{"title":"Correction to: Correlation between renal ablation zone in contrast‑enhanced CT and non‑enhanced MRI during the early period following percutaneous cryoablation.","authors":"Noriyuki Umakoshi, Toshihiro Iguchi, Takao Hiraki, Yusuke Matsui, Koji Tomita, Mayu Uka, Soichiro Kajita, Motoo Araki, Toshiharu Mitsuhashi, Hideo Gobara, Susumu Kanazawa","doi":"10.1007/s11604-022-01337-3","DOIUrl":"https://doi.org/10.1007/s11604-022-01337-3","url":null,"abstract":"","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 12","pages":"1316"},"PeriodicalIF":2.1,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9719882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33522034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Huanhuan Kang, Wei Xu, Shuxiang Chang, Jing Yuan, Xu Bai, Jing Zhang, Huiping Guo, Huiyi Ye, Haiyi Wang
{"title":"Mucinous tubular and spindle cell carcinomas of the kidney (MTSCC-Ks): CT and MR imaging characteristics.","authors":"Huanhuan Kang, Wei Xu, Shuxiang Chang, Jing Yuan, Xu Bai, Jing Zhang, Huiping Guo, Huiyi Ye, Haiyi Wang","doi":"10.1007/s11604-022-01294-x","DOIUrl":"10.1007/s11604-022-01294-x","url":null,"abstract":"<p><strong>Purpose: </strong>To strengthen the recognition of mucinous tubular and spindle cell carcinomas of the kidney (MTSCC-Ks) by analyzing CT and MR imaging findings of MTSCC-Ks.</p><p><strong>Materials and methods: </strong>This study retrospectively enrolled ten patients with pathologically confirmed MTSCC-Ks from 2007 to 2020. The main observed imaging characteristics included growth pattern, signal characteristics on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), hemorrhage, necrosis, cystic degeneration, lipid component, pseudocapsule and the enhancement pattern. Apparent diffusion coefficient (ADC) value of MTSCC-Ks and normal renal cortex were measured, respectively. All imaging features were evaluated in consensus by two genitourinary radiologists.</p><p><strong>Results: </strong>All patients (53.1 ± 6.5 years, male to female, 3:7) presented with a solitary renal tumor with the mean diameter of 3.5 ± 0.4 cm. All lesions showed iso- or slight hypoattenuation on non-contrast CT with no hemorrhage but cystic degeneration (10%) and necrosis (10%). On T2WI, all lesions showed predominantly slight hypointensity with focal hyperintensity. The ADC value of MTSCC-Ks was 0.845 ± 0.017 × 10<sup>-3</sup> mm<sup>2</sup>/s, and ADC<sub>tumor</sub>-to-ADC<sub>renal cortex</sub> value was 0.376 ± 0.084. Pseudocapsules existed in all MTSCC-Ks on MRI. There were seven lesions showed heterogeneous enhancement, while three lesions showed homogeneous enhancement. Among them, six MTSCC-Ks showed slight multiple patchy enhancement (60%) in the corticomedullary phase, while the remaining MTSCC-Ks showed homogeneously slight enhancement (30%) or slightly stratified enhancement (10%). All MTSCC-Ks exhibited slow and progressive enhancement in the late phases.</p><p><strong>Conclusion: </strong>Iso- or slight hypoattenuation on CT, slight hypointensity with focal hyperintensity on T2WI, marked diffusion restriction on DWI and ADC map, slight multiple patchy enhancement in the corticomedullary phase, and slow and progressive enhancement in the late phases are the imaging features of MTSCC-Ks, which may facilitate the diagnosis of MTSCC-Ks.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"1175-1185"},"PeriodicalIF":4.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48123885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Koji Tomita, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki
{"title":"Evidence on percutaneous radiofrequency and microwave ablation for liver metastases over the last decade.","authors":"Koji Tomita, Yusuke Matsui, Mayu Uka, Noriyuki Umakoshi, Takahiro Kawabata, Kazuaki Munetomo, Shoma Nagata, Toshihiro Iguchi, Takao Hiraki","doi":"10.1007/s11604-022-01335-5","DOIUrl":"https://doi.org/10.1007/s11604-022-01335-5","url":null,"abstract":"<p><strong>Purpose: </strong>This review aimed to summarize the treatment outcomes of percutaneous radiofrequency ablation (RFA) and microwave ablation (MWA) for metastatic liver tumors based on the findings of published studies over the last decade.</p><p><strong>Materials and methods: </strong>Literature describing the survival outcomes of ablation therapy for liver metastases was explored using the PubMed database on April 26, 2022, and articles published in 2012 or later were selected. The included studies met the following criteria: (i) English literature, (ii) original clinical studies, and (iii) literature describing overall survival (OS) of thermal ablation for metastatic liver tumors. All case reports and cohort studies with fewer than 20 patients and those that evaluated ablation for palliative purposes were excluded.</p><p><strong>Results: </strong>RFA was the most commonly used method for ablation, while MWA was used in several recent studies. RFA and MWA for liver metastases from various primary tumors have been reported; however, majority of the studies focused on colorectal cancer. The local control rate by RFA and MWA varied widely among the studies, ranging approximately 50-90%. Five-year survival rates of 20-60% have been reported following ablation for colorectal liver metastases by a number of studies, and several reports of 10-year survival rates were also noted.</p><p><strong>Conclusion: </strong>Comparative studies of local therapies for colorectal liver metastases demonstrated that RFA provides comparable survival outcomes to surgical metastasectomy and stereotactic body radiation therapy.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 10","pages":"1035-1045"},"PeriodicalIF":2.1,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529678/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33463664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Correction to: Stereotactic body radiation therapy for metastatic lung metastases.","authors":"Tomoki Kimura, Toshiki Fujiwara, Tsubasa Kameoka, Yoshinori Adachi, Shinji Kariya","doi":"10.1007/s11604-022-01342-6","DOIUrl":"https://doi.org/10.1007/s11604-022-01342-6","url":null,"abstract":"","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 10","pages":"1006-1008"},"PeriodicalIF":2.1,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529699/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33483585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Peng Hu, Liye Chen, Yaoying Zhong, Yudong Lin, Xiaojing Yu, Xi Hu, Xinwei Tao, Shushen Lin, Tianye Niu, Ran Chen, Xia Wu, Jihong Sun
{"title":"Effects of slice thickness on CT radiomics features and models for staging liver fibrosis caused by chronic liver disease.","authors":"Peng Hu, Liye Chen, Yaoying Zhong, Yudong Lin, Xiaojing Yu, Xi Hu, Xinwei Tao, Shushen Lin, Tianye Niu, Ran Chen, Xia Wu, Jihong Sun","doi":"10.1007/s11604-022-01284-z","DOIUrl":"10.1007/s11604-022-01284-z","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of slice thickness on CT radiomics features and models for staging liver fibrosis.</p><p><strong>Methods: </strong>A total of 108 pathologically confirmed liver fibrosis patients from a single center were retrospectively collected and divided into different groups. Both thick (5- or 7-mm) and thin slices (1.3- or 2-mm) were analyzed. A fivefold cross-validation with 100 repeats was conducted. The minimum redundancy-maximum relevance algorithm was used to reduce the radiomics features, and the top 10 ranking features were included for further analysis for each loop. The random forest was used for model establishment. The models with median AUC were selected for the assessment of the discriminative performance for both datasets. Mutual features selected by the models with AUC > 0.8 were searched and considered as the most predictive ones.</p><p><strong>Results: </strong>A total of 162 and 643 radiomics features with excellent reliability were selected from thick- and thin-slice datasets, respectively. The overall discriminative performance of the 500 AUCs from the thin-slice dataset was better than the thick slice. The median AUC values of the thick-sliced datasets were significantly lower than those of the thin-sliced datasets (0.78 and 0.90 for differentiating F1 vs. F2-4, 0.72 and 0.85 for differentiating F1-2 vs. F3-4, both P = 0.03). For differentiating F1-3 vs. F4, no significant difference was found (0.85 vs 0.94, P = 0.15). Six mutual predictive features across all the datasets were found.</p><p><strong>Conclusions: </strong>The radiomics features extracted from thin-slice images and their corresponding models were better and more stable for staging liver fibrosis.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"1061-1068"},"PeriodicalIF":4.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42973466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ming Lei, Meng Zhang, Hongyi Li, Jingfeng Liu, Jun Chen, Rulin Xu, Mengqiang Xiao
{"title":"The diagnostic performance of ultra-low-dose 320-row detector CT with different reconstruction algorithms on limb joint fractures in the emergency department.","authors":"Ming Lei, Meng Zhang, Hongyi Li, Jingfeng Liu, Jun Chen, Rulin Xu, Mengqiang Xiao","doi":"10.1007/s11604-022-01290-1","DOIUrl":"10.1007/s11604-022-01290-1","url":null,"abstract":"<p><strong>Background: </strong>The aim of the study was to evaluate whether ultra-low-dose computed tomography (ULD-CT) could replace conventional-dose CT (CD-CT) for diagnosis of acute wrist, ankle, knee, and shoulder fractures in emergency departments (ED).</p><p><strong>Methods: </strong>We developed CD-CT and ULD-CT scanning schemes for the various joints of the four limbs and scanned emergency patients prospectively. When performing CD-CT, a conventional bone reconstruction algorithm was used, while ULD-CT used both soft tissue and bone algorithms. A five-point scale was used to evaluate whether ULD-CT image quality affected surgical planning. The image quality and diagnostic performance of different types of scanned and reconstructed images for diagnosing fractures were evaluated and compared. Effective radiation dose of each group was calculated.</p><p><strong>Results: </strong>Our study included 56 normal cases and 185 fracture cases. The combination of bone and soft tissue algorithms on ULD-CT can improve diagnostic performance, such that on ULD-CT, the sensitivity improved from 96.7% to 98.9%, specificity from 98.2% to 100%, positive predictive value from 99.4% to 100%, negative predictive value from 90.2% to 96.6% and diagnostic accuracy ranged from 97.5% to 99.1%. There were no statistically significant differences between ULD-CT and CD-CT on diagnostic performance (p values, 0.40-1.00). The radiation doses for ULD-CT protocols were only 3.0-7.7% of those for CD-CT protocols (all p < 0.01).</p><p><strong>Conclusions: </strong>In the emergency department, the 320-row detector ULD-CT could replace CD-CT in the diagnosis of limb joint fractures. The combination of bone algorithm with soft tissue algorithm reconstruction can further improve the image quality and diagnostic performance.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"1079-1086"},"PeriodicalIF":4.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48272029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical utility of computed tomography-based evaluation of trunk muscles in primary sclerosing cholangitis.","authors":"Yuka Kikuchi, Daisuke Miyamori, Keishi Kanno, Susumu Tazuma, Hiroaki Kimura, Kenichi Yoshimura, Masahiro Serikawa, Kazuaki Chayama, Masanori Ito","doi":"10.1007/s11604-022-01283-0","DOIUrl":"10.1007/s11604-022-01283-0","url":null,"abstract":"<p><strong>Purpose: </strong>Sarcopenia is well recognized as a prognostic factor of chronic liver diseases. However, its impact on the clinical course of primary sclerosing cholangitis (PSC) is unclear. This study aimed to clarify the importance of trunk muscles evaluated by computed tomography (CT) in the pathophysiology of patients with PSC.</p><p><strong>Materials and methods: </strong>22 PSC patients (12 men, mean age 42.8 years) were enrolled in this study. Patients who died of hepatic failure or had to receive liver transplantation were defined as event group. 44 age- and gender-matched individuals without hepatic disorder were served as controls. At the level of third lumbar vertebrae, the area of psoas muscle and trunk muscle as well as the CT values of multifidus muscle and subcutaneous fat were evaluated. Based on these, skeletal muscle index (SMI), psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC) were calculated. Then we analyzed the relationship between these parameters and laboratory data, Fibrosis-4 index, MELD score and Mayo risk score.</p><p><strong>Results: </strong>At baseline evaluation, SMI and PMI were statistically lower in male PSC patients compared with those in controls (P < 0.05). In male PSC, regarding the laboratory data, PMI was associated with total bilirubin, ALT, ALP, and platelet count (P < 0.05). We found close relationship between PMI and MELD score (R<sup>2</sup> = 0.42, P = 0.02). PMI also decreased statistically in male Event group than in non-event group (4.85 vs 7.20, P = 0.01).</p><p><strong>Conclusion: </strong>Skeletal muscle mass evaluated by CT scan can be suitable for evaluating clinical and prognostic marker in male PSC.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"1053-1060"},"PeriodicalIF":4.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49195482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Diagnostic performance of dual-energy CT in nonspecific terminal ileitis.","authors":"Xingyuan Xu, Junting Zhu, Xia Wang, Chao Zhu, Xingwang Wu","doi":"10.1007/s11604-022-01288-9","DOIUrl":"10.1007/s11604-022-01288-9","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the value of dual-energy CT (DECT) imaging in the diagnosis of nonspecific terminal ileitis (NTI).</p><p><strong>Materials and methods: </strong>This is a retrospective study, enrolling patients with symptomatic terminal ileitis that underwent conventional multidetector CT (MDCT) enterography or DECT enterography. The sensitivity of the diagnosis of NTI between MDCT images and different kinds of DECT images (40-70 kev virtual monoenergetic images (VMIs) and iodine density images) was compared. The iodine concentrations of lesion bowel wall among NTI, Crohn's disease (CD) and intestinal tuberculosis (ITB) in DECT group and the value of lesion-to-non-lesion contrast ratios of all patients were measured. Receiver operator characteristic (ROC) curves for normalized iodine concentration (NIC) for differentiating among the three kinds of disease were drawn.</p><p><strong>Results: </strong>The sensitivity for the diagnosis of NTI in DECT group (including 40 kev, 50 keV VMIs, and iodine density images) were all 89.7%, significantly higher than that in MDCT group (65.1%) (P = 0.026). Statistical analysis did not reveal marked differences between 60 kev, 70 kev VMIs (86.2%) and MDCT images (65.1%) (P = 0.059). The NIC of NTI was (0.15 ± 0.04)100 µg/cm<sup>3</sup> and (0.45 ± 0.08)100 µg/cm<sup>3</sup>, significantly lower than that of CD (0.34 ± 0.09) 100 µg/cm<sup>3</sup>, (0.85 ± 0.06) 100 µg/cm<sup>3</sup> and that of ITB (0.29 ± 0.07) 100 µg/cm<sup>3</sup>, (0.88 ± 0.07) 100 µg/cm<sup>3</sup> at the enteric phase (EP) and portal venous phase (PVP) (P < 0.001, wholly). The area under the ROC curves (AUROCs) of NICEP and NICPVP were 0.910 and 0.980, respectively, for differentiating between NTI and CD. The value of lesion-to-non-lesion contrast ratios is maximum on the 40 keV VMI both EP and PVP. The value of lesion-to-non-lesion contrast ratios of NTI was lower than that of CD and ITB on each image. The AUROCs of NICEP and NICPVP were 0.875 and 0.940, respectively, for differentiating between NTI and ITB.</p><p><strong>Conclusions: </strong>DECT has higher sensitivity in the diagnosis of NTI than MDCT. Low-keV VMI and iodine density images of DECT can clearly show the NTI. DECT imaging can help to differentiate NTI from CD or ITB by comparing the NIC.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"1069-1078"},"PeriodicalIF":4.6,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45597360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stereotactic body radiation therapy for metastatic lung metastases.","authors":"Tomoki Kimura, Toshiki Fujiwara, Tsubasa Kameoka, Yoshinori Adachi, Shinji Kariya","doi":"10.1007/s11604-022-01323-9","DOIUrl":"https://doi.org/10.1007/s11604-022-01323-9","url":null,"abstract":"<p><p>Although systemic therapy is standard management for patients with metastatic disease, several recent reports have indicated that an addition of local therapies including stereotactic body radiation therapy (SBRT) for patients with oligometastatic disease (OMD) could improve survival. The lung is the most common site of distant metastasis from many solid tumors, and the strategy of SBRT, such as dose-fraction schedules, timing, etc., would be different depending on the type of primary tumor, location, and patterns of OMD. This review describes the role of SBRT with curative-intent for patients with pulmonary OMD for each of these variables. First, differences according to the type of primary tumor, for which many studies suggest that SBRT-mediated local control (LC) for patients with pulmonary OMD from colorectal cancer (CRC) is less successful than for those from non-CRC tumors. In addition, higher dose-fraction schedules seemed to correlate with higher LC; hence, different SBRT treatment strategies may be needed for patients with pulmonary OMD from CRC relative to other tumors. Second, differences according to location, where the safety of SBRT for peripheral pulmonary tumors has been relatively well established, but safety for central pulmonary tumors including pulmonary OMD is still considered controversial. To determine the optimal dose-fraction schedules, further data from prospective studies are still needed. Third, differences according to the patterns of OMD, the number of metastases and the timing of SBRT whereby 1-5 lesions in most patients and patients with synchronous or metachronous OMD are considered good candidates for SBRT. We conclude that there are still several problems in defining suitable indications for local therapy including SBRT, and that further prospective studies are required to resolve these issues.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 10","pages":"995-1005"},"PeriodicalIF":2.1,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33463663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Incidental pulmonary emboli are associated with a very high probability of progressive malignant disease on staging CT scans.","authors":"Lu Hern Goh, Sean C Tenant","doi":"10.1007/s11604-022-01280-3","DOIUrl":"10.1007/s11604-022-01280-3","url":null,"abstract":"<p><strong>Purpose: </strong>The link between malignancy and venous thromboembolism (VTE) is well established; the risk has been shown to be higher in certain tumour types and in patients receiving platinum-based chemotherapy regimens. 'Active' cancer is often quoted as being a particular risk factor for VTE, but the definition varies widely and the supporting evidence is weak. This study was conceived to establish whether incidental pulmonary emboli are associated with an increased likelihood of progressive disease on a staging computed tomography (CT) scan.</p><p><strong>Materials and methods: </strong>All CT scans containing incidental PEs over the course of a year in a large specialist cancer hospital were examined (n = 306). An age-matched control group was assembled. Multivariate logistic regression analysis was performed to establish the relationship of several independent variables, including progressive disease, with the dependent variable of the presence or absence of incidental pulmonary emboli.</p><p><strong>Results: </strong>Progressive disease was present in 144 of 306 (47.1%) of the patients in the PE group but only 63 of 306 (20.6%) of the control group patients. Progressive disease on the staging CT scan was found to have an odds ratio for incidental PE of 3.46, with a 95% CI of 2.38-5.01. Receiving platinum-based chemotherapy resulted in an odds ratio of 3.89 (2.41-6.28) for PE. Receiving non-platinum-based systemic anti-cancer therapy (SACT) resulted in an odds ratio for PE of 1.71 (1.16-2.50).</p><p><strong>Conclusion: </strong>The detection of an incidental PE on a staging CT scan is associated with a very high risk of progressive malignant disease.</p>","PeriodicalId":51226,"journal":{"name":"Japanese Journal of Radiology","volume":"40 1","pages":"914-918"},"PeriodicalIF":4.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48176369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}