Bangladesh Journal of Medicine最新文献

{"title":"Non-mycobacterial CNS infection: Approach to diagnosis","authors":"Ahmed Hossain Chowdhury","doi":"10.3329/bjm.v35i20.73396","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73396","url":null,"abstract":"Non-mycobacterial CNS infection includes some viral, pyogenic, fungal and parasitic infections in the CNS. Recently, we encountered the COVID-19 pandemic and the outbreak of dengue fever in Bangladesh. Both of the diseases had several central nervous system (CNS) manifestations. In the post-COVID period we are encountering increasing deep fungal infections. In the case of Dengue, most patients presented with headache, disorientation, convulsion, and vomiting. The clinical diagnosis was aseptic meningitis, dengue encephalitis, cerebellitis with opsoclonus, and dengue-associated vasculitis.\u0000The imaging findings by MRI & CT Scan included leptomeningeal enhancement, hemorrhagic encephalitis, necrotizing encephalitis, multiple small infarcts, and diffuse white matter demyelination. In the case of COVID-19, it mainly presented with headaches, unconsciousness, convulsions, and changes in cognition. Clinical diagnoses were hypoxic encephalopathy, aseptic meningitis, encephalitis, ADEM, Brainstem encephalitis, and acute transverse myelitis. Imaging findings included features of hypoxic encephalopathy, focal CNS demyelination, diffuse white matter change.  We had seen typical features of Herpes simplex encephalitis (also included hemorrhagic encephalitis), Japanese B encephalitis, Nipah encephalitis and mumps encephalitis, pyogenic meningitis, brain abscess, deep fungal infections and Hydatid cyst.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 138","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"62 s283","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Expanded Therapeutic Landscape of SGLT2 Inhibitors: Beyond Diabetes Management","authors":"Jugal Kishor Sharma","doi":"10.3329/bjm.v35i20.73403","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73403","url":null,"abstract":"Sodium-glucose Co transporter 2 inhibitors (SGLT2i) have traditionally been synonymous with their pivotal role in managing diabetes mellitus. However, recent research has unearthed a myriad of novel applications for these agents beyond their antihyperglycemic effects. This abstract delves into the expanding therapeutic horizon of SGLT2 inhibitors, elucidating their diverse pharmacological actions and emerging clinical applications.SGLT2 inhibitors primarily exert their effects by blocking renal glucose reabsorption, leading to glycosuria and subsequent glucose lowering. Beyond glycaemic control, these agents demonstrate multifaceted actions, including natriuresis, blood pressure reduction, and weight loss. Moreover, SGLT2 inhibitors have shown promising effects on mitigating cardiovascular and renal complications in patients with or without diabetes, attributed to their pleiotropic cardiovascular benefits. Beyond diabetes management, SGLT2 inhibitors have garnered attention for their potential in treating heart failure (HF) and chronic kidney disease (CKD). Clinical trials have showcased the remarkable efficacy of SGLT2 inhibitors in reducing HF hospitalizations and ameliorating renal function decline, irrespective of diabetes status. These findings have prompted guideline revisions, endorsing the use of SGLT2 inhibitors in HF and CKD management, ushering in a new era of personalized medicine. While generally well-tolerated, SGLT2 inhibitors are associated with unique adverse effects, including genitourinary infections and euglycemic diabetic ketoacidosis (DKA). Heightened awareness and vigilant monitoring are imperative to mitigate these risks, especially in vulnerable populations such as the elderly and those with impaired renal function. In conclusion, SGLT2 inhibitors transcend their traditional role in diabetes management, offering a paradigm shift in cardiovascular and renal disease therapeutics. Their pleiotropic benefits, encompassing glycemic control, cardiovascular protection, and renal preservation, underscore their versatility in addressing multifaceted disease processes. As ongoing research continues to unravel additional therapeutic avenues, SGLT2 inhibitors stand poised as a cornerstone in the holistic management of cardiometabolic disorders, heralding a new era of patient-centered care.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 143","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"327 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141380983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irritable Bowel Syndrome among Street Vendors in Bangladesh","authors":"Faridul Haque, H. Aftab","doi":"10.3329/bjm.v35i20.73452","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73452","url":null,"abstract":"Background: Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder with 8.5% prevalence rate in Bangladesh. The objectives of this study were to assess the prevalence of IBS and to determine the subtypes of IBS among street vendors in Bangladesh. Methods: This observational cross-sectional study was conducted among various street vendors in Dhaka South City Corporation (DSCC) from March 2022 to August 2023. Initially 156 vendors were approached. Among them 133 were responders and 23 were non responders. Following exclusion criteria, 115 were interviewed face to face. The diagnosis and sub typing of IBS was done following Rome IV criteria and Bristol Stool Form Scale. Results: Among 115 study participants 95 were male and 20 were female. Eighty percent of them was fruit seller. The mean age of the study participants was 38.54 ± 13.03 years. Among them, 101 were Non-IBS and 14 were IBS . The overall prevalence of IBS was 12.17%. Majority of the participants(14.3%) was in the 35-50 years age group. Among 14 IBS participants, 8 had constipation predominant (IBS-C), 2 had diarrhea predominant (IBS- D) and 4 had mixed type IBS (IBS-M). There was no unclassified IBS (IBS-U) subject was found .There was significant difference in bowel frequency and physician consultation pattern. Conclusion: Prevalence of IBS among street vendors in Bangladesh was 12.7% with constipation predominant (IBS-C).\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 170-171","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An approach to a child with arthritis.","authors":"M. K. Talukder","doi":"10.3329/bjm.v35i20.73400","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73400","url":null,"abstract":"Musculoskeletal and joint diseases appear to be increasing and continue to be a growing childhood health problem. Confusion over terminology and a lack of awareness of these conditions have probably contributed to their under-recognition. Musculoskeletal pain in children are common, affecting about 10-20 % of school children.2 Various local and systemic, acute and chronic, benign and malignant conditions are associated with musculoskeletal pain (Table-I). A correct diagnosis is essential for appropriate management. It is important to remember that all the limb and joint pains are not arthritis and all arthritis are not painful. A child presenting with arthritis is always a diagnostic challenge even for the most experienced clinicians. \u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 145-146","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"5 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case Report on Laryngeal histoplasmosis masquerading as Tuberculosis","authors":"Naznin Naher","doi":"10.3329/bjm.v35i20.73461","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73461","url":null,"abstract":"Immunocompromised patients typically develop laryngeal histoplasmosis as a result of the fungus spreading from the lungs to other organs. Primary isolated laryngeal histoplasmosis is uncommon. We reported a unique case of laryngeal histoplasmosis in a 25-year-old male who initially had a preliminary diagnosis of tuberculosis. A 25-year-old man complained of dysphagia and increasing hoarseness of voice for three months when he first came into the medical department. He has also had a cough and intermittent fever for 1 month. Bilateral post-TB fibrosis with bronchiectasis, a consequence of pulmonary tuberculosis infection, was the patient’s previous diagnosis. In addition to that, he is also receiving treatment for his chronic calcific pancreatitis with pancreatic enzyme supplements and dietary modifications. During physical examination, the patient showed mild anemia, no cervical lymphadenopathy or thyromegaly, and bronchiectasis features identified by lung auscultation findings. We thus reached a working diagnosis of disseminated tuberculosis including the larynx and lungs. The results of the blood profile showed normocytic normochromic anemia, low Hb, and high ESR. Fungal stain, gene X-pert for MTB/PCR, and microscopic analysis of the sputum were all normal, and the sputum C/S was consistent with the growth of normal flora. Vocal cords were normal, and fiber optic laryngoscopy revealed a swollen arytenoid region and granulo-nodularity in the posterior larynx. Under gross examination, the biopsy sample was found to consist of irregular grayish-white soft tissue fragments. Histology revealed granulation tissue, which was heavily infiltrated with acute and chronic inflammatory cells, as well as a small number of multinucleated giant cells. Furthermore, we used GMS and Pas staining to look for fungus, and the results showed round to oval yeast that was consistent with histoplasmosis. The fungus Histoplasmacapsulatum, which is a dimorphic fungus causes histoplasmosis, one of the most common causes of chronic granulomatous diseases.In North America, histoplasmosis is the most prevalent type of endemic mycosis. A portion of Africa, Australia, and Eastern Asia, especially India and Malaysia, are among the other endemic areas. Pharyngeal and laryngeal infections caused by Histoplasmacapsulatum are an uncommon manifestation that usually refers to the mucocutaneous type of chronic disseminated dissemination. The first signs and symptoms typically include fatigue malaise, loss of weight, hoarseness of voice, dysphagia, and odynophagia. Being a rare occurrence, laryngeal histoplasmosis is frequently misdiagnosed, which can have disastrous consequences for the patient. Diagnosis difficulties are probably one of the explanations for the small number of documented cases. When a patient exhibits symptoms of granulomatous inflammation or laryngeal masses, the physician should be aware of the possibility of laryngeal histoplasmosis and take it into consideration w","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"18 16","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141378897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methanol-induced bilateral optic neuropathy: an ever-present challenge to healthcare system","authors":"Md Intisar Kamal Sadat, L. Nizhu, Ahmad Mursel Anam","doi":"10.3329/bjm.v35i20.73473","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73473","url":null,"abstract":"Methanol is a highly toxic alcohol that can cause severe metabolic acidosis, leading to acute multiple organ failures and even blindness. Despite being a serious health concern, methanol poisoning remains a challenging issue due to the lack of acute medicine setup, available resources, and management protocols. Immediate multidisciplinary assessment and intervention are necessary for the management and survival of the patient. In this study, we present a case of a 27-year-old female who presented to the Department of Acute Medicine and High Dependency Unit with complaints of nausea, vomiting, and altered level of consciousness. She had consumed a significant amount of alcohol 12 hours before admission. Laboratory results revealed severe high anion gap metabolic acidosis that was not corrected by sodium bicarbonate and adequate fluid resuscitation. Her acidosis persisted, and after a session of Sustained Low-Efficiency Dialysis (SLED), metabolic acidosis was corrected. However, she developed sudden vision loss after 48 hours. A complete ophthalmic assessment was performed, and a referral was made to a neurologist for multidisciplinary management. On ophthalmo-logical evaluation, both pupils were dilated with absent pupillary response, visual acuity was reduced to hand motion. Brain magnetic resonance imaging showed acute methanol toxicity with hemorrhagic necrosis in the basal ganglia. Despite undergoing therapy, methanol-induced optic neuropathy continues to pose a significant healthcare challenge. It is a severe complication that can occur even after metabolic acidosis has been corrected. Therefore, early detection and timely treatment are crucial to prevent long-term health consequences.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 178-179","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"4 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141379622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dementia: Guide to diagnosis and management.","authors":"Maliha Hakim","doi":"10.3329/bjm.v35i20.73380","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73380","url":null,"abstract":"Dementia, now better known as neurocognitive disorder is an acquired condition characterized by substantial decline in any of the cognitive domains from previous level of function, severe enough to deteriorate activities of daily living. Currently, more than 55 million people are living with dementia, which is estimated to reach 152 million by 2050 (WHO, 2020). Death from dementia related diseases has also increased more than 2 times in last two decades (GBD, 2017). A national survey done in NINS and ICDDR,B in 2019 among persons aged more than 60 years, which reveals overall prevalence of dementia is 8.1%, burden is higher in northern region of the country, females are 2.7 times more affected than man and among many risk factors, depression and hypertension comprise the major part. Evaluation of dementia includes clinical assessment by history and examination, cognitive assessment tool (MMSE or MoCA) and investigation by routine biochemical tests to exclude potentially reversible causes and dementia mimics.  Among Irreversible causes, Alzheimer’s disease (AD) dementia is the most important and common cause (60-70%). Patients with AD typically presents with progressive amnestic features with subsequent appearance of other cognitive, behavioral and neuropsychiatric changes that impair social function. Mild cognitive impairment (MCI) is an in-between state of normal ageing and dementia but does not significantly disrupt daily activities. It can progress to dementia. Newer biomarkers include CSF Aβ42 level, pTau217, amyloid PET, Tau PET and FDG PET. Declining CSF Aβ42 level and increasing plasma Tau 217 starts to occur about 20 years prior to symptom onset of dementia. So early detection is very crucial because, early treatment can halt the process by 3 years. MRI has become one of the most important tools not only in diagnosis but also in monitoring therapeutic response of patients with dementia. Semiquantitative scales- Medial Temporal Atrophy (MTA) scale & parietal lobe atrophy (Koedam scale) for  AD, Fazeka scale for vascular dementia, Global cortical atrophy (GCA) scale have been quite useful in assessment of structural MRI. Nevertheless, for even greater precision other biomarkers need to be complemented along with MRI. The aim of treatment is to delay the progression of AD. Introduction of newer treatment by disease modifying drug/ monoclonal antibody (adecunamab and lecanenam), along with control of risk factors and symptomatic treatment (anti cholinesterase and NMDA receptor antagonist) at early stage are very crucial to delay the progression of AD.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 138-139","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"100 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keto Diet: Where Do We Stand Today?","authors":"Saifuddin M","doi":"10.3329/bjm.v35i20.73339","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73339","url":null,"abstract":"Ketogenic diet seems like the latest weight-loss craze, but it’s been around for nearly a century. Developed in 1920s, this ultra-low-carb, high-fat diet was originally used to treat seizures in people with epilepsy but grab attention and popular among young generation and Diabetic patients for rapid weight reduction and hope to get numerous health benefits against Diabetes, Cancer, certain neurological disorders including Alzheimer's disease. Diabetic patients are following the diet as some people claim that reversal to non-Diabetic state and controlling Diabetes without any medication is also possible with this diet. Ketogenic diet involves drastically reducing carbohydrate intake and replacing it with fat aiming to force the body into metabolizing fat instead of carbohydrates. Burning fat seems like an ideal way to lose weight and reduce appetite. The classic Ketogenic diet is not a balanced diet and has numerous risks. Ketogenic diet is high in saturated fat with link to atherosclerosis and heart disease. There is risk of Diabetic ketoacidosis due to discontinuation of Anti Diabetic medication or patients on SGLT2 inhibitor. Other potential risks include nutrient deficiency, deterioration of existing liver disease, renal problems due to protein overload and increased risk of osteoporosis. Available research on the Ketogenic diet for weight loss is still limited with a small number of participants for a limited period and without control groups. So long term outcome of Ketogenic diet is uncertain as very low carb diet is difficult to sustain with numerous risk and possibility of weight gain after giving up of Ketogenic diet.\u0000Bangladesh J Medicine, 2024; Vol. 35, No. 2, Supplementation: 148-149","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"141 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case of Antiphospholipid Syndrome in a 28-year-old Male with Discoid Lupus Erythematosus","authors":"Farzana Islam, Mohammad Rasel, Susmita Ghose, Sujan Kumar Das, Mohammad Zaid Hossain, Mostafa Kamal Rouf","doi":"10.3329/bjm.v35i20.73475","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73475","url":null,"abstract":"Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by thromboembolic events associated with antiphospholipid antibodies. While thrombosis is the most well-known pathogenic mechanism in this disorder, the relevance of some other mechanisms such as arterial stenosis is being increasingly recognized. The underlying patho-physiology of stenotic arterial vasculopathy is not fully understood but some recent studies revealed APS presenting with new insights into the molecular mechanism behind this endothelial cell activation in APS. We present a case of a 28-year-old male who presented with painful digital ischemia and generalized hyperpigmented papulo-necrotic cutaneous lesions. The presence of lupus anticoagulant (LA) antibody and skin biopsy consistent with DLE, confirmed the diagnosis of APS secondary to DLE. And the CT angiogram showed stenosis of radial and ulnar arteries and no evidence of thrombosis.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 179-180","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"92 s388","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141377280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Serum Ferritin Level in the Diagnosis of Non-Alcoholic Fatty Liver Disease (NAFLD)","authors":"M. G. Azam, Ali Arbab Chowdhury, S. M. Sajjad, I. K. Datta, Md Anisur Rahman, A. Rowshon","doi":"10.3329/bjm.v35i20.73426","DOIUrl":"https://doi.org/10.3329/bjm.v35i20.73426","url":null,"abstract":"Background: Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive liver fat accumulation and is a major cause of progressive liver disease. Serum ferritin is a biochemical parameter which is elevated in several clinical conditions including both acute and chronic liver diseases. It may indicate hepatic inflammation, necrosis and fibrosis progression in NAFLD due to its association with iron buildup and inflammation. The aim of the study is to assess the role of serum ferritin as an effective marker in the diagnosis of NAFLD. Methods: This cross sectional study was conducted at Bangladesh Institute of Research and Rehabilitation in Diabetes, Endocrine and Metabolic disorders (BIRDEM) General Hospital, Dhaka on patients attending department of Gastrointestinal, Hepatobiliary and Pancreatic Disorders (GHPD). Purposive sampling technique was applied to enroll the subjects according to selection criteria. Statistical significance was set at 0.05 level and confidence interval at 95% level. Results: This study included 206 patients. They were divided into two groups on the basis of ultrasonogram of abdomen. Among them 136 patients had NAFLD (Group-A) and 70 patients had normal liver (Group-B). Serum ferritin level was measured in all patients. The mean±SD of serum ferritin was significantly higher among Group-A (326.88±203.94) than Group-B (57.23±14.55) (p <0.001). ROC analysis for serum ferritin level yielded an AUC of 0.993. Sensitivity, specificity, PPV, NPV and accuracy at cut off value 77 ng/ml were 94%, 97%, 94%, 97%, 96%; at 78.5 ng/ml were 95%, 97%, 94%, 97%, 96%; at 81.5 ng/ml were 98%, 95%, 92%, 99%, 97%; at 82.6 ng/ml were 94%, 98%, 99%, 89%, 95% and at 86 ng/ml were 92%, 98%, 90%, 92% and 90% respectively. The cut-off value of serum ferritin e”81.50 ng/ml showed the highest accuracy. Conclusion: The findings of this study suggest serum ferritin is an important biochemical test of NAFLD.\u0000Bangladesh J Medicine 2024; Vol. 35, No. 2, Supplementation: 156-157","PeriodicalId":516125,"journal":{"name":"Bangladesh Journal of Medicine","volume":"62 s231","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141376490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}