Iranian Journal of Allergy, Asthma and Immunology最新文献

Single Mutation different Clinical Findings: IGLL1 Defect 单一突变的不同临床结果：IGLL1 缺陷

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16218

Sezin Naiboğlu, Alper Gezdirici, S. Ulaş, Işılay Turan, M. H. Celiksoy, Ç. Aydoğmuş

引用次数: 0

Efficacy of Single-port Thoracoscopic Resection of Benign Lung Tumors and Its Impacts on Respiratory Function and Inflammatory Factors: A Randomized Controlled Study 单孔胸腔镜切除良性肺肿瘤的疗效及其对呼吸功能和炎症因子的影响：随机对照研究

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16214

Qiang Wang, Mao Deng, Bo Wang

{"title":"Efficacy of Single-port Thoracoscopic Resection of Benign Lung Tumors and Its Impacts on Respiratory Function and Inflammatory Factors: A Randomized Controlled Study","authors":"Qiang Wang, Mao Deng, Bo Wang","doi":"10.18502/ijaai.v23i4.16214","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16214","url":null,"abstract":"Peripheral benign lung tumors are often asymptomatic and incidentally detected on chest radiographs. Surgical intervention is recommended when feasible. Single-port thoracoscopic resection has emerged as a promising technique for treating various chest diseases, including lung tumors. This study aimed to assess the clinical efficacy of single-port thoracoscopic resection for benign lung tumors and its impact on respiratory function and inflammatory factors. \u0000A total of 128 eligible patients diagnosed with benign lung tumors were randomly assigned to either the observation group (undergoing single-port thoracoscopic resection) or the control group (undergoing conventional thoracic surgery). Surgical outcomes, complications, pulmonary and respiratory function, and inflammatory factors were compared between the two groups. \u0000The observation group showed significantly lower intraoperative bleeding, shorter hospitalization time, and lower complication rates compared to the control group. Patients in the observation group exhibited higher vital capacity (VC), forced vital capacity (FVC), and total lung capacity (TLC) levels at 1/2 week and 1 month after surgery. Additionally, forced expiratory volume in one second (FEV1) and maximum ventilation volume per minute (MVV) levels were higher in the observation group post-surgery, with a lower Borg score. Levels of C-reactive protein (CRP), precalcitonin (PCT), and tumor necrosis factor (TNF-α) were lower in the observation group post-surgery. \u0000Single-port thoracoscopic resection demonstrates favorable clinical efficacy for treating benign lung tumors, reducing bleeding, and shortening hospital stays. Furthermore, it improves lung and respiratory function while reducing inflammatory factors. This technique is safe, effective, and holds promise for wider application in managing benign lung tumors.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Bronchial Asthma with Lung Cancer: A Systematic Review and Meta-analysis 支气管哮喘与肺癌的关系：系统回顾与元分析

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16209

Zhihui Lin, Li Yuan, Cuifang Zhang, Di Gui, Hailong Wang

引用次数: 0

Mitochondrial Pathogenic Mutations and Expression Pattern of Oxidative Phosphorylation Genes in COVID-19 Patients COVID-19 患者线粒体致病基因突变和氧化磷酸化基因的表达模式

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16212

Milad Shokuhi Nia, D. Kordi-Tamandani, Mohammad Kazem Momeni, Z. Bameri

{"title":"Mitochondrial Pathogenic Mutations and Expression Pattern of Oxidative Phosphorylation Genes in COVID-19 Patients","authors":"Milad Shokuhi Nia, D. Kordi-Tamandani, Mohammad Kazem Momeni, Z. Bameri","doi":"10.18502/ijaai.v23i4.16212","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16212","url":null,"abstract":"Mitochondrial missense mutations and pathogenic variants have been implicated in the pathogenesis of COVID‐19. This study evaluated the role of mitochondrial DNA (mtDNA) mutations and changes in gene expression in the progression of COVID-19 and their correlation with clinical characteristics. \u0000Next‐generation sequencing with high throughput was used to identify mtDNA mutations in 30 COVID-19 patients compared to 20 healthy controls. The potential impact of identified mutations on protein structure and stability was predicted using bioinformatic tools. Quantitative real-time polymerase chain reaction was employed to assess the expression levels of mtDNA-encoded genes involved in oxidative phosphorylation in COVID-19 patients and healthy controls. Correlations between gene expression levels, clinical parameters, including leukocyte, lymphocyte, neutrophil, and platelet count, as well as creatinine, alanine transaminase (ALT), aspartate transaminase (AST), and blood urea nitrogen (BUN) levels, and disease severity were analyzed. \u0000We found 8 different mtDNA mutations in ND1, ND5, CO3, ATP6, and CYB genes, which were predicted to alter amino acids and decrease protein stability. Two missense unique mutations, C9555T in CO3 and A12418T in ND5 were identified and correlated with Complexes I and IV, respectively. This downregulation was correlated with age, elevated levels of leukocytes, lymphocytes, neutrophils, platelets, creatinine, ALT, AST, and BUN, as well as disease severity. \u0000These findings suggest that mtDNA mutations and altered expression of oxidative phosphorylation genes contribute to mitochondrial dysfunction in COVID-19. Targeting mitochondrial dysfunction may represent a promising therapeutic strategy for COVID-19 treatment.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration 使用多位点蛋白疫苗通过鼻内和皮下注射对 BALB/c 小鼠进行免疫接种，使其免受宋内志贺菌感染

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16215

Shabnam Akhgar, Shamsi Noorpisheh Ghadimi, Ibrahim Farhani, A. Ghasemian, Shirin Mahmoodi, Mehdi Mardkhoshnood, A. Zarenezhad

{"title":"Immunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration","authors":"Shabnam Akhgar, Shamsi Noorpisheh Ghadimi, Ibrahim Farhani, A. Ghasemian, Shirin Mahmoodi, Mehdi Mardkhoshnood, A. Zarenezhad","doi":"10.18502/ijaai.v23i4.16215","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16215","url":null,"abstract":"As the most common cause of bacillary dysentery or shigellosis, Shigella sonnei (S nonnei) has spread throughout the world. Invasion of the colorectal epithelial cells by this facultative intracellular bacterium occurs via various virulence factors. The increase in the resistance rate highlights the need for novel interventions, particularly increasing the urgency of the development of Shigella vaccines that may offer an effective solution. \u0000A multiepitope protein vaccine (MEPV) construct previously designed using bioinformatics tools against Shigella species, was applied in vivo in BALB/C mice. The designed vaccine construct was expressed in a bacterial host, purified, and finally confirmed by Western blot analysis. \u0000The immunogenicity of the purified MEPV was assessed against S sonnei via intranasal and subcutaneous administration routes, followed by evaluating its protective efficiency. We observed that interferon-gamma, interleukin-4, and immunoglobulin G levels were increased in all experimental groups. \u0000Therefore, The MEPV effectively protected the mice against S sonnei.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"9 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-standing COVID-19 Disease in Immunocompromised and Immunocompetent Patients; Case Reports and Literature Review 免疫力低下和免疫力正常患者的长期 COVID-19 疾病；病例报告和文献综述

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16219

E. Mortaz, N. Roofchayee, H. Jamaati, M. Varahram, Z. Abtahian, Babak Mansourafshar, Mahsa Rekabi, Ian M Adcock, P. Tabarsi

{"title":"Long-standing COVID-19 Disease in Immunocompromised and Immunocompetent Patients; Case Reports and Literature Review","authors":"E. Mortaz, N. Roofchayee, H. Jamaati, M. Varahram, Z. Abtahian, Babak Mansourafshar, Mahsa Rekabi, Ian M Adcock, P. Tabarsi","doi":"10.18502/ijaai.v23i4.16219","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16219","url":null,"abstract":"Patients with immunodeficiency are at higher risk of severe disease and death following SARS-CoV-2 infection compared to the general population. Here, we describe humoral and cellular immune responses in 5 patients with immunodeficiency, 2 patients with multiple sclerosis, 1 patient with chronic lymphocytic leukemia (CLL), 1 patient with Good’s syndrome, and 1Human Immunodeficiency Virus (HIV) positive with developed Acquired immunodeficiency syndrome (AIDS)- patient. \u0000T-cell responses were evaluated using the QuantiFERON SARS-CoV-2 assay following incubation with the SARS-CoV-2 Ag1, Ag2, and Ag3 viral antigens. Immunophenotyping of CD4+ and CD8+ T cells and CD19+ and CD20+ B cells was determined by flow cytometry. \u0000All studied immunocompromised patients or those with acquired immune dysregulation patients showed reduced cellular immune responses (release of interferon (IFN)-g) to SARS-CoV-2 antigens than healthy controls [patients; Ag1, Ag2 and Ag3 and Nil (Median 5-95% percentile) (12 (1-95), 12 (1.5-78), 13.5 (12-95) and 3 (1-98) U/mL)], controls; Ag1, Ag2 and Ag3 and Nil (Median 5-95% percentile) 24.5 (7-89), 65 (31-173), 53.5 (13-71.5) and 3 (1-14) U/mL)]. The frequency of peripheral blood B cells was also reduced in these patients compared to healthy control subjects. \u0000T-cell-dependent antibody responses require the activation of B cells by helper T cells. Reduced B cell numbers in immunocompromised patients infected with SARS-CoV-2 indicate the need for these patients to take additional precautions to prevent COVID-19 infection. \u0000 ","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration 使用多位点蛋白疫苗通过鼻内和皮下注射对 BALB/c 小鼠进行免疫接种，使其免受宋内志贺菌感染

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16215

Shabnam Akhgar, Shamsi Noorpisheh Ghadimi, Ibrahim Farhani, A. Ghasemian, Shirin Mahmoodi, Mehdi Mardkhoshnood, A. Zarenezhad

{"title":"Immunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration","authors":"Shabnam Akhgar, Shamsi Noorpisheh Ghadimi, Ibrahim Farhani, A. Ghasemian, Shirin Mahmoodi, Mehdi Mardkhoshnood, A. Zarenezhad","doi":"10.18502/ijaai.v23i4.16215","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16215","url":null,"abstract":"As the most common cause of bacillary dysentery or shigellosis, Shigella sonnei (S nonnei) has spread throughout the world. Invasion of the colorectal epithelial cells by this facultative intracellular bacterium occurs via various virulence factors. The increase in the resistance rate highlights the need for novel interventions, particularly increasing the urgency of the development of Shigella vaccines that may offer an effective solution. \u0000A multiepitope protein vaccine (MEPV) construct previously designed using bioinformatics tools against Shigella species, was applied in vivo in BALB/C mice. The designed vaccine construct was expressed in a bacterial host, purified, and finally confirmed by Western blot analysis. \u0000The immunogenicity of the purified MEPV was assessed against S sonnei via intranasal and subcutaneous administration routes, followed by evaluating its protective efficiency. We observed that interferon-gamma, interleukin-4, and immunoglobulin G levels were increased in all experimental groups. \u0000Therefore, The MEPV effectively protected the mice against S sonnei.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"2 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic Treatment Approach for Pulmonary Fibrosis: Prednisone and Cyclophosphamide Regulation of Circular RNA MORF4L1 and MicroRNA-29a-3p Targeting BRD4 肺纤维化的协同治疗方法：泼尼松和环磷酰胺调控环状 RNA MORF4L1 和靶向 BRD4 的 MicroRNA-29a-3p

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16217

Dan Wang, Hao Zhao, Ben Li, Feng Quan

{"title":"Synergistic Treatment Approach for Pulmonary Fibrosis: Prednisone and Cyclophosphamide Regulation of Circular RNA MORF4L1 and MicroRNA-29a-3p Targeting BRD4","authors":"Dan Wang, Hao Zhao, Ben Li, Feng Quan","doi":"10.18502/ijaai.v23i4.16217","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16217","url":null,"abstract":"This study aimed to explore the effect of prednisone (PDN) combined with cyclophosphamide (CTX) on bleomycin-induced pulmonary fibrosis (PF) in rats via circular RNA mortality factor 4 like 1 (MORF4L1)/microRNA (miR)-29a-3p/Bromodomain protein 4 (BRD4) axis. \u0000A rat model of PF was induced by bleomycin and treated with PDN combined with CTX, and the lentiviral vectors that interfered with MORF4L1, miR-29a-3p, or BRD4 expression were injected into the tail vein at the same time. The mRNA expressions of MORF4L1, miR-29a-3p, BRD4, and fibrosis-associated proteins including fibronectin, connective tissue growth factor, and collagen I were detected by real-time quantitative polymerase chain reaction. The expression level of BRD4 protein in rat lungs was detected by Western blot analysis. Lung pathology of rats was observed by hematoxylin and eosin and Masson’s trichrome staining. Apoptosis was observed by terminal deoxynucleotidyl transferase dUTP nick end labeling staining. The targeting relationship between miR-29a-3p and MORF4L1 or BRD4 was verified by the bioinformatics website and dual luciferase reporter experiment. \u0000Bleomycin-induced PF enhanced MORF4L1 and BRD4 expression, inhibited miR-29a-3p expression, injured lung tissue, increased mRNA expression of fibrosis-related markers, and induced apoptosis in the lung tissue of rats. PDN combined with CTX had a therapeutic effect on PF in rats, which was further promoted by down-regulating MORF4L1 or up-regulating miR-29a-3p. After down-regulating miR-29a-3p or up-regulating BRD4, the effect of down-regulating MORF4L1 was reversed. MORF4L1 could bind to miR-29a-3p to target BRD4. \u0000In short, PDN combined with CTX can effectively improve PF through downregulating MORF4L1 to enhance miR-29a-3p-targeted regulation of BRD4.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"4 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141919964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Mild Cases to Critical Cases of COVID-19: The Role of Genes in Inflammasome and Mitochondrial Dynamics 从 COVID-19 的轻症病例到重症病例：炎症体和线粒体动力学中基因的作用

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16213

Azam Kia, Vahideh Hajhasan, M. Nadi, Sadeq Azimzadeh Jamalkandi, Shahram Parvin, Ali Saffaie, Pedram Basirjafar, Jafar Salimian, A. Samei

{"title":"From Mild Cases to Critical Cases of COVID-19: The Role of Genes in Inflammasome and Mitochondrial Dynamics","authors":"Azam Kia, Vahideh Hajhasan, M. Nadi, Sadeq Azimzadeh Jamalkandi, Shahram Parvin, Ali Saffaie, Pedram Basirjafar, Jafar Salimian, A. Samei","doi":"10.18502/ijaai.v23i4.16213","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16213","url":null,"abstract":"The coronavirus disease 2019 (CVOID-19) has varied clinical manifestations including mild to severe acute respiratory symptoms. Inflammasome complex and mitochondria play an important role in initiating inflammatory responses and could potentially be affected by this infection. To study the inflammasome and mitochondrial fission and fusion gene expression levels in COVID-19 patients, we designed this experiment. \u0000The inflammasome and mitochondrial gene expression profiles were determined by real-time polymerase chain reaction in the peripheral blood of 70 hospitalized CVOID-19 patients with mild to moderate symptoms (HOSP) and 30 ICU patients with severe symptoms (ICU) compared to 20 healthy controls (HC). \u0000The results indicated that the expression of the dynamin-related protein-1 was extremely suppressed in HOSP while it came back to the normal range in the ICU group. However, the expression of fission 1 protein had a non-significant increase in HOSP and a decrease in the ICU group. The mitofusin-1 and dominant optic atrophy genes showed high expression levels (10-fold) and (70-fold), respectively, in the HOSP group. However, mitofusin-2 significantly decreased in both groups. Although leucine-rich–containing family, pyrin domain–containing-3 (NLRP3) and apoptosis-associated speck-like protein containing a caspase activating and recruitment domain genes dramatically increased in both groups (10 and 4-fold), other inflammasome genes declined in both groups. Finally, Nuclear factor kappa-light-chain-enhancer of activate d B cells (NF-κB) extremely decreased, and Intreleukine-1 showed high expression in ICU patients (3-fold). \u0000CVOID-19 infection suppresses the fission genes and elevates the fusion gene expression in mitochondria, and it can cause activation of the inflammasome via the NLRP3 pathway.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141920568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Efficacy of Mometasone Nasal Spray Combined with different Doses of Desloratadine, and Montelukast in Childhood Allergic Rhinitis: A Randomized Clinical Trial 莫美他松鼻腔喷雾剂联合不同剂量地氯雷他定和孟鲁司特治疗儿童过敏性鼻炎的疗效比较：随机临床试验

Iranian Journal of Allergy, Asthma and Immunology Pub Date : 2024-08-10 DOI: 10.18502/ijaai.v23i4.16211

Niloufar Ghanbari, K. Eftekhari, Mohammadreza Samadzadeh-Mamaghani, Mohsen Sedighiyan, Diana Noemi Diaz, Alireza Shafiei

{"title":"Comparative Efficacy of Mometasone Nasal Spray Combined with different Doses of Desloratadine, and Montelukast in Childhood Allergic Rhinitis: A Randomized Clinical Trial","authors":"Niloufar Ghanbari, K. Eftekhari, Mohammadreza Samadzadeh-Mamaghani, Mohsen Sedighiyan, Diana Noemi Diaz, Alireza Shafiei","doi":"10.18502/ijaai.v23i4.16211","DOIUrl":"https://doi.org/10.18502/ijaai.v23i4.16211","url":null,"abstract":"Allergic rhinitis is a common childhood disease. Although various drugs have been used to treat allergic rhinitis, including nasal corticosteroids, antileukotrienes, and antihistamines, there is still controversy about the optimal dose and the best combination with the highest efficacy. Higher doses of antihistamines are recommended for better control of urticaria, but there is insufficient evidence regarding the efficacy of increased doses of antihistamines in allergic rhinitis. The aim of the study was to evaluate the effectiveness of different drug combinations in the treatment of children with allergic rhinitis. \u0000Sixty-four children with persistent moderate to severe allergic rhinitis were enrolled and randomly divided into 4 groups. All children received mometasone furoate nasal spray once daily. In addition to mometasone, each group received one of the following drugs or drug combinations: daily desloratadine, twice daily desloratadine, montelukast, or a combination of desloratadine and montelukast. The severity of symptoms before and after the intervention was evaluated based on the total nasal symptoms score, including sneezing, nasal congestion, nasal itching, and rhinorrhea. \u0000Sixty patients completed the study. The reduction of nasal congestion score and total nasal symptoms score in the groups receiving desloratadine twice a day and desloratadine plus montelukast was superior to the daily desloratadine group and daily montelukast groups \u0000According to this work, the treatment of allergic rhinitis with mometasone nasal spray with desloratadine twice a day or with the combination of desloratadine and montelukast was more effective than other treatment regimens.","PeriodicalId":516277,"journal":{"name":"Iranian Journal of Allergy, Asthma and Immunology","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0