Arthritis Research & Therapy最新文献

{"title":"Computational pathology for musculoskeletal conditions using machine learning: advances, trends, and challenges","authors":"M. Konnaris, M. Brendel, M. Fontana, M. Otero, L. Ivashkiv, Fei Wang, R. Bell","doi":"10.1186/s13075-021-02716-3","DOIUrl":"https://doi.org/10.1186/s13075-021-02716-3","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45810858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A machine learning-assisted model for renal urate underexcretion with genetic and clinical variables among Chinese men with gout","authors":"Mingshu Sun, Wenyan Sun, Xuetong Zhao, Zhiqiang Li, N. Dalbeth, A. Ji, Yuwei He, H. Qu, Guangmin Zheng, Lidan Ma, Jiayi Wang, Yongyong Shi, Xiangdong Fang, Hai-long Chen, T. Merriman, Changgui Li","doi":"10.1186/s13075-022-02755-4","DOIUrl":"https://doi.org/10.1186/s13075-022-02755-4","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44406689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell transcriptomics of popliteal lymphatic vessels and peripheral veins reveals altered lymphatic muscle and immune cell populations in the TNF-Tg arthritis model","authors":"H. M. Kenney, Chia-Lung Wu, A. Loiselle, L. Xing, C. Ritchlin, E. Schwarz","doi":"10.1186/s13075-022-02730-z","DOIUrl":"https://doi.org/10.1186/s13075-022-02730-z","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48815347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Angiopoietin-2/-1 ratios and MMP-3 levels as an early warning sign for the presence of giant cell arteritis in patients with polymyalgia rheumatica","authors":"Y. van Sleen, P. Therkildsen, B. D. Nielsen, K. V. D. van der Geest, I. Hansen, P. Heeringa, M. Posthumus, M. Sandovici, E. Toonen, J. Zijlstra, A. Boots, E. Hauge, E. Brouwer","doi":"10.1186/s13075-022-02754-5","DOIUrl":"https://doi.org/10.1186/s13075-022-02754-5","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45580829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amniotic suspension allograft improves pain and function in a rat meniscal tear-induced osteoarthritis model","authors":"K. Kimmerling, A. Gomoll, J. Farr, K. Mowry","doi":"10.1186/s13075-022-02750-9","DOIUrl":"https://doi.org/10.1186/s13075-022-02750-9","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46210750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal assessment of reactivity and affinity profile of anti-Jo1 autoantibodies to distinct HisRS domains and a splice variant in a cohort of patients with myositis and anti-synthetase syndrome.","authors":"Antonella Notarnicola, Charlotta Preger, Susanna L Lundström, Nuria Renard, Edvard Wigren, Eveline Van Gompel, Angeles S Galindo-Feria, Helena Persson, Maryam Fathi, Johan Grunewald, Per-Johan Jakobsson, Susanne Gräslund, Ingrid E Lundberg, Cátia Fernandes-Cerqueira","doi":"10.1186/s13075-022-02745-6","DOIUrl":"10.1186/s13075-022-02745-6","url":null,"abstract":"<p><strong>Background: </strong>To address the reactivity and affinity against histidyl-transfer RNA synthetase (HisRS) autoantigen of anti-Jo1 autoantibodies from serum and bronchoalveolar lavage fluid (BALF) in patients with idiopathic inflammatory myopathies/anti-synthetase syndrome (IIM/ASSD). To investigate the associations between the reactivity profile and clinical data over time.</p><p><strong>Methods: </strong>Samples and clinical data were obtained from (i) 25 anti-Jo1⁺ patients (19 sera with 16 longitudinal samples and 6 BALF/matching sera at diagnosis), (ii) 29 anti-Jo1^- patients (25 sera and 4 BALF/matching sera at diagnosis), and (iii) 27 age/gender-matched healthy controls (24 sera and 3 BALF/matching sera). Reactivity towards HisRS full-length (HisRS-FL), three HisRS domains (WHEP, antigen binding domain (ABD), and catalytic domain (CD)), and the HisRS splice variant (SV) was tested. Anti-Jo1 IgG reactivity was evaluated by ELISA and western blot using IgG purified from serum by affinity chromatography. In paired serum-BALF, anti-Jo1 IgG and IgA reactivity was analyzed by ELISA. Autoantibody affinity was measured by surface plasmon resonance using IgG purified from sera. Correlations between autoantibody reactivity and clinical data were evaluated at diagnosis and longitudinally.</p><p><strong>Results: </strong>Anti-Jo1 IgG from serum and BALF bound HisRS-FL, WHEP, and SV with high reactivity at the time of diagnosis and recognized both conformation-dependent and conformation-independent HisRS epitopes. Anti-HisRS-FL IgG displayed high affinity early in the disease. At the time of IIM/ASSD diagnosis, the highest autoantibody levels against HisRS-FL were found in patients ever developing interstitial lung disease (ILD) and arthritis, but with less skin involvement. Moreover, the reactivity of anti-WHEP IgG in BALF correlated with poor pulmonary function. Levels of autoantibodies against HisRS-FL, HisRS domains, and HisRS splice variant generally decreased over time. With some exceptions, longitudinal anti-HisRS-FL antibody levels changed in line with ILD activity.</p><p><strong>Conclusion: </strong>High levels and high-affinity anti-Jo1 autoantibodies towards HisRS-FL were found early in disease in sera and BALF. In combination with the correlation of anti-HisRS-FL antibody levels with ILD and ILD activity in longitudinal samples as well as of anti-WHEP IgG in BALF with poor pulmonary function, this supports the previously raised hypothesis that the lung might have a role in the immune reaction in anti-Jo1-positive patients.</p>","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":"62"},"PeriodicalIF":4.4,"publicationDate":"2022-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8889758/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43506030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between perinatal factors and future risk for gout—a nested case-control study","authors":"M. Dehlin, L. Jacobsson","doi":"10.1186/s13075-022-02749-2","DOIUrl":"https://doi.org/10.1186/s13075-022-02749-2","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48168606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Senescent skeletal cells cross-talk with synovial cells plays a key role in the pathogenesis of osteoarthritis","authors":"Chongjie Wu, Ri Liu, Song-wei Huan, Wang Tang, Yuzhe Zeng, Jun-cheng Zhang, Jie Yang, Zhen-yan Li, Ying Zhou, Z. Zha, Huan-Tian Zhang, Ning Liu","doi":"10.1186/s13075-022-02747-4","DOIUrl":"https://doi.org/10.1186/s13075-022-02747-4","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45801011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma interleukin-23 and circulating IL-17A+IFNγ+ ex-Th17 cells predict opposing outcomes of anti-TNF therapy in rheumatoid arthritis","authors":"Melanie J. Millier, N. Fanning, C. Frampton, L. Stamp, P. Hessian","doi":"10.1186/s13075-022-02748-3","DOIUrl":"https://doi.org/10.1186/s13075-022-02748-3","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47869150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical features of gout in adult patients with type Ia glycogen storage disease: a single-centre retrospective study and a review of literature","authors":"N. Xu, Xinxin Han, Yun Zhang, Xiaoming Huang, Weiguo Zhu, M. Shen, Wen Zhang, Jialin Chen, M. Wei, Z. Qiu, Xuejun Zeng","doi":"10.1186/s13075-021-02706-5","DOIUrl":"https://doi.org/10.1186/s13075-021-02706-5","url":null,"abstract":"","PeriodicalId":51225,"journal":{"name":"Arthritis Research & Therapy","volume":" ","pages":""},"PeriodicalIF":4.9,"publicationDate":"2022-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46992720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}