Frontiers in Bioengineering and Biotechnology最新文献

{"title":"Erratum: Estimating 3D kinematics and kinetics from virtual inertial sensor data through musculoskeletal movement simulations","authors":"","doi":"10.3389/fbioe.2024.1414850","DOIUrl":"https://doi.org/10.3389/fbioe.2024.1414850","url":null,"abstract":"","PeriodicalId":508781,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"13 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141017129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Bioengineering and biotechnology approaches in cardiovascular regenerative medicine, volume II","authors":"Mehdi Salar Amoli, Zhen Ma, Yuji Nakada, Keiichi Fukuda, Jianyi Zhang, Vahid Serpooshan","doi":"10.3389/fbioe.2024.1380646","DOIUrl":"https://doi.org/10.3389/fbioe.2024.1380646","url":null,"abstract":"","PeriodicalId":508781,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"44 21","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139961749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue engineering applications of recombinant human collagen: a review of recent progress","authors":"Lili Cao, Zhongfeng Zhang, Dan Yuan, Meiping Yu, Jie Min","doi":"10.3389/fbioe.2024.1358246","DOIUrl":"https://doi.org/10.3389/fbioe.2024.1358246","url":null,"abstract":"Recombinant human collagen applications in biomedical systems.","PeriodicalId":508781,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":"116 15","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139963513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mannose-decorated ginsenoside Rb1 albumin nanoparticles for targeted anti-inflammatory therapy.","authors":"Zhihui Fu,&nbsp;Xiaohui Wang,&nbsp;Xuan Lu,&nbsp;Ying Yang,&nbsp;Lingling Zhao,&nbsp;Lin Zhou,&nbsp;Kaikai Wang,&nbsp;Hanlin Fu","doi":"10.3389/fbioe.2022.962380","DOIUrl":"https://doi.org/10.3389/fbioe.2022.962380","url":null,"abstract":"<p><p>Ginsenoside Rb1 is a potential anti-inflammatory natural molecule, but its therapeutic efficacy was tremendously hampered by the low solubility and non-targeted delivery. In this study, we innovatively developed a mannose (Man)-modified albumin bovine serum albumin carrier (Man-BSA) to overcome the previously mentioned dilemmas of Rb1. The constructed Man-BSA@Rb1 NPs could improve the solubility and increase the cellular uptake of Rb1, finally leading to the enhanced anti-inflammatory effects. The robust therapeutics of Man-BSA@Rb1 NPs were measured in terms of nitrite, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) levels, which might be achieved by potently inhibiting nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways in lipopolysaccharide (LPS)-induced Raw264.7 cells. Moreover, the therapeutic efficacy of Man-BSA@Rb1 NPs was further confirmed in the d-Gal/LPS-induced liver injury model. The results indicated that Man-BSA may offer a promising system to improve the anti-inflammatory therapy of Rb1.</p>","PeriodicalId":508781,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":" ","pages":"962380"},"PeriodicalIF":5.7,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9420840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40335928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Subchondral Bone Cysts Cause Deterioration of Articular Cartilage in Medial OA of Knee: A 3D Simulation Study.","authors":"Adeel Anwar,&nbsp;Zhenwei Hu,&nbsp;Yufang Zhang,&nbsp;Yanming Gao,&nbsp;Cong Tian,&nbsp;Xiuying Wang,&nbsp;Muhammad Umar Nazir,&nbsp;Yanfeng Wang,&nbsp;Zhi Zhao,&nbsp;Decheng Lv,&nbsp;Zhen Zhang,&nbsp;Hu Zhang,&nbsp;Gang Lv","doi":"10.3389/fbioe.2020.573938","DOIUrl":"https://doi.org/10.3389/fbioe.2020.573938","url":null,"abstract":"<p><strong>Aims: </strong>To investigate the impact of subchondral bone cysts (SBCs) in stress-induced osseous and articular variations in cystic and non-cystic knee models using finite element analysis.</p><p><strong>Materials and methods: </strong>3D knee joint models were reconstructed from computed tomography (CT) and magnetic resonance imaging (MRI). Duplicate 3D models were also created with a 3D sphere mimicking SBCs in medial tibia. Models were divided into three groups. In group A, a non-cystic knee model was used, whereas in groups B and C, SBCs of 4 and 12 mm size were simulated, respectively. Cyst groups were further divided into three sub-groups. Each of sub-group 1 was composed of a solitary SBC in the anterior half of tibia adjacent to joint line. In sub-group 2, a solitary cyst was modeled at a lower-joint location, and in sub-group 3, two SBCs were used. All models were vertically loaded with weights representing double- and single-leg stances.</p><p><strong>Results: </strong>During single-leg stance, increase in subchondral bone stress in sub-groups B-1 and B-3 were significant (<i>p</i> = 0.044, <i>p</i> = 0.026). However, in sub-group B-2, a slight increase was observed than non-cystic knee model (9.93 ± 1.94 vs. 9.35 ± 1.85; <i>p</i> = 0.254). All the sub-groups in group C showed significantly increased articular stress (<i>p</i> < 0.001). Conversely, a prominent increase in peri-cystic cancellous bone stress was produced by SBCs in groups B and C (<i>p</i> < 0.001). Mean cartilage shear stress in sub-groups B-1 and B-2 (0.66 ± 0.56, 0.58 ± 0.54) was non-significant (<i>p</i> = 0.374, <i>p</i> = 0.590) as compared to non-cystic model (0.47 ± 0.67). But paired cysts of the same size (B-3) produced a mean stress of 0.98 ± 0.49 in affected cartilage (<i>p</i> = 0.011). Models containing 12 mm SBCs experienced a significant increase in cartilage stress (<i>p</i> = 0.001, <i>p</i> = 0.006, <i>p</i> < 0.001) in sub-groups C-1, C-2, and C-3 (1.25 ± 0.69, 1.01 ± 0.54, and 1.26 ± 0.59), respectively.</p><p><strong>Conclusion: </strong>The presence of large-sized SBCs produced an increased focal stress effect in articular cartilage. Multiple cysts further deteriorate the condition by increased osseous stress effect and high tendency of peripheral cyst expansion in simulated cystic knee models than non-cystic knee models.</p>","PeriodicalId":508781,"journal":{"name":"Frontiers in Bioengineering and Biotechnology","volume":" ","pages":"573938"},"PeriodicalIF":5.7,"publicationDate":"2020-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3389/fbioe.2020.573938","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38587060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}