Nano Select最新文献_第4页

Synthesis and characterization of tenofovir disoproxil fumarate loaded nanoparticles for HIV‐1 treatment 用于治疗 HIV-1 的富马酸替诺福韦二吡呋酯负载纳米粒子的合成与表征

Nano Select Pub Date : 2024-02-13 DOI: 10.1002/nano.202300157

O. Obisesan, L. Tshweu, Sipho Chauke, K. Malatji, B. Ramalapa, K. Alexandre, H. Mufhandu

{"title":"Synthesis and characterization of tenofovir disoproxil fumarate loaded nanoparticles for HIV‐1 treatment","authors":"O. Obisesan, L. Tshweu, Sipho Chauke, K. Malatji, B. Ramalapa, K. Alexandre, H. Mufhandu","doi":"10.1002/nano.202300157","DOIUrl":"https://doi.org/10.1002/nano.202300157","url":null,"abstract":"The remarkable ability of the human immunodeficiency virus (HIV) to evade the host's immune system and conventional antiretroviral therapy, has posed significant challenges in achieving complete eradication of the virus in people living with HIV (PLWHIV). However, nanotechnology has emerged as promising avenue for addressing some of the obstacles associated with the use of antiretroviral drugs by modifying drug molecules in nanoscale dimensions. Hence, the present study explores the utilization of poly(epsilon‐caprolactone) (PCL) as a carrier for encapsulating tenofovir disoproxil fumarate (TDF), offering an alternative treatment approach for HIV infection. TDF‐loaded polymeric nanoparticles were successfully prepared using double emulsion solvent evaporation technique and characterized. The characterization of TDF‐loaded polymeric nanoparticles at varied drug to polymer ratios showed that TDF was loaded in PCL with an encapsulation efficiency and drug loading capacity in the range of 23–46% and 4.8–19.9%, respectively. Of note, the neutralization efficacy of TDF‐loaded polymeric nanoparticles was more improved compared to free TDF. Encapsulation of TDF with PCL did not hinder the antiviral activity of TDF against HIV‐1 infection but rather enhanced its potency.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractionation of flavonols and anthocyanins in winemaking residues using molecularly imprinted cellulose‐synthetic hybrid particles with pyridyl active surface 使用具有吡啶基活性表面的分子印迹纤维素-合成杂化颗粒对酿酒残渣中的黄酮醇和花青素进行分馏

Nano Select Pub Date : 2024-02-07 DOI: 10.1002/nano.202300153

Catarina P. Gomes, R. Dias, Mário Rui P. F. N. Costa

{"title":"Fractionation of flavonols and anthocyanins in winemaking residues using molecularly imprinted cellulose‐synthetic hybrid particles with pyridyl active surface","authors":"Catarina P. Gomes, R. Dias, Mário Rui P. F. N. Costa","doi":"10.1002/nano.202300153","DOIUrl":"https://doi.org/10.1002/nano.202300153","url":null,"abstract":"Hybrid cellulose‐synthetic particles with surface active pyridyl moieties and molecularly imprinted cavities for quercetin were prepared via atom transfer radical polymerization. The functionalization of the materials with pyridyl groups was confirmed by FTIR and the SEM micrographs of the hybrid particles demonstrate a clear surface modification compared with the pristine cellulose. Competitive sorption/desorption testing of the imprinted and non‐imprinted particles with standard polyphenols show the achievement of an imprinting factor IF ∼8. Moreover, it was also confirmed the high retention capability of the hybrid materials for polyphenols, due to their strong binding with the surface pyridyl moieties, even when using hydroalcoholic solvents of high ethanol content (e.g., ethanol/water 80/20 v/v). The sorption capabilities of the synthesized materials for polyphenols were explored with the fractionation of flavonols and anthocyanins in winemaking residues. High concentration and enrichment factors were achieved for high‐added value compounds, namely five times for quercetin and 12 for quercetin‐3‐O‐glucuronide with a diatomaceous earth extract and up to 4 for flavonols in a grape pomace (e.g. myricetin and quercetin glucosides). This research demonstrates de feasibility for the combination between the development of engineered materials addressing sustainability with their application to the valorization of agro‐industrial wastes.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"29 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139795158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fractionation of flavonols and anthocyanins in winemaking residues using molecularly imprinted cellulose‐synthetic hybrid particles with pyridyl active surface 使用具有吡啶基活性表面的分子印迹纤维素-合成杂化颗粒对酿酒残渣中的黄酮醇和花青素进行分馏

Nano Select Pub Date : 2024-02-07 DOI: 10.1002/nano.202300153

Catarina P. Gomes, R. Dias, Mário Rui P. F. N. Costa

{"title":"Fractionation of flavonols and anthocyanins in winemaking residues using molecularly imprinted cellulose‐synthetic hybrid particles with pyridyl active surface","authors":"Catarina P. Gomes, R. Dias, Mário Rui P. F. N. Costa","doi":"10.1002/nano.202300153","DOIUrl":"https://doi.org/10.1002/nano.202300153","url":null,"abstract":"Hybrid cellulose‐synthetic particles with surface active pyridyl moieties and molecularly imprinted cavities for quercetin were prepared via atom transfer radical polymerization. The functionalization of the materials with pyridyl groups was confirmed by FTIR and the SEM micrographs of the hybrid particles demonstrate a clear surface modification compared with the pristine cellulose. Competitive sorption/desorption testing of the imprinted and non‐imprinted particles with standard polyphenols show the achievement of an imprinting factor IF ∼8. Moreover, it was also confirmed the high retention capability of the hybrid materials for polyphenols, due to their strong binding with the surface pyridyl moieties, even when using hydroalcoholic solvents of high ethanol content (e.g., ethanol/water 80/20 v/v). The sorption capabilities of the synthesized materials for polyphenols were explored with the fractionation of flavonols and anthocyanins in winemaking residues. High concentration and enrichment factors were achieved for high‐added value compounds, namely five times for quercetin and 12 for quercetin‐3‐O‐glucuronide with a diatomaceous earth extract and up to 4 for flavonols in a grape pomace (e.g. myricetin and quercetin glucosides). This research demonstrates de feasibility for the combination between the development of engineered materials addressing sustainability with their application to the valorization of agro‐industrial wastes.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"18 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139855233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical modeling of magnetocaloric effect in dense nanoparticle systems 致密纳米粒子系统中磁致效应的分析建模

Nano Select Pub Date : 2024-02-05 DOI: 10.1002/nano.202300196

M. Bohra, Vidya Alman, Mohd Ataullah Khan, Vidyadhar Singh, E. Toulkeridou, P. Grammatikopoulos

{"title":"Analytical modeling of magnetocaloric effect in dense nanoparticle systems","authors":"M. Bohra, Vidya Alman, Mohd Ataullah Khan, Vidyadhar Singh, E. Toulkeridou, P. Grammatikopoulos","doi":"10.1002/nano.202300196","DOIUrl":"https://doi.org/10.1002/nano.202300196","url":null,"abstract":"Determining the magnetocaloric effect (MCE) in dense nanoparticle systems (DNSs) poses a challenge due to the increased complexity of matter at the nanoscale. Given the interparticle magnetic interactions, diverse particle size and shape distributions, and the presence of inhomogeneous magnetic phases, selecting a suitable phenomenological model is essential to describe the temperature dependence of magnetic behavior in DNSs. Herein, we chose a cost‐effective Ni100‐xCrx DNS with adjustable magnetic transitions to showcase the resilience of the MCE across a broad temperature range (147–614 K). While the hyperbolic tangent model appears more fitting for materials with a single Curie temperature (TC), such as its parent bulk alloys, in the presence of a TC distribution a Gaussian distribution model proves to be better suited for DNSs. The latter model yields a magnetic entropy change, ΔSmax = 0.09–0.15 J kg‐K−1 in the DNS at a tiny field of 0.1T. The correlations between the broadening of the MCE peak and TC distribution are attributed to the particle size distribution and chemical inhomogeneity present in the DNS, paving the way for fine‐tuning MCE‐related properties such as the relative cooling power (13.17–33.45 J kg−1) and adiabatic temperature change (0.03–0.17 K). Our methodology not only enhances the potential for designing innovative MCE materials with broader operating ranges but also validates the universality of our phenomenological model for other families of nanocrystalline/nanogranular oxides/alloys thin films.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"12 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139864609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analytical modeling of magnetocaloric effect in dense nanoparticle systems 致密纳米粒子系统中磁致效应的分析建模

Nano Select Pub Date : 2024-02-05 DOI: 10.1002/nano.202300196

M. Bohra, Vidya Alman, Mohd Ataullah Khan, Vidyadhar Singh, E. Toulkeridou, P. Grammatikopoulos

{"title":"Analytical modeling of magnetocaloric effect in dense nanoparticle systems","authors":"M. Bohra, Vidya Alman, Mohd Ataullah Khan, Vidyadhar Singh, E. Toulkeridou, P. Grammatikopoulos","doi":"10.1002/nano.202300196","DOIUrl":"https://doi.org/10.1002/nano.202300196","url":null,"abstract":"Determining the magnetocaloric effect (MCE) in dense nanoparticle systems (DNSs) poses a challenge due to the increased complexity of matter at the nanoscale. Given the interparticle magnetic interactions, diverse particle size and shape distributions, and the presence of inhomogeneous magnetic phases, selecting a suitable phenomenological model is essential to describe the temperature dependence of magnetic behavior in DNSs. Herein, we chose a cost‐effective Ni100‐xCrx DNS with adjustable magnetic transitions to showcase the resilience of the MCE across a broad temperature range (147–614 K). While the hyperbolic tangent model appears more fitting for materials with a single Curie temperature (TC), such as its parent bulk alloys, in the presence of a TC distribution a Gaussian distribution model proves to be better suited for DNSs. The latter model yields a magnetic entropy change, ΔSmax = 0.09–0.15 J kg‐K−1 in the DNS at a tiny field of 0.1T. The correlations between the broadening of the MCE peak and TC distribution are attributed to the particle size distribution and chemical inhomogeneity present in the DNS, paving the way for fine‐tuning MCE‐related properties such as the relative cooling power (13.17–33.45 J kg−1) and adiabatic temperature change (0.03–0.17 K). Our methodology not only enhances the potential for designing innovative MCE materials with broader operating ranges but also validates the universality of our phenomenological model for other families of nanocrystalline/nanogranular oxides/alloys thin films.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders 金属添加剂制造粉末中可吸入部分的特征和健康风险

Nano Select Pub Date : 2024-01-19 DOI: 10.1002/nano.202300188

Andi Alijagic, Xuying Wang, N. Vallabani, Pelle Melin, Eva Särndahl, Hanna L. Karlsson, I. Odnevall

{"title":"Characteristics and health risks of the inhalable fraction of metal additive manufacturing powders","authors":"Andi Alijagic, Xuying Wang, N. Vallabani, Pelle Melin, Eva Särndahl, Hanna L. Karlsson, I. Odnevall","doi":"10.1002/nano.202300188","DOIUrl":"https://doi.org/10.1002/nano.202300188","url":null,"abstract":"Metal additive manufacturing (AM) is gaining traction but raises worker health concerns due to micron‐sized powders, including fine inhalable particles. This study explored particle and surface characteristics, electrochemical properties, metal release in artificial lysosomal fluid (ALF), and potential toxicity of virgin and sieved virgin Fe‐based powders, stainless steel (316L), Fe, and two tooling steels. Virgin particles ranged in size from 1 to 100 µm, while sieved particles were within the respirable size range (<5–10 µm). Surface oxide composition differed from bulk composition. The Fe powder showed low corrosion resistance and high metal release due to a lack of protective surface oxide. Sieved particles of 316L, Fe, and one tooling steel released more metals into ALF than virgin particles, with the opposite was observed for the other tooling steel. Sieved particles had no notable impact on cell viability or micronuclei formation in human bronchial epithelial cells. Inflammatory response in human macrophages was generally low, except for the Fe powder and one tooling steel, which induced increased interleukin‐8 (IL‐8/CXCL‐8) and monocyte chemoattractant protein‐1 (MCP‐1/CCL‐2) secretion. This study underscores distinctions between virgin and sieved Fe‐based powders and suggests relatively low acute toxicity.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"77 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139612836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of mixing in nanoparticle hetero‐aggregates by convolutional neural networks 利用卷积神经网络表征纳米粒子异质聚集体中的混合情况

Nano Select Pub Date : 2024-01-19 DOI: 10.1002/nano.202300128

Christoph Mahr, Jakob Stahl, B. Gerken, Valentin Baric, Max Frei, F. Krause, T. Grieb, M. Schowalter, T. Mehrtens, Einar Kruis, L. Mädler, A. Rosenauer

{"title":"Characterization of mixing in nanoparticle hetero‐aggregates by convolutional neural networks","authors":"Christoph Mahr, Jakob Stahl, B. Gerken, Valentin Baric, Max Frei, F. Krause, T. Grieb, M. Schowalter, T. Mehrtens, Einar Kruis, L. Mädler, A. Rosenauer","doi":"10.1002/nano.202300128","DOIUrl":"https://doi.org/10.1002/nano.202300128","url":null,"abstract":"Formation of hetero‐contacts between particles of different materials in nanoparticle hetero‐aggregates can lead to new functional properties. Improvement of the functional behavior requires a detailed characterization of mixing between the two types of particles, in order to correlate different mixing with the performance of the material. Scanning transmission electron microscopy (STEM) is an option for this task. To obtain statistically relevant results, STEM‐images of many hetero‐aggregates have to be acquired and evaluated. This can be time‐consuming if it is done manually. In the present work, the applicability of convolutional neural networks for the automated analysis of STEM‐images acquired from TiO2–WO3 nanoparticle hetero‐aggregates is investigated. Hetero‐aggregates are obtained in a double flame spray pyrolysis (DFSP) setup, in which a variation of setup parameters is expected to affect the mixing of TiO2 and WO3. Mixing is investigated by a measurement of cluster sizes (the number of connected particles of the same material within an aggregate) and coordination numbers (the number of particle contacts with particles of the same or the different material). Results show that the distribution of measured values is wide for both quantities, rendering it challenging to correlate mixing with parameters varied in the DFSP setup.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"16 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139613626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morphological design of PDVB‐based particles 基于 PDVB 的颗粒形态设计

Nano Select Pub Date : 2023-12-21 DOI: 10.1002/nano.202300064

S. Freese, Gunnar Glasser, Moritz Susewind, Ingo Lieberwirth, Thorsten Hofe, Ulrich Jonas

{"title":"Morphological design of PDVB‐based particles","authors":"S. Freese, Gunnar Glasser, Moritz Susewind, Ingo Lieberwirth, Thorsten Hofe, Ulrich Jonas","doi":"10.1002/nano.202300064","DOIUrl":"https://doi.org/10.1002/nano.202300064","url":null,"abstract":"Polymeric microspheres with complex architectures find application as stationary phases for size exclusion separation, solid supports for surface reactions, catalysis, and delivery systems. The microparticles are commonly made from divinylbenzene by precipitation polymerization or template swelling. Upon combining both methods and applying photopolymerization, we discovered new morphological features that are not solely explicable by the individual processes. Firstly, three types of templates were synthesized by precipitation polymerization: noncrosslinked, slightly crosslinked, and slightly crosslinked with noncrosslinked polystyrene fractions. All template types were swollen with divinylbenzene, which was polymerized by photoinitiation, followed by template extraction. Changes in particle size were tracked by light microscopy, while SEM revealed submicron features like hollow cores, toluene‐insoluble walls, and surface grooves from the collapse upon drying of the toluene‐swollen corona. Our investigations indicated that the corona results from chain transfer and crosslinking of the template during photoinitiation. Higher precrosslinking of the template reduced the core cavity volume of the extracted particle, while more mobile polystyrene chains led to larger cavities. These architectures are promising model systems for fundamental studies of particle interactions, aggregation, and structure formation in the field of colloidal physics.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"4 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139167059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication and lubrication performance of sustainable Pickering‐like water‐in‐water emulsions using plant protein microgels 利用植物蛋白微凝胶制造可持续的类 Pickering 水包水乳液并提高其润滑性能

Nano Select Pub Date : 2023-12-16 DOI: 10.1002/nano.202300160

Kwan-Mo You, Brent S. Murray, S. Connell, A. Sarkar

{"title":"Fabrication and lubrication performance of sustainable Pickering‐like water‐in‐water emulsions using plant protein microgels","authors":"Kwan-Mo You, Brent S. Murray, S. Connell, A. Sarkar","doi":"10.1002/nano.202300160","DOIUrl":"https://doi.org/10.1002/nano.202300160","url":null,"abstract":"Aqueous multiphasic systems have attracted a great deal of interest recently owing to the growing demands of sustainability for the development of stable “oil‐free” emulsions, often complicated by their limited stability against droplet coarsening. Although particles may provide ultrastability to water‐in‐water (W/W) emulsions formed in phase‐separating polymer systems, the need for lubrication in such W/W emulsions presents an important challenge for their use in diverse applications. Herein, W/W Pickering emulsions were stabilized by sustainable plant protein (pea)‐based microgels (PPM) using starch and xanthan gum as the biopolymers to generate the W/W phase separating droplet structures. The lubricity of these systems was compared with that of parallel systems stabilized by animal (whey) protein microgels (WPM). New results reveal that PPM are more soft and adhesive than WPM and outperform the latter in boundary lubrication performance, in striking contrast to the behavior of the non‐microgelled pea or whey proteins. Furthermore, the PPM tend to stabilize a different, less spherical type of W/W droplet than the WPM that may explain the lower friction observed in PPM‐stabilized systems. The novel approach of fabricating W/W emulsions stabilized by sustainable microgels opens up new solutions in designing aqueous lubricants for future nutritional and biomedical applications.","PeriodicalId":510500,"journal":{"name":"Nano Select","volume":"336 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139177245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision medicine in myocardial infarction: Nanotheranostic strategies 心肌梗塞的精准医疗：纳米治疗策略

Nano Select Pub Date : 2023-12-13 DOI: 10.1002/nano.202300127

Alexander Shao‐Rong Pang, Vishalli Dinesh, Natalie Yan‐Lin Pang, Tarini Dinesh, Kimberley Yun‐Lin Pang, G. W. Yip, B. Bay, Dinesh Kumar Srinivasan

引用次数: 0