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Frontiers in Molecular Neuroscience最新文献

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Editorial: Women in molecular neuroscience 社论：分子神经科学领域的女性
Frontiers in Molecular Neuroscience Pub Date : 2024-05-14 DOI: 10.3389/fnmol.2024.1422589
Eva Žerovnik
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引用次数: 0
Editorial: Molecular and cellular bases of peripheral neuropathies 社论：周围神经病的分子和细胞基础
Frontiers in Molecular Neuroscience Pub Date : 2024-05-13 DOI: 10.3389/fnmol.2024.1423363
Jorge Feito, Jose Antonio Vega
{"title":"Editorial: Molecular and cellular bases of peripheral neuropathies","authors":"Jorge Feito, Jose Antonio Vega","doi":"10.3389/fnmol.2024.1423363","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1423363","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"61 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140983644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: 2021 WHO classification of pediatric brain tumors: a final wedding between morphology and molecular biology? 社论：2021 年世界卫生组织小儿脑肿瘤分类：形态学与分子生物学的最后婚礼？
Frontiers in Molecular Neuroscience Pub Date : 2024-05-08 DOI: 10.3389/fnmol.2024.1423298
A. Mastronuzzi, Lucia Quaglietta, Elisabetta Schiavello, A. Carai
{"title":"Editorial: 2021 WHO classification of pediatric brain tumors: a final wedding between morphology and molecular biology?","authors":"A. Mastronuzzi, Lucia Quaglietta, Elisabetta Schiavello, A. Carai","doi":"10.3389/fnmol.2024.1423298","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1423298","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"16 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141001502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Development and function of GABAergic interneurons in physiology and pathologies 社论：生理学和病理学中 GABA 能中间神经元的发育和功能
Frontiers in Molecular Neuroscience Pub Date : 2024-05-03 DOI: 10.3389/fnmol.2024.1412738
Milena Cannella, Maria Vincenza Catania, Ferdinando Nicoletti
{"title":"Editorial: Development and function of GABAergic interneurons in physiology and pathologies","authors":"Milena Cannella, Maria Vincenza Catania, Ferdinando Nicoletti","doi":"10.3389/fnmol.2024.1412738","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1412738","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"25 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141014697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: The legacy of Dr. Rita Levi-Montalcini: advances in neurotrophic factors in brain disease development and treatment 社论：丽塔-列维-蒙塔尔奇尼博士的遗产：神经营养因子在脑疾病发育和治疗中的应用进展
Frontiers in Molecular Neuroscience Pub Date : 2024-04-25 DOI: 10.3389/fnmol.2024.1387026
Wei-Jung Chen, W. Kung, Muh-Shi Lin
{"title":"Editorial: The legacy of Dr. Rita Levi-Montalcini: advances in neurotrophic factors in brain disease development and treatment","authors":"Wei-Jung Chen, W. Kung, Muh-Shi Lin","doi":"10.3389/fnmol.2024.1387026","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1387026","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"7 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic modifications of DNA and RNA in Alzheimer’s disease 阿尔茨海默病中 DNA 和 RNA 的表观遗传修饰
Frontiers in Molecular Neuroscience Pub Date : 2024-04-25 DOI: 10.3389/fnmol.2024.1398026
Paula Martínez-Feduchi, Peng Jin, Bing Yao
{"title":"Epigenetic modifications of DNA and RNA in Alzheimer’s disease","authors":"Paula Martínez-Feduchi, Peng Jin, Bing Yao","doi":"10.3389/fnmol.2024.1398026","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1398026","url":null,"abstract":"Alzheimer’s disease (AD) is a complex neurodegenerative disorder and the most common form of dementia. There are two main types of AD: familial and sporadic. Familial AD is linked to mutations in amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2). On the other hand, sporadic AD is the more common form of the disease and has genetic, epigenetic, and environmental components that influence disease onset and progression. Investigating the epigenetic mechanisms associated with AD is essential for increasing understanding of pathology and identifying biomarkers for diagnosis and treatment. Chemical covalent modifications on DNA and RNA can epigenetically regulate gene expression at transcriptional and post-transcriptional levels and play protective or pathological roles in AD and other neurodegenerative diseases.","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"32 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140656321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synaptic proteomics decode novel molecular landscape in the brain 突触蛋白质组学解码大脑中的新分子景观
Frontiers in Molecular Neuroscience Pub Date : 2024-04-25 DOI: 10.3389/fnmol.2024.1361956
Yuki Ito, Sayaka Nagamoto, Tetsuya Takano
{"title":"Synaptic proteomics decode novel molecular landscape in the brain","authors":"Yuki Ito, Sayaka Nagamoto, Tetsuya Takano","doi":"10.3389/fnmol.2024.1361956","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1361956","url":null,"abstract":"Synapses play a pivotal role in forming neural circuits, with critical implications for brain functions such as learning, memory, and emotions. Several advances in synaptic research have demonstrated the diversity of synaptic structure and function, which can form thousands of connections depending on the neuronal cell types. Moreover, synapses not only interconnect neurons but also establish connections with glial cells such as astrocytes, which play a key role in the architecture and function of neuronal circuits in the brain. Emerging evidence suggests that dysfunction of synaptic proteins contributes to a variety of neurological and psychiatric disorders. Therefore, it is crucial to determine the molecular networks within synapses in various neuronal cell types to gain a deeper understanding of how the nervous system regulates brain function. Recent advances in synaptic proteome approaches, such as fluorescence-activated synaptosome sorting (FASS) and proximity labeling, have allowed for a detailed and spatial analysis of many cell-type-specific synaptic molecules in vivo. In this brief review, we highlight these novel spatial proteomic approaches and discuss the regulation of synaptic formation and function in the brain. This knowledge of molecular networks provides new insight into the understanding of many neurological and psychiatric disorders.","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"4 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140654080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma 用于生物标记物发现和疾病机制探索的眼液蛋白质组学研究进展：聚焦原发性开角型青光眼
Frontiers in Molecular Neuroscience Pub Date : 2024-04-24 DOI: 10.3389/fnmol.2024.1397461
V. M. Beutgen, Johannes Graumann
{"title":"Advances in aqueous humor proteomics for biomarker discovery and disease mechanisms exploration: a spotlight on primary open angle glaucoma","authors":"V. M. Beutgen, Johannes Graumann","doi":"10.3389/fnmol.2024.1397461","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1397461","url":null,"abstract":"Altered protein levels in the aqueous humor (AH) may be a valuable source of novel biomarkers in neurodegenerative retinal disease. The proximity of this body fluid to the disease focus, and its corresponding enrichment for tissue specific proteins, renders it an excellent matrix to study underlying molecular mechanisms. Novel proteomic methods accordingly hold large potential for insight into pathologies based on the composition of the AH proteome, including primary open angle glaucoma (POAG). Recent mass spectrometry-based studies use novel approaches to tackle the challenges arising from the combination of low available sample volume and protein concentration, thereby increasing proteome coverage. But despite significant improvements in mass spectrometry (MS), a different class of proteomic technologies is poised to majorly impact the analysis of ocular biofluids. Affinity proteomic workflows, having become available commercially recently, have started to complement data obtained by MS and likely will grow into a crucial tool for ophthalmological biomarker research. This review highlights corresponding approaches in proteome analysis of aqueous humor and discusses recent findings on alterations of the AH proteome in POAG.","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"40 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140665684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Molecular and network mechanisms underlying stress resilience 社论：压力复原力的分子和网络机制
Frontiers in Molecular Neuroscience Pub Date : 2024-04-15 DOI: 10.3389/fnmol.2024.1404375
Frederick L. Hitti, Brian F. Corbett
{"title":"Editorial: Molecular and network mechanisms underlying stress resilience","authors":"Frederick L. Hitti, Brian F. Corbett","doi":"10.3389/fnmol.2024.1404375","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1404375","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"315 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140703536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection 社论：感音神经性听力损失和听力保护的分子机制
Frontiers in Molecular Neuroscience Pub Date : 2024-04-03 DOI: 10.3389/fnmol.2024.1401219
J. Taymans, S. Vlajkovic, A. C. V´elez-Ortega, Jennie M E Cederholm
{"title":"Editorial: Molecular mechanisms of sensorineural hearing loss and hearing protection","authors":"J. Taymans, S. Vlajkovic, A. C. V´elez-Ortega, Jennie M E Cederholm","doi":"10.3389/fnmol.2024.1401219","DOIUrl":"https://doi.org/10.3389/fnmol.2024.1401219","url":null,"abstract":"","PeriodicalId":509130,"journal":{"name":"Frontiers in Molecular Neuroscience","volume":"183 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140746605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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