JU Open PlusPub Date : 2024-01-01DOI: 10.1097/ju9.0000000000000087
C. Mazeaud, D. Choksi, K. Tran, B. Schott, Yongchang Jang, B. Salazar, C. Karmonik, R. Khavari
{"title":"What Clinical Parameter Strongly Associates White Matter Tract Alterations in a Multiple Sclerosis Population With Voiding Dysfunction? A Prospective Exploratory Study","authors":"C. Mazeaud, D. Choksi, K. Tran, B. Schott, Yongchang Jang, B. Salazar, C. Karmonik, R. Khavari","doi":"10.1097/ju9.0000000000000087","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000087","url":null,"abstract":"\u0000 \u0000 To correlate clinical and urodynamics parameters in patients with multiple sclerosis (MS) presenting lower urinary tract symptoms (LUTS) with both Expanded Disability Status Scale (EDSS) and changes in white matter integrity as seen on diffusion tensor images (DTIs). LUTS worsen throughout MS, as does lesion burden. We investigated which symptoms correlated best with structural changes in the white matter structure.\u0000 \u0000 \u0000 \u0000 Ten adult women >18 years were recruited with stable MS for ≥ 3 months and voiding dysfunction defined as % of post-void residual/bladder volume (%PVR/BV) > 20%. Patients participated in a clinical Urodynamic Study and completed several questionnaires (ie, Hamilton Rating Scale, American Urologic Association Symptom Score, NBS-QoL). DTI images were acquired using a 7-Tesla Siemens MAGNETOM Terra MRI scanner. DTI maps were constructed, and individual patients were coregistered with the International Consortium of Brain Mapping-DTI-81 white matter atlas to extract fractional anisotropy and mean diffusivity (MD). Pearson's correlation test was performed between each white matter tracts (WMT) and clinical parameters and between clinical parameters and the EDSS score as well. P < 0.05 was considered significant.\u0000 \u0000 \u0000 \u0000 Of the clinical parameters, %PVR/BV obtained from the average of multiple un-instrumented uroflow assessments had significant correlations with the greatest number of WMTs. Furthermore, we observed that in all recorded clinical parameters, %PVR/BV was the only significant parameter correlated with the EDSS score.\u0000 \u0000 \u0000 \u0000 This study demonstrates that %PVR/BV can be used as an objective parameter to gauge WMT changes and disease progression in patients with MS. Future studies are needed to refine this model.\u0000","PeriodicalId":508272,"journal":{"name":"JU Open Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JU Open PlusPub Date : 2024-01-01DOI: 10.1097/ju9.0000000000000090
E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera
{"title":"Reply to Editorial Comment: Microbiomes in Post-DRE Urine Samples Are Linked to Prostate Cancer Risk","authors":"E. D. Crawford, R. Martin, Caleb D. Phillips, Whitney N. Stanton, A. van Bokhoven, M. S. Lucia, Paul Arangua, Francisco G. La Rosa, Zachary Grasmick, Ryan Terlecki, Margaret F. Meagher, Daisaku Hirano, J. C. Nickel, P. Werahera","doi":"10.1097/ju9.0000000000000090","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000090","url":null,"abstract":"","PeriodicalId":508272,"journal":{"name":"JU Open Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139631687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
JU Open PlusPub Date : 2024-01-01DOI: 10.1097/ju9.0000000000000095
Mikołaj Przydacz, Howard B. Goldman
{"title":"Editorial Comment: What Clinical Parameter Strongly Associates White Matter Tract Alterations in a Multiple Sclerosis Population with Voiding Dysfunction? A Prospective Pilot Study","authors":"Mikołaj Przydacz, Howard B. Goldman","doi":"10.1097/ju9.0000000000000095","DOIUrl":"https://doi.org/10.1097/ju9.0000000000000095","url":null,"abstract":"","PeriodicalId":508272,"journal":{"name":"JU Open Plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139454792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}