Frontiers in Microbiology最新文献_第5页

The impact of the donors’ COVID-19 status on the outcomes of allogeneic hematopoietic stem cell transplantation: a multi-center retrospective study 捐献者的 COVID-19 状态对异体造血干细胞移植结果的影响：一项多中心回顾性研究

Frontiers in Microbiology Pub Date : 2024-07-15 DOI: 10.3389/fmicb.2024.1415289

Yifei Huang, Z. Fan, Yingying Hu, Sizhou Feng, Shunqing Wang, Shanyu Zhang, Fen Huang, L. Xuan, Na Xu, Hui Liu, Zhixiang Wang, Jing Sun, Qi-fa Liu, Ren Lin

{"title":"The impact of the donors’ COVID-19 status on the outcomes of allogeneic hematopoietic stem cell transplantation: a multi-center retrospective study","authors":"Yifei Huang, Z. Fan, Yingying Hu, Sizhou Feng, Shunqing Wang, Shanyu Zhang, Fen Huang, L. Xuan, Na Xu, Hui Liu, Zhixiang Wang, Jing Sun, Qi-fa Liu, Ren Lin","doi":"10.3389/fmicb.2024.1415289","DOIUrl":"https://doi.org/10.3389/fmicb.2024.1415289","url":null,"abstract":"To explore the impact of donors’ COVID-19 status on allogeneic stem cell transplantation (allo-HSCT), we compared the transplant outcomes of 74 participants.This multi-center retrospective study included nine participants receiving grafts from COVID-19 positive donors (CPD), 45 from COVID-19 experienced donors (CED), and 20 from COVID-19 naive donors (CND). We evaluated engraftment, complications, and survival rates among the three groups.All apheresis procedures were successful with no significant differences in CD34+ cells or lymphocytes in grafts among the three groups. All patients achieved engraftment by day 30 post-HSCT. The incidence of grade II-IV acute graft-versus-host disease (aGVHD) was 55.6%, 20%, and 10% in the CPD, CED, and CND groups, respectively (p = 0.024). Multivariate analysis indicated that COVID-19 positivity in donors at the time of apheresis was an independent risk factor for II-IV aGVHD (p = 0.020, OR = 12.159, 95% CI 1.783 -135.760). No differences were observed among the groups in terms of chronic GVHD, viral infection, or sinusoidal obstruction syndrome. The 6-month overall survival and disease-free survival rates were also similar among the three groups.Our results suggest that the COVID-19-positive status of donors might not impact graft collection, engraftment, or short-term survival of allo-HSCT recipients but might increase the risk of aGVHD. Further research is needed to explore the influence of donors’ COVID-19 status on long-term complications and survival in allo-HSCT recipients.","PeriodicalId":509565,"journal":{"name":"Frontiers in Microbiology","volume":"42 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141645074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial: Untangle the broad connections and tight interactions between human microbiota and complex diseases through data-driven approaches, volume II 社论：通过数据驱动方法解开人类微生物群与复杂疾病之间的广泛联系和紧密互动，第 II 卷

Frontiers in Microbiology Pub Date : 2024-07-10 DOI: 10.3389/fmicb.2024.1449474

Qi Zhao, Zuo-Bin Zhu, Jian Li, Li Zhang, Liang Wang

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Editorial: Advancing molecular diagnostic tools for robust surveillance of microbial water quality 社论：推进分子诊断工具，有力监控微生物水质

Frontiers in Microbiology Pub Date : 2024-07-10 DOI: 10.3389/fmicb.2024.1452943

Lisa Paruch, Cristina García-Aljaro

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Editorial: Insights in infectious agents and disease: 2022 社论：传染性病原体和疾病的启示：2022

Frontiers in Microbiology Pub Date : 2024-07-09 DOI: 10.3389/fmicb.2024.1443636

Axel Cloeckaert

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Editorial: Biology of myxobacteria 社论：霉菌生物学

Frontiers in Microbiology Pub Date : 2024-07-05 DOI: 10.3389/fmicb.2024.1450345

Zhoukun Li, Honghui Zhu, David E. Whitworth, David C. Stevens

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Editorial: Acidophile microbiology: from extreme environments to biotechnological applications 社论：嗜酸微生物学：从极端环境到生物技术应用

Frontiers in Microbiology Pub Date : 2024-07-04 DOI: 10.3389/fmicb.2024.1454559

Elizabeth Watkin, Ivan Nancucheo, Axel Schippers

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Can the artificial exogenous addition really cause an increasing carbon emission driven by microbial community in grassland ecosystems? 人工外源添加真的会导致草地生态系统中微生物群落驱动的碳排放增加吗？

Frontiers in Microbiology Pub Date : 2024-07-04 DOI: 10.3389/fmicb.2024.1421325

Guanhong Liu, Ze Gu, Bingyi Li

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Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota 二甲双胍对调节肠道微生物群具有广泛影响的机制研究进展

Frontiers in Microbiology Pub Date : 2024-05-24 DOI: 10.3389/fmicb.2024.1396031

Yue Wang, Xianxian Jia, Bin Cong

{"title":"Advances in the mechanism of metformin with wide-ranging effects on regulation of the intestinal microbiota","authors":"Yue Wang, Xianxian Jia, Bin Cong","doi":"10.3389/fmicb.2024.1396031","DOIUrl":"https://doi.org/10.3389/fmicb.2024.1396031","url":null,"abstract":"Metformin is of great focus because of its high safety, low side effects, and various effects other than lowering blood sugar, such as anti-inflammation, anti-tumor, and anti-aging. Studies have shown that metformin has a modulating effect on the composition and function of the intestinal microbiota other than acting on the liver. However, the composition of microbiota is complex and varies to some extent between species and individuals, and the experimental design of each study is also different. Multiple factors present a major obstacle to better comprehending the effects of metformin on the gut microbiota. This paper reviews the regulatory effects of metformin on the gut microbiota, such as increasing the abundance of genus Akkermansia, enriching short-chain fatty acids (SCFAs)-producing bacterial genus, and regulating gene expression of certain genera. The intestinal microbiota is a large and vital ecosystem in the human body and is considered to be the equivalent of an “organ” of the human body, which is highly relevant to human health and disease status. There are a lot of evidences that the gut microbiota is responsible for metformin’s widespread effects. However, there are only a few systematic studies on this mechanism, and the specific mechanism is still unclear. This paper aims to summarize the possible mechanism of metformin in relation to gut microbiota.","PeriodicalId":509565,"journal":{"name":"Frontiers in Microbiology","volume":"3 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Osmotic response in Leptospirillum ferriphilum isolated from an industrial copper bioleaching environment to sulfate 从工业铜生物浸出环境中分离出来的铁锈肽杆菌对硫酸盐的渗透反应

Frontiers in Microbiology Pub Date : 2024-05-24 DOI: 10.3389/fmicb.2024.1369244

Dayana Arias, Víctor Zepeda, Ivan Nancucheo, Manuel Saldaña, Pedro A. Galleguillos

{"title":"Osmotic response in Leptospirillum ferriphilum isolated from an industrial copper bioleaching environment to sulfate","authors":"Dayana Arias, Víctor Zepeda, Ivan Nancucheo, Manuel Saldaña, Pedro A. Galleguillos","doi":"10.3389/fmicb.2024.1369244","DOIUrl":"https://doi.org/10.3389/fmicb.2024.1369244","url":null,"abstract":"Iron and sulfur-oxidizing microorganisms play important roles in several natural and industrial processes. Leptospirillum (L.) ferriphilum, is an iron-oxidizing microorganism with a remarkable adaptability to thrive in extreme acidic environments, including heap bioleaching processes, acid mine drainage (AMD) and natural acidic water. A strain of L. ferriphilum (IESL25) was isolated from an industrial bioleaching process in northern Chile. This strain was challenged to grow at increasing concentrations of sulfate in order to assess changes in protein expression profiles, cells shape and to determine potential compatible solute molecules. The results unveiled changes in three proteins: succinyl CoA (SCoA) synthetase, isocitrate dehydrogenase (IDH) and aspartate semialdehyde dehydrogenase (ASD); which were notably overexpressed when the strain grew at elevated concentrations of sulfate. ASD plays a pivotal role in the synthesis of the compatible solute ectoine, which was identified along with hydroxyectoine by using matrix-assisted laser desorption/ionization-time of flight mass spectrometry (MALDI-TOF). The relationship between IDH, SCoA, and ectoine production could be due to the TCA cycle, in which both enzymes produce metabolites that can be utilized as precursors or intermediates in the biosynthesis of ectoine. In addition, distinct filamentous cellular morphology in L. ferriphilum IESL25 was observed when growing under sulfate stress conditions. This study highlights a new insight into the possible cellular responses of L. ferriphilum under the presence of high sulfate levels, commonly found in bioleaching of sulfide minerals or AMD environments.","PeriodicalId":509565,"journal":{"name":"Frontiers in Microbiology","volume":"1 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141100521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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First laboratory-confirmed case of scrub typhus in Shijiazhuang City, Hebei Province 河北省石家庄市首例实验室确诊的恙虫病病例

Frontiers in Microbiology Pub Date : 2024-05-24 DOI: 10.3389/fmicb.2024.1409949

Huixiu Lu, Jianying Li, Rong Fan, Gaoyuan Hao, Meilan Sun, Yunchuan Liang

{"title":"First laboratory-confirmed case of scrub typhus in Shijiazhuang City, Hebei Province","authors":"Huixiu Lu, Jianying Li, Rong Fan, Gaoyuan Hao, Meilan Sun, Yunchuan Liang","doi":"10.3389/fmicb.2024.1409949","DOIUrl":"https://doi.org/10.3389/fmicb.2024.1409949","url":null,"abstract":"Defining whether a suspected case was due to scrub typhus through laboratory testing, to understand the prevalence of scrub typhus in Shijiazhuang City, Hebei Province.An epidemiological investigation was conducted on the suspected case, utilizing Weil-Felix test and indirect immunofluorescence assay (IFA) to detect specific antibodies against O. tsutsugamushi in serum specimens. Additionally, PCR amplification of the 56-kDa and groEL genes was performed, followed by constructing a phylogenetic tree to identify the genotype.The acute phase titer of the Weil-Felix test for the case was 1:160, which increased to 1:320 in the recovery phase. IFA assay revealed IgG titers against O. tsutsugamushi of 1:64 in the acute phase and 1:256 in the recovery phase. Sequence alignment of the PCR amplified fragment showed the highest similarity with the O. tsutsugamushi genotype. Kawasaki sequence, ranging from 99.71 to 100.00%. The strain exhibited the closest genetic relationship with the known O. tsutsugamushi Kawasaki genotype.This study confirms the presence of O. tsutsugamushi in Shijiazhuang City, Hebei Province, with the identified strain belonging to the Kawasaki genotype, marking the first diagnosis of this strain in the region.","PeriodicalId":509565,"journal":{"name":"Frontiers in Microbiology","volume":"53 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141102074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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