Applied Biosciences最新文献_第2页

Effects of Bone Marrow Sparing and TGF-β3 Treatment in Total Body Irradiation of C57BL/6J Mice C57BL/6J 小鼠全身辐照中骨髓疏松和 TGF-β3 处理的影响

Applied Biosciences Pub Date : 2024-04-04 DOI: 10.3390/applbiosci3020011

Ingunn Hanson, Jenny T. Vatne, Nina F. J. Edin

{"title":"Effects of Bone Marrow Sparing and TGF-β3 Treatment in Total Body Irradiation of C57BL/6J Mice","authors":"Ingunn Hanson, Jenny T. Vatne, Nina F. J. Edin","doi":"10.3390/applbiosci3020011","DOIUrl":"https://doi.org/10.3390/applbiosci3020011","url":null,"abstract":"Introduction: Mortality from acute radiation syndrome is frequently caused by hematopoietic or gastrointestinal radiotoxicity, the latter of which currently has no effective treatment. Transforming growth factor-beta 3 (TGF-β3) may decrease the severity of radiation-induced gastrointestinal damage in mice. In addition, treatment with TGF-β3 may alleviate radiation-induced fibrosis. Objectives: The current study aimed to investigate the effect of TGF-β3 treatment on acute and late radiotoxicity in whole body irradiated mice. Methods: C57BL/6J mice were total body irradiated with 8.5 Gy X-rays with or without shielding of one hind leg to alleviate hematopoietic radiotoxicity. The effects of intravenous TGF-β3 treatment were investigated. Body weight and pain expression were monitored. Intestine, lung, and liver tissues were preserved and analyzed. Alpha smooth muscle actin (α-SMA) expression in MRC-5 cells after 3.5 Gy X-irradiation combined with TGF-β3 treatment was analyzed using flow cytometry. Results: All total body irradiated animals died within ten days after irradiation. Ninety-three percent of femur-shielded mice survived until sampling or termination. No effect of TGF-β3 treatment was observed in either group. No increase in collagen content was detected in the lungs or liver from irradiated mice regardless of TGF-β3 treatment. In vitro, α-SMA expression increased synergistically after irradiation and TGF-β3 treatment. Conclusions: Shielding of the femur during total body irradiation decreased acute gastrointestinal radiation toxicity and increased survival. TGF-β3 treatment did not impact symptoms or survival. TGF-β3 treatment and irradiation increased α-SMA expression in MRC-5 cells synergistically.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"30 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Cellular Interactions of Flavonoids with Similar Structures in Cells Overexpressing the 70 kDa Human Heat Shock Protein 在过表达 70 kDa 人类热休克蛋白的细胞中探索具有相似结构的黄酮类化合物与细胞的相互作用

Applied Biosciences Pub Date : 2024-03-06 DOI: 10.3390/applbiosci3010009

Garyfallia Papa, Yannis V. Simos, Antrea M. Athinodorou, Konstantinos I. Tsamis, Dimitrios Peschos, C. Angelidis, Periklis Pappas, P. Vezyraki

{"title":"Exploring the Cellular Interactions of Flavonoids with Similar Structures in Cells Overexpressing the 70 kDa Human Heat Shock Protein","authors":"Garyfallia Papa, Yannis V. Simos, Antrea M. Athinodorou, Konstantinos I. Tsamis, Dimitrios Peschos, C. Angelidis, Periklis Pappas, P. Vezyraki","doi":"10.3390/applbiosci3010009","DOIUrl":"https://doi.org/10.3390/applbiosci3010009","url":null,"abstract":"Flavonoids share a common structural framework that serves as a hallmark indicative of their biological activity. In this study, we investigated the effects of two structurally similar flavonoids, fisetin and morin, through independent and combined in vitro assessments on embryonic mouse cells overexpressing the human 70 kDa heat shock protein (Hsp70) (Tg/Tg) and normal mouse fibroblast cell line (NIH/3T3). The primary objectives were to evaluate the biocompatibility and potential cytotoxicity of these flavonoids, along with assessing the cytoprotective role of Hsp70 in these cellular environments. To address these objectives, we conducted dose- and time-dependent cell survival tests. Additionally, we utilized flow cytometry to detect intracellular reactive oxygen species (ROS) production and to analyze apoptosis and the cell cycle. Throughout the experimental procedures, a notable observation was made: NIH/3T3 normal cells exhibited greater susceptibility compared to Tg/Tg cells when exposed to fisetin and morin. This difference in susceptibility is likely attributed to the robust cytoprotective effect of Hsp70 in Tg/Tg cells. Importantly, both cell lines demonstrated increased sensitivity to fisetin toxicity in comparison to morin, leading to significantly lower cell survival rates. These findings shed light on the differential responses of cell lines to flavonoid exposure, emphasizing the influence of Hsp70 and the distinct impact of fisetin and morin on cell viability.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"2 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140260834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus 使用 3D 打印半月板测试半月板修复的方法

Applied Biosciences Pub Date : 2024-02-06 DOI: 10.3390/applbiosci3010007

Andrew F. Nelson, Steven Voinier, Jeremy Tran, Kristin H. Gilchrist, Melvin Helgeson, Vincent B. Ho, G. Klarmann

{"title":"Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus","authors":"Andrew F. Nelson, Steven Voinier, Jeremy Tran, Kristin H. Gilchrist, Melvin Helgeson, Vincent B. Ho, G. Klarmann","doi":"10.3390/applbiosci3010007","DOIUrl":"https://doi.org/10.3390/applbiosci3010007","url":null,"abstract":"Torn and damaged menisci resulting from trauma are very common knee injuries, which can cause pain and mobility limitations and lead to osteoarthritis. Meniscal injuries can require surgery to repair the tissue damage and restore mobility. Here we describe the biomechanical testing of a 3D-printed meniscus to illustrate methods to determine if it has the strength and durability to effectively repair meniscal tears and restore knee biomechanics. This work was designed to demonstrate the steps needed to test novel meniscus repair devices prior to moving toward animal testing. The first testing step determined the ability of the 3D-printed meniscus to withstand surgical fixation by measuring the suture pull-out force. We show that vertical 2/0 silk or Fiberwire sutures need an average of 1.4 or 1.8 N, respectively, to pull through the meniscus, while horizontal sutures need only 0.7 and 1.2 N, respectively. The next step measured the compressive strength of normal, damaged, and repaired porcine meniscus tissue. Here, we show that meniscectomy decreased the stiffness of meniscus tissue from 26.7 ± 0.85 N to 7.43 ± 0.81 N at 25% strain. Menisci repaired with the 3D-printed tissue restored 66% of the measured force at 25% strain. The final step measured the contact pressures and areas in an ex vivo porcine knee before and after meniscal repair was made with the 3D-printed meniscus tissue. The example 3D-printed meniscus was successfully sutured into the porcine knee joint but failed to restore normal knee contact pressures. This work demonstrates the need for an iterative biomechanical testing process of biomaterial development, 3D-printing optimization, and knee kinematics to develop a durable and functional meniscus repair device. In summary, the methods described here serve as a guide for the functional evaluation of novel meniscus repair devices.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"38 20","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139798378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview 用于肉类保鲜的百里香和丁香精油的抗氧化和抗菌潜力--概述

Applied Biosciences Pub Date : 2024-02-06 DOI: 10.3390/applbiosci3010006

S. Ricardo-Rodrigues, M. Rouxinol, A. Agulheiro-Santos, M. E. Potes, M. Laranjo, Miguel Elias

{"title":"The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview","authors":"S. Ricardo-Rodrigues, M. Rouxinol, A. Agulheiro-Santos, M. E. Potes, M. Laranjo, Miguel Elias","doi":"10.3390/applbiosci3010006","DOIUrl":"https://doi.org/10.3390/applbiosci3010006","url":null,"abstract":"Consumers are looking for safer and more natural food options that are produced through natural methods without using synthetic preservatives. They also desire extended shelf life for their food products. Several medicinal and aromatic plants species combine food, spice, aromatic, and medicinal recognized attributes. The essential oils from these plants contain a unique mixture of compounds specific to each plant, showing notable antioxidant and antimicrobial properties. Essential oils are used widely as they are environmentally friendly, non-toxic, and biodegradable substitutes for harsh chemical preservatives. Thyme and clove are aromatic plants commonly used in traditional gastronomy, particularly in meat-based recipes. The preservation effects of these essential oils on fresh meat have not been widely studied. Therefore, the aim of this study is to review the use of thyme and clove essential oils in meat preservation, with particular emphasis on their antioxidant properties to mitigate lipid and protein oxidation. Different strategies have been used to boost the effects of essential oils in foods, which include mixtures of essential oils, encapsulation and nanoemulsification techniques, with or without edible coatings. The final objective is to promote the wide use of essential oils for meat preservation, eventually in combination with other innovative approaches.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"96 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus 使用 3D 打印半月板测试半月板修复的方法

Applied Biosciences Pub Date : 2024-02-06 DOI: 10.3390/applbiosci3010007

Andrew F. Nelson, Steven Voinier, Jeremy Tran, Kristin H. Gilchrist, Melvin Helgeson, Vincent B. Ho, G. Klarmann

{"title":"Methods for Testing Meniscal Repair Using a 3D-Printed Meniscus","authors":"Andrew F. Nelson, Steven Voinier, Jeremy Tran, Kristin H. Gilchrist, Melvin Helgeson, Vincent B. Ho, G. Klarmann","doi":"10.3390/applbiosci3010007","DOIUrl":"https://doi.org/10.3390/applbiosci3010007","url":null,"abstract":"Torn and damaged menisci resulting from trauma are very common knee injuries, which can cause pain and mobility limitations and lead to osteoarthritis. Meniscal injuries can require surgery to repair the tissue damage and restore mobility. Here we describe the biomechanical testing of a 3D-printed meniscus to illustrate methods to determine if it has the strength and durability to effectively repair meniscal tears and restore knee biomechanics. This work was designed to demonstrate the steps needed to test novel meniscus repair devices prior to moving toward animal testing. The first testing step determined the ability of the 3D-printed meniscus to withstand surgical fixation by measuring the suture pull-out force. We show that vertical 2/0 silk or Fiberwire sutures need an average of 1.4 or 1.8 N, respectively, to pull through the meniscus, while horizontal sutures need only 0.7 and 1.2 N, respectively. The next step measured the compressive strength of normal, damaged, and repaired porcine meniscus tissue. Here, we show that meniscectomy decreased the stiffness of meniscus tissue from 26.7 ± 0.85 N to 7.43 ± 0.81 N at 25% strain. Menisci repaired with the 3D-printed tissue restored 66% of the measured force at 25% strain. The final step measured the contact pressures and areas in an ex vivo porcine knee before and after meniscal repair was made with the 3D-printed meniscus tissue. The example 3D-printed meniscus was successfully sutured into the porcine knee joint but failed to restore normal knee contact pressures. This work demonstrates the need for an iterative biomechanical testing process of biomaterial development, 3D-printing optimization, and knee kinematics to develop a durable and functional meniscus repair device. In summary, the methods described here serve as a guide for the functional evaluation of novel meniscus repair devices.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"78 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139858369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview 用于肉类保鲜的百里香和丁香精油的抗氧化和抗菌潜力--概述

Applied Biosciences Pub Date : 2024-02-06 DOI: 10.3390/applbiosci3010006

S. Ricardo-Rodrigues, M. Rouxinol, A. Agulheiro-Santos, M. E. Potes, M. Laranjo, Miguel Elias

{"title":"The Antioxidant and Antibacterial Potential of Thyme and Clove Essential Oils for Meat Preservation—An Overview","authors":"S. Ricardo-Rodrigues, M. Rouxinol, A. Agulheiro-Santos, M. E. Potes, M. Laranjo, Miguel Elias","doi":"10.3390/applbiosci3010006","DOIUrl":"https://doi.org/10.3390/applbiosci3010006","url":null,"abstract":"Consumers are looking for safer and more natural food options that are produced through natural methods without using synthetic preservatives. They also desire extended shelf life for their food products. Several medicinal and aromatic plants species combine food, spice, aromatic, and medicinal recognized attributes. The essential oils from these plants contain a unique mixture of compounds specific to each plant, showing notable antioxidant and antimicrobial properties. Essential oils are used widely as they are environmentally friendly, non-toxic, and biodegradable substitutes for harsh chemical preservatives. Thyme and clove are aromatic plants commonly used in traditional gastronomy, particularly in meat-based recipes. The preservation effects of these essential oils on fresh meat have not been widely studied. Therefore, the aim of this study is to review the use of thyme and clove essential oils in meat preservation, with particular emphasis on their antioxidant properties to mitigate lipid and protein oxidation. Different strategies have been used to boost the effects of essential oils in foods, which include mixtures of essential oils, encapsulation and nanoemulsification techniques, with or without edible coatings. The final objective is to promote the wide use of essential oils for meat preservation, eventually in combination with other innovative approaches.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"3 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139800356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractance Window Drying as an Alternative Method for Brewer’s Spent Grain Preservation 折射窗口干燥法作为啤酒糟保存的替代方法

Applied Biosciences Pub Date : 2024-02-01 DOI: 10.3390/applbiosci3010005

N. C. Silva, Andressa O. Santos, C. Duarte, M. Barrozo

{"title":"Refractance Window Drying as an Alternative Method for Brewer’s Spent Grain Preservation","authors":"N. C. Silva, Andressa O. Santos, C. Duarte, M. Barrozo","doi":"10.3390/applbiosci3010005","DOIUrl":"https://doi.org/10.3390/applbiosci3010005","url":null,"abstract":"Brewer’s spent grain (BSG) is a residue that holds significant potential for various applications. Given its inherently high moisture levels, it becomes imperative to explore methods for preserving it. This study investigates the use of refractance window (RW) for drying BSG. The final moisture content, water activity, and drying kinetics were assessed. Various kinetic models were analyzed, including Lewis, Page, Overhults, Brooker, and Midilli. Employing a central composite design, this study also investigated the effects of the variables temperature (55.9 to 84.1 °C) and drying time (1.6 to 4.4 h) on the quality of the dried product. The quality was assessed based on the content of bioactive compounds: phenolics, flavonoids, citric acid, and ascorbic acid. The results suggest that refractance window (RW) drying can yield a product with reduced moisture content and water activity levels (lower than 10.0% and 0.600, respectively). The phenolic, flavonoid, and citric acid higher contents were found at 70 °C and 3 to 4 h of drying. The best ascorbic acid results were found at 55 to 65 °C after 3 h of drying. The use of RW emerges as an interesting alternative for processing BSG, offering a sustainable approach to better utilize this residue.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"20 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139816099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Refractance Window Drying as an Alternative Method for Brewer’s Spent Grain Preservation 折射窗口干燥法作为啤酒糟保存的替代方法

Applied Biosciences Pub Date : 2024-02-01 DOI: 10.3390/applbiosci3010005

N. C. Silva, Andressa O. Santos, C. Duarte, M. Barrozo

{"title":"Refractance Window Drying as an Alternative Method for Brewer’s Spent Grain Preservation","authors":"N. C. Silva, Andressa O. Santos, C. Duarte, M. Barrozo","doi":"10.3390/applbiosci3010005","DOIUrl":"https://doi.org/10.3390/applbiosci3010005","url":null,"abstract":"Brewer’s spent grain (BSG) is a residue that holds significant potential for various applications. Given its inherently high moisture levels, it becomes imperative to explore methods for preserving it. This study investigates the use of refractance window (RW) for drying BSG. The final moisture content, water activity, and drying kinetics were assessed. Various kinetic models were analyzed, including Lewis, Page, Overhults, Brooker, and Midilli. Employing a central composite design, this study also investigated the effects of the variables temperature (55.9 to 84.1 °C) and drying time (1.6 to 4.4 h) on the quality of the dried product. The quality was assessed based on the content of bioactive compounds: phenolics, flavonoids, citric acid, and ascorbic acid. The results suggest that refractance window (RW) drying can yield a product with reduced moisture content and water activity levels (lower than 10.0% and 0.600, respectively). The phenolic, flavonoid, and citric acid higher contents were found at 70 °C and 3 to 4 h of drying. The best ascorbic acid results were found at 55 to 65 °C after 3 h of drying. The use of RW emerges as an interesting alternative for processing BSG, offering a sustainable approach to better utilize this residue.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139875697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles 热休克蛋白通过细胞外小泡介导肿瘤微环境中的细胞间通信

Applied Biosciences Pub Date : 2024-01-01 DOI: 10.3390/applbiosci3010003

Renata F. Saito, Camila Longo Machado, Ana Luiza Oliveira Lomba, A. Otake, Maria Cristina Rangel

{"title":"Heat Shock Proteins Mediate Intercellular Communications within the Tumor Microenvironment through Extracellular Vesicles","authors":"Renata F. Saito, Camila Longo Machado, Ana Luiza Oliveira Lomba, A. Otake, Maria Cristina Rangel","doi":"10.3390/applbiosci3010003","DOIUrl":"https://doi.org/10.3390/applbiosci3010003","url":null,"abstract":"From an evolutive perspective, tumor cells endure successive turnover upon stress conditions and pressure to adapt to new environments. These cells use exceptional communication skills to share biological information to “survive upon every metabolic cost”. The tumor microenvironment (TME) is a miscellaneous collection of cells, factors, and extracellular vesicles (EVs). EVs are small lipid bilayer-delimited particles derived from cells with sizes ranging from 100 to 1000 nm. Exosomes (<160 nm) are the minor subtype of EVs, originating from the endosomal pathways. The TME also contains “giant” vesicles, microvesicles (100–1000 nm, MV), originated from membrane blebbing. EVs can act as intercellular communication mediators, contributing to many biological processes, by carrying different biomolecules, such as proteins, lipids, nucleic acids, and metabolites. EV secretion can promote either tumor cell survival or manage their stress to death. Tumor-derived EVs transfer adaptative stress signaling to recipient cells, reprograming these cells. Heat shock proteins (HSP) are prominent stress response regulators, specifically carried by exosomes. HSP-loaded EVs reprogram tumor and TME cells to acquire mechanisms contributing to tumor progression and therapy resistance. The intercellular communication mediated by HSP-loaded EVs favors the escape of tumor cells from the endoplasmic reticulum stress, hypoxia, apoptosis, and anticancer therapies. Extracellular HSPs activate and deactivate the immune response, induce cell differentiation, change vascular homeostasis, and help to augment the pre-metastatic niche formation. Here we explore EVs’ mechanisms of HSP transmission among TME cells and the relevance of these intercellular communications in resistance to therapy.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"88 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Integration of Artificial Intelligence into Clinical Practice 人工智能与临床实践的结合

Applied Biosciences Pub Date : 2024-01-01 DOI: 10.3390/applbiosci3010002

V. Karalis

{"title":"The Integration of Artificial Intelligence into Clinical Practice","authors":"V. Karalis","doi":"10.3390/applbiosci3010002","DOIUrl":"https://doi.org/10.3390/applbiosci3010002","url":null,"abstract":"The purpose of this literature review is to provide a fundamental synopsis of current research pertaining to artificial intelligence (AI) within the domain of clinical practice. Artificial intelligence has revolutionized the field of medicine and healthcare by providing innovative solutions to complex problems. One of the most important benefits of AI in clinical practice is its ability to investigate extensive volumes of data with efficiency and precision. This has led to the development of various applications that have improved patient outcomes and reduced the workload of healthcare professionals. AI can support doctors in making more accurate diagnoses and developing personalized treatment plans. Successful examples of AI applications are outlined for a series of medical specialties like cardiology, surgery, gastroenterology, pneumology, nephrology, urology, dermatology, orthopedics, neurology, gynecology, ophthalmology, pediatrics, hematology, and critically ill patients, as well as diagnostic methods. Special reference is made to legal and ethical considerations like accuracy, informed consent, privacy issues, data security, regulatory framework, product liability, explainability, and transparency. Finally, this review closes by critically appraising AI use in clinical practice and its future perspectives. However, it is also important to approach its development and implementation cautiously to ensure ethical considerations are met.","PeriodicalId":512246,"journal":{"name":"Applied Biosciences","volume":"126 27","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139453603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0