Frontiers in Neuroscience最新文献_第7页

Classification and transfer learning of sleep spindles based on convolutional neural networks 基于卷积神经网络的睡眠棘波分类和迁移学习

Frontiers in Neuroscience Pub Date : 2024-04-24 DOI: 10.3389/fnins.2024.1396917

Jun Liang, Abdelkader Nasreddine Belkacem, Yanxin Song, Jiaxin Wang, Zhiguo Ai, Xuanqi Wang, Jun Guo, Lingfeng Fan, Changming Wang, Bowen Ji, Zengguang Wang

{"title":"Classification and transfer learning of sleep spindles based on convolutional neural networks","authors":"Jun Liang, Abdelkader Nasreddine Belkacem, Yanxin Song, Jiaxin Wang, Zhiguo Ai, Xuanqi Wang, Jun Guo, Lingfeng Fan, Changming Wang, Bowen Ji, Zengguang Wang","doi":"10.3389/fnins.2024.1396917","DOIUrl":"https://doi.org/10.3389/fnins.2024.1396917","url":null,"abstract":"Sleep plays a critical role in human physiological and psychological health, and electroencephalography (EEG), an effective sleep-monitoring method, is of great importance in revealing sleep characteristics and aiding the diagnosis of sleep disorders. Sleep spindles, which are a typical phenomenon in EEG, hold importance in sleep science.This paper proposes a novel convolutional neural network (CNN) model to classify sleep spindles. Transfer learning is employed to apply the model trained on the sleep spindles of healthy subjects to those of subjects with insomnia for classification. To analyze the effect of transfer learning, we discuss the classification results of both partially and fully transferred convolutional layers.The classification accuracy for the healthy and insomnia subjects’ spindles were 93.68% and 92.77%, respectively. During transfer learning, when transferring all convolutional layers, the classification accuracy for the insomnia subjects’ spindles was 91.41% and transferring only the first four convolutional layers achieved a classification result of 92.80%. The experimental results demonstrate that the proposed CNN model can effectively classify sleep spindles. Furthermore, the features learned from the data of the normal subjects can be effectively applied to the data for subjects with insomnia, yielding desirable outcomes.These outcomes underscore the efficacy of both the collected dataset and the proposed CNN model. The proposed model exhibits potential as a rapid and effective means to diagnose and treat sleep disorders, thereby improving the speed and quality of patient care.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"75 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140659408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EBV and multiple sclerosis: expression of LMP2A in MS patients EB 病毒与多发性硬化症：多发性硬化症患者体内 LMP2A 的表达

Frontiers in Neuroscience Pub Date : 2024-04-24 DOI: 10.3389/fnins.2024.1385233

S. Agostini, R. Mancuso, Domenico Caputo, M. Rovaris, Mario Clerici

{"title":"EBV and multiple sclerosis: expression of LMP2A in MS patients","authors":"S. Agostini, R. Mancuso, Domenico Caputo, M. Rovaris, Mario Clerici","doi":"10.3389/fnins.2024.1385233","DOIUrl":"https://doi.org/10.3389/fnins.2024.1385233","url":null,"abstract":"Several evidences, including increased serum titers of Epstein–Barr virus (EBV)-specific antibodies and the presence of EBV DNA in brain of patients suggest a possible role of this virus in the pathogenesis of Multiple Sclerosis (MS), a chronic neurodegenerative disease with an unknown etiopathology. Aim of the present study is to verify if the expression of LMP2A and EBNA-1, two EBV genes, is altered in MS patients. EBV viral load, LMP2A and EBNA-1 gene expression and EBNA-1 antibodies titers were evaluated in blood of EBV-seropositive MS patients (n = 57; 31 relapsing remitting –RRMS- and 26 progressive -PMS-patients) and age- and sex-matched healthy controls (HC, n = 49). Results showed that EBNA-1 and VCA antibodies titers are significantly augmented in MS patients compared to HC (p < 0.05 for both antibodies); detection of EBV DNA was more frequent as well in MS patients compared to HC, although without reaching statistical significance. Regarding viral gene expression, LMP2A was significantly more frequently detected and more expressed in MS patients compared to HC (p < 0.005) whereas no differences were observed for EBNA-1. Considering patients alone, EBNA-1 was significantly more frequent in PMS compared to RRMS (p < 0.05), whereas no differences were observed for LMP2A. Increased expression of the LMP2A latency-associated gene in MS patients supports the hypothesis that EBV plays a role in disease etiopathology.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"76 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance 普罗布考通过调节大脑氧化还原和胰岛素抵抗减轻高脂饮食引起的认知和社交障碍

Frontiers in Neuroscience Pub Date : 2024-04-23 DOI: 10.3389/fnins.2024.1368552

Han-ming Wu, Yang Vivian Yang, Na-Jun Huang, Li-Ping Fan, Ying-Ying Dai, Ke-Ting Hu, Tian-Yu Tang, Lin Liu, Yue Xu, Dong-Tai Liu, Ze-Xin Cai, Xiao-Yu Niu, Xin-Yi Ren, Zheng-Hao Yao, Hao-Yu Qin, Jian-Zhen Chen, Xi Huang, Cixiong Zhang, Xiang You, Chen Wang, Ying He, Wei Hong, Yu-Xia Sun, Yi-Hong Zhan, Shu-Yong Lin

{"title":"Probucol mitigates high-fat diet-induced cognitive and social impairments by regulating brain redox and insulin resistance","authors":"Han-ming Wu, Yang Vivian Yang, Na-Jun Huang, Li-Ping Fan, Ying-Ying Dai, Ke-Ting Hu, Tian-Yu Tang, Lin Liu, Yue Xu, Dong-Tai Liu, Ze-Xin Cai, Xiao-Yu Niu, Xin-Yi Ren, Zheng-Hao Yao, Hao-Yu Qin, Jian-Zhen Chen, Xi Huang, Cixiong Zhang, Xiang You, Chen Wang, Ying He, Wei Hong, Yu-Xia Sun, Yi-Hong Zhan, Shu-Yong Lin","doi":"10.3389/fnins.2024.1368552","DOIUrl":"https://doi.org/10.3389/fnins.2024.1368552","url":null,"abstract":"Probucol has been utilized as a cholesterol-lowering drug with antioxidative properties. However, the impact and fundamental mechanisms of probucol in obesity-related cognitive decline are unclear. In this study, male C57BL/6J mice were allocated to a normal chow diet (NCD) group or a high-fat diet (HFD) group, followed by administration of probucol to half of the mice on the HFD regimen. Subsequently, the mice were subjected to a series of behavioral assessments, alongside the measurement of metabolic and redox parameters. Notably, probucol treatment effectively alleviates cognitive and social impairments induced by HFD in mice, while exhibiting no discernible influence on mood-related behaviors. Notably, the beneficial effects of probucol arise independently of rectifying obesity or restoring systemic glucose and lipid homeostasis, as evidenced by the lack of changes in body weight, serum cholesterol levels, blood glucose, hyperinsulinemia, systemic insulin resistance, and oxidative stress. Instead, probucol could regulate the levels of nitric oxide and superoxide-generating proteins, and it could specifically alleviate HFD-induced hippocampal insulin resistance. These findings shed light on the potential role of probucol in modulating obesity-related cognitive decline and urge reevaluation of the underlying mechanisms by which probucol exerts its beneficial effects.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"59 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140668062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using artificial intelligence methods to study the effectiveness of exercise in patients with ADHD 利用人工智能方法研究运动对多动症患者的疗效

Frontiers in Neuroscience Pub Date : 2024-04-23 DOI: 10.3389/fnins.2024.1380886

Dan Yu, Jia hui Fang

{"title":"Using artificial intelligence methods to study the effectiveness of exercise in patients with ADHD","authors":"Dan Yu, Jia hui Fang","doi":"10.3389/fnins.2024.1380886","DOIUrl":"https://doi.org/10.3389/fnins.2024.1380886","url":null,"abstract":"Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder that significantly affects children and adults worldwide, characterized by persistent inattention, hyperactivity, and impulsivity. Current research in this field faces challenges, particularly in accurate diagnosis and effective treatment strategies. The analysis of motor information, enriched by artificial intelligence methodologies, plays a vital role in deepening our understanding and improving the management of ADHD. The integration of AI techniques, such as machine learning and data analysis, into the study of ADHD-related motor behaviors, allows for a more nuanced understanding of the disorder. This approach facilitates the identification of patterns and anomalies in motor activity that are often characteristic of ADHD, thereby contributing to more precise diagnostics and tailored treatment strategies. Our approach focuses on utilizing AI techniques to deeply analyze patients' motor information and cognitive processes, aiming to improve ADHD diagnosis and treatment strategies. On the ADHD dataset, the model significantly improved accuracy to 98.21% and recall to 93.86%, especially excelling in EEG data processing with accuracy and recall rates of 96.62 and 95.21%, respectively, demonstrating precise capturing of ADHD characteristic behaviors and physiological responses. These results not only reveal the great potential of our model in improving ADHD diagnostic accuracy and developing personalized treatment plans, but also open up new research perspectives for understanding the complex neurological logic of ADHD. In addition, our study not only suggests innovative perspectives and approaches for ADHD treatment, but also provides a solid foundation for future research exploring similar complex neurological disorders, providing valuable data and insights. This is scientifically important for improving treatment outcomes and patients' quality of life, and points the way for future-oriented medical research and clinical practice.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"132 45","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140669133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond nodes and edges: a bibliometric analysis on graph theory and neuroimaging modalities 超越节点和边缘：图论和神经成像模式的文献计量分析

Frontiers in Neuroscience Pub Date : 2024-04-23 DOI: 10.3389/fnins.2024.1373264

Makliya Mamat, Ziteng Wang, Ling Jin, Kailong He, Lin Li, Yiyong Chen

{"title":"Beyond nodes and edges: a bibliometric analysis on graph theory and neuroimaging modalities","authors":"Makliya Mamat, Ziteng Wang, Ling Jin, Kailong He, Lin Li, Yiyong Chen","doi":"10.3389/fnins.2024.1373264","DOIUrl":"https://doi.org/10.3389/fnins.2024.1373264","url":null,"abstract":"Understanding the intricate architecture of the brain through the lens of graph theory and advanced neuroimaging techniques has become increasingly pivotal in unraveling the complexities of neural networks. This bibliometric analysis explores the evolving landscape of brain research by focusing on the intersection of graph theoretical approaches, neuroanatomy, and diverse neuroimaging modalities. A systematic search strategy was used that resulted in the retrieval of a comprehensive dataset of articles and reviews. Using CiteSpace and VOSviewer, a detailed scientometric analysis was conducted that revealed emerging trends, key research clusters, and influential contributions within this multidisciplinary domain. Our review highlights the growing synergy between graph theory methodologies and neuroimaging modalities, reflecting the evolving paradigms shaping our understanding of brain networks. This study offers comprehensive insight into brain network research, emphasizing growth patterns, pivotal contributions, and global collaborative networks, thus serving as a valuable resource for researchers and institutions navigating this interdisciplinary landscape.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"27 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140672508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Theoretical advances and practical applications of spiking neural networks 社论：尖峰神经网络的理论进展与实际应用

Frontiers in Neuroscience Pub Date : 2024-04-22 DOI: 10.3389/fnins.2024.1406502

Gaetano Di Caterina, Malu Zhang, Jundong Liu

引用次数: 0

Potential roles of gangliosides in chemical-induced neurodegenerative diseases and mental health disorders 神经节苷脂在化学物质诱发的神经退行性疾病和精神疾病中的潜在作用

Frontiers in Neuroscience Pub Date : 2024-04-22 DOI: 10.3389/fnins.2024.1391413

Yutaka Itokazu, Alvin V. Terry

引用次数: 0

Relationship between depression and sex steroid hormone among women with epilepsy 女性癫痫患者抑郁与性类固醇激素的关系

Frontiers in Neuroscience Pub Date : 2024-04-22 DOI: 10.3389/fnins.2024.1370533

L. Ogunjimi, A. Alabi, Ibironke Oyenuga, Jeremiah Ogunkunle, Emmanuel Kasumu, Oluwaseun Ogunsanya, Oluwatobiloba Oluseyije, Pelumi Ogunbayo, Omorojo Idume, Adeola Kasali, Sarah Adesi, Mariam Oyebowale, Damilola Ogungbemi, A. Aderinola, Emmanuel Irokosu, Abdullahi A. Murtala, B. Osalusi

{"title":"Relationship between depression and sex steroid hormone among women with epilepsy","authors":"L. Ogunjimi, A. Alabi, Ibironke Oyenuga, Jeremiah Ogunkunle, Emmanuel Kasumu, Oluwaseun Ogunsanya, Oluwatobiloba Oluseyije, Pelumi Ogunbayo, Omorojo Idume, Adeola Kasali, Sarah Adesi, Mariam Oyebowale, Damilola Ogungbemi, A. Aderinola, Emmanuel Irokosu, Abdullahi A. Murtala, B. Osalusi","doi":"10.3389/fnins.2024.1370533","DOIUrl":"https://doi.org/10.3389/fnins.2024.1370533","url":null,"abstract":"Sex steroid hormones are emerging significant biomarkers of depression among Women with Epilepsy (WWE) with promising prognostic potential and therapeutic end point. Therefore, the study is aimed at exploring the association between sex steroids hormones, Anti-seizure Medication (ASM) and depression among WWE.A baseline questionnaire was used to obtain socio-demographics and clinical characteristic from one hundred and twelve (112) WWE and 50 age matched healthy control. The diagnosis of epilepsy and Electroencephalography (EEG) description was based on 2017 International League Against Epilepsy (ILAE) criteria. Blood samples were collected from cases and control during Luteal Phase (LP) and Follicular Phase (FP). The Zung Self-Rating Depression Scale (ZSRDS) was used to assess depression.The prevalence of depression among WWE is 18.8%, with a significant difference between the level of formal education (p0.000), age (p0.000), and mean ZSRDS (p0.000) among cases and control. There is a statistical difference in hormonal levels between cases and control with regards to higher testosterone [3.28 ± 9.99 vs. 0.31 ± 0.30; p0.037], lower FP prolactin [16.37 ± 20.14 vs. 17.20 ± 7.44; p0.778], and lower LP prolactin [15.74 ± 18.22 vs. 17.67 ± 7.27; p0.473]. Testosterone (p0.024), FP Follicle Stimulating Hormone (FSH) (p0.009), FP Estradiol (p0.006), LP FSH (p0.031), LP Progesterone (p0.023), and LP Prolactin (p0.000) were associated with depression. However, only prolactin (p0.042) and testosterone (p0.000) predicts depression among WWE.There was higher mean depression score, lower prolactin and higher testosterone level among cases compared to control. Furthermore, there was lower prolactin and higher testosterone level in Carbamazepine (CBZ) group compared to Levetiracetam (LEV) groups.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"31 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140676338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research status and prospects of pituitary adenomas in conjunction with neurological and psychiatric disorders and the tumor microenvironment 垂体腺瘤与神经和精神疾病以及肿瘤微环境的研究现状和前景

Frontiers in Neuroscience Pub Date : 2024-04-22 DOI: 10.3389/fnins.2024.1294417

Siyuan Cui, Sainan Chen, Xuechao Wu, Qing Wang

{"title":"Research status and prospects of pituitary adenomas in conjunction with neurological and psychiatric disorders and the tumor microenvironment","authors":"Siyuan Cui, Sainan Chen, Xuechao Wu, Qing Wang","doi":"10.3389/fnins.2024.1294417","DOIUrl":"https://doi.org/10.3389/fnins.2024.1294417","url":null,"abstract":"Patients with pituitary neuroendocrine tumors (PitNETs) often experience neuropsychiatric disorders due to factors such as hormonal imbalances, and inadequate management of medications, surgeries, and radiation therapies. Commonly observed disorders include depression, anxiety, and cognitive dysfunction, which significantly impact patients’ quality of life and prognosis. PitNETs have a significant presence of immune cells within the tumor microenvironment (TME), predominantly macrophages and T lymphocytes. These immune cells secrete a variety of cytokines, growth factors, and chemokines, which regulate the biological behaviors of PitNETs, including tumor initiation, proliferation, migration, invasion, and angiogenesis. In addition, this review provides a pioneering summary of the close relationships between the aberrant secretion of proinflammatory cytokines within the TME of PitNETs and the occurrence of neuropsychiatric disorders, along with their potential underlying mechanisms. The cytokines produced as a result of TME dysregulation may affect various aspects of the central nervous system, including neurotransmitter metabolism, neuroendocrine function, and neurovascular plasticity, thereby leading to a higher susceptibility to neurobehavioral disorders in PitNET patients.","PeriodicalId":509131,"journal":{"name":"Frontiers in Neuroscience","volume":"6 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140673420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Commentary: Aripiprazole disrupts cellular synchrony in the suprachiasmatic nucleus and enhances entrainment to environmental light–dark cycles in mice 评论阿立哌唑会破坏小鼠视上核的细胞同步性，并增强小鼠对环境光暗周期的适应能力

Frontiers in Neuroscience Pub Date : 2024-04-19 DOI: 10.3389/fnins.2024.1371195

Tsuyoshi Kitajima

引用次数: 0