The journal of Tehran Heart Center最新文献

{"title":"Pay Heed and Proceed: Acute Ascending Aortic Dissection Presenting as Acute Left Main Coronary Artery Occlusion.","authors":"Sriram Veeraraghavan, Bharath Raj Kidambi, Vasundhara Ponnaganti","doi":"10.18502/jthc.v19i4.17619","DOIUrl":"10.18502/jthc.v19i4.17619","url":null,"abstract":"","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 4","pages":"302-305"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126195/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of Oxidative Stress Markers and Risk of Coronary Artery Calcification.","authors":"Seyedeh Sahar Nazemi, Sara Samadi, Sara Rahsepar, Batool Zarei, Amir Hooshang Mohammadpour, Farshad Abedi, Navid Omidkhoda, Majid Sezavar","doi":"10.18502/jthc.v19i4.17606","DOIUrl":"10.18502/jthc.v19i4.17606","url":null,"abstract":"<p><strong>Background: </strong>Early diagnosis of atherosclerosis, particularly in its subclinical phase, is crucial for reducing mortality and morbidity associated with cardiovascular diseases. This study aims to investigate the relationship between oxidative stress markers and coronary artery calcification (CAC), enhancing our understanding of the pathophysiology of CAC.</p><p><strong>Methods: </strong>In October 2022, we conducted a systematic search of the Web of Science, Scopus, PubMed, and Embase databases without language or time restrictions, screening a total of 557 records. We excluded studies involving animals, in vitro experiments, reviews, case reports, clinical trials, editorials, and clinical guidelines. Eligible human observational studies (cohort and cross-sectional) that examined the link between CAC and oxidative stress markers were included. The Newcastle-Ottawa Scale was employed to assess the quality of the included studies.</p><p><strong>Results: </strong>Our systematic review encompassed 40 studies, all of which included both male and female participants, predominantly using cross-sectional designs. Participants included individuals at low, intermediate, or high risk of coronary artery disease, patients with type 2 diabetes, those with existing cardiovascular disease, and asymptomatic individuals. The studies investigated various oxidative stress markers, including serum uric acid and 8-isoprostane, both of which showed strong correlations with CAC incidence and severity.</p><p><strong>Conclusion: </strong>Oxidative stress markers may positively correlate with CAC scores, indicating a potential avenue for identifying individuals at heightened risk. This review underscores the need for further studies to facilitate early diagnosis of cardiovascular complications and the establishment of novel pharmacological targets.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 4","pages":"230-242"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126191/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Ventricular Dyssynchrony Measured by Tissue Doppler Indices in Fetuses of Diabetic Mothers: A Case-Control Study.","authors":"Mojgan Kalai Moghadam, Mohammad Nasir Hemmatian, Majid Mirmohammadkhani, Mojgan Rahmanian","doi":"10.18502/jthc.v19i4.17614","DOIUrl":"10.18502/jthc.v19i4.17614","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effects of overt maternal diabetes on fetal cardiac function.</p><p><strong>Methods: </strong>In this case-control study, 26 pregnant women with overt diabetes (the case group) and 26 women with uncomplicated pregnancies (the control group) were examined using tissue Doppler echocardiography. Cardiac function was assessed twice in the fetal period (18-22 weeks and 28 weeks of gestation) and once in the neonatal period (1 week postnatal). Fetal cardiac function was assessed using early-diastolic maximum velocity index (Em), end-diastolic maximum velocity index (Am), Em/Am, left ventricular myocardial function index (LVMPI), and interventricular mechanical delay index (IVMDI).</p><p><strong>Results: </strong>The case and control groups were not significantly different in maternal and gestational age in fetal Doppler evaluation. Em (P=0.007), Am (P<0.001), LVMPI (P=0.003), and IVMDI (P=0.026) were significantly higher in the case group than in the control group, while there was no significant difference in Em/Am (P=0.264). Eight fetuses (30.8%) of diabetic mothers had dyssynchrony, while no cases of dyssynchrony were seen in fetuses of non-diabetic mothers (P=0.004). Infants of diabetic mothers were 8.8 times more likely to develop adverse neonatal outcomes than infants of healthy mothers (RR: 8.8, 95% CI: 1.71 to 45.31, P=0.009).</p><p><strong>Conclusion: </strong>The findings of the current study revealed significant cardiac dysfunction and dyssynchrony in fetuses of diabetic pregnant women. Additionally, IVMDI and LVMPI can be used to predict adverse neonatal outcomes in pregnancies complicated with overt diabetes.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 4","pages":"276-282"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12126184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Albumin 20% and Hydroxyethyl Starch 6% on Bleeding and Interleukin-6 Levels as Priming Solutions for Cardiopulmonary Bypass: A Randomized Controlled Trial.","authors":"Alireza Hosseini, Mehran Shahzamani, Atefe Hashemabsdi, Alireza Andalib","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Cardiopulmonary bypass (CPB) can adversely affect coagulation and systemic inflammatory response. Given that the optimal strategy for priming CPB in cardiac surgery remains a matter of debate, this study aimed to investigate the effects of albumin 20% and hydroxyethyl starch 6% as priming solutions on bleeding and interleukin-6 (IL-6) levels during CPB.</p><p><strong>Methods: </strong>This randomized clinical trial involved 40 patients undergoing coronary artery bypass surgery at Shahid Chamran Hospital between July 2021 and July 2022. Participants were assigned to 2 groups: the first group received 50 mL of albumin 20% as the priming solution for the CPB circuit, while the second group received 500 mL of hydroxyethyl starch 6%. Bleeding and IL-6 levels were assessed before and after the intervention.</p><p><strong>Results: </strong>The albumin group comprised 80.0% men and 20.0% women, with a mean age of 66.45±5.84 years. The hydroxyethyl starch 6% group consisted of 85.0% men and 15.0% women, with a mean age of 63.05±5.92 years (P>0.05). The findings revealed that 12 hours after CPB, the IL-6 level in the hydroxyethyl starch 6% group (mean: 171.6±77.71 pg/mL) was significantly higher than that in the albumin group (mean: 105.8±36.45 pg/mL; P=0.002). At 48 hours after CPB, the mean bleeding was not significantly different between the groups (P=0.950).</p><p><strong>Conclusion: </strong>Albumin 20% was more effective than hydroxyethyl starch 6% concerning IL-6 levels. However, no significant differences in bleeding were observed between the groups at 48 hours post-CPB.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"162-169"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conditioned Medium from Human Amniotic Membrane-Derived Mesenchymal Stem Cells Modulates Inflammatory and Myofibrotic Factors in Vivo.","authors":"Gazaleh Asgharnezhad, Sachli Mohamadi, Mahdieh Mehrab Mohseni, Neda Mousvi-Niri, Maryam Naseroleslami","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Heart failure (HF) is a prevalent diagnosis with a significant mortality rate. Various therapeutic approaches exist for treating HF, and human adipose-derived mesenchymal stem cells-conditioned medium (hAMSCs-CM) therapy has emerged as a promising option. Despite its potential efficacy, the precise mechanism of action underlying hAMSCs-CM treatment remains unclear. To address this knowledge gap, we conducted a novel animal study to investigate the mechanism of action of hAMSCs-CM in an HF model, with a specific focus on transforming growth factor-β (TGF-β)/galectin-3, monocyte chemoattractant protein-1 (MCP1), B-type natriuretic peptide (BNP), and aldosterone (ALD).</p><p><strong>Methods: </strong>Forty adult male Wistar rats were divided into 4 groups: control, HF, culture medium, and CM. All rats, except those in the control group, received an injection of isoproterenol to induce an animal model of HF. The CM group was administered the CM, while those in the culture medium group received standard culture media. Subsequently, serum levels of fibrotic factors, including TGF-β/galectin-3, MCP1, BNP, and ALD, were measured using ELISA. Statistical analysis was performed using one-way analysis of variance and the Tukey test.</p><p><strong>Results: </strong>Serum levels of TGF-β/galectin-3, MCP1, BNP, and ALD were significantly elevated in the HF, CM, and culture medium groups compared with the control group (P<0.001). Additionally, these fibrotic factors were significantly reduced in the CM group compared with the HF group (P<0.001). Notably, CM therapy could not restore TGF-β/galectin-3, MCP1, BNP, or ALD levels to the normal range observed in the control group.</p><p><strong>Conclusion: </strong>Our findings indicate that hAMSCs-CM modulates the expression of inflammatory and fibrotic cytokines, such as TGF-β/galectin-3, MCP1, BNP, and ALD, in isoproterenol-induced HF in male rats. These results contribute to a better understanding of the therapeutic mechanisms underlying hAMSCs-CM treatment for HF.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"198-205"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144016187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"The Impact of Mean Arterial Pressure during Cardiopulmonary Bypass on Postoperative Outcomes in Coronary Artery Bypass Graft Surgery\".","authors":"Muhammet Hüseyin Erkan, Abdullah Güner","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"227"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014177/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tracheostomy Cuff Herniation following Cardiac and Pulmonary Arrest.","authors":"Yasmin Chaibakhsh, Mohammad Ziae Totonchi Ghorbani, Nader Givtaj, Nahid Aghdaei, Maryam Ghadimi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Tracheostomy is a common procedure performed on patients who require long-term airway maintenance and ventilation support. It is preferred over endotracheal intubation due to its reduced airway resistance, lower risk of displacement compared with the endotracheal tube, increased patient comfort, improved weaning from mechanical ventilation, and enhanced suction capabilities. According to the literature, patients needing airway support for fewer than 12 days can undergo translaryngeal intubation, while tracheostomy is indicated for patients requiring ventilatory support for more than 20 days. Although tracheostomy is frequently performed in ICUs and operating rooms, several complications can arise following the procedure. These complications include leakage, obstruction of the tracheal tube, minor or major bleeding or oozing, barotrauma, infections, tracheoesophageal fistula, stenosis, and injury to surrounding peripheral tissues such as arteries, veins, and nerves.¹ While herniation of the endotracheal cuff is a more common cause of airway obstruction and hypoxia, tracheostomy tube cuff herniation is a rare complication of this procedure.^1-7 In this report, we present a rare case of cardiopulmonary arrest following the implantation of a tracheostomy tube cuff in a female patient and its management.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"216-219"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014174/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pericardial Effusion in the Transverse Sinus.","authors":"Neda Toofaninejad, Ali Hosseinsabet","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"225-226"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144065250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Echocardiographic Findings to Improve Diagnostic and Prognostic Assessments in Moderate Aortic Valve Stenosis: A Comprehensive Review.","authors":"Mohammad Sahebjam, Akbar Shafiee","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Aortic valve stenosis (AS) is the most common valvular heart disease in developed countries, with its prevalence on the rise due to aging populations. While severe AS has long been recognized as high-risk, recent studies have shed light on the significant association between moderate AS and cardiovascular morbidity and mortality. Yet, the data are still inconclusive. With noninvasive multi-modality imaging techniques advancing rapidly, we now have more insight into the underlying biology of AS. Echocardiography continues to serve as the primary noninvasive imaging modality for diagnosing and grading AS. This comprehensive review delves into the role of echocardiography in diagnosing moderate AS and how the findings can support clinicians in making well-informed decisions that impact patients' prognoses.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"153-161"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Demographic and Lifestyle Characteristics of Patients with Familial Hypercholesterolemia Referred to a Dyslipidemia Clinic: A Cross-Sectional Single-Center Study.","authors":"Maryam Moshkani Farahani, Danial Samiei Nasr, Alireza Nasiri, Mohamad Javad Soltanpour","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Familial hypercholesterolemia (FH) is one of the most prevalent dyslipidemia disorders. This study investigated the demographic and lifestyle characteristics of patients with FH referred to a dyslipidemia clinic.</p><p><strong>Methods: </strong>This 5-year, single-center cross-sectional study focused on patients with low-density lipoprotein cholesterol (LDL-C) levels higher than 190 mg/dL referred to a dyslipidemia clinic in Tehran, Iran, between 2017 and 2022. The study examined their demographics, physical activity, and anxiety within the FH cohort.</p><p><strong>Results: </strong>A total of 1724 patients were referred to the dyslipidemia clinic. Of these patients, 44 were diagnosed with definite FH. The mean age and LDL-C level of the FH cohort were 38.84±16.85 years and 315.95±81.73 mg/dL, respectively. A significant correlation was found between LDL-C and body mass index (BMI) (correlation coefficient = -0.31, P=0.031) and total sleep duration (correlation coefficient = -0.40, P<0.000). No correlation was observed between age and physical activity or LDL-C levels. Additionally, no significant correlation was detected between the Dutch score and patients' LDL-C, BMI, age, or physical activity. Regression analysis indicated that BMI and total sleep duration were independent predictors of LDL-C in the FH cohort.</p><p><strong>Conclusion: </strong>Investigating and identifying patients' demographic and lifestyle characteristics is the first step in planning efficient and effective management strategies for chronic diseases, such as FH. Establishing a patient registry for chronic diseases enhances understanding of the target population and enables healthcare providers to design and implement appropriate preventive and control strategies.</p>","PeriodicalId":510886,"journal":{"name":"The journal of Tehran Heart Center","volume":"19 3","pages":"192-197"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12014172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}