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Pharmacokinetic interactions between ritonavir-boosted darunavir and NNRTIs: a report of 3 cases. 利托那韦增强的达那韦与NNRTIs的药代动力学相互作用:附3例报告。
Aids Reader Pub Date : 2008-09-01
Holly E Rawizza, Paul E Sax
{"title":"Pharmacokinetic interactions between ritonavir-boosted darunavir and NNRTIs: a report of 3 cases.","authors":"Holly E Rawizza,&nbsp;Paul E Sax","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pharmacokinetic interactions among antiretroviral agents may influence the potency or toxicity of coadministered drugs. Here we present 3 patients with extensive protease inhibitor and NRTI resistance for whom ritonavir-boosted darunavir (DRV/r) and an NNRTI were components of a successful antiretroviral regimen. These cases provide a context in which to review pharmacokinetic data pertaining to the coadministration of DRV/r and an antiretroviral agent from the NNRTI class. Although dose adjustments are not currently recommended when DRV/r is given in combination with any of the commonly prescribed NNRTIs, plasma levels of both darunavir and these NNRTIs are altered when they are used concomitantly. Understanding these pharmacokinetic changes might allow clinicians to predict which patients may be more vulnerable to adverse effects or inadequate antiviral activity caused by this drug interaction.</p>","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 9","pages":"466-72, 478-9"},"PeriodicalIF":0.0,"publicationDate":"2008-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27705693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial comment: neuropsychiatric aspects of HIV/HCV coinfection--what every HIV care provider needs to know and address. 编辑评论:HIV/HCV合并感染的神经精神病学方面——每个HIV护理提供者需要了解和解决的问题。
Aids Reader Pub Date : 2008-08-01
Glenn J Treisman
{"title":"Editorial comment: neuropsychiatric aspects of HIV/HCV coinfection--what every HIV care provider needs to know and address.","authors":"Glenn J Treisman","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"440-1"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of changing demographics of HIV/AIDS on role of primary care. 艾滋病毒/艾滋病人口结构变化对初级保健作用的影响。
Aids Reader Pub Date : 2008-08-01
William M Valenti
{"title":"Impact of changing demographics of HIV/AIDS on role of primary care.","authors":"William M Valenti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"402-4, 412"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Government cancels testing of experimental AIDS vaccine; large-scale study to be scaled back after similar drug failed. 政府取消实验性艾滋病疫苗的测试;类似药物失败后，大规模研究将缩减。
Aids Reader Pub Date : 2008-08-01
{"title":"Government cancels testing of experimental AIDS vaccine; large-scale study to be scaled back after similar drug failed.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"396"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New drug resistance test gives hope to TB fight. 新的耐药试验给抗击结核病带来希望。
Aids Reader Pub Date : 2008-08-01
{"title":"New drug resistance test gives hope to TB fight.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"396, 420"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27659664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Merck, FDA expand Gardasil warnings. 默克和FDA扩大了加德西警告。
Aids Reader Pub Date : 2008-08-01
{"title":"Merck, FDA expand Gardasil warnings.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"442"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load. 一名病毒载量检测不到的持续性淋巴细胞减少患者，替诺福韦转阿巴卡韦后CD4计数改善。
Aids Reader Pub Date : 2008-08-01
David V Condoluci, Maryanne Andrews, Andrew D Luber
{"title":"CD4 count improvement following tenofovir to abacavir switch in a patient with persistent lymphopenia despite an undetectable viral load.","authors":"David V Condoluci,&nbsp;Maryanne Andrews,&nbsp;Andrew D Luber","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Many different antiretroviral regimens can be used as initial therapy for infection with HIV. While all recommended regimens have been shown to be highly effective in suppressing HIV replication to undetectable levels, some differences may exist with regard to the level of immune reconstitution (eg, CD4+ cell population) that occurs. We report a case of a patient with profound and prolonged lymphopenia, despite undetectable HIV RNA levels, that reversed following a switch from a fixed-dose combination of tenofovir/emtricitabine to abacavir/lamivudine in the patient's regimen.</p>","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"410-2"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Images in HIV/AIDS. Patterns of renal injury in HIV-positive persons. 艾滋病毒/艾滋病图像。hiv阳性患者肾损伤的模式。
Aids Reader Pub Date : 2008-08-01
Giovanna M Crisi
{"title":"Images in HIV/AIDS. Patterns of renal injury in HIV-positive persons.","authors":"Giovanna M Crisi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"405-6"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Keratinization: a biologic alternative to male circumcision in the prevention of HIV infection? 角化术:男性包皮环切术预防HIV感染的生物学替代方法?
Aids Reader Pub Date : 2008-08-01
Jeffrey Laurence
{"title":"Keratinization: a biologic alternative to male circumcision in the prevention of HIV infection?","authors":"Jeffrey Laurence","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"394-5"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27656505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roche to suspend HIV research, seeing no advances. 罗氏暂停艾滋病毒研究，因未见进展。
Aids Reader Pub Date : 2008-08-01
{"title":"Roche to suspend HIV research, seeing no advances.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":50834,"journal":{"name":"Aids Reader","volume":"18 8","pages":"396"},"PeriodicalIF":0.0,"publicationDate":"2008-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27659663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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