Suranaree Journal of Science and Technology最新文献_第5页

THE FIRST GENERATION AND SECOND-GENERATION ANTIPSYCHOTIC DRUGS AND THEIR PHARMACOLOGY IN TREATMENT OF SCHIZOPHRENIA 第一代和第二代抗精神病药物及其在治疗精神分裂症中的药理作用

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0828

Afroj Ayyaj Shaikh, Jaydeep Pawar

{"title":"THE FIRST GENERATION AND SECOND-GENERATION ANTIPSYCHOTIC DRUGS AND THEIR PHARMACOLOGY IN TREATMENT OF SCHIZOPHRENIA","authors":"Afroj Ayyaj Shaikh, Jaydeep Pawar","doi":"10.55766/sujst-2023-06-e0828","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0828","url":null,"abstract":"Schizophrenia is a complex and severe psychiatric disorder that affects millions of people worldwide. Antipsychotic drugs have been widely used for the treatment of schizophrenia for over 60 years. The first-generation antipsychotic drugs (FGAs) were introduced in the 1950s and revolutionized the treatment of schizophrenia. However, their use is associated with a number of adverse effects, including Extrapyramidal Symptoms (EPS) and Tardive Dyskinesia (TD). Second-generation antipsychotic drugs (SGAs), also known as atypical antipsychotics, were developed in the 1990s and have become the preferred treatment for schizophrenia due to their lower incidence of EPS and TD. They also have a broader range of therapeutic effects, such as improving negative symptoms and cognitive impairment associated with schizophrenia. This review article summarizes the pharmacology of both FGAs and SGAs, including their mechanism of action, pharmacokinetics, and adverse effects. The efficacy and safety of these drugs in the treatment of schizophrenia are also discussed. In addition, this review examines the controversy surrounding the use of SGAs and their potential metabolic side effects, such as weight gain, hyperlipidemia, and diabetes. Despite the availability of SGAs, FGAs still have a role in the treatment of schizophrenia, particularly for patients who are unresponsive to SGAs or experience intolerable side effects. Furthermore, research continues to identify new pharmacological targets and treatment strategies for schizophrenia. Understanding the pharmacology and clinical use of antipsychotic drugs is essential for optimizing the treatment of schizophrenia and improving patient outcomes.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"11 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139803656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PREVALENCE OF BOVINE MASTITIS AND THE FIRST DETECTION OF MYCOPLASMA BOVIS IN VIETNAM’S DAIRY FARMS 越南奶牛场的牛乳腺炎流行情况和首次发现牛支原体

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e01836

My Tran Trung, Thien Le Van, Binh Dang Xuan, Lan Dang Thi Mai, Duc Vu Minh

{"title":"PREVALENCE OF BOVINE MASTITIS AND THE FIRST DETECTION OF MYCOPLASMA BOVIS IN VIETNAM’S DAIRY FARMS","authors":"My Tran Trung, Thien Le Van, Binh Dang Xuan, Lan Dang Thi Mai, Duc Vu Minh","doi":"10.55766/sujst-2023-06-e01836","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01836","url":null,"abstract":"Mastitis still remains an economic disease in dairy farms all over the world. This study aimed to report the prevalence of this disease in large-scale farms in Vietnam, the pathogens profile, and first report the detection of Mycoplasma bovis (M. bovis) by applying conventional culture and real-time PCR (polymerase chain reaction) methods. We examined 64,802 enrolled dairy cows from six farms in Vietnam, yielding 1,874 (2.9%) total cases of clinical mastitis. The majority of the 14 pathogens were identified. Klebsiella spp. accounted for 21.0% of the total isolates. Streptococcus uberis (S. uberis), Escherichia coli (E. coli), other Streptococcus spp, and Coagulase-Negative Staphylococci (CNS), followed at 12.6, 7.6, 6.0, and 5.5 percent, respectively. The rest pathogens include Pseudomonas spp., Enterococcus faecalis, Enterobacter spp., Bacillus spp., Citrobacter spp., Pasteurella spp., Proteus spp., and Staphylococcus aureus were isolated with less than 1% each. To the best of our knowledge, this is the first report for detecting M. bovis in mastitis milk samples in Vietnam, where 35 out of 1,422 samples submitted in 2022 were M. bovis positive. Moreover, of the 35 positive cases, 11 cases had only M. bovis, while 24 cases had M. bovis and other pathogens, including 13 Enterobacteriaceae, 7 Streptococcus spp., and 4 CNS.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"17 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTIPLE DRUG RESISTANT PATHOGENS IN ACTION AFTER COVID PANDEMIC 科维德病毒大流行后，多重抗药性病原体开始行动

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0930

Navneet Kumar, Ms. Minal Thakkar

引用次数: 0

IDENTIFYING ANTI-DIABETIC POTENTIAL OF ALPHA-AMYLASE INHIBITORS IN OCIMUM BASILICUM USING IN VITRO AND IN SILICO APPROACHES 利用体外和硅学方法确定乌头罗勒草中α-淀粉酶抑制剂的抗糖尿病潜力

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e01323

Suraksha Vinod, Shruthy Rajesh, Shanti K.N., P. Karunakar

{"title":"IDENTIFYING ANTI-DIABETIC POTENTIAL OF ALPHA-AMYLASE INHIBITORS IN OCIMUM BASILICUM USING IN VITRO AND IN SILICO APPROACHES","authors":"Suraksha Vinod, Shruthy Rajesh, Shanti K.N., P. Karunakar","doi":"10.55766/sujst-2023-06-e01323","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01323","url":null,"abstract":"Type 2 Diabetes (T2D), a chronic metabolic disorder and the most common type of diabetes, is caused by reduced insulin secretion or insulin resistance in the body, leading to ineffective glucose uptake by the cells and eventually resulting in hyperglycemia. Metformin, sulfonylureas, and glitazones are the currently available commercial drugs used to treat T2D. These drugs either reduce the blood glucose level or elevate the insulin produced. However, the high cost, unavailability, and various side effects occurring from the use of these drugs have resulted in people looking for healthier and cost-effective ways to treat this disorder, including the use of plant extracts. This study highlights the alpha-amylase inhibition properties of Ocimum basilicum (basil) extracts through in vitro qualitative and quantitive inhibition assays. It also focuses on in silico approaches such as molecular docking and molecular dynamics simulation to determine the strength of the alpha-amylase inhibition. In vitro study revealed 1:20 diluted ethanolic, methanolic, and aqueous extracts of O. basilicum strongly inhibited salivary amylase. In silico analysis revealed Gamma Sitosterol, a compound present in relative abundance in O. basilicum, could be one of the phytocompounds responsible for this anti-diabetic property of O. basilicum. Thus, Gamma Sitosterol can be used as a potential therapeutic for T2D alongside other measures such as physical exercise and diet because the findings in this paper, although pertaining to human salivary amylase, can be extrapolated to human pancreatic amylase as salivary amylase and pancreatic amylase are known isoenzymes and share ~97% sequence homology.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"29 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139864704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EFFECT OF LIGHTING LEVELS AND LAMP TYPES FOR CRIME PREVENTION IN THAI PEDESTRIAN WALKWAYS 泰国人行道照明水平和灯具类型对预防犯罪的影响

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e0129

Panwadee Rojanasiri, N. Tuaycharoen

{"title":"EFFECT OF LIGHTING LEVELS AND LAMP TYPES FOR CRIME PREVENTION IN THAI PEDESTRIAN WALKWAYS","authors":"Panwadee Rojanasiri, N. Tuaycharoen","doi":"10.55766/sujst-2023-06-e0129","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0129","url":null,"abstract":"The effects of illuminance level and lamp type were investigated for crime prevention in Thai pedestrian walkways aimed to examine the effects of illuminance on perceived safety, pedestrian behaviour, and criminal identification as part of crime prevention. Laboratory tests were carried out at the Faculty of Architecture, Kasetsart University. Five levels of illuminance: 10, 20, 50, 100, and 200 lux, and the types of lamps—HPS, LED Daylight and LED Warm White were investigated. Experimental tests were performed using a 3D model with DIALux simulation. Results showed that each lamp type required a different illuminance to optimize crime prevention. The HPS lamp with an illuminance of 200 lux was found to be the most suitable level for perceived safety, while 10 lux was suitable for pedestrian behaviour and 10 lux was suitable for criminal identification. For the LED Daylight lamp, the illuminance of 200 lux was the most appropriate level for perceived safety, while 20 lux was suitable for pedestrian behaviour and 10-20 lux was enough for criminal identification. For the LED Warm-white lamp, the illuminance of 10 lux was the most appropriate level for perceived safety, with 20 lux for pedestrian behaviour, and 10-20 lux for criminal identification.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"34 7-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOVEL CHIMPANZEE MATING INSPIRED OPTIMIZATION ALGORITHM FOR REAL POWER LOSS REDUCTION 受黑猩猩交配启发的新型优化算法，用于降低实际功率损耗

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e0871

L. Kanagasabai

引用次数: 0

ENERGY & EXERGY ANALYSIS OF A PV PANEL WITH PASSIVE COOLING MECHANISM 具有被动冷却机制的光伏电池板的能量和放能分析

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e01379

Babita Panda, Sampurna Panda, Rakesh Kumar, C. Jena, L. Nanda, Arjyadhara Pradhan

{"title":"ENERGY & EXERGY ANALYSIS OF A PV PANEL WITH PASSIVE COOLING MECHANISM","authors":"Babita Panda, Sampurna Panda, Rakesh Kumar, C. Jena, L. Nanda, Arjyadhara Pradhan","doi":"10.55766/sujst-2023-06-e01379","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01379","url":null,"abstract":"A photovoltaic (PV) array is grately responsive to changes in temperature; contrarily, reduction in temperature is the major factor that subsidize to an raise in the electrical efficiency and output power of a PV system. To optimize the production of energy by PV panels and reduce their temperature, a photovoltaic (PV) cooling system is basically used. Nonetheless, more insolation is generally associated with higher temperatures, which is ambiguous for photovoltaic (PV) panels because they rely on that irradiance to create power. These extreme temperature rises have a devastating effect on how skillfully photovoltaic (PV) panels transforms energy. A solar photovoltaic (PV) system can opearte more accurately with an adequate cooling system on its surface. In this paper, a passive cooling model for the PV panel has been devloped which cools down the PV panel by employing dry grass and water at the back surface. A correlation has been made with a non-cooled panel. Two PV panels are simultaneously tested. Electrical output properties of both the PV panels have been recorded and energy and exergy analysis for the system has been presented to have a more detailed understanding of the cooling effect on PV panel performance. The cooled panel has an increase in efficiency by 47%. Along with the electrical efficiency, the thermal efficiency has also been presented in this paper for performance evaluation in the form of overall efficiency.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"57 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE EFFECT OF SPIN COATING’S SPEED ON GRAPHENE-OXIDE’S LAYER TOPOGRAPHY AND QCM VISCOELASTICITY 旋涂速度对氧化石墨烯层形貌和 qcm 粘弹性的影响

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e01688

Masruroh Masruroh, I. W. Wira Yuda, D. Santjojo

{"title":"THE EFFECT OF SPIN COATING’S SPEED ON GRAPHENE-OXIDE’S LAYER TOPOGRAPHY AND QCM VISCOELASTICITY","authors":"Masruroh Masruroh, I. W. Wira Yuda, D. Santjojo","doi":"10.55766/sujst-2023-06-e01688","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01688","url":null,"abstract":"Spin coating speed controls the deposition process, affecting the formation of the layer’s topography of graphene oxide and the viscoelastic properties of quartz crystal microbalance (QCM). In this work, the graphene oxide was deposited on the QCM surface by spin coating method with speeds ranging from 500 to 800 rpm. The layer’s surface topography was subsequently measured and analyzed using a roughness multiparameter, which included the area average (Sa), area roughness deviation (Sq), localized surface roughness (Sz), surface skewness (Ssk), and surface kurtosis (Sku). The Sa, Sq, and Sz, which were decreased as the spinning speed increased. The measurements indicated that the graphene oxide layer deposited at 500 rpm had a rough and clumpy texture, while at a high speed of 800 rpm, the layer had a much smoother texture. A detailed analysis using the Sku and Ssk parameters revealed that the clumpy texture in the 500 rpm sample contains tapered sharp graphene oxide structures and a small amount of porosity. On the other hand, the sharp structures were significantly reduced, and porosity was dominant in the sample deposited at high speeds of 700 rpm and 800 rpm. The effect of the spinning speed and the topography on the viscoelasticity was studied using an impedance analyzer. The impedance of the layer deposited at 500 rpm was relatively higher than that at 800 rpm. The frequency shift was also relatively significant for the sample deposited at low speed and was reduced at higher speed. The impedance analysis demonstrated that the layer’s viscosity is affected by its mass, roughness, texture, and porosity.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140505351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AN INVESTIGATION ON THE EFFECT OF NI-CR COATING THICKNESS ON THE SCRATCH RESISTANCE OF PARTICLE- 镍铬涂层厚度对颗粒材料耐划伤性的影响研究

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e0864

Sivaprakash Palleda, Kagathur Goud Satish

引用次数: 0

OPTIMIZING SHRINKAGE DEFECTS IN GREY CAST IRON BUTTERFLY VALVE CASTING: A SIMULATION AND EXPERIMENT-BASED APPROACH 优化灰铸铁蝶阀铸件的收缩缺陷：基于模拟和实验的方法

Suranaree Journal of Science and Technology Pub Date : 2024-01-17 DOI: 10.55766/sujst-2023-06-e01681

Vaibhav Maniar, Pinank Patel

引用次数: 0