Suranaree Journal of Science and Technology最新文献_第3页

DENDRIMERS IN NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW 新型给药系统中的树枝状聚合物：最新综述

Suranaree Journal of Science and Technology Pub Date : 2024-02-06 DOI: 10.55766/sujst-2023-06-e01194

Sanjita Das, Rohan Verma, Vikash Chauhan

{"title":"DENDRIMERS IN NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW","authors":"Sanjita Das, Rohan Verma, Vikash Chauhan","doi":"10.55766/sujst-2023-06-e01194","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01194","url":null,"abstract":"Nanoscale molecules known as dendrimers possess clearly defined, uniform, and monodisperse structures. They’re composed of a symmetrical core with an outside and interior shell. Due to their multiple beneficial features, dendrimers are an excellent choice in the medical field; this page compiles all of their different uses. Many different kinds of poly (propylene imine) and poly (amidoamine) dendrimers integrated with imatinib, sunitinib, cisplatin, melphalan, doxorubicin, paclitaxel, and methotrexate have shown advantages over the drug molecule alone. Dendrimers have undergone extensive research for their potential as anti-cancer agents. The mainstay of the inflammatory medicine was dendrimer complexes of indomethacin, piroxicam, ketoprofen ibuprofen, and diflunisal. Given the circumstances, the growth of bacterial strains resilient to antibiotics, fluoroquinolone, macrolide, beta-lactamine, and aminoglycoside dendrimer complexes have shown positive outcomes. In relation to treatment with antiviral drugs, There has been a study to create dendrimers being conjugated with tenofovir, maraviroc, zidovudine, oseltamivir, and other antivirals. Additionally, dendrimers have successfully allured much interest in cardiovascular medicine. Large, multi-component macromolecules constitute dendrimers. The present review enlists all kinds of related scientific and valuable aspects of dendrimers to help the researcher working with dendrimers.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"201 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139799713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DENDRIMERS IN NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW 新型给药系统中的树枝状聚合物：最新综述

Suranaree Journal of Science and Technology Pub Date : 2024-02-06 DOI: 10.55766/sujst-2023-06-e01194

Sanjita Das, Rohan Verma, Vikash Chauhan

{"title":"DENDRIMERS IN NOVEL DRUG DELIVERY SYSTEM: AN UPDATED REVIEW","authors":"Sanjita Das, Rohan Verma, Vikash Chauhan","doi":"10.55766/sujst-2023-06-e01194","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01194","url":null,"abstract":"Nanoscale molecules known as dendrimers possess clearly defined, uniform, and monodisperse structures. They’re composed of a symmetrical core with an outside and interior shell. Due to their multiple beneficial features, dendrimers are an excellent choice in the medical field; this page compiles all of their different uses. Many different kinds of poly (propylene imine) and poly (amidoamine) dendrimers integrated with imatinib, sunitinib, cisplatin, melphalan, doxorubicin, paclitaxel, and methotrexate have shown advantages over the drug molecule alone. Dendrimers have undergone extensive research for their potential as anti-cancer agents. The mainstay of the inflammatory medicine was dendrimer complexes of indomethacin, piroxicam, ketoprofen ibuprofen, and diflunisal. Given the circumstances, the growth of bacterial strains resilient to antibiotics, fluoroquinolone, macrolide, beta-lactamine, and aminoglycoside dendrimer complexes have shown positive outcomes. In relation to treatment with antiviral drugs, There has been a study to create dendrimers being conjugated with tenofovir, maraviroc, zidovudine, oseltamivir, and other antivirals. Additionally, dendrimers have successfully allured much interest in cardiovascular medicine. Large, multi-component macromolecules constitute dendrimers. The present review enlists all kinds of related scientific and valuable aspects of dendrimers to help the researcher working with dendrimers.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"116 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139859612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POTENTIAL OF COMPOST EXTRACT ON PHYSICO-CHEMICAL PROPERTIES OF SOIL AFTER HARVEST 堆肥提取物对收获后土壤理化性质的影响潜力

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0759

T. F. Oyewusi, J. Osunbitan, G. Ogunwande, T. Ademiju, Comfort Oluwaseun Opadoja, Monsuru Olukayode Amoo

{"title":"POTENTIAL OF COMPOST EXTRACT ON PHYSICO-CHEMICAL PROPERTIES OF SOIL AFTER HARVEST","authors":"T. F. Oyewusi, J. Osunbitan, G. Ogunwande, T. Ademiju, Comfort Oluwaseun Opadoja, Monsuru Olukayode Amoo","doi":"10.55766/sujst-2023-06-e0759","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0759","url":null,"abstract":"In an attempt to improve soil physico-chemical properties for subsequent production of crop, the potential of compost extract was investigated along with effect of its processing parameters on some soil physico-chemical properties after harvest. This compost extract (liquid organic fertilizer) was produced from composted chicken manure under three processing parameters. The parameters are compost/water ratio (1:6, 1:4, and 1:3), immersion period (24, 48 and 72 h) and water temperature (25, 35 and 45˚C). The application of compost extract made was applied to the soil by means of an improvised drip irrigation system to produced two vegetables (A. cruentus and C. argentea) via pot experiment in a greenhouse. The soil physico-chemical properties were analyzed before planting and after harvest using standard methods. The result showed an improvement in the soil physico-chemical properties after harvest. The study shows that processing parameters under different compost/water ratio, immersion period and water temperature significantly affected soil physico-chemical properties. The highest physico-chemical properties of pH (6.53 and 6.59), EC (2.42 and 2.47 mS cm-1), TN (1.68 and 1.79%), TP (7.24 and 7.34 g kg-1) and TK (7.49 and 7.73 g kg-1) were observed for A. cruentus and C. argentea soils, correspondingly after harvest. These were obtained for 1:3 compost/water ratio at 72 h immersion period under water temperature of 25˚C. Hence, compost extract produced was found to be suitable for improvement of soil physico-chemical properties even for subsequent production of vegetable in another planting seasons without any additional soil amendment.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139805683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A LINKAGE BETWEEN INFLAMMATORY BOWEL DISEASES AND TYPE 2 DIABETES 炎症性肠病与 2 型糖尿病之间的联系

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0736

Ştefan Ţălu, Davide Frumento

{"title":"A LINKAGE BETWEEN INFLAMMATORY BOWEL DISEASES AND TYPE 2 DIABETES","authors":"Ştefan Ţălu, Davide Frumento","doi":"10.55766/sujst-2023-06-e0736","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0736","url":null,"abstract":"Inflammatory Bowel Diseases (IBDs) are a class of gastrointestinal chronic inflammations, comprehending Ulcerative Colitis (UC) and/or Crohn Disease (CD) and affecting genetically predisposed subjects. IBDs represent a high cost for the health system, and they are characterized by a very specific co-morbidity. For such reasons, and since a positive correlation between IBDs and Diabetes Mellitus (DM) has been observed in the past, the aim of this work is to provide such result with a more solid basis through a cohort study, considering 49 consecutive patients comorbid with IBDs and Type 2 Diabetes (T2D). A high correlation between IBDs and T2D was observed. Interestingly, UC was showed the higher correlation, with a particularly high peak within the 65 to 74 years old range. Being T2D a both environmentally and genetically driven pathology (like IBDs), these diseases association could be due to environmental factors. Furthermore, 70.8% of case-control patients (48 cases versus 96 controls, consecutively selected) were suffering from UC, while CD held the remaining 25.0% (4.2% stood for undetermined colitis). This evidences that, among IBDs, the most related to DM is UC, although CD remains a related pathology. Interestingly, CD was found to be absent in the 55-64 years old range. Conversely, cohort study highlighted 73.81% of cohort was suffering from UC, while CD held the remaining 21.43% (4.76% was for non-determined colitis). This confirms that, among IBDs, the most linked to T2D is UC.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"143 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139862763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IDENTIFYING ANTI-DIABETIC POTENTIAL OF ALPHA-AMYLASE INHIBITORS IN OCIMUM BASILICUM USING IN VITRO AND IN SILICO APPROACHES 利用体外和硅学方法确定乌头罗勒草中α-淀粉酶抑制剂的抗糖尿病潜力

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e01323

Suraksha Vinod, Shruthy Rajesh, Shanti K.N., P. Karunakar

{"title":"IDENTIFYING ANTI-DIABETIC POTENTIAL OF ALPHA-AMYLASE INHIBITORS IN OCIMUM BASILICUM USING IN VITRO AND IN SILICO APPROACHES","authors":"Suraksha Vinod, Shruthy Rajesh, Shanti K.N., P. Karunakar","doi":"10.55766/sujst-2023-06-e01323","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01323","url":null,"abstract":"Type 2 Diabetes (T2D), a chronic metabolic disorder and the most common type of diabetes, is caused by reduced insulin secretion or insulin resistance in the body, leading to ineffective glucose uptake by the cells and eventually resulting in hyperglycemia. Metformin, sulfonylureas, and glitazones are the currently available commercial drugs used to treat T2D. These drugs either reduce the blood glucose level or elevate the insulin produced. However, the high cost, unavailability, and various side effects occurring from the use of these drugs have resulted in people looking for healthier and cost-effective ways to treat this disorder, including the use of plant extracts. This study highlights the alpha-amylase inhibition properties of Ocimum basilicum (basil) extracts through in vitro qualitative and quantitive inhibition assays. It also focuses on in silico approaches such as molecular docking and molecular dynamics simulation to determine the strength of the alpha-amylase inhibition. In vitro study revealed 1:20 diluted ethanolic, methanolic, and aqueous extracts of O. basilicum strongly inhibited salivary amylase. In silico analysis revealed Gamma Sitosterol, a compound present in relative abundance in O. basilicum, could be one of the phytocompounds responsible for this anti-diabetic property of O. basilicum. Thus, Gamma Sitosterol can be used as a potential therapeutic for T2D alongside other measures such as physical exercise and diet because the findings in this paper, although pertaining to human salivary amylase, can be extrapolated to human pancreatic amylase as salivary amylase and pancreatic amylase are known isoenzymes and share ~97% sequence homology.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POTENTIAL OF COMPOST EXTRACT ON PHYSICO-CHEMICAL PROPERTIES OF SOIL AFTER HARVEST 堆肥提取物对收获后土壤理化性质的影响潜力

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0759

T. F. Oyewusi, J. Osunbitan, G. Ogunwande, T. Ademiju, Comfort Oluwaseun Opadoja, Monsuru Olukayode Amoo

{"title":"POTENTIAL OF COMPOST EXTRACT ON PHYSICO-CHEMICAL PROPERTIES OF SOIL AFTER HARVEST","authors":"T. F. Oyewusi, J. Osunbitan, G. Ogunwande, T. Ademiju, Comfort Oluwaseun Opadoja, Monsuru Olukayode Amoo","doi":"10.55766/sujst-2023-06-e0759","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0759","url":null,"abstract":"In an attempt to improve soil physico-chemical properties for subsequent production of crop, the potential of compost extract was investigated along with effect of its processing parameters on some soil physico-chemical properties after harvest. This compost extract (liquid organic fertilizer) was produced from composted chicken manure under three processing parameters. The parameters are compost/water ratio (1:6, 1:4, and 1:3), immersion period (24, 48 and 72 h) and water temperature (25, 35 and 45˚C). The application of compost extract made was applied to the soil by means of an improvised drip irrigation system to produced two vegetables (A. cruentus and C. argentea) via pot experiment in a greenhouse. The soil physico-chemical properties were analyzed before planting and after harvest using standard methods. The result showed an improvement in the soil physico-chemical properties after harvest. The study shows that processing parameters under different compost/water ratio, immersion period and water temperature significantly affected soil physico-chemical properties. The highest physico-chemical properties of pH (6.53 and 6.59), EC (2.42 and 2.47 mS cm-1), TN (1.68 and 1.79%), TP (7.24 and 7.34 g kg-1) and TK (7.49 and 7.73 g kg-1) were observed for A. cruentus and C. argentea soils, correspondingly after harvest. These were obtained for 1:3 compost/water ratio at 72 h immersion period under water temperature of 25˚C. Hence, compost extract produced was found to be suitable for improvement of soil physico-chemical properties even for subsequent production of vegetable in another planting seasons without any additional soil amendment.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"39 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139865696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NYCTANTHES ARBORTRITIS LINN: AN ETHNOPHARMACOLOGICAL MIRACULOUS NATURAL RESOURCE 荨麻：一种神奇的民族药学自然资源

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e01198

Sanjita Das, Vikash Chauhan, Rohan Verma

引用次数: 0

THE FIRST GENERATION AND SECOND-GENERATION ANTIPSYCHOTIC DRUGS AND THEIR PHARMACOLOGY IN TREATMENT OF SCHIZOPHRENIA 第一代和第二代抗精神病药物及其在治疗精神分裂症中的药理作用

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0828

Afroj Ayyaj Shaikh, Jaydeep Pawar

{"title":"THE FIRST GENERATION AND SECOND-GENERATION ANTIPSYCHOTIC DRUGS AND THEIR PHARMACOLOGY IN TREATMENT OF SCHIZOPHRENIA","authors":"Afroj Ayyaj Shaikh, Jaydeep Pawar","doi":"10.55766/sujst-2023-06-e0828","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e0828","url":null,"abstract":"Schizophrenia is a complex and severe psychiatric disorder that affects millions of people worldwide. Antipsychotic drugs have been widely used for the treatment of schizophrenia for over 60 years. The first-generation antipsychotic drugs (FGAs) were introduced in the 1950s and revolutionized the treatment of schizophrenia. However, their use is associated with a number of adverse effects, including Extrapyramidal Symptoms (EPS) and Tardive Dyskinesia (TD). Second-generation antipsychotic drugs (SGAs), also known as atypical antipsychotics, were developed in the 1990s and have become the preferred treatment for schizophrenia due to their lower incidence of EPS and TD. They also have a broader range of therapeutic effects, such as improving negative symptoms and cognitive impairment associated with schizophrenia. This review article summarizes the pharmacology of both FGAs and SGAs, including their mechanism of action, pharmacokinetics, and adverse effects. The efficacy and safety of these drugs in the treatment of schizophrenia are also discussed. In addition, this review examines the controversy surrounding the use of SGAs and their potential metabolic side effects, such as weight gain, hyperlipidemia, and diabetes. Despite the availability of SGAs, FGAs still have a role in the treatment of schizophrenia, particularly for patients who are unresponsive to SGAs or experience intolerable side effects. Furthermore, research continues to identify new pharmacological targets and treatment strategies for schizophrenia. Understanding the pharmacology and clinical use of antipsychotic drugs is essential for optimizing the treatment of schizophrenia and improving patient outcomes.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"8 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139863740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MULTIPLE DRUG RESISTANT PATHOGENS IN ACTION AFTER COVID PANDEMIC 科维德病毒大流行后，多重抗药性病原体开始行动

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e0930

Navneet Kumar, Ms. Minal Thakkar

引用次数: 0

TEXTILE EFFLUENT TREATMENT METHODS AND LIMITATIONS: A SUSTAINABLE AND ECOLOGICAL ASPECT 纺织污水处理方法和局限性：可持续和生态方面

Suranaree Journal of Science and Technology Pub Date : 2024-02-05 DOI: 10.55766/sujst-2023-06-e01655

Preeti Chaurasia, Nakuleshwar Dut Jasuja, Sanjeev Kumar

{"title":"TEXTILE EFFLUENT TREATMENT METHODS AND LIMITATIONS: A SUSTAINABLE AND ECOLOGICAL ASPECT","authors":"Preeti Chaurasia, Nakuleshwar Dut Jasuja, Sanjeev Kumar","doi":"10.55766/sujst-2023-06-e01655","DOIUrl":"https://doi.org/10.55766/sujst-2023-06-e01655","url":null,"abstract":"Industrial wastewater causes water and soil pollution, leading to life-threatening issues. Wastewater comprises several dyes, detergents, phenols, chemical salts, and heavy metals which enhance temperature, pH, Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD) load, total suspended solids, Total Dissolved Solids (TDS), chlorides, sulfate, and nitrate of affected sites. Dye effluent is highly toxic and leads to mutagenic and carcinogenic outcomes on living beings. Environmental laws are being passed more frequently to control mostly azo-based dyes in the environment. The effluent must be treated before being discarded directly into the ecological ecosystem so that it can be reutilised and recycled for domestic purposes. In the present scenario, using a physicochemical-based approach is inefficient for eliminating contaminants as the process is expensive, and a secondary pollutant, sludge, is produced after the treatment. Being cheap and eco-friendly, the therapy of dye-laden water using microorganisms is a trend. The authors of the current review study have tried to bridge the gap in the bioremediation of dye wastewater. The review imparts an overview of the textile industry, the generation of wastewater by it, the environmental pollution caused, and its impact on the ecosystem. The discussion mainly focuses on the detailed analysis of the last few decades on the decolorisation efficiencies of numerous bioremediation techniques involved in treating textile dye effluent. Additionally, the authors have tried to include the most recent developments in this area. By using eco-friendly methods, this study will undoubtedly help dyestuff companies and researchers.","PeriodicalId":509211,"journal":{"name":"Suranaree Journal of Science and Technology","volume":"14 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139804103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0