CANADIAN JOURNAL OF HOSPITAL PHARMACY最新文献

{"title":"Resolving Medication Reconciliation.","authors":"Robert MacLaren","doi":"10.4212/cjhp.3324","DOIUrl":"10.4212/cjhp.3324","url":null,"abstract":"","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 3","pages":"155-156"},"PeriodicalIF":0.6,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245410/pdf/cjhp-75-155.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10485668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploration de l’association possible entre la consommation d’antibiotiques et l’émergence de résistance dans un centre hospitalier universitaire mère-enfant.","authors":"Aurélie Bleuse, Hélène Roy, Denis Lebel, Philippe Ovetchkine, Julie Blackburn, Jean-François Bussières","doi":"10.4212/cjhp.3183","DOIUrl":"10.4212/cjhp.3183","url":null,"abstract":"<p><strong>Background: </strong>The emergence of antibiotic resistance has contributed to the development of multidrug-resistant bacteria, which is a major concern.</p><p><strong>Objectives: </strong>The primary objective was to explore the possible association between antibiotic use and the emergence of resistance in a mother-child university hospital.</p><p><strong>Method: </strong>This retrospective study was conducted in a university hospital centre. Antibiotic-bacteria pairs were established, taking into account the number of isolates, actual antibiotic use, and clinical relevance. For each pair, a comparison of 2 variables (antibiotic utilization and rate of resistance) was quantified with the Pearson coefficient. Three analyses were conducted: no lag between utilization and resistance, 1-year lag, and 2-year lag.</p><p><strong>Results: </strong>Thirty antibiotic-bacteria pairs were selected from hematology-oncology and 18 from neonatology. In hematology-oncology, 6 pairs had a positive correlation (Pearson coefficient > 0.7): 2 pairs involving meropenem, 2 involving ceftazidime, and 2 involving piperacillin-tazobactam. In 3 of these cases, there was no lag between consumption of antibiotics and presence of resistance. In neonatology, 3 antibiotic-bacteria pairs had a positive correlation, 1 each involving vancomycin, cloxacillin, and meropenem.</p><p><strong>Conclusions: </strong>It is possible to explore the potential association between consumption of antibiotics and emergence of resistance in a particular centre. Our exploratory approach was based on manual data processing. It would be interesting to consider a continuous systematic approach, allowing automatic generation of correlations.</p>","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 3","pages":"201-209"},"PeriodicalIF":0.6,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245413/pdf/cjhp-75-201.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10485667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La résolution du bilan comparatif des médicaments.","authors":"Robert MacLaren","doi":"10.4212/cjhp.3327","DOIUrl":"10.4212/cjhp.3327","url":null,"abstract":"","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 3","pages":"157-158"},"PeriodicalIF":0.6,"publicationDate":"2022-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9245402/pdf/cjhp-75-157.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10490173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Effectiveness and Safety of Palbociclib plus Endocrine Therapy in Hormone Receptor-Positive, HER2-Negative Metastatic Breast Cancer: Real-World Results\".","authors":"","doi":"10.4212/cjhp.v75i2.3285","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3285","url":null,"abstract":"[This corrects the article on p. 26 in vol. 75, PMID: 34987260.].","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"128"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44396196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rhabdomyolysis Possibly Triggered by Clozapine, Paliperidone, Hyponatremia, and Rapid Correction of Hyponatremia: A Case Report.","authors":"M. Lemelin, Nicolas Gagnon, Emmanuelle Jacques, Philippe Sirois, Alexandrine Coulombe","doi":"10.4212/cjhp.v75i2.3129","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3129","url":null,"abstract":"","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"122-127"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47081172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"L'autre épidémie.","authors":"C. Chant","doi":"10.4212/cjhp.v75i2.3293","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3293","url":null,"abstract":"","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"69-70"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43134935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2022 CSHP National Awards Program Winners.","authors":"Various Authors","doi":"10.4212/cjhp.v75i2.3297","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3297","url":null,"abstract":"","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"131-132"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46360567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reasons for Low Regulatory Body Discipline Rates for Canadian Hospital Pharmacists.","authors":"Ariane Fung, Ai-Leng Foong-Reichert, S. Houle, K. Grindrod","doi":"10.4212/cjhp.v75i2.3123","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3123","url":null,"abstract":"Background\u0000Past research on disciplinary action by pharmacist regulatory bodies has shown that most cases concern community pharmacists, with few occurring in a hospital setting.\u0000\u0000\u0000Objective\u0000To investigate how discipline-related issues involving pharmacists are dealt with by hospital pharmacy departments in Canada.\u0000\u0000\u0000Methods\u0000Hospital pharmacy directors and managers from small, medium, and large hospitals across Canada were invited to participate in semi-structured telephone interviews. The interview questions focused on the discipline process in participants' organizations, the situations when reporting to the regulatory body is deemed to be warranted, possible penalties, and recommendations for improving the regulatory body or organizational discipline process.\u0000\u0000\u0000Results\u0000Ten participants, from British Columbia, Saskatchewan, Ontario, New Brunswick, Prince Edward Island, and Newfoundland and Labrador, agreed to be interviewed. Five key themes emerged as contributing to lower rates of hospital pharmacist discipline cases being escalated to the regulatory college level: robust organizational discipline processes independent from the regulatory college, a practice environment promoting competence, union representation, preference for a remedial approach to discipline, and lack of clarity about when to report to the regulatory authority.\u0000\u0000\u0000Conclusions\u0000This study identified a number of reasons why discipline of hospital pharmacists by a regulatory body may be less prevalent than discipline relating to community pharmacists. The main reasons may be lack of clarity about when to report a case to the regulator and a lack of transparency, given that many cases are handled internally within hospitals. Environmental supports for competence and employee protections (e.g., through a union) may also reduce discipline cases.","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"97-103"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45411711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ambulatory Heart Function and Transplant Patients' Perceptions of Drug-Drug Interactions: A Qualitative Study.","authors":"David Poon, M. Legal, Louise Lau, Harkaryn Bagri, K. Dahri","doi":"10.4212/cjhp.v75i2.3074","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3074","url":null,"abstract":"Background\u0000Drug-drug interactions (DDIs) can cause adverse drug events, leading to hospitalizations and an increase in the risk of morbidity and mortality. Until now, patients' perceptions of DDIs have represented an understudied area of research.\u0000\u0000\u0000Objectives\u0000To explore patients' perceptions of DDIs and identify factors important to patients' understanding of their medications.\u0000\u0000\u0000Methods\u0000Participants were recruited from 2 ambulatory clinics (heart function and transplant) in Vancouver, British Columbia. Participants engaged in key informant interviews and were asked to provide their demographic information, rate their understanding of their own medications, and define a DDI. Afterward, participants were interviewed to gather their perceptions of DDIs and factors important to their understanding of their medications.\u0000\u0000\u0000Results\u0000A total of 7 patients were recruited. Participants struggled to define a DDI and were unsure if they had ever experienced a DDI. There was a reliance on health care professionals to help manage DDIs. Participants did not identify barriers preventing them from accessing medication information from health care professionals; however, they independently sought medication information found on the internet.\u0000\u0000\u0000Conclusions\u0000Patients in this study had an incomplete understanding of DDIs and had difficulties differentiating DDIs from side effects of medications. As a result of their limited understanding of DDIs, patients relied on health care professionals to inform and manage their DDIs. Although patients did not identify barriers to accessing medication information, their pervasive use of the internet suggests that there are unidentified barriers preventing patients from speaking directly to their health care professionals regarding their medication therapy.","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"71-78"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49406162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Point Prevalence Survey of Antimicrobial Usage in New Brunswick Hospitals.","authors":"Rachel Cormier, Timothy D. MacLaggan, Daniel Landry, R. Harris, Andrew J. Flewelling","doi":"10.4212/cjhp.v75i2.3093","DOIUrl":"https://doi.org/10.4212/cjhp.v75i2.3093","url":null,"abstract":"Background\u0000Prevalence surveys are useful tools for assessing the appropriateness of antimicrobial therapy.\u0000\u0000\u0000Objectives\u0000The primary objective was to assess patterns of antimicrobial utilization and appropriateness in New Brunswick hospitals. The secondary objective was to assess the impact of hospital size and the presence of a penicillin allergy label on antimicrobial appropriateness.\u0000\u0000\u0000Methods\u0000A point prevalence survey was conducted of inpatients taking 1 or more systemic antimicrobials during admission to hospitals in New Brunswick. A structured protocol and web-based data collection tool (National Antimicrobial Prescribing Survey) were used for this survey. Data regarding hospital size and presence of a penicillin allergy label were also collected. Antimicrobial utilization was assessed in terms of guideline compliance and appropriateness. Results were summarized descriptively. A χ2 analysis was performed to describe secondary outcomes.\u0000\u0000\u0000Results\u0000Ten hospitals participated, and a total of 2200 patients were admitted at the time of the survey. The overall prevalence of antimicrobial use was 22.7% (500/2200). A total of 648 antimicrobials were ordered. The most frequently prescribed antimicrobials by class were first-generation cephalosporins (14.0%, 91/648), third-generation cephalosporins (11.3%, 73/648), and piperacillin-tazobactam (10.2%, 66/648). The most common indications for antimicrobial therapy were respiratory tract infections (27.3%, 177/648), urinary tract infections (12.2%, 79/648), and intra-abdominal infections (11.4%, 74/648). Compliance with local or regional treatment guidelines, where applicable, was 66.2% (188/284). Provincially, 68.1% (441/648) of the antimicrobial orders were deemed appropriate. Larger centres had substantially higher rates of appropriateness (p < 0.001). The presence of a penicillin allergy label had no impact on appropriateness (p = 0.21).\u0000\u0000\u0000Conclusions\u0000Several opportunities for targeted interventions were identified to improve antimicrobial prescribing, including decreasing the use of broad-spectrum antimicrobials, increasing guideline compliance, and ensuring documentation of antimicrobial duration by prescribers.","PeriodicalId":51646,"journal":{"name":"CANADIAN JOURNAL OF HOSPITAL PHARMACY","volume":"75 2 1","pages":"79-88"},"PeriodicalIF":0.9,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49453264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}