{"title":"脑深部刺激用于缺血性中风康复:从啮齿动物到人类","authors":"Ruxu Geng, Yuhe Wang, Renzhi Wang, X. Bao","doi":"10.37819/hb.3.1779","DOIUrl":null,"url":null,"abstract":"Ischemic stroke survivors often suffer from severe disability and impaired quality of life, and the current treatments are inadequate. Deep brain stimulation (DBS) is a promising strategy to enhance recovery and alleviate symptoms, as it can modulate the electrical activity of neural circuits and facilitate neuroprotection and regeneration. In this review, we conducted a comprehensive literature search and summarized the chronic sequelae and mechanisms of ischemic stroke. Then we discuss the common targets and outcomes of DBS in preclinical and clinical studies, as well as the challenges and opportunities of DBS for ischemic stroke treatment.","PeriodicalId":507717,"journal":{"name":"Human Brain","volume":"60 20","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Deep Brain Stimulation for Ischemic Stroke Rehabilitation: from Rodents to Human\",\"authors\":\"Ruxu Geng, Yuhe Wang, Renzhi Wang, X. Bao\",\"doi\":\"10.37819/hb.3.1779\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Ischemic stroke survivors often suffer from severe disability and impaired quality of life, and the current treatments are inadequate. Deep brain stimulation (DBS) is a promising strategy to enhance recovery and alleviate symptoms, as it can modulate the electrical activity of neural circuits and facilitate neuroprotection and regeneration. In this review, we conducted a comprehensive literature search and summarized the chronic sequelae and mechanisms of ischemic stroke. Then we discuss the common targets and outcomes of DBS in preclinical and clinical studies, as well as the challenges and opportunities of DBS for ischemic stroke treatment.\",\"PeriodicalId\":507717,\"journal\":{\"name\":\"Human Brain\",\"volume\":\"60 20\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-01-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Human Brain\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.37819/hb.3.1779\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Human Brain","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.37819/hb.3.1779","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Deep Brain Stimulation for Ischemic Stroke Rehabilitation: from Rodents to Human
Ischemic stroke survivors often suffer from severe disability and impaired quality of life, and the current treatments are inadequate. Deep brain stimulation (DBS) is a promising strategy to enhance recovery and alleviate symptoms, as it can modulate the electrical activity of neural circuits and facilitate neuroprotection and regeneration. In this review, we conducted a comprehensive literature search and summarized the chronic sequelae and mechanisms of ischemic stroke. Then we discuss the common targets and outcomes of DBS in preclinical and clinical studies, as well as the challenges and opportunities of DBS for ischemic stroke treatment.