Journal of the Faculty of Medicine Baghdad最新文献

{"title":"Parental Knowledge, Attitudes, and Practice toward their Epileptic Children, Baghdad, Iraq 2022","authors":"Sama Al-Kaisi, Faris H. Lami, Eman Ali","doi":"10.32007/jfacmedbagdad.2112","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.2112","url":null,"abstract":"Background: Epilepsy is one of the most common neurological disorders. People who know less about epilepsy tend to have negative ideas about the disease. KAP of parents on epilepsy is crucial, especially to children below 13, as the child in this stage mostly depends on parents to get the answers to their concerns. Still, the over-protection from their families will create insecurity and reduce their self-esteem when they grow older.\u0000Objectives: To assess the knowledge, attitude, and practice (KAP) and measure their association with sociodemographic characteristics.\u0000Methods: A cross-sectional study involved 107 parents with children who were diagnosed and received treatment for epilepsy. This study was conducted in the consultation clinics in the Children Welfare Teaching Hospital, Medical City in Baghdad-Iraq, from January through July 2022. A questionnaire was developed and filled out through direct interviews with the participants. The questionnaire was composed of five parts. The first part included primary sociodemographic data. The second part concerns the particular child’s basic characteristics and epilepsy history. The third part concerns the parents' knowledge about child epilepsy. The fourth part concerns parents' attitudes toward children with epilepsy. The fifth part is concerned with the practice of parents toward child epilepsy.\u0000Results: Good knowledge, attitude, and practices were seen among 61 (57.0%), 70 (65.4%), and 90 (84.1%) parents, respectively. Good parents’ knowledge of epilepsy was significantly associated with higher education (college) and with fewer family Members (<5) (P<0.001 and P=0.0002), respectively. In addition, a good parents’ attitude towards epilepsy was significantly associated with higher education (college) (P=0.015).\u0000Conclusion: About half of the parents have good knowledge, two third have a good attitude, and most have good practices towards epilepsy.\u0000Received: April. 2023\u0000Accepted: Jul. 2023\u0000Published: Jan 2024\u0000 ","PeriodicalId":516152,"journal":{"name":"Journal of the Faculty of Medicine Baghdad","volume":"109 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Tissue Polypeptide Specific Antigen and Vascular Endothelial Growth Factor in Colorectal Cancer Patients and their Relation with P53 Expression and Global DNA Methylation","authors":"Dalya Falih, Rakad AL-Jumaily","doi":"10.32007/jfacmedbagdad.2081","DOIUrl":"https://doi.org/10.32007/jfacmedbagdad.2081","url":null,"abstract":"Background: Colorectal cancer is a high risk disease with rapidly progression medical problems and high mortality rate. Tissue polypeptide specific antigen can be classified as biomarker candidates in colorectal cancer and other kinds of cancer. Vascular endothelial-derived growth factor has a curial role in the formation of new blood vessels. DNA methylation may decrease invasiveness of cancer.\u0000Objectives: This study was designed to measure the potential role of some serological biomarkers in the progression of colorectal cancer as well as their relations to P53 expression, global 5-methylcytosine.\u0000Patients and Methods: This study involved of 60 patients with colorectal cancer who attended Oncology Teaching Hospital in Baghdad, Iraq and compared with 30 apparently healthy volunteers. All participants were checked for serological biomarker levels using an enzyme-linked immunosorbent assay. Also, DNA and RNA extracted and the levels of 5-methylcytosine and P53 expression were evaluated. The SPSS version 24.0 program was used for all statistical analysis done in this study.\u0000Results: The analysis of serological biomarker data has shown that the mean of tissue polypeptide specific antigen and vascular endothelial growth factor was significantly higher for patients with colorectal cancer, while it was lower for control subjects (356.4 ± 16.9, 139.75 ± 7.31) and (1127.82±65.41, 388.93±35.86), respectively. Also, a significant positive relation between tissue polypeptide specific antigen and vascular endothelial growth factor in the tumor area was significantly associated with control (P≤ 0.001). However, there was significant correlation in the levels of P53 expression and global DNA methylation between studied groups as well as tissue polypeptide specific antigen and vascular endothelial growth factor (P ≥ 0.05).\u0000Conclusion: The serological biomarkers include tissue polypeptide specific antigen and vascular endothelial growth factor and they play a critical role in the development of colorectal cancer. Serum vascular endothelial growth factor is useful in distinguishing colorectal cancer from healthy controls, whereas tissue polypeptide specific antigen is an independent prognostic factor for colorectal cancer proliferation.\u0000Received: Mar. 2023\u0000Accepted: Jun 2023\u0000Published: Oct.2023\u0000 ","PeriodicalId":516152,"journal":{"name":"Journal of the Faculty of Medicine Baghdad","volume":"17 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}