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Ernüchterndes Studienergebnis bei primärer mitochondrialer Myopathie 原发性线粒体肌病的研究结果令人警醒
Fortschritte der Neurologie · Psychiatrie Pub Date : 2023-12-01 DOI: 10.1055/a-2163-2430
{"title":"Ernüchterndes Studienergebnis bei primärer mitochondrialer Myopathie","authors":"","doi":"10.1055/a-2163-2430","DOIUrl":"https://doi.org/10.1055/a-2163-2430","url":null,"abstract":"Primäre mitochondriale Myopathien (PMMs) sind genetische Erkrankungen mit einer beeinträchtigten mitochondrialen oxidativen Phosphorylierung. Es resultieren Einschränkungen der körperlichen Funktion und Leistungsfähigkeit sowie der Lebensqualität. Frühe klinische Studien gaben Hinweise auf eine Wirksamkeit von Elamipretid, die in einer Phase-III-Studie überprüft werden sollten.","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":"58 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139192362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Frailty ist mit dem Auftreten von Parkinson assoziiert 虚弱与帕金森病的发病有关
Fortschritte der Neurologie · Psychiatrie Pub Date : 2023-12-01 DOI: 10.1055/a-2163-2522
{"title":"Frailty ist mit dem Auftreten von Parkinson assoziiert","authors":"","doi":"10.1055/a-2163-2522","DOIUrl":"https://doi.org/10.1055/a-2163-2522","url":null,"abstract":"Querschnittstudien konnten zeigen, dass Patient*innen mit neu diagnostizierter Parkinsonerkrankung (PD) häufiger Aspekte einer körperlichen Gebrechlichkeit (frail) aufweisen als nicht an PD Erkrankte. Longitudinal erhobene Daten gab es dazu bislang nicht.","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":"28 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139193001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kandidatenwirkstoffe zur Therapie symptomatischer zerebraler Mikroangiopathien 治疗症状性脑微血管病的候选药物
Fortschritte der Neurologie · Psychiatrie Pub Date : 2023-12-01 DOI: 10.1055/a-2163-2485
{"title":"Kandidatenwirkstoffe zur Therapie symptomatischer zerebraler Mikroangiopathien","authors":"","doi":"10.1055/a-2163-2485","DOIUrl":"https://doi.org/10.1055/a-2163-2485","url":null,"abstract":"Zerebrale Mikroangiopathien sind eine wichtige Ursache von lakunären Schaganfällen und vaskulär bedingten kognitiven Beeinträchtigung. Spezifische Therapien für zerebrale Mikroangiopathien gibt es bislang nicht. Eine Studie prüfte jetzt Machbarkeit, Sicherheit und Wirksamkeit einer einjährigen Behandlung von Patient*innen mit lakunären Infarkten mit Isosorbidmononitrat (ISMN) und Cilostazol.","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":"19 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139191955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The Psychotherapist and Neurologist Ernst Jolowicz (1882-1958): An International Career in the Shadow of Anti-semitism and Emigration]. [心理治疗师和神经学家恩斯特·乔洛维茨(1882-1958):反犹主义和移民阴影下的国际职业生涯]。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-12-01 Epub Date: 2021-09-06 DOI: 10.1055/a-1562-1857
Georg Bornemann, Holger Steinberg
{"title":"[The Psychotherapist and Neurologist Ernst Jolowicz (1882-1958): An International Career in the Shadow of Anti-semitism and Emigration].","authors":"Georg Bornemann,&nbsp;Holger Steinberg","doi":"10.1055/a-1562-1857","DOIUrl":"https://doi.org/10.1055/a-1562-1857","url":null,"abstract":"<p><p>The study focuses on the life and work of the German-Jewish neurologist Dr. Ernst Jolowicz who was born in 1882. Originally from Poznan in present-day Poland, Jolowicz had gained his initial professional experience in the German Empire before serving as a neurologist at the Western Front during the First World War. After the war, he opened a private psychotherapeutic practice in Leipzig, published numerous scientific papers and was involved in the General Medical Society for Psychotherapy. In his writings, Jolowicz appeared as an undogmatic adherent of suggestive techniques and came up with his own methods for a patient-centered, psychagogic psychotherapy. In addition, he wrote numerous cultural and social scientific essays showing a wide range of interest. Shortly after the seizure of power by the National Socialists, he emigrated to Paris and supported the anti-fascist resistance in a Strasbourg radio station. After the occupation of France, Jolowicz fled to the United States in 1941 and gained a foothold there once more before he died of a heart disease in New York City in 1958.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"580-588"},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Konzepte der Sturzrisikoabschätzung bei neurogeriatrischen Patienten. 在研究神经损伤患者的俯险角度
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-12-01 Epub Date: 2022-12-02 DOI: 10.1055/a-1801-3310
Ken Möhwald, Roman Schniepp
{"title":"Konzepte der Sturzrisikoabschätzung bei neurogeriatrischen Patienten.","authors":"Ken Möhwald,&nbsp;Roman Schniepp","doi":"10.1055/a-1801-3310","DOIUrl":"https://doi.org/10.1055/a-1801-3310","url":null,"abstract":"<p><p>Neurogeriatric patients are prone to falls. Particularly, patients with central neurological diseases (e. g., Parkinson's disease, cerebellar disorders) fall more often and more severe compared to patients with peripheral neurological disorders (e. g., peripheral neuropathy, bilateral vestibulopathy). Falls can lead to severe injuries with prolonged hospital treatment with subsequently impaired mobility, reduced quality of life and fear of falling. This article depicts general, clinical and mobility-based fall risk factors in neurogeriatric patients and gives an overview how to identify patients with a high risk of falling. Furthermore, a multimodal fall risk assessment is illustrated, which expands the diagnostic approach utilising clinical, instrument-based and mobile motion analysis.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"589-599"},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40559017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Substitution Treatment for Opiate Addicts in Forensic Hospitals under the Penal System]. [刑事制度下法医医院对鸦片成瘾者的替代治疗]。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-12-01 Epub Date: 2022-01-31 DOI: 10.1055/a-1669-9033
Michael Soyka, Herbert Steinböck
{"title":"[Substitution Treatment for Opiate Addicts in Forensic Hospitals under the Penal System].","authors":"Michael Soyka,&nbsp;Herbert Steinböck","doi":"10.1055/a-1669-9033","DOIUrl":"https://doi.org/10.1055/a-1669-9033","url":null,"abstract":"<p><p>Opiate addiction is common among offenders, and many opiate-dependent lawbreakers are treated in the correctional system according to § 64 STGB. While substitution treatment in prisons has become common practice, substitution treatment in forensic hospitals in the traditionally abstinence-oriented prison system is controversial and also varies from region to region. Basic data on this are lacking so far. The problem is discussed against the background of a current expert opinion case. Current figures from a large forensic hospital in Munich-East show that almost 30% of the patients are treated with substitutes (n=186). The problem of substitution treatment in the prison system is discussed.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"559-564"},"PeriodicalIF":0.6,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39875467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
[Autoimmune Encephalitis]. (自身免疫性脑炎)。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-11-01 Epub Date: 2022-11-07 DOI: 10.1055/a-1803-8805
Rosa Rößling, Harald Prüß
{"title":"[Autoimmune Encephalitis].","authors":"Rosa Rößling,&nbsp;Harald Prüß","doi":"10.1055/a-1803-8805","DOIUrl":"https://doi.org/10.1055/a-1803-8805","url":null,"abstract":"<p><p>Autoimmune encephalitides form a heterogeneous group of neurological and psychiatric diseases. In antibody-mediated encephalitis, autoantibodies are pathogenic and directly cause the encephalitis. In antibody-associated encephalitis, which is paraneoplastic most of the time, autoantibodies serve as diagnostic biomarkers and are able to predict the underlying tumour.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"529-542"},"PeriodicalIF":0.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40460180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Traumatization and Schizophrenic Disorders - A Multidimensional View]. [精神创伤和精神分裂症-多维视角]。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-11-01 Epub Date: 2021-08-13 DOI: 10.1055/a-1535-1655
Georg Juckel, Paraskevi Mavrogiorgou
{"title":"[Traumatization and Schizophrenic Disorders - A Multidimensional View].","authors":"Georg Juckel,&nbsp;Paraskevi Mavrogiorgou","doi":"10.1055/a-1535-1655","DOIUrl":"https://doi.org/10.1055/a-1535-1655","url":null,"abstract":"<p><p>Prevalence of traumatizing of patients with schizophrenia is higher as in the normal community. Meta analyses show significant relationships between traumatic experiences in childhood and psychotic disorders. Patients with schizophrenia as well as those with posttraumatic stress disorder (PTSD) are characterized by brain morphological changes (mygdala und Hippocampus). In these two patient groups, neuroendocrinological disturbances (cortisol und α-amylase) as well as a worse clinical outcome could be additionally found. In the psychodynamic theoretical discussion, there are only few approaches concerning trauma and psychosis. Specifically here, the name of Frieda Fromm-Reichmann should be noted, who already pointed out the great meaning of child traumatization (especially physical and sexual abuse) for the later manifestation of schizophrenia. She also developed first principles of analytic psychosis therapy with the working on the deep life anxiety caused by the trauma in the here and now of the transference situation. It is assumed that schizophrenic disorders and PTSD have to be understood as trauma consequence diseases, which occur in comorbidty in a so far unknown extent.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"512-522"},"PeriodicalIF":0.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39308163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
[Autoimmune Encephalitis]. (自身免疫性脑炎)。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-11-01 Epub Date: 2022-11-07 DOI: 10.1055/a-1935-9139
Elisabeth Kaufmann, Marianne Dieterich
{"title":"[Autoimmune Encephalitis].","authors":"Elisabeth Kaufmann,&nbsp;Marianne Dieterich","doi":"10.1055/a-1935-9139","DOIUrl":"https://doi.org/10.1055/a-1935-9139","url":null,"abstract":"","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"501-502"},"PeriodicalIF":0.6,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40460179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Adult Spinal Muscular Atrophy]. 成人脊髓性肌萎缩症。
IF 0.6
Fortschritte der Neurologie · Psychiatrie Pub Date : 2022-09-01 Epub Date: 2022-09-14 DOI: 10.1055/a-1801-3785
Maggie C Walter, Miriam Hiebeler
{"title":"[Adult Spinal Muscular Atrophy].","authors":"Maggie C Walter,&nbsp;Miriam Hiebeler","doi":"10.1055/a-1801-3785","DOIUrl":"https://doi.org/10.1055/a-1801-3785","url":null,"abstract":"<p><p>5q spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease affecting 1: 11000 live births and ranging from intrauterine to early adult onset. The course of the disease is progressive, the phenotype varies within a disease continuum and is mainly determined by the <i>SMN2</i> copy number. So far, three disease modifying treatments (Nusinersen/Spinraza, Onasemnogene abeparvovec/Zolgensma, Risdiplam/Evrysdi) have been approved; however, gene replacement therapy with Onasemnogen abeparvovec is mainly applied from birth to toddler age. SMA treatment requires a multidisciplinary management in specialized neuromuscular centers. Since October 2021, SMA is part of the newborn screening in Germany. When SMA is clinically suspected, timely genetic diagnostics is crucial for a rapid start of treatment, since \"time is motor neuron\". The different therapeutic options must be discussed with patients and families, and patient expectations must be managed. Assessment of long-term data in disease-specific registries is highly encouraged world-wide and mandatory in Germany.</p>","PeriodicalId":509563,"journal":{"name":"Fortschritte der Neurologie · Psychiatrie","volume":" ","pages":"421-430"},"PeriodicalIF":0.6,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40358204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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