Frontiers in Public Health最新文献

{"title":"Whole-genome sequencing-based genetic diversity, transmission dynamics, and drug-resistant mutations in Mycobacterium tuberculosis isolated from extrapulmonary tuberculosis patients in western Ethiopia","authors":"Basha Chekesa, Harinder Singh, Norberto Gonzalez-Juarbe, Sanjay Vashee, Rosana Wiscovitch-Russo, Christopher L. Dupont, M. Girma, O. Kerro, B. Gumi, G. Ameni","doi":"10.3389/fpubh.2024.1399731","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1399731","url":null,"abstract":"Extrapulmonary tuberculosis (EPTB) refers to a form of Tuberculosis (TB) where the infection occurs outside the lungs. Despite EPTB being a devastating disease of public health concern, it is frequently overlooked as a public health problem. This study aimed to investigate genetic diversity, identify drug-resistance mutations, and trace ongoing transmission chains.A cross-sectional study was undertaken on individuals with EPTB in western Ethiopia. In this study, whole-genome sequencing (WGS) was employed to analyze Mycobacterium tuberculosis (MTB) samples obtained from EPTB patients. Out of the 96 genomes initially sequenced, 89 met the required quality standards for genetic diversity, and drug-resistant mutations analysis. The data were processed using robust bioinformatics tools.Our analysis reveals that the majority (87.64%) of the isolates can be attributed to Lineage-4 (L4), with L4.6.3 and L4.2.2.2 emerging as the predominant sub-lineages, constituting 34.62% and 26.92%, respectively. The overall clustering rate and recent transmission index (RTI) were 30 and 17.24%, respectively. Notably, 7.87% of the isolates demonstrated resistance to at least one anti-TB drug, although multi-drug resistance (MDR) was observed in only 1.12% of the isolates.The genetic diversity of MTBC strains in western Ethiopia was found to have low inter-lineage diversity, with L4 predominating and exhibiting high intra-lineage diversity. The notably high clustering rate in the region implies a pressing need for enhanced TB infection control measures to effectively disrupt the transmission chain. It’s noteworthy that 68.75% of resistance-conferring mutations went undetected by both GeneXpert MTB/RIF and the line probe assay (LPA) in western Ethiopia. The identification of resistance mutations undetected by both GeneXpert and LPA, along with the detection of mixed infections through WGS, emphasizes the value of adopting WGS as a high-resolution approach for TB diagnosis and molecular epidemiological surveillance.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"4 25","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"External RF-EMF alters cell number and ROS balance possibly via the regulation of NADPH metabolism and apoptosis","authors":"Sheung-Ching Chow, Yang Zhang, Raymond W. M. Ng, Shu-Yuen Ron Hui, I. Solov’yov, Wing-Yee Lui","doi":"10.3389/fpubh.2024.1425023","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1425023","url":null,"abstract":"The influence of weak radio-frequency electromagnetic field (RF-EMF) on living organisms raises new concern because of the Industrial, Scientific, and Medical (ISM) frequency band at 6.78 MHz being promoted by the AirFuel Alliance for mid-range wireless power transfer (WPT) applications and product development. Human exposure to the RF-EMF radiation is unavoidable. In this study, we employed in vitro cell culture and molecular biology approach coupled with integrated transcriptomic and proteomic analyses to uncover the effects of RF-EMF on cells at molecular and cellular levels. Our study has demonstrated that weak RF-EMF is sufficient to exert non-thermal effects on human umbilical vein endothelial cells (HUVEC). Exposure of weak RF-EMF promotes cell proliferation, inhibits apoptosis and deregulates ROS balance. Alteration of several signaling pathways and key enzymes involved in NADPH metabolism, cell proliferation and ferroptosis were identified. Our current study provide solid evidence for the first time that the present safety standards that solely considered the thermal effect of RF-EMF on cell tissue are inadequate, prompt response and modification of existing Guidelines, Standards and Regulation are warranted.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"17 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the impact of vaccination and medical resource allocation on infectious disease outbreak management: a case study of COVID-19 in Taiyuan City","authors":"Jiaming Guo, Yuxin Luo, Yifei Ma, Shujun Xu, Jiantao Li, Tong Wang, Lijian Lei, Lu He, Hongmei Yu, Jun Xie","doi":"10.3389/fpubh.2024.1368876","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1368876","url":null,"abstract":"Amidst an emerging infectious disease outbreak, the rational allocation of vaccines and medical resources is crucial for controlling the epidemic’s progression.Analysing COVID-19 data in Taiyuan City from December 2022 to January 2023, this study constructed a SV1V2V3EIQHR dynamics model to assess the impact of COVID-19 vaccination and resource allocation on epidemic trends.Vaccination significantly reduces infection rates, hospitalisations, and severe cases, while also curtailing strain on medical resources by reducing congestion periods. An early and sufficient reserve of medical resources can delay the onset of medical congestion, and with increased maximum capacity of medical resources, the congestion’s end can be accelerated. Stronger resource allocation capabilities lead to earlier congestion resolution within a fixed total resource pool.Integrating vaccination and medical resource allocation can effectively reduce medical congestion duration and alleviate the epidemic’s strain on medical resource capacity (CCMR).","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Needs of social isolation, loneliness, and intergenerational interventions in the United States: a scoping review","authors":"Jeremy Holloway, Dara L. James, Alyssa Robillard, Janice Hermer, Nanako A Hawley, Owais Sayeed","doi":"10.3389/fpubh.2024.1386651","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1386651","url":null,"abstract":"Social isolation and loneliness are major health concerns for older adults in the United States. This scoping review examines the effectiveness of intergenerational interventions aimed at reducing social isolation and loneliness among older adults in the United States, specifically through programs that engage university students from healthcare-related fields in one-on-one settings with older adults, as reports of lacking geriatric training of healthcare students causes older adult neglect to persist in the healthcare workforce. The importance of addressing these issues is underscored by significant health risks and substantial economic burdens, with social isolation and loneliness potentially increasing mortality and costing Medicare an estimated $6.7 billion annually. Covering literature from 2010 to 2022, this review critically assesses the role of such interventions in fostering social connections and improving both physical and mental health outcomes. Despite the positive preliminary results indicating significant reductions in loneliness and enhancements in social networks among participants, the review highlights considerable gaps in current research, particularly in structured intervention curricula, demographic reporting and detailed intervention descriptions. This underscores the need for more rigorous and standardized research methodologies to better understand the effectiveness and potential of intergenerational programs as interventions against the detrimental effects of social isolation and loneliness among older adults.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"37 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influenza vaccination for heart failure patients: a cost-effectiveness analysis from the perspective of Chinese healthcare system","authors":"Minting Zhao, Fuqiang Liu, Lan Wang, Dan Chen","doi":"10.3389/fpubh.2024.1348207","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1348207","url":null,"abstract":"Influenza infection induces cardiovascular events in heart failure (HF) patients, with potential risk reduction through vaccination. This study aims to evaluate the cost-effectiveness of influenza vaccination for HF patients in China.We developed a Markov model with a 3-month cycle to simulate the cost-effectiveness of administering the influenza vaccine to patients with HF over a 3-year period. Patients in the model received either the influenza vaccine or a placebo, in addition to standard HF treatment. Cost data, sourced from the China Healthcare Statistic Yearbook and other public records, and effectiveness data from the IVVE (Influenza Vaccine to Prevent Adverse Vascular Events in HF) trial, were incorporated. Specifically, the cost of the influenza vaccine was 75 Chinese Yuan (CNY) (11 USD), the cost of hospitalization for heart failure (HHF) was 9,326 CNY (1,386 USD), and the cost of treatment for pneumonia was 5,984 CNY (889 USD). The study’s primary outcome, the incremental cost-effectiveness ratio (ICER), quantifies the incremental cost (CNY and USD) per incremental quality-adjusted life year (QALY). Additional outcomes included total cost, total effectiveness, incremental cost, and incremental effectiveness. We conducted one-way and probabilistic sensitivity analyses (PSA) to assess certainty and uncertainty, respectively. Scenario analysis, considering various situations, was performed to evaluate the robustness of the results.In the base case analysis, influenza vaccine, compared to placebo, among Chinese HF patients, resulted in a cost increase from 21,004 CNY (3,121 USD) to 21,062 CNY (3,130 USD) and in QALYs from 1.89 to 1.92 (2.55 life years vs. 2.57 life years) per patient. The resulting ICER was 2,331 CNY (346 USD) per QALY [2,080 CNY (309 USD) per life year], falling below the willingness-to-pay threshold based on per capita GDP. One-way sensitivity analysis revealed that disparities in HHF and cardiovascular death rates between groups had the most significant impact on the ICER, while the cost of vaccines had a marginal impact. PSA and scenario analysis collectively affirmed the robustness of our findings.This study suggests that adding the influenza vaccine to standard treatment regimens for Chinese patients with HF may represent a highly cost-effective option. Further real-world data studies are essential to validate these findings.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"7 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aerobic exercise combined with resistance training on body composition and metabolic health in children and adolescents with overweight or obesity: systematic review and meta-analysis","authors":"Xuan Liu, Qiang Li, FuXiang Lu, Dongsheng Zhu","doi":"10.3389/fpubh.2024.1409660","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1409660","url":null,"abstract":"To systematically review the effects of aerobic exercise and resistance training on Metabolic Health in children and adolescents with overweight/obesity.Employing a retrieval strategy that combines subject terms and free terms, searches were conducted in the CNKI, WanFangData, VIP, PubMed, Web of Science, Embase, and Cochrane Library databases up to October 31, 2023.A total of 29 studies involving 2,195 subjects were included. The combination of aerobic and resistance training significantly reduces body composition and metabolic health in children and adolescents with overweight or obesity, as evidenced by changes in various parameters (BMI, WC, FM, BF%, VO2max, TG, TC, HDL-C, LDL-C, HOMA-IR, FPG, INS). However, there were no significant differences observed in hs-CRP. Subgroup analyses further showed that changes in intervention measurement had a significant effect on the effectiveness of the intervention.Aerobic exercise combined with resistance training has a positive impact on the physical health of children and adolescents with overweight/obesity. The recommended exercise prescription is at least three sessions of more than 60 min per week for 12 weeks or more for better health benefits.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"55 39","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in all-cause mortality among people experiencing homelessness in Toronto, Canada during the COVID-19 pandemic: a cohort study","authors":"Lucie Richard, Brooke Carter, Linda Wu, Stephen W. Hwang","doi":"10.3389/fpubh.2024.1401662","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1401662","url":null,"abstract":"People experiencing homelessness have historically had high mortality rates compared to housed individuals in Canada, a trend believed to have become exacerbated during the COVID-19 pandemic. In this matched cohort study conducted in Toronto, Canada, we investigated all-cause mortality over a one-year period by following a random sample of people experiencing homelessness (n = 640) alongside matched housed (n = 6,400) and low-income housed (n = 6,400) individuals. Matching criteria included age, sex-assigned-at-birth, and Charlson comorbidity index. Data were sourced from the Ku-gaa-gii pimitizi-win cohort study and administrative databases from ICES. People experiencing homelessness had 2.7 deaths/100 person-years, compared to 0.7/100 person-years in both matched unexposed groups, representing an all-cause mortality unadjusted hazard ratio (uHR) of 3.7 (95% CI, 2.1–6.5). Younger homeless individuals had much higher uHRs than older groups (ages 25–44 years uHR 16.8 [95% CI 4.0–70.2]; ages 45–64 uHR 6.8 [95% CI 3.0–15.1]; ages 65+ uHR 0.35 [95% CI 0.1–2.6]). Homeless participants who died were, on average, 17 years younger than unexposed individuals. After adjusting for number of comorbidities and presence of mental health or substance use disorder, people experiencing homelessness still had more than twice the hazard of death (aHR 2.2 [95% CI 1.2–4.0]). Homelessness is an important risk factor for mortality; interventions to address this health disparity, such as increased focus on homelessness prevention, are urgently needed.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"54 35","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between physical activity level and diabetes incidence among Chinese middle-aged and older adults: a cross-sectional study from the China health and retirement longitudinal study","authors":"Yunqing Zhang, Fanhao Meng, Xueyin Fei, Ke Wang, Yigao Wu, Xueting Wang","doi":"10.3389/fpubh.2024.1430229","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1430229","url":null,"abstract":"It has been shown that diabetes is associated with insufficient physical activity among middle-aged and older adults, but the association between different physical activity levels (PAL) and diabetes incidence needs to be further explored.This study aims to explore the correlation and dose–response relationship between different PAL and the diabetes incidence in middle-aged and older adults.Utilizing data from the 2018 China Health and Retirement Longitudinal Study (CHARLS), this cross-sectional analysis included 17,226 middle-aged and older adults aged 45 and above. Binary logistic regression models and restricted cubic spline (RCS) were used to explore the correlation and dose–response relationship between different PAL and the incidence of diabetes in the total middle-aged and older adults population as well as in subgroups. Sensitivity analyses were also performed to verify the robustness of the findings.In the entire study population, compared with the lowest PAL, participants in the third and fourth quartiles PAL saw diabetes incidence significantly reduced by 16% (p = 0.005) and 33% (p < 0.001), respectively (pfor trend < 0.001). In subgroup analyses, the fourth quartile PAL significantly reduced the diabetes incidence among females, individuals aged 60–69, and rural residents by 25% (p = 0.011), 38% (p < 0.001) and 28% (p < 0.001), respectively. For males, middle-aged (45–59 years), and urban residents, the third quartile PAL reduced diabetes incidence by 22% (p = 0.004), 24% (p = 0.012), 21% (p = 0.013), respectively. When the fourth quartile PAL was reached, the diabetes incidence was significantly reduced in these populations by 41% (p < 0.001), 39% (p < 0.001), and 41% (p < 0.001), respectively. There was a negative dose–response relationship between physical activity and diabetes incidence in specific Chinese middle-aged and older adults population. In addition, sensitivity analyses indicated the robustness of the findings.Higher PAL was associated with lower diabetes incidence in specific Chinese middle-aged and older adults population. It is feasible to use physical activity to predict diabetes incidence in this demographic, and high PAL may be an effective means of preventing and controlling diabetes.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"3 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141921880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender differences in responses to an altruistic message regarding rubella vaccination","authors":"Hideo Okuno, H. Satoh, Satoru Arai, Motoi Suzuki, Toshiko Kikkawa","doi":"10.3389/fpubh.2024.1353091","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1353091","url":null,"abstract":"The supplementary immunization activity (SIA) for the rubella vaccination of adult men born between 1962 and 1978 began in 2019 in Japan because of a vaccine gap in the cohort, as vaccination was not mandatory for those born in that period. However, SIA coverage remains low, despite an active campaign and financial support.We conducted a randomized controlled study based on a 2 (scenario: self-vaccination, child vaccination) × 2 (message: self-interest, group-interest) factorial design, using a Japanese online panel. Participants with children were assigned to the child vaccination scenario in Intervention 1, whereas others were assigned to the self-vaccination scenario. After Intervention 1, all participants were given the same information about rubella. In Intervention 2, participants assigned to self-interest messages received a message emphasizing the risk of rubella, and those assigned to group-interest messages received a message emphasizing herd immunity. After Intervention 2, we evaluated the effects using a questionnaire.Among the 2,206 participants, information regarding rubella was evaluated as more reliable in the group—than in the self-interest message condition, especially among women. Women evaluated the necessity of rubella vaccination for adult men and women to be higher in the child-vaccination scenario and group-interest messages. However, no differences were found among men. By contrast, men exposed to the self-interest message positively evaluated the reliability of the rubella explanation.The findings indicate that emphasizing self-interest messages is more effective for men in promoting herd immunity against rubella.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"53 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141923888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with food insecurity among pregnant women in Gedeo zone public hospitals, Southern Ethiopia","authors":"Abriham Shiferaw Areba, D. Akiso, Arega Haile, Belayneh Genoro Abire, G. G. Kanno, Lire Lemma Tirore, D. E. Abame","doi":"10.3389/fpubh.2024.1399185","DOIUrl":"https://doi.org/10.3389/fpubh.2024.1399185","url":null,"abstract":"Food insecurity refers to a lack of consistent access to sufficient food for active, better health. Around two billion people worldwide suffer from food insecurity and hidden hunger. This study focuses on food insecurity and associated factors among pregnant women in Gedeo Zone Public Hospitals, Southern Ethiopia.An institutional-based cross-sectional study was conducted among pregnant women in Gedeo zone public hospitals from May to June 2021. Primary data of 506 pregnant women were collected using interviewer-administered structured questionnaire and a multi-stage sampling technique was used to select study participants. The household food insecurity access scale of the questionnaire was used and a woman was considered as food insecure when it has any of the food insecurity conditions mild, moderate, or severe food insecure, otherwise, it was classified as food secure. Adjusted odds ratio (AOR) and their 95% confidence intervals (CI) determined the association between various factors and outcomes.Of all study participants, 67.39% of the women were food insecure, and the remaining 32.6% had food security. The pregnant women from rural areas [AOR = 0.532, 95% CI: 0.285, 0.994], married [AOR = 0.232, 95% CI: 0.072, 0.750], had a secondary education [AOR = 0.356, 95%CI: 0.154, 0.822], and be employed [AOR = 0.453, 95% CI: 0.236, 0.872], the wealth index middle [AOR = 0.441, 95% CI: 0.246, 0.793] and rich [AOR = 0.24, 95% CI: 0.128, 0.449] were factors associated with food insecurity.The study area had a high prevalence of food insecurity. Food insecurity was reduced in those who lived in rural areas, were married, had a secondary education, were employed, and had a wealth index of middle and rich.","PeriodicalId":510753,"journal":{"name":"Frontiers in Public Health","volume":"15 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141925920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}