Frontiers in Network Physiology最新文献_第2页

Modulation of the expression of connexins 37, 40, and 43 in endothelial cells in a culture 培养液中内皮细胞中连接蛋白 37、40 和 43 的表达调控

Frontiers in Network Physiology Pub Date : 2024-03-15 DOI: 10.3389/fnetp.2024.1199198

Wenqing Zhuang, Nicholas Mitrou, Steve Kulak, W. Cupples, B. Braam

{"title":"Modulation of the expression of connexins 37, 40, and 43 in endothelial cells in a culture","authors":"Wenqing Zhuang, Nicholas Mitrou, Steve Kulak, W. Cupples, B. Braam","doi":"10.3389/fnetp.2024.1199198","DOIUrl":"https://doi.org/10.3389/fnetp.2024.1199198","url":null,"abstract":"Connexin (Cx) 37, 40, and 43 are implicated in vascular function, specifically in the electrical coupling of endothelial cells and vascular smooth-muscle cells. In the present study, we investigated whether factors implicated in vascular dysfunction can modulate the gene expression of Cx37, Cx40, and Cx43 and whether this is associated with changes in endothelial layer barrier function in human microvascular endothelial cells (HMEC-1). First, HMEC-1 were subjected to stimuli for 4 and 8 h. We tested their responses to DETA-NONOate, H2O2, high glucose, and angiotensin II, none of which relevantly affected the transcription of the connexin genes. Next, we tested inflammatory factors IL-6, interferon gamma (IFNγ), and TNFα. IFNγ (10 ng/mL) consistently induced Cx40 expression at 4 and 8 h to 10–20-fold when corrected for the control. TNFα and IL-6 resulted in small but significant depressions of Cx37 expression at 4 h. Two JAK inhibitors, epigallocatechin-3-gallate (EGCG) (100–250 μM) and AG490 (100–250 μM), dose-dependently inhibited the induction of Cx40 expression by IFNγ. Subsequently, HMEC-1 were subjected to 10 ng/mL IFNγ for 60 h, and intercellular and transcellular impedance was monitored by electric cell-substrate impedance sensing (ECIS). In response to IFNγ, junctional-barrier impedance increased more than cellular-barrier impedance; this was prevented by AG490 (5 μM). In conclusion, IFNγ can strongly induce Cx40 expression and modify the barrier properties of the endothelial cell membrane through the JAK/STAT pathway. Moreover, the Cx37, Cx40, and Cx43 expression in endothelial cells is stable and, apart from IFNγ, not affected by a number of factors implicated in endothelial dysfunction and vascular diseases.","PeriodicalId":509566,"journal":{"name":"Frontiers in Network Physiology","volume":"8 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging wearable technologies for multisystem monitoring and treatment of Parkinson’s disease: a narrative review 用于帕金森病多系统监控和治疗的新兴可穿戴技术：综述

Frontiers in Network Physiology Pub Date : 2024-02-13 DOI: 10.3389/fnetp.2024.1354211

Yasmine M. Kehnemouyi, Todd P. Coleman, Peter A. Tass

{"title":"Emerging wearable technologies for multisystem monitoring and treatment of Parkinson’s disease: a narrative review","authors":"Yasmine M. Kehnemouyi, Todd P. Coleman, Peter A. Tass","doi":"10.3389/fnetp.2024.1354211","DOIUrl":"https://doi.org/10.3389/fnetp.2024.1354211","url":null,"abstract":"Parkinson’s disease (PD) is a chronic movement disorder characterized by a variety of motor and nonmotor comorbidities, including cognitive impairment, gastrointestinal (GI) dysfunction, and autonomic/sleep disturbances. Symptoms typically fluctuate with different settings and environmental factors and thus need to be consistently monitored. Current methods, however, rely on infrequent rating scales performed in clinic. The advent of wearable technologies presents a new avenue to track objective measures of PD comorbidities longitudinally and more frequently. This narrative review discusses and proposes emerging wearable technologies that can monitor manifestations of motor, cognitive, GI, and autonomic/sleep comorbidities throughout the daily lives of PD individuals. This can provide more wholistic insight into real-time physiological versus pathological function with the potential to better assess treatments during clinical trials and allow physicians to optimize treatment regimens. Additionally, this narrative review briefly examines novel applications of wearables as therapy for PD patients.","PeriodicalId":509566,"journal":{"name":"Frontiers in Network Physiology","volume":"130 36","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139780723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging wearable technologies for multisystem monitoring and treatment of Parkinson’s disease: a narrative review 用于帕金森病多系统监控和治疗的新兴可穿戴技术：综述

Frontiers in Network Physiology Pub Date : 2024-02-13 DOI: 10.3389/fnetp.2024.1354211

Yasmine M. Kehnemouyi, Todd P. Coleman, Peter A. Tass

{"title":"Emerging wearable technologies for multisystem monitoring and treatment of Parkinson’s disease: a narrative review","authors":"Yasmine M. Kehnemouyi, Todd P. Coleman, Peter A. Tass","doi":"10.3389/fnetp.2024.1354211","DOIUrl":"https://doi.org/10.3389/fnetp.2024.1354211","url":null,"abstract":"Parkinson’s disease (PD) is a chronic movement disorder characterized by a variety of motor and nonmotor comorbidities, including cognitive impairment, gastrointestinal (GI) dysfunction, and autonomic/sleep disturbances. Symptoms typically fluctuate with different settings and environmental factors and thus need to be consistently monitored. Current methods, however, rely on infrequent rating scales performed in clinic. The advent of wearable technologies presents a new avenue to track objective measures of PD comorbidities longitudinally and more frequently. This narrative review discusses and proposes emerging wearable technologies that can monitor manifestations of motor, cognitive, GI, and autonomic/sleep comorbidities throughout the daily lives of PD individuals. This can provide more wholistic insight into real-time physiological versus pathological function with the potential to better assess treatments during clinical trials and allow physicians to optimize treatment regimens. Additionally, this narrative review briefly examines novel applications of wearables as therapy for PD patients.","PeriodicalId":509566,"journal":{"name":"Frontiers in Network Physiology","volume":"223 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139840622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Astrocytes as critical players of the fine balance between inhibition and excitation in the brain: spreading depolarization as a mechanism to curb epileptic activity 星形胶质细胞是大脑抑制与兴奋之间微妙平衡的关键参与者：扩散去极化是抑制癫痫活动的一种机制

Frontiers in Network Physiology Pub Date : 2024-02-09 DOI: 10.3389/fnetp.2024.1360297

Rune Enger, Kjell Heuser

引用次数: 0

Astrocytes as critical players of the fine balance between inhibition and excitation in the brain: spreading depolarization as a mechanism to curb epileptic activity 星形胶质细胞是大脑抑制与兴奋之间微妙平衡的关键参与者：扩散去极化是抑制癫痫活动的一种机制

Frontiers in Network Physiology Pub Date : 2024-02-09 DOI: 10.3389/fnetp.2024.1360297

Rune Enger, Kjell Heuser

引用次数: 0

Feedback control of collective dynamics in an oscillator population with time-dependent connectivity 具有时间相关性的振荡器群体集体动力学的反馈控制

Frontiers in Network Physiology Pub Date : 2024-02-02 DOI: 10.3389/fnetp.2024.1358146

Michael Rosenblum

引用次数: 0

Feedback control of collective dynamics in an oscillator population with time-dependent connectivity 具有时间相关性的振荡器群体集体动力学的反馈控制

Frontiers in Network Physiology Pub Date : 2024-02-02 DOI: 10.3389/fnetp.2024.1358146

Michael Rosenblum

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Editorial: Measurements of cardiorespiratory coupling applied to sports and rehabilitation medicine: insights, implications and perspectives 社论：应用于运动和康复医学的心肺耦合测量：见解、影响和前景

Frontiers in Network Physiology Pub Date : 2024-01-24 DOI: 10.3389/fnetp.2024.1370452

Raphael Martins de Abreu, Victor Ribeiro Neves, Beatrice Cairo

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The time-evolving epileptic brain network: concepts, definitions, accomplishments, perspectives 随时间演变的癫痫脑网络：概念、定义、成就和观点

Frontiers in Network Physiology Pub Date : 2024-01-16 DOI: 10.3389/fnetp.2023.1338864

T. Bröhl, T. Rings, Jan Pukropski, R. von Wrede, Klaus Lehnertz

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No change in network connectivity measurements between separate rsfMRI acquisition times 在不同的 rsfMRI 采集时间之间，网络连通性测量结果没有变化

Frontiers in Network Physiology Pub Date : 2024-01-15 DOI: 10.3389/fnetp.2024.1342161

Elliot G. Neal, Samantha Schimmel, Zeegan George, Molly Monsour, A. Alayli, Gavin Lockard, Keaton Piper, Stephanie Maciver, Fernando L. Vale, Yarema B. Bezchlibnyk

{"title":"No change in network connectivity measurements between separate rsfMRI acquisition times","authors":"Elliot G. Neal, Samantha Schimmel, Zeegan George, Molly Monsour, A. Alayli, Gavin Lockard, Keaton Piper, Stephanie Maciver, Fernando L. Vale, Yarema B. Bezchlibnyk","doi":"10.3389/fnetp.2024.1342161","DOIUrl":"https://doi.org/10.3389/fnetp.2024.1342161","url":null,"abstract":"The role of resting state functional MRI (rsfMRI) is increasing in the field of epilepsy surgery because it is possible to interpolate network connectivity patterns across the brain with a high degree of spatial resolution. Prior studies have shown that by rsfMRI with scalp electroencephalography (EEG), an epileptogenic network can be modeled and visualized with characteristic patterns of connectivity that are relevant to both seizure-related and neuropsychological outcomes after surgery. The aim of this study is to show that a 5-min acquisition time provides reproducible results related to the relevant connectivity metrics when compared to a separately acquired 5-min scan. Fourteen separate rsfMRI sessions from ten different patients were used for comparison, comprised of patients with temporal lobe epilepsy both pre- and post-operation. Results showed that there was no significant difference in any of the connectivity metrics when comparing both 5-min scans to each other. These data support the continued use of a 5-min scan for epileptogenic network modeling in future studies because the inter-scan variability is sufficiently low as not to alter the output metrics characterizing the network connectivity.","PeriodicalId":509566,"journal":{"name":"Frontiers in Network Physiology","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139623079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0