Canadian liver journal最新文献_第6页

Identifying patients with diagnosed cirrhosis in administrative health databases: a validation study. 在行政健康数据库中识别已确诊的肝硬化患者：一项验证研究。

Canadian liver journal Pub Date : 2024-02-26 eCollection Date: 2024-02-01 DOI: 10.3138/canlivj-2023-0013

Nabiha Faisal, Lisa M Lix, Randy Walld, Alexander Singer, Eberhard Renner, Harminder Singh, Leanne Kosowan, Alyson Mahar

{"title":"Identifying patients with diagnosed cirrhosis in administrative health databases: a validation study.","authors":"Nabiha Faisal, Lisa M Lix, Randy Walld, Alexander Singer, Eberhard Renner, Harminder Singh, Leanne Kosowan, Alyson Mahar","doi":"10.3138/canlivj-2023-0013","DOIUrl":"https://doi.org/10.3138/canlivj-2023-0013","url":null,"abstract":"Objectives: Case ascertainment algorithms were developed and validated to identify people living with cirrhosis in administrative health data in Manitoba, Canada using primary care electronic medical records (EMR) to define the reference standards.Methods: We linked provincial administrative health data to primary care EMR data. The validation cohort included 116,675 Manitobans aged >18 years with at least one primary care visit between April 1998 and March 2015. Hospital records, physician billing claims, vital statistics, and prescription drug data were used to develop and test 93 case-finding algorithms. A validated case definition for primary care EMR data was the reference standard. We estimated sensitivity, specificity, positive and negative predictive values (PPV, NPV), Youden's index, area under the receiver operative curve, and their 95% confidence intervals (CIs).Results: A total of 116,675 people were in the validation cohort. The prevalence of cirrhosis was 1.4% (n = 1593). Algorithm sensitivity estimates ranged from 32.5% (95% CI 32.2-32.8) to 68.3% (95% CI 68.0-68.9) and PPV from 17.4% (95% CI 17.1-17.6) to 23.4% (95% CI 23.1-23.6). Specificity (95.5-98.2) and NPV (approximately 99%) were high for all algorithms. The algorithms had slightly higher sensitivity estimates among men compared with women, and individuals aged ≥45 years compared to those aged 18-44 years.Conclusion: Cirrhosis algorithms applied to administrative health data had moderate validity when a validated case definition for primary care EMRs was the reference standard. This study provides algorithms for identifying diagnosed cirrhosis cases for population-based research and surveillance studies.","PeriodicalId":510884,"journal":{"name":"Canadian liver journal","volume":"7 1","pages":"16-27"},"PeriodicalIF":0.0,"publicationDate":"2024-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10946181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140178588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Survivor guilt. The ghost that haunts us. 幸存者内疚困扰我们的幽灵

Canadian liver journal Pub Date : 2024-02-26 eCollection Date: 2024-02-01 DOI: 10.3138/canlivj-2023-0012

Karen Stacey

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Annual Meeting of the Canadian Association for the Study of the Liver (CASL), the Canadian Network on Hepatitis C (CANHEPC) and the Canadian Association of Hepatology Nurses (CAHN) 2024 Abstracts. 加拿大肝脏研究协会（CASL）、加拿大丙型肝炎网络（CANHEPC）和加拿大肝病护士协会（CAHN）2024 年年会摘要。

Canadian liver journal Pub Date : 2024-02-26 eCollection Date: 2024-02-01 DOI: 10.3138/canlivj-7.1-abst

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Equitable access to direct-acting antivirals: Canada's path to a hepatitis C-free tomorrow. 公平获取直接作用抗病毒药物：加拿大通往无丙型肝炎明天之路。

Canadian liver journal Pub Date : 2024-02-26 eCollection Date: 2024-02-01 DOI: 10.3138/canlivj-2023-0038

Faranak Canani, Jordan J Feld, Mia J Biondi

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Hepatology and the humanities. 肝病学与人文科学

Canadian liver journal Pub Date : 2024-02-26 eCollection Date: 2024-02-01 DOI: 10.3138/canlivj-2024-0005

Eric M Yoshida, Natasha Chandok

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Timing of elimination of hepatitis C virus in Canada's provinces. 加拿大各省消灭丙型肝炎病毒的时间安排。

Canadian liver journal Pub Date : 2022-11-07 eCollection Date: 2022-11-01 DOI: 10.3138/canlivj-2022-0003

Jordan J Feld, Marina B Klein, Yasmine Rahal, Samuel S Lee, Shawn Mohammed, Alexandra King, Daniel Smyth, Yuri Sanchez Gonzalez, Arlene Nugent, Naveed Z Janjua

{"title":"Timing of elimination of hepatitis C virus in Canada's provinces.","authors":"Jordan J Feld, Marina B Klein, Yasmine Rahal, Samuel S Lee, Shawn Mohammed, Alexandra King, Daniel Smyth, Yuri Sanchez Gonzalez, Arlene Nugent, Naveed Z Janjua","doi":"10.3138/canlivj-2022-0003","DOIUrl":"10.3138/canlivj-2022-0003","url":null,"abstract":"BACKGROUND: Infection with chronic hepatitis C virus is a global public health concern. A recent study concluded that Canada is on track to achieve hepatitis C elimination goals set by the World Health Organization if treatment levels are maintained. However, recently a falling temporal trend in treatments in Canada was observed, with most provinces seeing a decrease before the global coronavirus pandemic. This study assesses the timing of elimination of hepatitis C in the 10 provinces of Canada. METHODS: Previously published disease and economic burden model of hepatitis C infection was populated with the latest epidemiological and cost data for each Canadian province. Five scenarios were modelled: maintaining the status quo, decreasing diagnosis and treatment levels by 10% annually, decreasing diagnosis and treatment levels by 20% annually, increasing them by 10% annually, and assuming a scenario with no post-coronavirus pandemic recovery in treatment levels. Year of achieving hepatitis C elimination, necessary annual treatments for elimination, and associated disease and economic burden were determined for each province. RESULTS: If status quo is maintained, Manitoba, Ontario, and Québec are off track to achieve hepatitis C elimination by 2030 and would require 540, 7,700, and 2,800 annual treatments, respectively, to get on track. Timely elimination would save 170 lives and CAD $122.6 million in direct medical costs in these three provinces. CONCLUSIONS: Three of Canada's provinces-two of them the most populous in the country-are off track to achieve the hepatitis C elimination goal. Building frameworks and innovative approaches to prevention, testing, and treatment will be necessary to achieve this goal.","PeriodicalId":510884,"journal":{"name":"Canadian liver journal","volume":"5 4","pages":"493-506"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10735197/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139033153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Corrigendum. 更正。

Canadian liver journal Pub Date : 2022-11-07 eCollection Date: 2022-11-01 DOI: 10.3138/canlivj-2022-10-03

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