Langmuir最新文献_第10页

Probing IonicStrength Effects on miR-141 HybridizationKinetics by Surface Plasmon Resonance 通过表面等离子体共振探测离子强度对miR-141杂交动力学的影响

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-15 DOI: 10.1021/acs.langmuir.6c04875

Francesca Pancrazi,Anna Rita Bizzarri

{"title":"Probing Ionic\u0000Strength Effects on miR-141 Hybridization\u0000Kinetics by Surface Plasmon Resonance","authors":"Francesca Pancrazi,Anna Rita Bizzarri","doi":"10.1021/acs.langmuir.6c04875","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c04875","url":null,"abstract":"Abstract MicroRNAs (miRNAs) are short noncoding RNAs involved in numerous cellular processes, and their dysregulation is frequently associated with human diseases. Consequently, the development of reliable strategies for miRNA detection has become increasingly important for diagnostic purposes. Many miRNA detection methods employ a complementary strand as the capture probe immobilized on a substrate and a target free in solution. Because of electrostatic repulsion between the negatively charged RNA strands, a relatively high ionic strength is required to promote hybridization. However, this can limit the sensitivity in many biosensing methods. In this work, we applied surface plasmon resonance (SPR) to investigate the hybridization kinetics between miR-141 and its complementary strand (anti-miR-141) immobilized on the chip, over a 50–400 mM ionic strength range, covering relevant physiological and biosensing conditions. For a comprehensive characterization of the interaction between the partners, both single-cycle kinetics and multicycle kinetics modes were used. At the lowest ionic strength (50 mM), a marked increase in hybridization occurred from monovalent to divalent salts, suggesting a strategy for improving the detection. In all cases, the interaction was accurately described by a 1:1 Langmuir binding model over the entire ionic strength range. On the basis of the results, an SPR biosensing strategy was developed, achieving the best limit of detection (LoD) of 0.2 nM at an ionic strength of 300 mM. These results provide a quantitative description of the influence of ionic strength on miRNA hybridization and offer a rational framework for optimizing nucleic acid hybridization and designing miRNA biosensing platforms.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"40 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects ofPolymer Morphology on Humic Acid Adsorptiononto Model Microplastics and Nanoplastics 聚合物形态对腐植酸在模型微塑料和纳米塑料上吸附的影响

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-15 DOI: 10.1021/acs.langmuir.6c04610

Cameron D. Smith,Evan J. Easley,Wenlin Zhang

{"title":"Effects of\u0000Polymer Morphology on Humic Acid Adsorption\u0000onto Model Microplastics and Nanoplastics","authors":"Cameron D. Smith,Evan J. Easley,Wenlin Zhang","doi":"10.1021/acs.langmuir.6c04610","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c04610","url":null,"abstract":"Abstract Eco-coronae, formed by natural organic matter, such as humic and fulvic acids, on micro- and nanoplastics (MNPs), can enhance surface oxidation, increase human exposure to contaminants, and affect interactions between MNPs and plasma membranes. To better understand the formation of eco-coronae around MNPs, we investigate the influence of crystallinity, an intrinsic property of most commercial semicrystalline plastics, including polyolefins and polyamides, on the adsorption of a model humic acid (HA) in aqueous conditions using all-atom molecular dynamics. Adsorption was found to be thermodynamically favorable across all polymers and morphologies. Crystalline surfaces promote binding by providing planar hydrophobic interfaces that maximize contact with the aromatic groups of HA, and the presence of polar groups on crystalline MNP surfaces enables additional dipole–dipole interactions. Diffusive interfaces of amorphous polyolefins extend the polymer–HA interaction range and, in turn, yield stronger net binding affinities than those of crystalline surfaces. Reduced segmental dynamics in glassy amorphous polyamides hinder structural reorganization upon HA association, mitigating the hydrophobic contacts that drive adsorption. Overall, our simulations demonstrate the effects of MNP surface morphology on HA adsorption and provide molecular-level insights into the factors controlling eco-corona formation on MNPs.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"13 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triphase ReactionSystem with Micro- and Nano-scaleHierarchical Gas Channels for Efficient Photocatalytic AchmatowiczRearrangement 微纳米级气通道三相反应体系的高效光催化achmatowitz重排

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-15 DOI: 10.1021/acs.langmuir.6c04773

Yajie Ni,Jiamin Yu,Aaron Feng,Weiqian Liao,Xia Sheng

{"title":"Triphase Reaction\u0000System with Micro- and Nano-scale\u0000Hierarchical Gas Channels for Efficient Photocatalytic Achmatowicz\u0000Rearrangement","authors":"Yajie Ni,Jiamin Yu,Aaron Feng,Weiqian Liao,Xia Sheng","doi":"10.1021/acs.langmuir.6c04773","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c04773","url":null,"abstract":"Abstract Photocatalytic Achmatowicz rearrangement of furfuryl alcohol (FFA) is a sustainable route to synthesizing high-value pyranone (PN) bioactive intermediates. The conversion of O2 to singlet oxygen (1O2) is critical for selective PN formation. Constructing a gas–liquid–solid triphase system offers an alternative strategy to boost such O2-involved catalysis. However, current triphase systems are typically fabricated by depositing hydrophilic catalysts on superhydrophobic substrates. The triphasic interface only forms at the regions where the catalyst is in contact with the substrate, whereas O2 inside the catalyst layer still suffers from sluggish diffusion and insufficient local concentration. Herein, we design and construct a triphase system with micro- and nano-scale hierarchical gas channels for photocatalytic Achmatowicz rearrangement. Core–shell silicalite-1@TiO2 (S-1@TiO2) is synthesized by coating TiO2 on zeolite silicalite-1 (S-1). The internal nano-scale hydrophobic channels of S-1 act as O2 storage reservoirs and transport pathways, forming localized microscopic triphase interfaces within the catalyst layer. A hierarchical triphase interface system is constructed by further immobilizing S-1@TiO2 onto superhydrophobic substrates with micro-scale pores, enabling continuous atmospheric O2 to diffuse into the nano-scale hydrophobic channels. Benefiting from the synergistic effect of micro- and nano-scale hierarchical gas channels, the hierarchical triphase system exhibits much improved PN production and selectivity, and its catalytic active site utilization efficiency reaches 5-fold that of conventional triphase systems. This work provides insights into the rational regulation of triphase microenvironments for the construction of high-efficiency photocatalytic systems.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"12 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Wettability-TunedPolydopamine-Modified Surfaces forEnhanced Dropwise Condensation and Water Harvesting 润湿性调节的聚多巴胺修饰表面增强滴状冷凝和水收集

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-15 DOI: 10.1021/acs.langmuir.6c04242

Nai-Ci Zheng,Bo-Yan Huang,Li-Jen Chen

{"title":"Wettability-Tuned\u0000Polydopamine-Modified Surfaces for\u0000Enhanced Dropwise Condensation and Water Harvesting","authors":"Nai-Ci Zheng,Bo-Yan Huang,Li-Jen Chen","doi":"10.1021/acs.langmuir.6c04242","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c04242","url":null,"abstract":"Abstract Low-surface-energy superhydrophobic surfaces facilitate droplet removal but often exhibit a high nucleation energy barrier, hindering water-harvesting efficiency. To address this limitation, appropriately increasing surface hydrophilicity offers a promising strategy to enhance droplet nucleation while preserving sufficient droplet mobility. In this study, the surface wettability of SiO2 nanoparticle-textured superhydrophobic substrates (SHB) was systematically regulated by controlling the polydopamine (PDA) reaction time. Increasing the PDA reaction time gradually enhanced surface hydrophilicity, resulting in asynchronous transitions in sessile-droplet wetting and condensation mode. The Cassie-to-Wenzel transition of sessile droplets occurred at a PDA reaction time of 9 min. In contrast, the transition from dropwise condensation (DWC) to filmwise condensation (FWC) was delayed until a PDA reaction time of 11 min. The PDA10 substrate (the surface prepared at a PDA reaction time of 10 min) exhibited the optimal condensation performance, achieving enhanced droplet nucleation without excessive loss of droplet mobility. Compared with the PDA0 (SHB) substrate, the PDA10 substrate increased the condensate mass collection rate by 62.0% and the heat transfer coefficient by 61.4%. These findings demonstrate that temporal control of PDA modification enables regulation of distinct wetting and condensation transition thresholds, providing a design strategy to improve condensation-based water harvesting and heat transfer.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"17 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Learning DropletWetting from Kinetic Theory: Lattice-Boltzmann-DrivenPhysics-Informed Neural Networks for Rough Surfaces 从动力学理论学习微滴：粗糙表面的晶格玻尔兹曼驱动物理信息神经网络

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c03526

Ganesh Sahadeo Meshram,Partha Pratim Chakrabarti,Suman Chakraborty

{"title":"Learning Droplet\u0000Wetting from Kinetic Theory: Lattice-Boltzmann-Driven\u0000Physics-Informed Neural Networks for Rough Surfaces","authors":"Ganesh Sahadeo Meshram,Partha Pratim Chakrabarti,Suman Chakraborty","doi":"10.1021/acs.langmuir.6c03526","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c03526","url":null,"abstract":"Abstract We introduce a lattice Boltzmann-driven Kinetic Physics-Informed Neural Network (K-PINN) for the predictive modeling of droplet dynamics on rough and structured surfaces by embedding the continuous, discrete-velocity Boltzmann–BGK equation, evaluated via automatic differentiation, as the physics-informed learning constraint, with discrete lattice Boltzmann method (LBM) simulations used solely to generate reference training data. Unlike conventional PINNs constrained by macroscopic continuum equations, the proposed framework operates at the mesoscopic kinetic level, preserving the essential physics of the lattice Boltzmann method, including Shan–Chen pseudopotential interactions, within a data-efficient neural framework. Across randomly rough substrates and periodically textured pillar arrays, the K-PINN accurately captures complex interfacial phenomena, including contact line pinning, anisotropic spreading, and capillary hysteresis, while maintaining physical consistency, including mass conservation to within 1.5%. A U-Net-based encoder–decoder architecture achieves a 50–75% reduction in prediction error relative to baseline networks, yielding near-perfect agreement with high-resolution lattice Boltzmann simulations (L2 ≈ 0.021–0.026, R2 ≈ 0.999). Robust convergence across diverse surface morphologies is achieved through curriculum-guided training and adaptive two-stage optimization. Once trained, the model delivers real-time predictions exceeding 104 evaluations per second, offering orders-of-magnitude acceleration over direct numerical simulation and enabling rapid parametric exploration and inverse surface design. By integrating a lattice Boltzmann-based kinetic approach with physics-informed learning, this work presents a mesoscopic physics-informed learning framework for the efficient and accurate prediction of multiphase droplet dynamics.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"32 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reshaping InsulinFibrillation at the Nano-Bio InterfaceUsing Carbon Quantum Dots: Implications for Amyloid Inhibition 利用碳量子点在纳米生物界面上重塑胰岛素纤颤：淀粉样蛋白抑制的意义

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c02631

Prachi Joshi,Rajesh Mishra

{"title":"Reshaping Insulin\u0000Fibrillation at the Nano-Bio Interface\u0000Using Carbon Quantum Dots: Implications for Amyloid Inhibition","authors":"Prachi Joshi,Rajesh Mishra","doi":"10.1021/acs.langmuir.6c02631","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c02631","url":null,"abstract":"Abstract Insulin (Ins), a 51-residue α-helical hormone, is prone to forming insoluble aggregates during administration, production, and storage, which poses significant challenges to its stability, effectiveness, and formulation. In this regard, nanoparticles have attracted tremendous interest owing to their unique physicochemical properties and high affinity for biomolecules. Carbon quantum dots are one of the newly emerged nanoparticles found effective against amyloid fibrillation due to aromaticity, hydrophobicity, and strong H-bonding ability. Herein, we studied the effect of hydrothermally synthesized CQDs on the Ins fibrillation under normal conditions. The 2–3 nm CQDs with graphitic-core and oxygenic surface functionalities were synthesized using l-ascorbic acid and their effect on Ins fibrillation kinetics was studied. Thioflavin-T (ThT) fluorescence assay showed that CQDs can reduce Ins fibrillation in a dose-dependent manner. Transmission electron microscopy indicated significant inhibition of fibril formation in 1.5 mg/mL Ins with 0.15 mg/mL CQDs at physiological pH. This was further validated by the disappearance of the β-sheet signature peak in CD spectra and lower β-sheet content in the amide-I region of the Raman spectra. Thermodynamic analysis suggested that the interaction between CQDs and Ins relies largely on H-bonding and dispersion forces, leading to ground-state complexation and static fluorescence quenching of Ins. Importantly, CQDs helped maintain the secondary structure of Ins and improved the retention of tertiary structure as revealed by the ANS binding assay. These findings highlight the potential of CQDs as effective nanomaterial-based inhibitors of insulin fibrillation while offering insights into their binding interactions. However, further research regarding their long-term compatibility and safe pharmacological formulation is required for clinical translation. This work will help develop next-generation nanotherapeutic strategies aiming at improved Ins stability and storage.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"69 2 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topography-Driven Liquid Repellency in PFAS-Free Spherical-ParticleCoating 无pfas球形颗粒涂层中地形驱动的液体驱避性

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c03964

Talya A. Scheff,Jinde Zhang,Hanna Dodiuk,Samuel Kenig,Margaret A. Auerbach,Timothy J. Lawton,Joey Mead

{"title":"Topography-Driven Liquid Repellency in PFAS-Free Spherical-Particle\u0000Coating","authors":"Talya A. Scheff,Jinde Zhang,Hanna Dodiuk,Samuel Kenig,Margaret A. Auerbach,Timothy J. Lawton,Joey Mead","doi":"10.1021/acs.langmuir.6c03964","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c03964","url":null,"abstract":"Abstract The development of PFAS-free (per- and polyfluoroalkyl substances), liquid-repellent surfaces require a fundamental understanding of how surface geometry governs wetting-state stability. However, the independent role of interparticle spacing remains poorly understood because it is often coupled with changes in particle size, surface chemistry, or hierarchical morphology. Here, we present a geometry-driven strategy to systematically investigate the influence of spacing using re-entrant spherical architectures with controlled spacing ratios. Monodisperse 1 μm silica particles were immobilized within an epoxy matrix, while sacrificial 1 μm polystyrene spheres served as inert spacers to precisely tune interparticle distance without altering particle size or surface chemistry. After spacer removal and conformal hydrophobic silanization, wetting behavior was evaluated using ethanol–water mixtures with surface tensions ranging from 71.93 to 22.28 mN m–1. The apparent contact angle exhibits a nonmonotonic dependence on spacing ratio for liquids with surface tensions above approximately 25 mN m–1, reflecting a critical trade-off between reduced solid–liquid contact fraction, which enhances repellency, and diminished Cassie–Baxter state stability, which promotes wetting transition. As surface tension decreases, the optimal spacing ratio shifts toward smaller values, indicating increasingly stringent geometric requirements for sustaining the suspended wetting state. A theoretical framework integrating the Cassie–Baxter and Wenzel models with a breakthrough-pressure criterion quantitatively captures the experimental trends. These findings establish predictive design rules for geometry-controlled wetting and provide a scalable pathway for engineering high-performance, PFAS-free liquid-repellent coatings.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"11 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SuperhydrophobicHNTs-TiN-SA Composite Coating withExcellent Corrosion Resistance and Anti-Icing/Deicing Capabilities 具有优异耐腐蚀和防冰/除冰能力的超疏水性hnts - tin - sa复合涂层

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c05159

Shuai Yan,Zongxue Yu,Chao Peng,Yunfeng Tian,Yifang Chen,Lidan Deng,Junlei Tang,Aymen Ihsan Hadi

{"title":"Superhydrophobic\u0000HNTs-TiN-SA Composite Coating with\u0000Excellent Corrosion Resistance and Anti-Icing/Deicing Capabilities","authors":"Shuai Yan,Zongxue Yu,Chao Peng,Yunfeng Tian,Yifang Chen,Lidan Deng,Junlei Tang,Aymen Ihsan Hadi","doi":"10.1021/acs.langmuir.6c05159","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c05159","url":null,"abstract":"Abstract Superhydrophobic coatings have broad application prospects due to their advantages such as self-cleaning, antifouling, anti-icing, and deicing. However, traditional superhydrophobic coatings contain fluorine-containing components, which pose environmental and health risks. Developing fluorine-free stable superhydrophobic coatings with multifunctionality and environmental friendliness remains a challenge. In this paper, stearic acid was used to modify the surface of titanium nitride and halloysite nanotube micronanoparticles connected by tetraethyl orthosilicate, and an epoxy resin was used as the matrix to prepare a fluorine-free multifunctional superhydrophobic coating via a one-step spraying method. The wettability, chemical and mechanical stability, photothermal performance, low-temperature anti-icing behavior, and corrosion resistance were systematically evaluated. The results indicate that the coating exhibits a water contact angle of 161.2° and a sliding angle of only 1.3°; it can withstand immersion in acid, alkali, and salt solutions as well as repeated mechanical abrasion and possesses good environmental adaptability. Under near-infrared light, the surface temperature of the coating can rapidly rise to 111.1 °C; in an environment of −25 °C, the icing delay time can reach 270 s, and photothermal deicing can be completed within 90 s. Electrochemical impedance spectroscopy tests show that the coating has an initial low-frequency impedance of 1.48 × 1010 Ω·cm2 in 3.5 wt % NaCl solution, and it remains at 6.89 × 108 Ω·cm2 after 30 days of immersion. In summary, fluorine-free composite coatings provide a feasible approach for long-term corrosion protection and anti-icing protection of metal components, with significant research value and engineering application potential.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"24 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Localized LipidDelivery Regulates Exogenous LipidBehavior at Persistent Defects in Stratum Corneum Lipid Bilayers 局部脂质输送调节角质层脂质双层中持久性缺陷的外源性脂质行为

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c05482

Xindong Yu,Xuejing Liu,Heng Zhang,Yingjuan Cao,Shiling Yuan

{"title":"Localized Lipid\u0000Delivery Regulates Exogenous Lipid\u0000Behavior at Persistent Defects in Stratum Corneum Lipid Bilayers","authors":"Xindong Yu,Xuejing Liu,Heng Zhang,Yingjuan Cao,Shiling Yuan","doi":"10.1021/acs.langmuir.6c05482","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c05482","url":null,"abstract":"Abstract Disruption of the stratum corneum (SC) lipid matrix compromises the skin barrier function; however, the molecular mechanisms by which exogenous lipids promote its repair remain unclear. Here, all-atom molecular dynamics (MD) simulations were employed to investigate how initially dispersed lipid molecules and preassembled nanoparticles influence the direct rearrangement behavior of exogenous lipids at a localized defect in ceramide (CER)/cholesterol (Chol)/free fatty acid (FFA) ternary lipid bilayers. The results show that barrier repair efficiency depends strongly on both delivery format and lipid species. Initially dispersed lipids, limited by inefficient random diffusion, exhibit effective local repair but constrained overall efficiency. In contrast, preassembled lipid nanoparticles follow an “adsorption-spreading-reassembly” pathway, where localized high-concentration delivery overcomes diffusional barriers and significantly enhances repair efficiency. The three lipid species exhibit different molecular repair mechanisms at the damage site, governed by their unique molecular structures: CER shows stronger enrichment, FFA displays greater diffusion and dynamic reorganization, and Chol forms a denser and more stable bilayer. This study provides a molecular-level reconstruction associated with barrier repair and offers guidance for developing more effective topical lipid repair formulations.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"15 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Active Gas-SuppliedSuperhydrophobic Porous GroovedInterfaces for Broadening the Effective Range of Underwater GroovedDrag Reduction 主动气供超疏水多孔沟槽界面扩大水下沟槽减阻有效范围

IF 3.9 2区化学

Langmuir Pub Date : 2026-10-14 DOI: 10.1021/acs.langmuir.6c05021

Duanyi Zhu,Mingzhe Xin,Qian Li,Qiang Liu,Saifeng Zhong

{"title":"Active Gas-Supplied\u0000Superhydrophobic Porous Grooved\u0000Interfaces for Broadening the Effective Range of Underwater Grooved\u0000Drag Reduction","authors":"Duanyi Zhu,Mingzhe Xin,Qian Li,Qiang Liu,Saifeng Zhong","doi":"10.1021/acs.langmuir.6c05021","DOIUrl":"https://doi.org/10.1021/acs.langmuir.6c05021","url":null,"abstract":"Abstract Reducing underwater drag is important for improving the endurance and energy efficiency of marine equipment. Grooved surfaces and superhydrophobic coatings hold promise for drag reduction; however, conventional grooves require scale matching with near-wall turbulent structures, whereas passive superhydrophobic surfaces suffer from air film depletion under high-speed flow. In this study, an active gas-supplied superhydrophobic porous grooved interface is proposed for drag reduction. The interface consists of a selective laser-melted, three-dimensionally interconnected porous steel substrate, grooves, and a superhydrophobic coating. The porous substrate acts as an internal gas transport and distribution layer, and streamwise grooves confine the supplied air film. The active gas supply reconstructs the gas–liquid interface inside the grooves, shifts the near-wall velocity profile upward, suppresses near-wall vorticity, and reduces wall shear stress. At Re = 74000, the optimized surface achieved a maximum drag reduction rate of 31.9% under a regulated gas supply. By coupling active air film replenishment with groove confinement, this strategy reduces the dependence of grooved surfaces on strict scale matching and extends the effective operating range. Furthermore, a piezo-air pump with a high-pressure load capability was introduced as a self-supplied gas source, enabling localized gas compensation at Re = 46000. This study provides an active air-film regulation strategy for miniaturized drag reduction applications in marine equipment.","PeriodicalId":50,"journal":{"name":"Langmuir","volume":"27 1","pages":""},"PeriodicalIF":3.9,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149210175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0