Medical Journal of Tabriz University of Medical Sciences最新文献

{"title":"Hsa-Mir-1 and Hsa-Mir-1229 expression levels in recurrent miscarriage patients before and after lymphocyte therapy in comparison to control groups","authors":"M. Raeisi, Mehdi Yousefi, Javad Ahmadian Haris, Shahla Danaii, Mohammad Tofighifard, Pouya Bahlouli, L. Aghebati-Maleki","doi":"10.34172/mj.2024.010","DOIUrl":"https://doi.org/10.34172/mj.2024.010","url":null,"abstract":"Background. Recurrent pregnancy loss is defined as at least two consecutive clinical pregnancy losses before 20th week of gestation. In this study, we investigated microRNA-1 and microRNA-1229 in recurrent miscarriage patients before and after lymphocyte therapy in comparison to control group. Methods. First, a written and informed consent will be obtained from the target population of this study, who are people with RPL referring to Waliasr International Hospital. According to the standard protocol, the number of 2×107 is injected subcutaneously to patients. Real-time PCR technique will be used to check the expression level of microRNA-1 and microRNA-1229. Results. The gene expression level of micro-RNA 1 in RPL women before of lymphocyte therapy was 2.030±1.445 and the gene expression level of the same micro-RNA after the lymphocyte therapy of the mother was 1.101±0.4780. Also, the expression level of micro-RNA 1229 in these women was reported to be 2.100±0.6296 before treatment and 1.247±0.9631 after treatment with lymphocytes. This level of gene expression in control group, for micro-RNA 1 and micro-RNA 1229 genes is 1.000±0.08334 and 1.000±0.08091, respectively. Conclusion. The results of our study showed a noticeable decrease in the gene expression of microRNAs under study, both microRNAs 1 and 1229, in women with a history of three consecutive injections of the father's subcutaneous lymphocytes. Practical Implications. This study can show the therapeutic effect of lymphocyte for patients with recurrent miscarriage so that this treatment can be used along with other treatment methods.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"176 s418","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140428772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical findings of patients with Kawasaki disease manifestations in COVID-19 pandemic in Tabriz, Iran","authors":"Golnaz Mobayen, Azar Dastranji, Mahnaz Sadeghi shabestari","doi":"10.34172/mj.2024.015","DOIUrl":"https://doi.org/10.34172/mj.2024.015","url":null,"abstract":"Background. Kawasaki disease is an acute and rare febrile disease that affects children and is characterized by conjunctivitis, redness of the lips and mouth, diffuse skin lesions, edema and redness of the hands and feet, and cervical lymphadenopathy. Since the start of the COVID-19 pandemic, Kawasaki disease has become much more prevalent and has more diverse manifestations. Methods. This retrospective cohort study included patients diagnosed with Kawasaki symptoms between January and October 2021 at the Tabriz Children's Education and Therapeutic Center. The diagnosis was made using the guidelines of the American Heart Association (2017) and the American College of Rheumatology. Results. All referred patients had fever, and additional symptoms may include skin involvement (93%), mucosal involvement (87%), end changes in the peripheral exterimities in the form of erythema and scaling (75%), gastrointestinal manifestations (51%), cardiac manifestations (42%), followed by respiratory (27%), and finally cervical lymphadenopathy (18%). Conclusion. Manifestations of Kawasaki disease during the COVID-19 pandemic can be much more diverse and severe. Knowing the variety of clinical symptoms and uncommon findings of Kawasaki disease in these patients can help to early distinguishing between Kawasaki and Kawasaki like disease and prevent the progression of the disease. Practical Implications. It was noteworthy that patients with complete Kawasaki manifestations were less than five years old. The age range of the patients was between 11 months and 13 years, and the average age range was between 5 and 6 years (65±37 months).","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"38 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140452823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extracting brain behavior change in patients with migraine by quantitative analysis of electroencephalogram signal of patients compared to healthy people","authors":"Yashar Sarbaz, Farnaz Garehdaghi, Saeed Meshgini","doi":"10.34172/mj.2024.013","DOIUrl":"https://doi.org/10.34172/mj.2024.013","url":null,"abstract":"Background. Migraine disease is the second most common cause of headaches. Despite the high prevalence, the exact etiology of migraine is yet unknown. In this study, to evaluate the behavior change of electroencephalography (EEG) signals in migraine patients, various features of the EEG signals of migraine patients and healthy controls (HCs) were extracted and compared. Methods. This cross-sectional analytical study was conducted on 21 HCs and 18 migraine patients. Various features, such as fractal dimension (FD), approximate entropy (ApEn), and largest Lyapunov exponent (LLE), were calculated from the EEG signals of migraine patients and HCs. Then different frequency sub-bands of delta, theta, alpha, beta, and gamma were extracted using the wavelet transform, and the energy of these sub-bands was computed. By calculating the mean and variance of the features and applying statistical tests, the feature changes were compared between two groups, and channels with significant differences were identified. Results. The mean of ApEn, FD and energy of all frequency sub-bands in most of the analyzed channels was higher in migraine patients than in HCs. The mean LLE was mostly lower in migraine patients than in healthy controls. According to the statistical tests, the energy of theta and delta frequency sub-bands with 36 and 35 channels was the feature with the highest number of channels, with a significant difference. In this study, P values less than 0.05 were considered statistically significant. Conclusion. Migraine patients may have a less sophisticated brain dynamic system due to an increase in irregularity and randomness, as indicated by an increase in ApEn and a decrease in FD in their EEG signals compared to HCs. Anxiety, tension, and other intense sentiments and emotions, as well as the creation of new neural circuits in the brain, can all contribute to an overall increase in energy across all frequency sub-bands in migraine patients. Practical Implications. Considering the EEG signal behavior as the response of a dynamic system, we can say that the brain function of migraine patients, even in the inter-ictal phase, leaves the definite chaotic state, which is a healthy brain behavior, and enters the random state.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"230 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychopathology of latent toxoplasmosis in infected individuals: roles of age, duration of infection, and sex","authors":"Abbas Rahiminezhad, Ashkan Latifi, Reza Rostami, H. Farahani","doi":"10.34172/mj.2024.014","DOIUrl":"https://doi.org/10.34172/mj.2024.014","url":null,"abstract":"Background. The present study examined the relationship between latent toxoplasmosis and mental disorders. Methods. The sample included 117 toxoplasma-positive volunteers on Facebook, Twitter, and Instagram. Data were collected online using the 71-item abbreviated form of the Minnesota Multiphasic Personality Inventory (MMPI). Results. According to the results, a) the psychological profile of latent toxoplasmosis patients in the eight clinical scales of MMPI was within the normal range; b) in the male group, ‘duration of infection’ significantly predicted the scores for the four clinical scales of depression, psychopathic deviate, psychasthenia, and schizophrenia; also, ‘age’ predicted the scores for hypochondriasis and schizophrenia in men; c) in the female group, only ‘age’ was able to predict the scores for the scales of hysteria, paranoia, mental weakness, and social deviance; and d) there was no significant difference between male and female groups in any of the clinical scales. Conclusion. Duration of infection with latent toxoplasmosis was associated with depression, psychopathtic deviation, psychasthenia, and schizophrenia in infected males, but this was not the case for the infected females in any of the clinical scales of the 71-item abbreviated form of MMPI. Practical Implications. In mental health screening of individuals with latent toxoplasmosis, males should be screened on the scales of depression, psychopathtic deviation, psychasthenia, and schizophrenia according to the increase in the duration of infection.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"93 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140461691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory effect of swimming exercise and genistein in combination in the pancreas of ovariectomized diabetic rats","authors":"Balal Khalilzadeh, Mohammad Zayer, Hadi Yousefi","doi":"10.34172/mj.2024.012","DOIUrl":"https://doi.org/10.34172/mj.2024.012","url":null,"abstract":"Background. Menopause is associated with an increase in blood sugar and an increase in inflammatory cytokines. Exercise and genistein have biological activities, including anti-inflammatory and antidiabetic activity. This study examined the combined effects of regular swimming exercise and genistein as a preventive strategy against inflammation and pancreatic cell damage in ovariectomized diabetic rats. Methods. A total of 42 female Wistar rats were divided into six groups: Sham, ovariectomy (OVX), diabetic ovariectomy (OVX.D), diabetic ovariectomy + exercise (OVX.D.E), diabetic ovariectomy + genistein (OVX.D.G), and diabetic ovariectomy + exercise + genistein (OVX.D.E.G). Animals underwent swimming training or received genistein or a combination of both for eight weeks. At the end of this period, the levels of TNF-α, Nf-κB, IL-1β, and SIRT1 proteins were evaluated using western blot in pancreatic tissue. Results. Ovariectomy increased the expression of TNF-α, Nf-κB, and IL-1β and decreased the expression of SIRT1, and these effects were more significant in ovariectomized diabetic rats. Treatment with genistein and swimming exercise individually reversed these changes in the level of proteins and improved the inflammation, but the combined effect of these two interventions exhibited more effect. Conclusion. The combination of genistein and regular swimming exercise provides enhanced protection for pancreatic tissue and effectively prevents damage to it. Therefore, performing appropriate physical activities and consuming compounds containing phytoestrogens can prevent the occurrence of disorders such as diabetes during menopause. Practical Implications. The results of this study can guide health policymakers to prevent disorders and complications caused by menopause.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"33 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of mindfulness on rumination and cognitive regulation of emotion in students with depressive symptoms","authors":"Ezatolah Ahmadi, Hossein Rostami, Zahra Javani","doi":"10.34172/mj.2024.016","DOIUrl":"https://doi.org/10.34172/mj.2024.016","url":null,"abstract":"Background. Having problems in regulating the emotions is considered as the main core of depression disorder and rumination is one of the cognitive components in individuals with depression disorder. The objective of this study was to consider the effect of mindfulness training on rumination and cognitive regulation of emotion in students with depressive symptoms. Methods. This study was a semi-experimental method with a pre-test-post-test design with a control group. The statistical population included all 350 students of the Faculty of Nursing of Tabriz University of Medical Sciences in 2023-2022, among whom the Beck Depression Questionnaire was administered. Among them, 30 students with symptoms of depression (15 as experimental and 15 as control) were selected by purposive sampling method. The emotion regulation scale and rumination questionnaire were used to collect data. Results. The findings showed a significant difference between the experimental and control groups in terms of rumination and cognitive regulation of emotion (P<0.001). The mean of rumination in the experimental group was significantly reduced compared to the pre-test and the control group, and the mean of the cognitive regulation of emotion was significantly increased. Conclusion. The results of the research showed that mindfulness training has an effect on rumination and cognitive regulation of emotion in students with depressive symptoms. Practical Implications. The results of the present study can be used to prevent and treat people with symptoms of depression, especially students.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"37 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140462234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Ccomparison of the content of prenatal care during the CovidCOVID-19 pandemic with the same time last yearone year before the pandemic in Qazvin, Iran: a cross-sectional study","authors":"Zinat Jourabchi, Z. Hosseinkhani, Zainab Alimoradi, Yeganeh Chavoshi","doi":"10.34172/mj.2024.018","DOIUrl":"https://doi.org/10.34172/mj.2024.018","url":null,"abstract":"Background. Since prenatal care may have been affected during the covidCOVID-19 pandemic, this study aimed to compare the content of prenatal care during the COVIDcovid-19 pandemic with the same time lastone year before the pandemic year in Qazvin , Irancity. Methods. This cross-sectional-analytical study was conductedincluded in 2018 and 2019 for 722 pregnant mothers (361 before and 361 during the COVIDcovid-19 pandemic) referring to Qazvin health centers in 2018 and 2019. The checklist \"Evaluation of Care during Pregnancy\" checklist was used to collect information. The information was extracted from the Integrated Health System (known as SIB)Sib system, reporting offices of health centers. SPSS version 25 software was used to analyze the data. Results. The results showed a decrease in the number of prenatal care in all care times during the COVIDcovid-19 pandemic compared to the pre-pandemic period (P<0.001). The rate of preterm pregnancies increased during the pandemic period (P<0.001). Performing the first round of screening, the first and second rounds of ultrasound and the second round of laboratory tests, respectively decreased by 23.8%percent, 11.1%percent, 13.3% percent (P<0.001), and 7% percent (P=0.004) in the pandemic period (P<0.001). The follow-up rate of referrals also decreased during the pandemic period (P<0.001). Conclusion. The results showed a decrease in the number and content of prenatal care during the COVIDcovid-19 pandemic. Practical Implications. The number and content of prenatal care during the COVIDCovid-19 crisis decreased in this study.Therefore, effective measures should be planned for this reduction and its effects. There is also a need to provide necessary training and preparations to the providers of prenatal care in critical times.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"301 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140474140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the effects of permanent subcutaneous insulin infusion versus multiple daily insulin injections on glycated hemoglobin (HbA1c) levels in patients with type 2 diabetes: a systematic review and meta-analysis based on clinical trials","authors":"Abdollah Mohammadian Hafshejani, S. Kheiri, Zahra Karimi","doi":"10.34172/mj.2024.009","DOIUrl":"https://doi.org/10.34172/mj.2024.009","url":null,"abstract":"Background. Diabetes is one of the most common chronic and metabolic diseases. This systematic review and meta-analysis study aimed to compare the effects of multiple daily insulin injections against permanent subcutaneous insulin injections on glycated hemoglobin (HbA1c) levels in type 2 diabetic patients. Methods. Studies that compared the impacts of multiple daily insulin injections against permanent subcutaneous insulin injections on HbA1c levels and were published until the end of 2022 in international databases were searched and retrieved (nine randomized clinical trial studies). The Chi-squared test and I2 were used to determine the presence and size of heterogeneity. Results. The results of the analysis demonstrated that compared to the group of multiple daily insulin injections, HbA1c was significantly reduced in the group of permanent subcutaneous insulin injections, so that the standardized mean difference was equal to -0.26 (95% confidence interval: -0.46– -0.06 P=0.025). According to the results of Egger’s (P=0.333) and Begg’s (P=0.667) tests, publication bias was not observed in this study. Conclusion. Based on the available evidence, permanent subcutaneous injection of insulin could be significantly successful in reducing and controlling the level of HbA1c because the patients in the permanent subcutaneous injection group had lower levels of HbA1c. Practical Implications. In patients with type 2 diabetes, insulin treatment with the permanent subcutaneous injection method can better control the level of HbA1c than the multiple daily injection method.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"253 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140483893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of electromyography of the masseter and temporal muscles in children with Down syndrome aged 2 to 12 years during maximal voluntary isometric contraction and rest","authors":"Abdolreza Yavari, Mahdi Panahian, Hossein Soltaninejad, Mohamadreza Arab, Marzieh Babaei","doi":"10.34172/mj.2024.017","DOIUrl":"https://doi.org/10.34172/mj.2024.017","url":null,"abstract":"Background. Muscle weakness and low muscle tone may cause chewing and swallowing disorders in people with Down syndrome. This study investigated the electromyography of the masseter and temporal muscles in children with Down syndrome, aged 2 to 12, during maximal voluntary isometric contraction and rest. Methods. The current descriptive-analytical and case-control study investigated the electromyography frequency indicators of the masseter and temporal muscles at maximum voluntary contraction and resting states in 15 children aged 2 to 12 with Down syndrome and 15 normal children of the same age. Results. The average frequency of the mean and median in the electrical signal of the masseter and temporal muscles on the left and right sides and in two different positions in children with Down syndrome is lower than in normal children. In comparing the average frequency of the mean, except for the left and right temporal muscles in the maximum voluntary isometric contraction and the left master muscle during rest, there is a significant difference in the rest. Also, in comparing the average frequency of the median, except for the left and right temporal muscles in the resting state, there are non-significant differences in the rest of the cases. Conclusion. The average frequency of the electrical signal of the masseter and temporal muscles in children with Down syndrome is lower than that of normal children. Unlike typically developing children, those with Down syndrome struggle with chewing and swallowing. Practical Implications. The data obtained from this study contributes to the enhancement of interventions and treatments for patients with Down syndrome.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"18 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140482186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of persian version of morbid curiosity scale in students","authors":"Ali Ghaemi, L. Vaghef, Behzad Shalchi","doi":"10.34172/mj.2024.001","DOIUrl":"https://doi.org/10.34172/mj.2024.001","url":null,"abstract":"Background. The success of horror films, the attention to violent crimes and the prevalence of violence in the news show that morbid curiosity is a common psychological trait. However, research on morbid curiosity is largely absent in the psychological research literature. one of the reasons being the lack of a suitable Scale for Iranian society. Therefore, the purpose of this study was to investigate the reliability and validity of the Persian version of the Morbid Curiosity Scale. Methods. The research design was descriptive factor analysis and the statistical population of the study was all students of Zanjan University in the academic year 1400-1401, from which 500 people were selected by cluster sampling. For the study, Morbid Curiosity Scale was used. Results. The results showed that Cronbach's alpha for the subscales of the Minds of Dangerous People is 0.79, Body Violation is 0.81, Supernatural Danger is 0.79, and Interpersonal Violence is 0.80 and the total scale is 0.85. The results of Confirmatory Factor Analysis also confirmed the significant relationship between explicit variables and latent structures and showed that the four-factor structure has a good fit in the samples. Conclusion. The morbid curiosity scale among students has good reliability and validity and the use of this scale in future research is reliable. Practical Implications. The findings of this research can be used in psychotherapy, psychological research, media psychology, and advertising psychology.","PeriodicalId":515435,"journal":{"name":"Medical Journal of Tabriz University of Medical Sciences","volume":"18 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}