One Health Journal最新文献

{"title":"EPIDEMIOLOGICAL INVESTIGATION OF A FATAL CASE OF DIPHTHERIA IN A RESIDENT OF KYIV OBLAST","authors":"N. S. Rodyna, V.V. Maiboroda, D. Karamyshev, V.Y. Lipchanchuk, T. I. Kupriyanova","doi":"10.31073/onehealthjournal2024-iii-03","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-03","url":null,"abstract":"Ukraine still has diphtheria. This infection is developed with toxins secreted by pathogens of three Corynebacteria species, such as Corynebacterium diphtheria, Corynebacterium ulcerans, and Corynebacterium pseudotuberculosis. In January 2024, for the first time in recent decade, a fatal case of diphtheria in a resident of the Kyiv oblast was registered in Ukraine. The results of laboratory testing showed the toxigenic microorganism Corynebacterium ulcerans. The diagnosis was established based on the results of the pathological and anatomical autopsy and confirmed by laboratory testing during the examination of sectional samples. When a woman sought medical attention with certain clinical signs, medical care personal did not collect biological samples from the patient for testing on the causative agents of respiratory diseases of viral or bacterial origin, and the primary diagnosis did not contain information about the warnings of diphtheria. This indicates a low alertness of doctors regarding the possibility of the occurrence and spread of diphtheria. The anti-vaccination attitude of the population and migration processes under martial law contribute to a decrease in the level of immunization in the Kyiv oblast and pose a threat to diphtheria outbreaks.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"81 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141708775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EXPERIMENTAL ASSESSMENT OF THE ACUTE TOXICITY OF \"KUBAZOL\" – SOLUTION FOR EXTERNAL APPLICATION BASED ON BIRCH TAR","authors":"M.V. Kychan, R. О. Vasiv, R. M. Sachuk, T. A. Velesik","doi":"10.31073/onehealthjournal2024-iii-02","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-02","url":null,"abstract":"Laboratory studies were conducted to determine the acute toxicity of the veterinary drug \"Kubazol\" on white rats. The drug \"Kubazol\" - a veterinary drug (spray for external use, solution) contains birch tar in its composition. Intended for the treatment and prevention of lesions of the skin (wounds, dermatitis, eczema), claws (injuries, superficial panaritium), hooves and hooves (foot rot, etc.) in dogs, wild pigs, wild birds and sports horses. According to the results of determining the parameters of the acute toxicity of the drug \"Kubazol\" (spray for external use, solution), in the case of a single intragastric administration, the LD50 for male rats is 7328.87±878.80 mg/kg of body weight, which allows us to classify it as toxic up to V class - practically non-toxic substances (LD50 5001-15000 mg/kg), and according to the degree of danger - up to IV class - low-hazard substances (LD50 > 5000 mg/kg). According to the results of toxicological studies of the veterinary drug \"Kubazol\" (spray for external use, solution), the LD50 indicator could not be calculated, since the death of laboratory animals was not detected within 14 days after application to the skin of rats. At the same time, the maximum dose of the drug \"Kubazol (spray for external use, solution) applied to the skin of rats (based on the absolute weight of the drug) was 15,000.0 mg/kg of body weight, which allows the drug to be classified according to the degree of danger to the IV class - low-hazardous substances (LD50Сut>2500.0 mg/kg of body weight). Further studies will be the next stage of pre-registration tests aimed at studying the chronic toxicity of \"Kubazol\", which is mandatory material in the section \"Studies on safety and residues\" of the dossier for this drug.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"109 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141714252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CURRENT STATUS OF THE LEGAL FRAMEWORK IN THE PLANT PROTECTION AND ECOLOGY AND HYGIENE MONITORING DOMAIN IN UKRAINE","authors":"A. Antonenko, A. Borysenko, F.S. Melnichuk, I. Tkachenko","doi":"10.31073/onehealthjournal2024-iii-07","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-07","url":null,"abstract":"Presently chemical plant protection products are an inseparable part of agriculture. They have not only their main purpose of plant assistance, but they also have the potential risk of negative impact on biocenosis species (birds, bees, soil microflora, algae, etc.) and the human body and its health respectively. The purpose of our study was to aggregate data on the existing legal framework of plant protection products in Ukraine and assess their ecology and hygiene monitoring. For analysis of the plant chemical protection, we used as the basic documents the regulatory framework of domestic legislation in toxicological and hygiene, ecology assessment, and ecology and hygiene monitoring domains. Currently, many laws and legal acts regulate the use of pesticides by state and private agricultural farms in Ukraine. This number of documents covers not only pre-registration studies of pesticides but also their post-registration monitoring in the environment. The key entities that control potential negative risks of these products through the regulations are the State Emergency Service, Ministry of Environmental Protection, Ministry of Health, Ministry of Housing and Communal Services, Ministry of Agriculture Policy, State Agency of Water Resources, State Committee of Land Resources, State Agency of the Forest Resources. However, the impact of xenobiotics on non-target species of the ecosystem is currently quite underestimated. The decline in biodiversity directly depends on the condition of the environment and the negative impact on it. Instances of acute oral, inhalation, or dermal poisoning of birds, bees, and aquatic invertebrates with pesticides are quite common and among the factors that affect public health. That is why ecology and hygiene monitoring is essential in line with the assessment of the risks of the inappropriate release of pesticides. These should be treated as a critical component of managing environmental sustainability and safety for public health. The implementation of global approaches to monitoring and controlling the post- registration impact of pesticides on the ecology and hygiene in Ukraine can also take into account the far-reaching consequences of their negative impact, accumulation, and environmental pollution. As a result, this will help to avoid adverse impacts on animal, insect, and bird populations, as well as human health.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141703143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CHALLENGES OF FASCIOLOSIS SPREADING IN CATTLE IN UKRAINE IN 2021-2023","authors":"O. P. Lytvynenko, O. I. Miroshnichenko, O. V. Pishanskiy, V. Kovalenko, A. Gerilovych","doi":"10.31073/onehealthjournal2024-iii-04","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-04","url":null,"abstract":"The paper presents a comparative analysis of the epizootic process of cattle Fasciolosis dynamics in Ukraine from 2021 to 2023. The data are broken down by region. The risk zones are determined, and the territory of Ukraine is conditionally divided into dangerous, threatened, and temporarily not-dangerous areas. Grazing ruminants' helminths are common worldwide and harm cattle productivity and food security. The concern that climate change can increase the frequency and intensity of helminth infections has been growing. In Ukraine, this concern stems from case reports and theoretical life-cycle models, which allow us to assess the impact of climate change on helminth epidemiology. We believe that this study is the first attempt to investigate geographic and climatic trends in cattle helminth infections spreading by region. In the total of 474209 conducted tests, 6967 cases had positive results, and the average infection rate of cattle with Fasciola from 2021 to 2023 was 1.5 % in the regions with mild climate. Fasciolosis infection spread depends on the elevation of the farm and agricultural region. The studies show that meteorological changes can significantly contribute to understanding the impact of climate on infectious disease dynamics. If local environmental conditions are taken into account, the impact of climate change on disease dynamics can be clearer on a local scale. We recommend developing a strategy for extensive sample selection across Ukraine to monitor changes in helminthic disease risk and inform on adaptation strategies to increase productivity and protect the health of the cattle.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"86 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141696094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NON-STEROIDAL ANTI-INFLAMMATORY DRUGS \"CELEXIB\" AND \"DIBUTALIASTIN\" EFFICACY IN INDUCED INFLAMMATION IN RATS","authors":"V. Hunchak, M.L. Kondratuik, R. О. Vasiv","doi":"10.31073/onehealthjournal2024-iii-01","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-01","url":null,"abstract":"Non-steroid Anti-Inflammatory Drugs (NSAIDs) are the most widely used analgesics in veterinary medicine. Induced inflammation in laboratory animals is one of the most common methods to determine the anti-inflammatory and analgesic properties of new drugs. We studied the anti-inflammatory properties of the drugs \"Celexib\", with the celecoxib (100 mg in 1 ml) active pharmaceutical ingredient and \"Dibutalastin” ointment (1 g of the drug contains 61.0 mg of methyl salicylate). The studies resulted in the following, after supplantation of 1% carrageenan solution into laboratory rats, animals of the control and experimental groups developed an acute inflammatory process (swelling, increased volume of the paw, hyperemia, and tenderness). The most significant changes were observed in rats of all groups three hours after carrageenan administration. It was found that rats of the control group that did not receive anti-inflammatory drugs had the volume of the paw increased on the 4th and 6th hours of the experiment. The animals of experimental E1 and E2 groups, after 4 hours showed decreased intensity of the inflammatory process under the influence of \"Celecoxib\" and \"Diclofenac” anti- inflammation drugs. The volume of the paw was 25.6, 8.2, and 14.3% less in the E1 , and E2 groups of animals, compared to the period before induction of inflammatio. By the 6th hour of the study, the animals of group E1 had virtually no visible clinical signs of the inflammatory process caused by carrageenan, which confirms the anti-inflammation effectiveness of the “Celecoxib” drug. It was found that inflammation induced by allyl isothiocyanate and formalin in rats, the investigated drug \"Dibutalastin\" ointment also showed peculiar analgesic properties. It was observed that its analgesic and anti-inflammatory effects were like the reference drug \"Dolaren-gel\".","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141712508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE LABORATORY TESTING OF THE PCR-BASED PROTOCOL OF DETECTION OF THE RABBIT HAEMORRHAGIC DISEASE VIRUS RNA","authors":"I. Korovin, A.O. Rusanova, A. Gerilovych","doi":"10.31073/onehealthjournal2024-iii-05","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-05","url":null,"abstract":"Rabbit Haemorrhagic Disease (RHD), also known as Rabbit Viral Haemorrhagic Disease (RVHD), is a highly contagious and often fatal viral disease that affects domestic and wild rabbits. It's caused by two related viruses: Rabbit Haemorrhagic Disease Virus (RHDV) and Rabbit Haemorrhagic Disease Virus 2 (RHDV2). The disease is endemic in many European, Asian and American countries, but the agent is still recognized as an emergent infection, associated with mass losses and extremely high mortality in rabbits of all breeds. One Health Scientific and Research Institute, PSI in collaboration with SRI ‘Veterinary Biotechnologies’, LLC developed the in house PCR-based protocol for RHDV detection and RHDV-2 differentiation, that requires fast implementation. This diagnostics kit evaluation in described under OIE requirements with determination of the sensitivity, specificity, repeatability and domain-specificity. Detection kit is recommended for practical application.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"153 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141695116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ONE HEALTH MULTIMODAL SURVEILLANCE IN TIME OF CHANGE: LESSONS NOT LEARNT FROM CASE STUDY OF A/H5N1 SPILLOVER TO MAMMALS IN GDAŃSK METROPOLITAN AREA","authors":"A. Jarynowski, M. Romanowska, S. Maksymowicz, V. Belik","doi":"10.31073/onehealthjournal2024-iii-06","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-iii-06","url":null,"abstract":"This case study of A/H5N1 spillover to mammals in the Gdańsk area underlines the complexities of managing emerging One Health threats in significant political and economic aspects. We compared the relatively successful rapid regional response with the utterly lost battle in communication and cooperation, emphasising the need for improved interdisciplinary regional and international cooperation and robust surveillance systems in an era of anthropogenic and natural change.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"274 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141692043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ЕПІЗООТИЧНА СИТУАЦІЯ В СВІТІ З ТРАНСКОРДОННИХ ХВОРОБ ТВАРИН","authors":"Л. Є. Корнієнко, В. В. Уховський, М. С. Карпуленко, О. А. Мороз, Т. М. Царенко, М. Л. Радзиховський, М. Є. Руда","doi":"10.31073/onehealthjournal2024-ii-06","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-ii-06","url":null,"abstract":"Стаття присвячена вивченню ретроспективного аналізу спалахів транскордонних інфекційних захворювань тварин та птиці на основі наукових літературних джерел та матеріалів баз WOAH (OIE) та Pro Med. Висвітлено епізоотичну ситуацію, яка склалась у світі протягом останніх 7–15 років з африканської чуми коней, африканської чуми свиней, близькосхідного респіраторного синдрому, везикулярної хвороби свиней, везикулярного стоматиту, віспи овець і кіз, гарячки долини Ріфт, геморагічної септицемії, високопатогенного пташиного грипу, заразного вузликового дерматиту, катаральної хвороби овець (блутангу), класичної чуми свиней, контагіозної плевропневмонії великої рогатої худоби, ньюкаслської хвороби, чуми дрібних жуйних, ящура. Доведена необхідність контролю зазначених хвороб, адже вони завдають значних збитків міжнародній торгівлі внаслідок втрати довіри між торговельними партнерами, загрожують виробництву продовольства через недоотримання продукції тваринництва і небезпеки виникнення хвороб у людини, в наслідок зоонозного потенціалу останніх.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"23 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140743999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ВИЗНАЧЕННЯ ПАРАМЕТРІВ ТОКСИЧНОСТІ БІОЦИДНОГО ЗАСОБУ «ЙОДОСАН» НА МОДЕЛІ ЛАБОРАТОРНИХ ТВАРИН","authors":"Г. А. Бучковська, О. М. Чечет, В. Л. Коваленко, О. І. Віщур, О. І. Горбатюк, В. С. Баранов, С. В. Захарін, М. Р. Асанова","doi":"10.31073/onehealthjournal2024-ii-02","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-ii-02","url":null,"abstract":"У статті наведені результати лабораторних досліджень показників гострої токсичності, сенсибілізуючої та подразнювальної дії за умов впливу біоцидного засобу «Йодосан» на основі йоду та молочної кислоти на моделі лабораторних тварин. Визначали показники гострої токсичності на клінічно здорових білих мишах. Препарат «Йодосан» вводили тваринам одноразово внутрішньошлунково (зондом) та інгаляційно (обробка кліток). Дослідження подразнювальної та сенсибілізуючої дії препарату «Йодосан» у різних концентраціях проводили на окремих групах клінічно здорових мурчаках шляхом щоденного нашкірного нанесення на спину та боки впродовж 30 днів та експозиції шляхом занурення хвостів тварин у аналогічних концентраціях впродовж 30 хв. У експерименті використовували сучасні гуманні методи догляду та використання лабораторних тварин. Визначено, що за одноразового внутрішньошлункового введення біоцидного засобу «Йодосан» середня летальна доза (LD50) для білих мишей становила 5515,0 мг/кг маси тіла. Доведено, що препарат «Йодосан» у формі 0,3 % розчину проявляє тимчасову подразнювальну і сенсибілізуючу дію та не має негативного впливу на показники кровотворення в організмі білих мишей. Отже, за підсумком результатів досліджень визначено, що препарат «Йодосан» не володіє кумулюючими та сенсибілізуючими властивостями, не чинить подразнювальної та шкірно-резорбтивної дії, не спричинює змін показників гемопоезу та не проявляє супресивну дію щодо росту і розвитку тварин, що вказує на екологічну безпечність та нешкідливість дослідного експериментального біоцидного засобу.","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PREVALENCE OF ROTAVIRUS AND CORONAVIRUS ORIGIN DISEASES BY AGE GROUPS AMONG CALVES IN THE NORTH-WEST REGION OF AZERBAIJAN","authors":"S. Zeynalova, V. Abbasov, B. Bagyrzade","doi":"10.31073/onehealthjournal2024-ii-05","DOIUrl":"https://doi.org/10.31073/onehealthjournal2024-ii-05","url":null,"abstract":"The purpose of the study was to identify the prevalence of diarrhea caused by rotavirus and coronavirus in newborn calves located in the North-West region of the republic using rapid testing. The study was conducted among 45 heads of calves of local races and crosses in 20 farms of the Ismailli, Gabala, and Zagatala districts. In 14 heads of calves out of 45 calves (35.5%), pathogens were not identified, and in 31 heads of calves pathogens were identified in single or mixed cases. The identified pathogens among them were distributed as follows: rotavirus in 22 calves (48.9%), coronavirus in 3 calves (6.7%), in 8 calves – (Cryptosporodium parvum) 17.8%), in 5 calves – Giardia (11.1%) and another 5 calves had E. coli K99 (11.1%). The results of the study show that the causes of diarrhea in calves in the North-West region of the republic, among other pathogens, include rotavirus and coronavirus infections, and it is important that this be taken into account when carrying out treatment and preventive measures","PeriodicalId":514786,"journal":{"name":"One Health Journal","volume":"52 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140745235","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}