with diabetes. Here, we demonstrate that trained immunity mediates diabetes-induced NET priming in neutrophils. Under diabetic conditions, neutrophils exhibit robust metabolic reprogramming comprising enhanced glycolysis via the pentose phosphate pathway and fatty acid oxidation, which result in the accumulation of acetyl-coenzyme A. Adenosine 5′-triphosphate-citrate lyase-mediated accumulation of acetyl-coenzyme A and histone acetyltransferases further induce the acetylation of lysine residues on histone 3 (AcH3K9, AcH3K14, and AcH3K27) and histone 4 (AcH4K8). The pharmacological inhibition of adenosine 5′-triphosphate-citrate lyase and histone acetyltransferases completely inhibited high-glucose-induced NET priming. The trained immunity of neutrophils was further confirmed in neutrophils isolated from patients with diabetes. Our findings suggest that trained immunity mediates functional changes in neutrophils in diabetic environments, and targeting neutrophil-trained immunity may be a potential therapeutic target for controlling inflammatory complications of diabetes.","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging Janus Substrates as a Confined "Interfacial Reactor" to Synthesize Ultra-permeable Polyamide Nanofilms 利用 Janus 基质作为封闭的 "界面反应器 "合成超渗透性聚酰胺纳米薄膜
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0359
Cheng‐Ye Zhu, Hao-nan Li, Bian-Bian Guo, Yu Fang, Chang Liu, Hao-Cheng Yang, Chao Zhang, Hong-Qing Liang, Zhikun Xu
{"title":"Leveraging Janus Substrates as a Confined \"Interfacial Reactor\" to Synthesize Ultra-permeable Polyamide Nanofilms","authors":"Cheng‐Ye Zhu, Hao-nan Li, Bian-Bian Guo, Yu Fang, Chang Liu, Hao-Cheng Yang, Chao Zhang, Hong-Qing Liang, Zhikun Xu","doi":"10.34133/research.0359","DOIUrl":"https://doi.org/10.34133/research.0359","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment 口服水凝胶利用瘤内微生物组和微生物组相关免疫反应促进结直肠癌治疗
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0364
Lei Li, Shouhua He, Boyi Liao, Manchun Wang, Hui-Wei Lin, Ben Hu, Xinyue Lan, Zhilin Shu, Chao Zhang, Meng Yu, Zhaowei Zou
{"title":"Orally Administrated Hydrogel Harnessing Intratumoral Microbiome and Microbiota-Related Immune Responses for Potentiated Colorectal Cancer Treatment","authors":"Lei Li, Shouhua He, Boyi Liao, Manchun Wang, Hui-Wei Lin, Ben Hu, Xinyue Lan, Zhilin Shu, Chao Zhang, Meng Yu, Zhaowei Zou","doi":"10.34133/research.0364","DOIUrl":"https://doi.org/10.34133/research.0364","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Non-Alcoholic Steatohepatitis and Atherosclerosis in LDLR-/- Hamsters 重塑肠道微生物群可缓解 LDLR-/- 仓鼠严重的联合高脂血症诱导的非酒精性脂肪性肝炎和动脉粥样硬化
Research Pub Date : 2024-04-04 DOI: 10.34133/research.0363
X. Xian, Guolin Miao, Jiabao Guo, Pingping Lai, Wenxi Zhang, Yitong Xu, Jingxuan Chen, Lianxin Zhang, Zihao Zhou, Yufei Han, Gonglie Chen, Jinxuan Chen, Yijun Tao, Lemin Zheng, Ling Zhang, Wei Huang, Yuhui Wang
{"title":"Remodeling Intestinal Microbiota Alleviates Severe Combined Hyperlipidemia-Induced Non-Alcoholic Steatohepatitis and Atherosclerosis in LDLR-/- Hamsters","authors":"X. Xian, Guolin Miao, Jiabao Guo, Pingping Lai, Wenxi Zhang, Yitong Xu, Jingxuan Chen, Lianxin Zhang, Zihao Zhou, Yufei Han, Gonglie Chen, Jinxuan Chen, Yijun Tao, Lemin Zheng, Ling Zhang, Wei Huang, Yuhui Wang","doi":"10.34133/research.0363","DOIUrl":"https://doi.org/10.34133/research.0363","url":null,"abstract":"","PeriodicalId":516495,"journal":{"name":"Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140741268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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