Human Brain Pub Date : 2024-07-11 DOI: 10.37819/hb.1.1811

Xuebing Feng, Yunying Feng, Jie Wang, Xin Xu, Yueqiao Xu

{"title":"Direct mechanical thrombectomy with or without thrombolysis for acute ischemic stroke","authors":"Xuebing Feng, Yunying Feng, Jie Wang, Xin Xu, Yueqiao Xu","doi":"10.37819/hb.1.1811","DOIUrl":"https://doi.org/10.37819/hb.1.1811","url":null,"abstract":"The efficacy of direct mechanical thrombectomy (MT) and thrombectomy combined with intravenous thrombolysis (MT+IVT) in patients with acute ischemic stroke is still unclear. To comprehensively analyze the two strategies, we conducted a meta-analysis of randomized controlled trials (RCTs). Six RCTs were recruited from Ovid Medline, Embase, and Cochrane Central Register of Controlled Trials and published from 2020 to 2023, including 1164 in the MT group and 1170 in the MT + IVT group. There was no significant difference between the MT group and MT+IVT group in 90-day favorable outcome (OR 0.93, 95% CI 0.79-1.09, P=0.37, I2=0%,) and excellent outcome (OR 0.98, 95% CI 0.82-1.18, P=0.82, I2=0%). Similarly, there was no significant difference in 90-day mortality (OR 1.08, 95% CI 0.86-1.35, P=0.52, I2=0%) and symptomatic intracranial hemorrhage (OR 0.82, 95% CI 0.57-1.19, P=0.30, I2=0%). However, the successful recanalization rate of the MT group was significantly lower than that of the MT+IVT group (OR 0.73, 95% CI 0.57-0.94, P=0.01, I2=0%). There was no significant difference in functional outcome and safety endpoints between direct MT and MT+IVT, but the successful recanalization rate of MT+IVT was higher.","PeriodicalId":507717,"journal":{"name":"Human Brain","volume":"76 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141658200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anatomical distribution of histone H3 acetylation in human hippocampus 组蛋白 H3 乙酰化在人类海马中的解剖分布

Human Brain Pub Date : 2024-07-03 DOI: 10.37819/hb.1.1900

Bingyue Cao, Fengling Luo, Wenwen Zhang, Renwei Luo, Lile Cai, Yongchang Wei, Yanqing Wang, Pan Liu

引用次数: 0

Roles of microglial calcium channels in neurodegenerative diseases 小胶质细胞钙通道在神经退行性疾病中的作用

Human Brain Pub Date : 2024-04-09 DOI: 10.37819/hb.1.1806

Shasha Wang, Jinyu Zhang, Jingdan Zhang, Ao Li, Zengqiang Yuan, Jinbo Cheng

引用次数: 0

Progress in the nerve ultrasound of inflammatory peripheral neuropathies 炎症性周围神经病的神经超声研究进展

Human Brain Pub Date : 2024-01-10 DOI: 10.37819/hb.3.1776

J. Niu, Mingsheng Liu

{"title":"Progress in the nerve ultrasound of inflammatory peripheral neuropathies","authors":"J. Niu, Mingsheng Liu","doi":"10.37819/hb.3.1776","DOIUrl":"https://doi.org/10.37819/hb.3.1776","url":null,"abstract":"Objective: In recent years, high-resolution nerve ultrasound has been increasingly used as a complementary tool to nerve conduction studies in the diagnosis of peripheral neuropathies. Inflammatory peripheral neuropathies include a heterogeneous group of neuropathies mainly including chronic inflammatory demyelinating polyneuropathies (CIDP), multifocal motor neuropathy (MMN), systemic vasculitic neuropathy (SVN), and Guillain-Barre syndrome (GBS). We describe the ultrasonic characteristics of different inflammatory neuropathies. \u0000Data sources and study selection: The MEDLINE database was searched to find studies on nerve sonography in inflammatory peripheral neuropathies. Reported studies up to December 2022 were included in this review. \u0000Results: In neuropathies, the changes in ultrasound include enlarged nerve size, nerve echo-intensity, fascicle diameter and vascularity. Most CIDP patients have moderately enlarged CSA, some have dramatically enlarged CSA, and few have CSA within the normal range. Since the enlargement patterns are different, ultrasound is useful to help differentiate CIDP from CMT1. In follow-ups after immune treatment, nerve CSAs in CIDP could decrease, increase, or remain unchanged. Regional enlargement next to normal segments predominated in MMN. Nerve enlargement and hyper vascularization were found in vasculitic neuropathy. In GBS patients, there were enlarged peripheral nerve and nerve roots, which became normal at follow-up. \u0000Conclusions: High-resolution nerve ultrasound is complementary to the diagnosis of inflammatory peripheral neuropathies. CSA enlargement and its distribution are the most useful and quantifiable parameters in the evaluation of peripheral nerves. For patients suspected to have inflammatory neuropathies, we advise measuring the CSA of several pre-determined sites in the median, ulnar nerve, C5-8 cervical roots, and brachial plexus.","PeriodicalId":507717,"journal":{"name":"Human Brain","volume":" 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139627003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimated Pulse Wave Velocity is Associated with Intracranial Arterial Stenosis: A Secondary Analysis Based on A Korean Population 估计脉搏波速度与颅内动脉狭窄有关：基于韩国人群的二次分析

Human Brain Pub Date : 2024-01-10 DOI: 10.37819/hb.3.1777

Yaping Zhou, Xiuli Shang, Weizhen Tang, Jun Ni

{"title":"Estimated Pulse Wave Velocity is Associated with Intracranial Arterial Stenosis: A Secondary Analysis Based on A Korean Population","authors":"Yaping Zhou, Xiuli Shang, Weizhen Tang, Jun Ni","doi":"10.37819/hb.3.1777","DOIUrl":"https://doi.org/10.37819/hb.3.1777","url":null,"abstract":"The estimated pulse wave velocity (ePWV) was recently proposed to indicate artery stiffness. Although arterial stiffness contributes to intracranial arterial stenosis (ICAS), the correlation between ePWV and ICAS remains unclear. This secondary analysis included 1,011 neurologically healthy Korean participants from a cross-sectional database to explore the association between ePWV and prevalent ICAS. Brain magnetic resonance angiography (MRA) was performed for all patients at their presentation to access the ICAS. The ePWV was derived as: ePWV = 9.587 − 0.402 × age + 4.560 × 10 −3 × age2 − 2.621 × 10-5 × age2 × mean blood pressure (MBP) + 3.176 × 10-3 × age × MBP – 1.832 ×10-2 × MBP. The prevalence of ICAS was 9.99% (n=101). In multivariable logistic regression analyses, per 1m/s increment of ePWV causes 1.36 times the risk of ICAS prevalence after fully adjusting potential confounders. When dividing ePWV into tertiles, the ICAS risk increased by 1.98 times when ePWV increased from the first tertile to the third tertile. Moreover, the relationship between ePWV and ICAS was linear and robust, as suggested by smooth curve fitting and stratification analysis. In conclusion, the ePWV was positively and independently associated with prevalent ICAS in the Korean population.","PeriodicalId":507717,"journal":{"name":"Human Brain","volume":"67 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deep Brain Stimulation for Ischemic Stroke Rehabilitation: from Rodents to Human 脑深部刺激用于缺血性中风康复：从啮齿动物到人类

Human Brain Pub Date : 2024-01-10 DOI: 10.37819/hb.3.1779

Ruxu Geng, Yuhe Wang, Renzhi Wang, X. Bao

引用次数: 0

Regional- and cell type-specific changes of the human brain during aging 衰老过程中人脑区域和细胞类型的特异性变化

Human Brain Pub Date : 2024-01-10 DOI: 10.37819/hb.3.1780

Yanxi Chen, Gaoyu Zu, Bill Ling Feng Zhang, Zhixin Bai, Qiong Liu, Wensheng Li, Linya You

引用次数: 0

Application of proteomics in brain's aging research 蛋白质组学在大脑老化研究中的应用

Human Brain Pub Date : 2024-01-10 DOI: 10.37819/hb.3.1778

Yujia Tan, Fengling Luo, Yongchang Wei, Pan Liu

引用次数: 0

2023 China Alzheimer’s disease: facts and figures 2023 年中国阿尔茨海默病：事实与数据

Human Brain Pub Date : 2023-12-07 DOI: 10.37819/hb.3.1771

Jinwen Xiao, Jianping Li, Jintao Wang, Xingyu Zhang, Cong Wang, Guoping Peng, Hua Hu, Huayan Liu, Jun Liu, Lu Shen, Nan Zhang, Ning Yan, Qinying Ma, Wanzhong Xu, Z. Liao, Rujing Ren, Mingwei Wang, Enyan Yu, Jinzhou Tian, Huali Wang, Yong’an Sun, Hengge Xie, Gang Wang

引用次数: 0

Blood biomarkers in MCI conversion to Alzheimer’s disease: a systematic review and meta-analysis 从 MCI 转为阿尔茨海默病的血液生物标志物：系统回顾和荟萃分析

Human Brain Pub Date : 2023-11-24 DOI: 10.37819/hb.2.1758

Hai-Xia Li, Jin-Tao Wang, Yu Dong, Jian-Ping Li, Jinwen Xiao, Ru-jing Ren, Chun-bo Li, Gang Wang

{"title":"Blood biomarkers in MCI conversion to Alzheimer’s disease: a systematic review and meta-analysis","authors":"Hai-Xia Li, Jin-Tao Wang, Yu Dong, Jian-Ping Li, Jinwen Xiao, Ru-jing Ren, Chun-bo Li, Gang Wang","doi":"10.37819/hb.2.1758","DOIUrl":"https://doi.org/10.37819/hb.2.1758","url":null,"abstract":"Background: The predictive effects of blood biomarkers (BBMs) in the progression of Alzheimer’s disease (AD) have been reported recently. However, controversies still exist. In the present study, we aim to identify the predictive performances of BBMs in the conversion from Mild cognitive impairment (MCI) to AD. Methods: PubMed, Embase, Cochrane Library, and Web of Science from inception to June 10, 2023 were searched. Predictive potentials were evaluated by pooling the ratio of means (ROMs), relative risks (RRs), and diagnostic indexes from MCI-converters (MCI-c: MCI patients who convert to AD) and MCI-non converters (MCI-nc) based on fixed-effects or random-effects. Newcastle–Ottawa Quality Assessment Scale (NOS) was applied for quality assessment. Results: A total of 44 studies with 9343 participants from 28 cohorts were included in the meta-analysis, whereas the other 45 articles were included in the qualitative review. The average score of 44 studies included in the meta-analysis was 7.125. In pooled ROMs, plasma Aβ42/Aβ40 was lower, whereas Aβ40, T-tau, P-tau 181, P-tau 217, NFL, and GFAP were higher in MCI-c than MCI-nc. In pooled RRs, P-tau (RR=2.50, 95%CI: 2.04-3.06) as a continuous variable, Aβ42/Aβ40 as a categorical variable (RR=1.28, 95%CI: 1.01-1.61) could predict future conversion risk of MCI patients. In diagnostic indexes, the diagnostic odds ratio (DOR) was 42 for P-tau 217 (sensitivity: 91%; specificity: 81%), 15 for P-tau 181 (sensitivity: 81%; specificity: 78%), 12.71 for GFAP (sensitivity: 71%; specificity: 86%), 6 for Aβ42/Aβ40 (sensitivity: 86%; specificity: 49%, and 6 for NFL (sensitivity: 80%; specificity: 61%). Conclusion: Here, our results indicated that blood biomarkers held promising potential in predicting MCI conversion. However, more prospective cohorts based on particular MCI types and high-sensitivity assays are warranted to validate the results next.","PeriodicalId":507717,"journal":{"name":"Human Brain","volume":"3 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139240565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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