Medical Sains : Jurnal Ilmiah Kefarmasian最新文献

FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS 用于啮齿动物脂肪肝诱导模型的高脂饮食饲料的配方和营养评估

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-05-14 DOI: 10.37874/ms.v9i2.1233

Putri Anggreini, J. Levita, Hadi Kuncoro, Andi Tenri Kawareng, S. Sumiwi

{"title":"FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS","authors":"Putri Anggreini, J. Levita, Hadi Kuncoro, Andi Tenri Kawareng, S. Sumiwi","doi":"10.37874/ms.v9i2.1233","DOIUrl":"https://doi.org/10.37874/ms.v9i2.1233","url":null,"abstract":"Non-alcoholic fatty Liver Disease (NAFLD) is one of the most prevalent lipid disorders worldwide. In the pursuit of drug discovery and development, animal modeling is crucial to elucidate the mechanisms underlying a disease. One form of animal model of NAFLD involves the induction of a high-fat diet (HFD). However, most HFDs exhibit complexity in the formulation, and commercial HFDs tend to be costly. This study aimed to formulate an HFD feed with minimal ingredients that are capable of inducing liver steatosis. This study commenced with the development of 4 dietary formulations (F1, F2, F3, and F4) comprising various food components with specific proportions and treatments. A proximate analysis was conducted for each formulation. Subsequently, the most promising formulation was administered to the rats for 14 days. On day 15, liver organs were harvested for histological analysis. The results showed that among the four formulations developed, HFD F4 exhibited the best physical appearance and nutritional proximate components, characterized by its stability in form and high fat (41.8%), high protein (21.5%), and low carbohydrate (23.2%) content. Histology examination revealed that two weeks of administration of F4 administration led to severe degeneration, inflammation, and necrosis in rat hepatocytes compared to the normal group (p < 0.001), thus confirming that HFD F4 may be developed as an inducer of steatosis in rats.\u0000 Keywords: experimental animal model; high-fat diet; liver steatosis ; NAFLD","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"74 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140978727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-05-03 DOI: 10.37874/ms.v9i2.1092

Syahru Rohman, Wawang Anwarudin, Nur Azizah, Mochammad Nur Isnaeni Mauludin, Anna Khalida Sya’bany

{"title":"HEALTH-RELATED QUALITY OF LIFE IN POSTMENOPAUSAL WOMEN WITH ADVANCED BREAST CANCER RECEIVING ADJUVANT HORMONE THERAPY (RIBOCICLIB AND LETROZOLE)","authors":"Syahru Rohman, Wawang Anwarudin, Nur Azizah, Mochammad Nur Isnaeni Mauludin, Anna Khalida Sya’bany","doi":"10.37874/ms.v9i2.1092","DOIUrl":"https://doi.org/10.37874/ms.v9i2.1092","url":null,"abstract":"Breast cancer is a type of cancer that affects many women in Indonesia. Adjuvant hormone therapies, such as letrozole and ribociclib, have succeeded in improving the patient's quality of life. This study aimed to assess the quality of life of postmenopausal women with advanced breast cancer who received adjuvant hormone therapy with ribociclib and letrozole. A cross-sectional study was conducted using retrospective data from postmenopausal female breast cancer patients at Dharmais Cancer Hospital between 2020 and 2023 who met the inclusion criteria. To determine the impact of sociodemographics on patient quality of life, data were examined using the quality of life score (EQ5D5L) and Spearman test. There were 29 patients, with a mean age of 54.9 years (SD = 8.65); the highest education level was high school (34.5%); The majority of occupations are housewives (69%), and the majority are stage IV (34.5%). The mean utility and VAS values of Ribociclib were 0.885 and 81.66, respectively, whereas those for letrozole were 0.725 and 78.46, respectively. Analysis of the relationship between quality of life and patient characteristics showed that the quality of life of patients with breast cancer treated with adjuvant ribociclib and letrozole therapy was influenced by the stage of breast cancer (p = 0.008). These findings indicate that patients receiving ribociclib and letrozole therapy have a good quality of life, which quality of life quality of life is influenced by the stage of malignancy.\u0000 Keywords: breast cancer, quality of life, letrozole, ribociclib, post menopause","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"128 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141015258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECT OF HOME PHARMACY CARE EDUCATION ON BLOOD PRESSURE CONTROL AND KNOWLEDGE LEVEL OF HYPERTENSIVE PATIENTS AT KENDALSARI PUBLIC HELATH CENTRE MALANG 家庭药房护理教育对 Kendalsari 公共医疗中心高血压患者血压控制和知识水平的影响

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-03-05 DOI: 10.37874/ms.v9i1.1041

Nanang Ardianto, Allis Soraya Setyokanti Winarning, Rudy Mardianto, Ayesi Dewi Safitri

{"title":"THE EFFECT OF HOME PHARMACY CARE EDUCATION ON BLOOD PRESSURE CONTROL AND KNOWLEDGE LEVEL OF HYPERTENSIVE PATIENTS AT KENDALSARI PUBLIC HELATH CENTRE MALANG","authors":"Nanang Ardianto, Allis Soraya Setyokanti Winarning, Rudy Mardianto, Ayesi Dewi Safitri","doi":"10.37874/ms.v9i1.1041","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1041","url":null,"abstract":"Hypertension is one of the ten most common degenerative diseases and has a high mortality rate. In 2020, the prevalence of hypertension in Malang City reached 35,641 cases. The role of pharmacists as caregivers in home pharmacy care can help to control hypertension and reduce morbidity. The main objective of this study was to determine the effect of home pharmacy care on hypertension patients’ knowledge and blood pressure management. This study used a quantitative experimental design with a Randomized Control Trial method, with a total of 34 respondents divided into 2 groups: the control group and the test group of 17 respondents each. Using an accidental sampling technique. The research location was Kendalsari Public Health Centre Malang in August 2023. Blood pressure data were measured using a tensimeter, and knowledge level data were obtained using a knowledge questionnaire. Data analysis was performed using paired and pooled t-tests. The results of the analysis of the effect of home pharmacy care on the level of patient knowledge about hypertension with a significance value (2tailed) p = 0.000, and analysis of the effect of home pharmacy care on systolic and diastolic blood pressure with a significance value (2tailed) p = 0.030. The results of this study concluded that home pharmacy care for hypertensive patients had a positive effect on blood pressure control and increased knowledge at the Kendalsari Public Health Center, Malang.\u0000Keywords: Home pharmacy care, hypertension, blood pressure control, knowledge level.","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"116 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140079279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EVALUATION OF ANTIBIOTIC USE USING THE ATC/DD AND DU 90% METHODS IN OUTPATIENT PATIENTS IN PUSKESMAS RI TENAYAN RAYA 使用 Atc/dd 和 du 90% 方法对 Puskesmas ri Tenayan raya 门诊病人的抗生素使用情况进行评估

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-03-03 DOI: 10.37874/ms.v9i1.1047

Novia Sinata, Delvi Regika, Mira Febrina

{"title":"EVALUATION OF ANTIBIOTIC USE USING THE ATC/DD AND DU 90% METHODS IN OUTPATIENT PATIENTS IN PUSKESMAS RI TENAYAN RAYA","authors":"Novia Sinata, Delvi Regika, Mira Febrina","doi":"10.37874/ms.v9i1.1047","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1047","url":null,"abstract":"Infectious diseases are one of the health problem that threaten developing countries, including Indonesia. Riau as one of the provinces with its coastal coverage is not spared from this problem. Inaccurate use of antibiotics is found in the wider community, which can be a cause of negative risks such as antibiotic resistance. Antibiotics are drugs that are used to treat diseases caused by microbes. The improper use of antibiotics can lead to a risk of resistance. Resistance can be avoided using antibiotics. This study aimed to classify antibiotic use using ATC codes and determine the quantity of antibiotic use in outpatients by calculating the DDD. This research method was observational, with a descriptive design and retrospective data collection using secondary data by searching medical records. The sample in this study consisted of outpatients at the Tenayan Raya Inpatient Health Center Outpatient Installation between January and December 2022 who received antibiotic therapy with an ATC code and DDD value in accordance with the provisions of the WHO Collaborating Center, using a total sampling technique.The results of the study showed that based on the ATC/DDD and DU 90% methods, there were 3 antibiotics with the highest quantity of use, namely amoxicillin at 165,92 DDD/1000 KPRJ with a percentage of 67,02%, ciprofloxacin at 41,07 DDD/1000 KPRJ with a percentage of 16,59 %, and cefixime as much as 14,69 DDD/1000 KPRJ with a percentage of 5,93%.\u0000 Keywords: antibiotics, ATC/DD, DU 90%, resistance","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"18 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140081089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REVIEW: THE USE OF TOFU RESIDUE IN THE PHARMACEUTICS 回顾：豆腐渣在制药学中的应用

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-03-01 DOI: 10.37874/ms.v9i1.1096

Ine Suharyani, I. Indawati, Encu Asep Setiadi, Maisya Mauliana Insani, Ibnu Mas'ud

{"title":"REVIEW: THE USE OF TOFU RESIDUE IN THE PHARMACEUTICS","authors":"Ine Suharyani, I. Indawati, Encu Asep Setiadi, Maisya Mauliana Insani, Ibnu Mas'ud","doi":"10.37874/ms.v9i1.1096","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1096","url":null,"abstract":"Tofu is a processed soy product consisting of soft solids made by clumping soy protein extracts. The residual result of tofu processing is called the tofu dredging waste. In Indonesia, tofu waste remains an unsolved problem. Many people argue that the waste from tofu processing (tofu residue waste) does not have high economic value and is only used as feed for livestock and is even thrown carelessly into the river, which causes damage to the ecosystem. Tofu pulp has high nutritional content, such as protein (26.6%), fat (18.3%), carbohydrates (41.3%), phosphorus (0.29%), calcium (0.19%), iron (0.04%), and water (0.09%). The purpose of this journal review is to determine the use of tofu residue waste and solve the problem of tofu residue waste in the community. The method used was collecting various research journals through the Google Scholar website with keywords for the use of tofu residue in the pharmaceutical field. Based on the 7 journals reviewed, tofu pulp can be used as an anti-aging, adsorbent, anti-diabetes, anti-inflammatory, bioethanol, and excipient in tablet production.\u0000Keywords: Tofu, tofu residue, pharmaceutical","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"31 24","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140083106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tectona grandis Linn. : ANTIDIABETIC ACTIVITY OF THE FRACTIONS USING AN IN VIVO APPROACH Tectona grandis Linn.：采用活体方法检测碎片的抗厌食活性

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-19 DOI: 10.37874/ms.v9i1.1058

Nurramadhani ASida, Rifa’atul Mahmudah, Nita Trinovitasari, Nada Shofa, Parawansah, Nuralifah, Abd Rafid, Risma

{"title":"Tectona grandis Linn. : ANTIDIABETIC ACTIVITY OF THE FRACTIONS USING AN IN VIVO APPROACH","authors":"Nurramadhani ASida, Rifa’atul Mahmudah, Nita Trinovitasari, Nada Shofa, Parawansah, Nuralifah, Abd Rafid, Risma","doi":"10.37874/ms.v9i1.1058","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1058","url":null,"abstract":"The exploration of Tectona grandis Linn. from Indonesia, especially its use as an anti-diabetes agent is still quite limited. This study aims to determine the antidiabetic activity of the fractions from Tectona grandis Linn. leaves in male Rattus norvegicus. The animal blood glucose level was measured first as T0, then the animals were injected with streptozotocin (STZ) 40 mg/Kg BW to induce diabetes mellitus (DM), and then the blood was collected to determine the blood glucose level (T1). The animal was divided into six groups, namely normal group (NC) without treatment, positive control (K+) (DM+glibenclamide 5 mg), negative control (K-) (DM+NaCMC 0.5%), fractions group (DM+nHexane fraction (P1), DM+chloroform fraction (P2), and DM+ethyl acetate fraction (P3), each dose 300 mg/kg BW). The duration of treatment was 7 days, and at the end of treatment, the blood glucose levels were determined. The T0, T1, and T2 are analyzed using One-Way ANOVA and post-hoc LSD. The results obtained that the K+, P3, P2, and P1 groups were able to reduce the animals' blood glucose levels significantly (p<0.05), with the blood glucose levels are 97.01; 110.96; 129.38; and 111.46 mg/dL, respectively. The percentage of reduction in blood glucose level shows that the K+ group has the highest percentage at 66.8%, followed by the P3 group at 64.0%. The n-hexane, chloroform, and ethyl acetate fractions showed similar effectiveness to glibenclamide in reducing blood glucose levels statistically (p>0.05). Consequently, Tectona grandis Linn ...","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"10 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139958640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REVIEW: PENGARUH ENKAPSULASI KURKUMIN TERHADAP AKTIVITAS ANTIOKSIDAN 回顾：姜黄素封装对抗氧化活性的影响

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-02-17 DOI: 10.37874/ms.v9i1.897

Syamsul Ma’arif, Jason Merari Peranginangin, Wiwin Herdwiani

{"title":"REVIEW: PENGARUH ENKAPSULASI KURKUMIN TERHADAP AKTIVITAS ANTIOKSIDAN","authors":"Syamsul Ma’arif, Jason Merari Peranginangin, Wiwin Herdwiani","doi":"10.37874/ms.v9i1.897","DOIUrl":"https://doi.org/10.37874/ms.v9i1.897","url":null,"abstract":"Kurkumin memiliki aktivitas antioksidan yang rentan dipengaruhi oleh cahaya, pH, suhu, oksigen dan dapat bereaksi dengan senyawa lain. Enkapsulasi dapat melindungi senyawa bioaktif. Systematic literature review (SLR) merupakan sebuah pendekatan penelitian secara sistematis untuk mengidentifikasi, mengevaluasi dan menafsirkan semua studi yang relevan mengenai topik tertentu. Penelitian SLR ini bertujuan untuk mengetahui pengaruh enkapsulasi kurkumin terhadap aktivitas antioksidan dan rekomendasi metode serta penyalut untuk enkapsulasi kurkumin. Penelitian ini menggunakan metode SLR yang dilakukan dalam beberapa tahap yaitu perencanaan (planning) dengan menentukan elemen PICO, dataset, kata kunci pencarian, kriteria inklusi dan eksklusi. Tahap pengumpulan data (conducting) meliputi skrining data dari judul dan abstrak, seleksi teks lengkap, penilaian kualitas artikel serta analisis dan sintesis data. Tahap pelaporan (reporting) melaporkan hasil review. Hasil penelitian menunjukkan enkapsulasi mampu meningkatkan aktivitas antioksidan kurkumin. Kurkumin yang dienkapsulasi mempunyai aktivitas antioksidan yang lebih baik daripada kurkumin yang tidak dienkapsulasi. Metode electrostatic complexation, dan penyalut alami laktoferin dan pektin adalah metode dan penyalut yang direkomendasikan untuk enkapsulasi kurkumin. Hal ini berdasarkan data enkapsulasi kurkumin dengan metode dan penyalut tersebut mempunyai karakteristik enkapsulasi yang baik dan aktivitas antioksidan paling tinggi.\u0000Kata kunci: Systematic literature review, Kurkumin, Antioksidan, Enkapsulasi.","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"76 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139959955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF TOTAL PHENOLIC AND TOTAL FLAVONOID LEVELS ON THE ANTIOXIDANT POWER OF WATER EXTRACT, ETHANOL AND CHLOROFORM OF GREEN TEA LEAVES (Camellia sinensis L) 总酚和总芳香烃含量对绿茶叶（Camellia sinensis L）水提取物、乙醇和氯仿抗氧化能力的影响

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-01-20 DOI: 10.37874/ms.v9i1.940

Ahwan Ahwan, Anik Suwarni, Reni Ariastuti, Rosyadah Hafidz, Sinta Mei Enjelina

{"title":"EFFECT OF TOTAL PHENOLIC AND TOTAL FLAVONOID LEVELS ON THE ANTIOXIDANT POWER OF WATER EXTRACT, ETHANOL AND CHLOROFORM OF GREEN TEA LEAVES (Camellia sinensis L)","authors":"Ahwan Ahwan, Anik Suwarni, Reni Ariastuti, Rosyadah Hafidz, Sinta Mei Enjelina","doi":"10.37874/ms.v9i1.940","DOIUrl":"https://doi.org/10.37874/ms.v9i1.940","url":null,"abstract":"Tea (Camellia sinensis L.) was originally used as a refresh drink. Tea has many benefits, especially for health and beauty. The most widely used tea in the market is green tea, because its properties can be used as a daily drink to improve the quality of life in carrying out daily activities. The aim of this study was to determine the effect of the relationship between total phenolic and total flavonoid levels in water extract (EA), ethanol (EE), and chlorophorom (EK) of green tea leaves on antioxidant power. This experimental study used the extraction method, qualitative analysis, quantitative analysis using the colorimetric method, and antioxidant power using the DPPH method. The data obtained were statistically analyzed using SPPS and Microsoft Excel. The results obtained in The extraction process yielded extracts: EA (21.44%), EE (11.20 %), and EK (3.58 %). Qualitative analysis of flavonoid and phenolic compounds in all the extracts revealed the presence of these compounds. In the total phenolic test, the levels were: 229.07 ± 0.99 (EA); 573.70 ± 3.93 (EE); 45.27 ± 0.73 mg/g (EK) GAE (Galic Acid Equivalent). Meanwhile, the flavonoid content was 13.10 ± 0.31 (EA); 40.49 ± 0.67 (EE); 20.94 ± 0.50 mg/g (EK) QE (Quercetin Equivalent). The antioxidant results have an IC50 (Inhibitory Concentration) value of 34.64 ± 0.74 (EA); 7.02 ± 0.15 (EE); 99.11 ± 1.23; positive control 5.94 ± 0.07 µg/mL (vitamin C) ...","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"9 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139523908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FORMULASI SEDIAAN FACE WASH EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora P.) DALAM SEDIAAN GEL DAN CAIR FORMULASI SEDIAAN FACE WASH EXTRACT DAUN KELOR (Moringa oleifera L.) DAN EXTRACT BIJI KOPI ROBUST (Coffea canephora P.) DALAM SEDIAAN GEL DAN CAIR

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-01-20 DOI: 10.37874/ms.v9i1.762

Rahmat Hidayat, N. Sugihartini, Hari Susanti

{"title":"FORMULASI SEDIAAN FACE WASH EKSTRAK DAUN KELOR (Moringa oleifera L.) DAN EKSTRAK BIJI KOPI ROBUSTA (Coffea canephora P.) DALAM SEDIAAN GEL DAN CAIR","authors":"Rahmat Hidayat, N. Sugihartini, Hari Susanti","doi":"10.37874/ms.v9i1.762","DOIUrl":"https://doi.org/10.37874/ms.v9i1.762","url":null,"abstract":"Sediaan pembersih wajah (face wash) berfungsi untuk membersihkan sekaligus mencegah timbulnya masalah kulit wajah. Penambahan bahan aktif berupa ekstrak daun kelor dan ekstrak biji kopi diharapkan akan meningkatkan manfaat sediaan face wash tersebut. Tujuan dari penelitian ini untuk mengetahui jenis sediaan yang paling optimal antara sediaan gel dan cair serta variasi komposisi yang optimal antara kedua ekstrak dalam formulasi face wash. Face wash diformulasikan dalam bentuk sediaan gel dan cair dengan variasi komposisi ekstrak daun kelor (Moringa oleifera L.) dan ekstrak biji kopi robusta (Coffea canephora P.) secara berturut-turut yaitu 1:1, 1:2, 2:1. Sediaan dievaluasi berdasarkan parameter organoleptis, pH, viskositas, tinggi busa dan stabilitas busa serta daya hambat terhadap bakteri Staphylococcus aureus. Data yang diperoleh kemudian di analisa Two Way Anova dalam aplikasi SPSS versi 23. Berdasarkan uji diketahui bahwa face wash gel lebih baik pada uji organoleptis, pH, tinggi busa dan stabilitas busa, viskositas dan daya hambat terhadap bakteri. Peningkatan komposisi ekstrak biji kopi robusta menyebabkan peningkatan pH pada jenis sediaan face wash gel maupun cair. Berdasarkan data maka dapat disimpulkan jenis sediaan face wash gel pada varian komposisi zat aktif ekstrak biji kopi robusta 10% dan ekstrak daun kelor 20% lebih baik dan paling sesuai standar yang ditetapkan SNI (Standar Nasional Indonesia).\u0000Kata kunci : Face wash, Ekstrak daun kelor, Ekstrak kopi robusta, gel","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"11 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139524754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE 综述：关于使用 GOTU KOLA（积雪草）提取物治疗痤疮的研究

Medical Sains : Jurnal Ilmiah Kefarmasian Pub Date : 2024-01-18 DOI: 10.37874/ms.v9i1.1010

Endang Diyah Ikasari, T. H. Pebriani

{"title":"REVIEW: A STUDY ON THE USE OF GOTU KOLA EXTRACT (Centella asiatica (L.) Urb.) AS A TREATMENT FOR ACNE","authors":"Endang Diyah Ikasari, T. H. Pebriani","doi":"10.37874/ms.v9i1.1010","DOIUrl":"https://doi.org/10.37874/ms.v9i1.1010","url":null,"abstract":"Acne is an inflammatory skin condition caused by sebaceous follicles and characterized by skin inflammation in the form of a buildup of bacteria and oil that clogs pores and causes acne. Centella asiatica (L.) Urb., often known as gotu kola, has antibacterial properties that inhibit Propionibacterium acnes, thereby reducing papules, pustules, and nodules. Antioxidants, asiatic acid, and madecassic acid found in gotu kola (Centella asiatica (L.) Urb.) can treat wounds. Skin damaged by acne can be repaired and rejuvenated with gotu kola antioxidants, which also help collagen formation more quickly in the skin. This research aims to examine the ability of gotu kola (Centella asiatica (L.) Urb.) extract to inhibit acne-causing bacteria (Propionibacterium acnes) resulting from a literature review. This research method is a literature review or literature review. Research journals that met the inclusion criteria (activity test results suppressing bacterial growth activity) were collected, and a journal summary was made. A summary of the research journals is included in the table sorted by the year of publication of the journal. Based on the results of a literature review carried out by researchers, Gotu kola can be extracted using the maceration method by soaking the plant material in an extraction solvent such as ethanol or water for a specified time. This process was used to remove the active components from the plant material. The inhibition zone formed was evaluated to determine the effectiveness of the extracts or preparations containing gotu kola extract in preventing bacterial growth ...","PeriodicalId":509889,"journal":{"name":"Medical Sains : Jurnal Ilmiah Kefarmasian","volume":"65 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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