Frontiers in Genetics最新文献

{"title":"Editorial: Cancer genetics and epigenetics: theranostic targets and mechanisms","authors":"Aisha Farhana, Nabiha Yusuf, Zafar Rasheed","doi":"10.3389/fgene.2024.1446474","DOIUrl":"https://doi.org/10.3389/fgene.2024.1446474","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"29 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141801300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Mesenchymal and induced-pluripotent stem cells as models to study biological processes","authors":"Melvin A. Ambele, Catarina O. Miranda","doi":"10.3389/fgene.2024.1439306","DOIUrl":"https://doi.org/10.3389/fgene.2024.1439306","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"61 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141802592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Role of non-coding RNAs (emphasis on the emerging role of circular RNAs) in cancer. Application potential for molecular diagnostics and therapeutics of cancer","authors":"Srivatsava Naidu, Srikanth Karnati, Harikrishnan Radhakrishnan, Anand Gupta","doi":"10.3389/fgene.2024.1450309","DOIUrl":"https://doi.org/10.3389/fgene.2024.1450309","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"54 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141805536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: RNA-chromatin interactions: biology, mechanism, disease, and therapeutics—volume 2","authors":"Malik Bisserier, Luciano G. Martelotto, A. El-Osta, P. Mathiyalagan","doi":"10.3389/fgene.2024.1461574","DOIUrl":"https://doi.org/10.3389/fgene.2024.1461574","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141808444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Genomics assisted improvement of crop plants for adaptation to marginal environments","authors":"Prashant Vikram, S. Shokat, Amita Mohan, Deepmala Sehgal, Mayank Kashyap","doi":"10.3389/fgene.2024.1461709","DOIUrl":"https://doi.org/10.3389/fgene.2024.1461709","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"79 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141817642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Karyotype depends on sperm head morphology in some amniote groups","authors":"","doi":"10.3389/fgene.2024.1462463","DOIUrl":"https://doi.org/10.3389/fgene.2024.1462463","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"116 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141822208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Epigenetic and gene regulation underlying crosstalk in plant development and stress responses","authors":"R. Seth, Massimo Iorizzo, T. Maritim, Ram Kumar Sharma","doi":"10.3389/fgene.2024.1427102","DOIUrl":"https://doi.org/10.3389/fgene.2024.1427102","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":" 40","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141825504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Recent advances in the molecular genetics of glioma","authors":"Caroline Chung, Pawel Buczkowicz","doi":"10.3389/fgene.2024.1435186","DOIUrl":"https://doi.org/10.3389/fgene.2024.1435186","url":null,"abstract":"","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":" 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141830929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing genomics confidence and learning needs in Australian nurses and midwives: an educational program evaluation","authors":"Kim E. Alexander, Melanie Rolfe, Michael T Gabbett","doi":"10.3389/fgene.2024.1419302","DOIUrl":"https://doi.org/10.3389/fgene.2024.1419302","url":null,"abstract":"Introduction: The mainstreaming of genomics across healthcare specialties necessitates that all nurses and midwives have a high literacy in genomics.Methods: We aimed to design, develop, implement and evaluate a genomics education workshop for nurses and midwives using action research principles.Results: Registered nurses and midwives completed an online survey regarding genomics confidence and learning needs (n = 274). The results of this survey were used to develop the genomics education workshop. The workshop was run three times (n = 105) with evaluation data being collected both before and after each workshop. Significant improvements in confidence across all learning domains was found following the workshops (p < 0.001). A desire for more education across all learning domains except for genetics knowledge was also identified (p < 0.001).Discussion: Genomics education workshops were found to increase the confidence of nurses and midwives across a range of specialties. Nurses and midwives also expressed a desire for further education in genomics.","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"2 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141642256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of the CDH18 gene associated with age-related macular degeneration using weighted gene co-expression network analysis","authors":"Guina Liu, Mingqi Tan, Rui Liu, Xuejin Lu, Xiaoshuang Jiang, Yunpeng Bai, Zhigang Guo, Fang Lu","doi":"10.3389/fgene.2024.1378340","DOIUrl":"https://doi.org/10.3389/fgene.2024.1378340","url":null,"abstract":"Purpose: Age-related macular degeneration (AMD) is a chronic and progressive macular degenerative disease that culminates in a gradual deterioration of central vision. Despite its prevalence, the key biomarkers for AMD have not yet been fully elucidated. In this study, we aimed to efficiently identify biomarkers crucial for diagnosing AMD.Methods: Three datasets pertaining to retinal pigment epithelium (RPE)/choroid tissues associated with AMD were selected from the GEO database. The GSE50195 dataset was utilized to conduct weighted gene co-expression network analysis (WGCNA) for identifying module genes linked to AMD. KEGG and GO enrichment analyses were subsequently conducted on these module genes. GSE29801 and GSE135092 datasets were subjected to differential expression analysis to pinpoint the DEGs intersecting with the module genes. Subsequently, wet AMD (wAMD) and dry AMD (dAMD) mouse models were developed, from which RPE/choroid tissues were harvested to validate the hub genes via RT-qPCR and Western blot.Results: Using the WGCNA, we selected the “antiquewhite4” module (r = 0.91 and p = 7e-07), which contains a total of 325 genes. Through the intersection of module genes with DEGs, nine hub genes were identified. Pathways involved in complement and coagulation cascades, ECM–receptor interactions, unsaturated fatty acid biosynthesis, and fatty acid elongation play important roles in AMD. Notably, CDH18 demonstrated notable variance across all three datasets. Post validation using RT-qPCR experiments revealed a significant downregulation of CDH18 in both dAMD and wAMD. EGLN3 was expressed at low levels in wAMD. In dAMD, EYA2, LTB, and PODXL were significantly downregulated, whereas APOC1 was notably upregulated. Western blot confirmed that CDH18 was lowly expressed in dAMD and wAMD mouse models.Conclusion: CDH18 was identified as the key gene involved in the pathogenesis of AMD. An imbalance of the complement and coagulation cascades is a potential mechanism of AMD. This study provides a novel idea for diagnosing and treating AMD in the future.","PeriodicalId":510338,"journal":{"name":"Frontiers in Genetics","volume":"1 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141641058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}