Elina Theodorakopoulou, Shino Bay Aguilera, D. Duncan
{"title":"A New Therapeutic Approach With Rose Stem Cell Derived Exosomes and Non-Thermal Microneedling for the Treatment of Facial Pigmentation","authors":"Elina Theodorakopoulou, Shino Bay Aguilera, D. Duncan","doi":"10.1093/asjof/ojae060","DOIUrl":"https://doi.org/10.1093/asjof/ojae060","url":null,"abstract":"\u0000 \u0000 \u0000 Facial dyspigmentation is a challenging concern which cannot easily be corrected. While the application of topical exosomes has shown some efficacy, there is still scarce data addressing the role of plant derived exosomes for skin hyperpigmentation.\u0000 \u0000 \u0000 \u0000 This study using rose stem cell derived extracellular vesicles (RSCE) was performed as a proof-of-concept case series to evaluate the efficacy and safety of microneedling and topical RSCE, for the reduction of pigmentation and photoaging in adult volunteers.\u0000 \u0000 \u0000 \u0000 Twelve female volunteers were recruited, with a mean age of 46.64 years and a moderate to severe facial pigmentation, due to solar lentigines, melasma, post inflammatory hyperpigmentation and periorbital hyperpigmentation. Three treatments were performed at three weeks intervals. These consisted of the topical application of RSCE with microneedling and a 20 minute LED-light with an RSCE infused mask. A 3D facial analyzer was used to quantify improvement in superficial, deep pigmentation, skin redness and wrinkles at baseline, weeks 3, 6, and 12. GAIS, DLQI and MELASQoL scores were noted at the same timepoints.\u0000 \u0000 \u0000 \u0000 Gais scores improved by at least one scale point. Superficial pigmentation and spots decreased by 12.95% and deep pigmentation improved by 15.9%, by week 12. Skin redness was reduced by 7.34% at the same timepoint. Measured wrinkle reduction was 6.34%. DLQI scores were reduced by 10 points, and MELASQoL scores had a mean reduction of 30 points at week 12.\u0000 \u0000 \u0000 \u0000 Improvement of facial pigmentation is possible when combining non-thermal microneedling and the use of topical RSCE.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"3 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maurice Nahabedian, Steven R. Sigalove, Allen Gabriel, K. Movassaghi
{"title":"Aesthetic Breast Reconstruction: An Expert Video Roundtable Discussion","authors":"Maurice Nahabedian, Steven R. Sigalove, Allen Gabriel, K. Movassaghi","doi":"10.1093/asjof/ojae055","DOIUrl":"https://doi.org/10.1093/asjof/ojae055","url":null,"abstract":"","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"46 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141803946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tara Behroozian, Victor Ripan, Patrick J. Kim, Morgan Yuan, L. Gallo, Kathryn Ulhman, Mark McRae, Dale Podolsky, Jamil Ahmad
{"title":"Assessment of Harms Reporting Quality in Randomized Controlled Trials of Aesthetic Rhinoplasty: A Systematic Review","authors":"Tara Behroozian, Victor Ripan, Patrick J. Kim, Morgan Yuan, L. Gallo, Kathryn Ulhman, Mark McRae, Dale Podolsky, Jamil Ahmad","doi":"10.1093/asjof/ojae057","DOIUrl":"https://doi.org/10.1093/asjof/ojae057","url":null,"abstract":"\u0000 \u0000 \u0000 Rhinoplasty is one of the most common aesthetic plastic surgery procedures. Complications can lead to both aesthetic and functional impairments. The Consolidated Standards of Reporting Trials (CONSORT) Harms statement was developed to promote improved reporting of harm across RCTs.\u0000 \u0000 \u0000 \u0000 The aim of this systematic review is to assess harms reporting quality across RCTs on aesthetic rhinoplasty.\u0000 \u0000 \u0000 \u0000 A literature search was conducted in Ovid MEDLINE and Embase databases (January 1st, 2005 to August 4th, 2023). RCTs which compared two or more interventions in rhinoplasty with primarily aesthetic indications and assessed patient-important outcomes were included. The reporting quality was assessed by following a 40-item checklist endorsed by the 2022 CONSORT Harms Extension update.\u0000 \u0000 \u0000 \u0000 A total of 58 RCTs met the inclusion criteria. Fifteen RCTs addressed harms of treatment in some capacity. Overall, the reporting quality across RCTs was poor, with a median CONSORT Harms score of 33% (range: 16-83%). A reporting adherence of ≥50% was met by only eight studies. There was no significant difference in reporting adherence between studies based on journal endorsement of CONSORT or industry vs. non-industry funding sources (p > 0.05). A high journal impact factor was significantly associated with a higher reporting quality (p = 0.044).\u0000 \u0000 \u0000 \u0000 CONSORT Harms reporting adherence was poor across the majority of included RCTs. Future trials on aesthetic rhinoplasty should aim to follow the reporting recommendations endorsed by the CONSORT Harms statement to increase transparency and minimize heterogeneity in harms reporting across studies.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Shridharani, Jean Carruthers, Michael A C Kane, Lawrence Bass
{"title":"Innovations in Injectables: An Expert Video Roundtable Discussion","authors":"S. Shridharani, Jean Carruthers, Michael A C Kane, Lawrence Bass","doi":"10.1093/asjof/ojae054","DOIUrl":"https://doi.org/10.1093/asjof/ojae054","url":null,"abstract":"","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"40 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141816888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jeffrey A. Gusenoff, David Sieber, Douglas Steinbrech
{"title":"High-Definition Liposuction: An Expert Video Roundtable Discussion","authors":"Jeffrey A. Gusenoff, David Sieber, Douglas Steinbrech","doi":"10.1093/asjof/ojae056","DOIUrl":"https://doi.org/10.1093/asjof/ojae056","url":null,"abstract":"","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"8 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Bibliometric Analysis of the Top 100 Papers on Gluteal Augmentation","authors":"Kian Daneshi, Hamid Reza Khademi Mansour, Niels Pacheco-Barrios, Ayobami Asaju, Mauricio Perez Pachon, Alfredo E Hoyos, Ankur Khajuria","doi":"10.1093/asjof/ojae053","DOIUrl":"https://doi.org/10.1093/asjof/ojae053","url":null,"abstract":"\u0000 \u0000 \u0000 Gluteoplasty or gluteal augmentation is a popular cosmetic procedure that is used to improve the volume, shape, and contour of the buttocks.\u0000 \u0000 \u0000 \u0000 This bibliometric analysis aims to characterise emerging research trends and to assess the methodological quality of the highest impact gluteoplasty research.\u0000 \u0000 \u0000 \u0000 The 100 most cited publications in gluteoplasty were identified on Web of Science, across all available journal years (from Inception to August 2023). Study details, including the citation count, main content focus, and outcome measures were extracted and tabulated from each publication. Oxford Centre for Evidence Based Medicine (OCEBM) Levels of Evidence (LOE) of each study were assessed.\u0000 \u0000 \u0000 \u0000 The 100 most cited publications regarding gluteoplasty were cited by a total of 2375 publications. Citations per publication ranged from 5 to 176 (mean 23.75 ± 25.86), with the highest-cited study being authored by Simonacci, discussing autologous fat grafting (n = 176). Most publications were LOE 5 (n = 55), representative of the large number of case series and reports. The number of publications for LOE 1, 2, 3, 4 was 1, 9, 13 and 22 respectively. The main content focus was ‘surgical technique’ in 38 publications, followed by ‘outcomes’ (n = 34) and’risk factors/prognosis’ (n = 10). Patient reported outcome measures (PROMs) were used in 20 publications, and 33 publications reported aesthetic outcome measures.\u0000 \u0000 \u0000 \u0000 This analysis demonstrates a need for the improvement in research methodologies regarding gluteoplasty research. This advancement would be facilitated with robust, high-quality research via randomised control trials and multicentre studies as well the further development of validated patient reported outcome measures (PROMs) for gluteoplasty.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"106 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141667157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Targeted Verifiable Subcision for Management of Cellulite on the Buttock and Thigh: Incorporation Into Real-World Lower Body Rejuvenation Approaches","authors":"Johnny Franco, M. Calobrace, Matthew R Schulman","doi":"10.1093/asjof/ojae050","DOIUrl":"https://doi.org/10.1093/asjof/ojae050","url":null,"abstract":"\u0000 \u0000 \u0000 Cellulite affects 80 to 98% of post-pubertal females, and most patients with the condition are bothered by it. Targeted Verifiable Subcision™ (TVS; Avéli® [Revelle Aesthetics, Inc., Mountain View, CA]) is a minimally invasive mechanical subcision device which reduces the appearance of cellulite dimples in the buttocks and thighs. While clinical trials have demonstrated efficacy, information on real-world, surgical and non-surgical approaches on the buttocks and thighs is needed.\u0000 \u0000 \u0000 \u0000 To describe how TVS is being used by the authors to improve patient outcomes in the lower body in both the surgical and non-surgical setting.\u0000 \u0000 \u0000 \u0000 Each of the authors described their current practices using TVS for lower body rejuvenation. Author practices have varied proportions of surgical vs. non-surgical cases (from 10 to 100% surgical cases) and a variety of focuses, ranging from primarily facial aesthetics to near exclusive focus on body contouring.\u0000 \u0000 \u0000 \u0000 The authors’ diverse approaches to integrating TVS into clinical practice are detailed, along with pearls for clinical success. TVS is discussed as a companion treatment for surgical procedures, while the patient is already under anesthesia, as well as part of a non-surgical approach, where the local anesthesia required for TVS can make additional energy-based procedures more comfortable for the patient. The authors provide several examples and include considerations for optimal timing and ordering of treatments.\u0000 \u0000 \u0000 \u0000 TVS may become a valuable addition to the treatment armamentarium for surgical or nonsurgical buttock and thigh rejuvenation and can be integrated into surgical and non-surgical workflows.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"96 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141683717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cameron A Etebari, Sterling E Braun, Maria C Vazquez-Machado, James A Butterworth
{"title":"Who Posts on Instagram? Using Natural Language Processing to Assess the Relationship Between Training Background and Content of 700,000 Posts","authors":"Cameron A Etebari, Sterling E Braun, Maria C Vazquez-Machado, James A Butterworth","doi":"10.1093/asjof/ojae048","DOIUrl":"https://doi.org/10.1093/asjof/ojae048","url":null,"abstract":"\u0000 \u0000 \u0000 Instagram is a major platform for the dissemination of plastic surgery (PS) information, but the training background of users is difficult to ascertain.\u0000 \u0000 \u0000 \u0000 We sought to better characterize the source and content of PS related posts on Instagram.\u0000 \u0000 \u0000 \u0000 Metadata from publicly available Instagram posts containing PS relevant hashtags was collected from December 2018 through August 2020 using Node.js (Node.js Foundation, San Francisco, CA). The data was characterized by account type and post topics were analyzed using a custom dictionary of PS procedures applied with natural language processing. All data analyses were performed with ‘R’.\u0000 \u0000 \u0000 \u0000 Board Certified Plastic Surgeons account for 38% of posts on Instagram, followed by Organizations (31%), non-plastics trained physicians (19%), Facial Plastics (5%), Oculoplastics (1%), and non-physician providers (5%). Oculoplastics had the highest engagement rate with their posts (3.7 ± 5.1) while Plastic Surgeons had the lowest (2.7 ± 4.2). Breast aesthetics was the predominant topic posted by Plastic Surgeons (42%, p < 0.001), and board certification phrases distinguished their posts from other account types (23%, p < 0.001). Non-physician posts focused on non-surgical aesthetics like Botox and fillers (80%). However, non-plastics trained physicians and organizations significantly contributed to procedural sub-categories in a similar distribution to Plastic Surgeons.\u0000 \u0000 \u0000 \u0000 Board Certified Plastic Surgeons are not the predominant source of PS content on Instagram. Furthermore, posts by Plastic Surgeons have the lowest rate of engagement out of all account types studied. Though declarations of Board Certification distinguish content from Plastics disciplines, they are only used in 21% of posts.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"118 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141341872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temperance With TXA: Increased Risk of Venous Thromboembolism in Abdominoplasty","authors":"Sarah A Mess, Katarina N Stephanos","doi":"10.1093/asjof/ojae044","DOIUrl":"https://doi.org/10.1093/asjof/ojae044","url":null,"abstract":"\u0000 \u0000 \u0000 Tranexamic acid (TXA) is used widely in surgery to mitigate blood loss by inhibiting the fibrinolytic degradation of clot. The occurrence of venous thromboembolism (VTE) with TXA has not been reported in the plastic surgery literature. In the realm of plastic surgery, abdominoplasty has the highest rate of VTE.\u0000 \u0000 \u0000 \u0000 The purpose of this study is to report five cases of VTE with TXA.\u0000 \u0000 \u0000 \u0000 A single surgeon reviewed the records of five patients who incurred VTE with TXA. TXA was added to the tumescent fluid, 20 mg/kg total. Four of the five patients underwent abdominoplasty combined with liposuction and breast surgery and the fifth, fat transfer to the breast. The abdominoplasty patients had received chemoprophylaxis. Upon presentation of symptoms, the patients were sent to the hospital for anticoagulation and hematology consultation.\u0000 \u0000 \u0000 \u0000 The five patients survived their VTE events; two only required oral anticoagulation, two required IV Heparin then oral, and one required TPA then oral. VTE with abdominoplasty occurred in 0 of 399 cases prior to use of TXA and in 4 of 98 cases after the use of TXA in the tumescent.\u0000 \u0000 \u0000 \u0000 Although the occurrence of VTE with abdominoplasty increased with the use of TXA for the senior author, this retrospective case study does not prove a causal relationship between TXA and VTE.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141372019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine H. Carruthers, W. G. Austen, Katya Remy, Ryoko Hamaguchi, Sofia Liu, Krishna Vyas, Branko Bojovic
{"title":"Improving the Retention of Low-Volume Autologous Fat Grafting: A Comparative Analysis of Lipoaspirate Processing Techniques for Facial Feminization","authors":"Katherine H. Carruthers, W. G. Austen, Katya Remy, Ryoko Hamaguchi, Sofia Liu, Krishna Vyas, Branko Bojovic","doi":"10.1093/asjof/ojae043","DOIUrl":"https://doi.org/10.1093/asjof/ojae043","url":null,"abstract":"\u0000 \u0000 \u0000 Outcomes following autologous fat grafting have historically been unpredictable due to variability in fat retention rates. The novel Poloxamer wash, absorption, mesh filtration system (PWAS) uses proprietary technology to stabilize and concentrate lipoaspirate. Its use in low-volume fat grafting has not been reported. This study aimed to compare PWAS technology to traditional lipoaspirate processing techniques in low-volume fat grafting procedures.\u0000 \u0000 \u0000 \u0000 Medical charts were reviewed to determine a consecutive cohort of patients who underwent fat grafting for facial feminization. All patients had obtained preoperative and postoperative three-dimensional facial imaging. Patients were grouped based on the method of lipoaspirate processing. Analysis software was used to measure change in facial volume, and percent retention was calculated.\u0000 \u0000 \u0000 \u0000 Between September 2021 and February 2023, eleven facial fat grafting procedures occurred using the PWAS system, and five occurred using traditional lipoaspirate osmotic filtration with Telfa. Age and BMI were statistically similar between both groups (p>0.1). The average volume of lipoaspirate that was grafted was 23.4 mL (S.D. 10.9mL) and similar between both groups (p>0.1). The mean follow-up duration was 7.1 (S.D. 3.1) months (7.2 S.D. 3.5 months in the PWAS group versus 7.0 S.D. 2.2 months in the osmotic filtration group, p>0.5). The average fat volume retention was 73.1% (S.D. 6.8%) in patients where the PWAS system was used as compared to 46.1% (S.D. 5.2%) in patients where osmotic filtration was used (p<0.01).\u0000 \u0000 \u0000 \u0000 For patients undergoing low-volume fat grafting, the PWAS technology may result in improved fat retention rates as compared to traditional lipoaspirate processing with Telfa.\u0000","PeriodicalId":512050,"journal":{"name":"Aesthetic Surgery Journal Open Forum","volume":"21 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141269046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}