Hematology & Transfusion International Journal最新文献

Seroprevalence of transfusion -transmitted infections among blood donors in a tertiary care hospital in and around Koodapakkam, Puducherry, India 印度普都切里 Koodapakkam 及其周边地区一家三级护理医院献血者中输血传播感染的血清流行率

Hematology & Transfusion International Journal Pub Date : 2024-07-02 DOI: 10.15406/htij.2024.12.00329

Purshotam Paudel, Pammy Sinha, Pooja Shri Jayakumar, Sabina Dc

{"title":"Seroprevalence of transfusion -transmitted infections among blood donors in a tertiary care hospital in and around Koodapakkam, Puducherry, India","authors":"Purshotam Paudel, Pammy Sinha, Pooja Shri Jayakumar, Sabina Dc","doi":"10.15406/htij.2024.12.00329","DOIUrl":"https://doi.org/10.15406/htij.2024.12.00329","url":null,"abstract":"Introduction: Even though blood transfusion safety has come a long way, Transfusion-Transmitted Infections (TTI), which include bacterial, viral, parasitic, and prions, can still spread with each transfusion. The main goal of this study was to determine the seroprevalence of the five TTIs that are required to be tested in India among blood donors at our facility. Accurate estimates of the risk of TTIs are essential for monitoring the safety of the blood supply. Methodology: This was a retrospective descriptive study conducted in the blood centre of a tertiary care teaching hospital in Puducherry, from 2017 to 2023. Records from blood banks were reviewed to collect data on all donors who underwent appropriate testing for HIV, hepatitis C, Hepatitis B, syphilis, and malaria. Enzyme-linked immunosorbent assay was done for HIV, HCV, HBsAg/hepatitis B surface antigen, and rapid card testing was done for syphilis and malaria. Results: There was a total of 2570 donors during the study period. In the present study, the overall seroprevalence of TTIs was 1.40%. The individual seropositivity rates were 0.03% for HIV, 0.93 % for HBsAg, and 0.43 % for syphilis. There were no cases of malaria and HCV detected in the study period. The highest percentage of prevalence was observed for HBV, followed by Syphilis and HIV. Conclusion: The overall seroprevalence of TTI in Puducherry was smaller than those reported elsewhere in the country. It was comparatively lesser than the national average for HIV, HCV, and HBV and much higher for syphilis.","PeriodicalId":507715,"journal":{"name":"Hematology & Transfusion International Journal","volume":"31 5‐6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141686825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FVIII tolerance in the Emicizumab era: Why yes? Emicizumab 时代的 FVIII 耐受性：为什么是？

Hematology & Transfusion International Journal Pub Date : 2024-02-21 DOI: 10.15406/htij.2024.12.00324

Manuel Lopez, Ramiro J Nuñez Vazquez, M. Á. Álvarez Román

引用次数: 0

Myxoid liposarcoma of the right lower limb 右下肢肌样脂肪肉瘤

Hematology & Transfusion International Journal Pub Date : 2024-01-11 DOI: 10.15406/htij.2023.12.00321

Gallardo Navarro Elias, García Rodríguez Francisco Mario, Mancera Steiner Carlos, Adame Paredes Raúl, Mansilla Alba Armando, García Cabrera Daniel

引用次数: 0

Clear cell carcinoma of Müllerian origin 缪勒氏清细胞癌

Hematology & Transfusion International Journal Pub Date : 2023-12-19 DOI: 10.15406/htij.2023.11.00319

Gallardo Navarro Elias, Mancera Steiner Carlos, Francisco García Rodríguez

引用次数: 0

P-selectin level in haemoglobin-S variants steady-state subjects in Port Harcourt Nigeria 尼日利亚哈科特港血红蛋白-S 变体稳态受试者的 P-选择素水平

Hematology & Transfusion International Journal Pub Date : 2023-12-04 DOI: 10.15406/htij.2023.11.00316

Ransom Baribefii Jacob, Stella Urekweru Ken-Ezihuo, Ebirien-Agana Samuel Bartimaeus, Evelyn Mgbeoma Eze

{"title":"P-selectin level in haemoglobin-S variants steady-state subjects in Port Harcourt Nigeria","authors":"Ransom Baribefii Jacob, Stella Urekweru Ken-Ezihuo, Ebirien-Agana Samuel Bartimaeus, Evelyn Mgbeoma Eze","doi":"10.15406/htij.2023.11.00316","DOIUrl":"https://doi.org/10.15406/htij.2023.11.00316","url":null,"abstract":"Introduction: P-selectin is a cell adhesion molecule that play key roles in vaso-occlusive crisis, atherosclerosis, inflammation and is highly implicated in sickle cell diseases. This cross-sectional study determines the level of P-selectin in haemoglobin-S variants steady state subjects in Port Harourt Nigeria. Materials and Methods: Eighty (80) subjects comprising of haemoglobin-S variants in steady-state and apparently healthy haemoglobin A (HbAA) male and female aged within 5-60years were recruited for the study. Five millilitres (5mls) of venous blood were aseptically collected by venepuncture from each participant into plain tube and analysed using Elabsceince ELISA kits. Data obtained were analysed using SPSS version 24, and results considered to be significant at p<0.05. Results: P-selectin levels were all within detectable normal reference ranges with highest value observed in HbSS subjects (10.98±2.72ng/ml) followed by HbSC subjects (9.58±3.51ng/ml), HbAA subjects (9.42±3.17ng/ml) and lowest value in HbAS subjects (8.01±3.19ng/ml) respectively (p=0.037). Comparison of P-selectin level based on gender showed no statistically significant difference across the various groups (p>0.05). Conclusion: The study revealed a higher P-selectin level in HbSS and HbSC subjects although all within normal detectable reference ranges. It further demonstrated that gender has no effect on the expression of P-selectin in haemoglobin-S variant steady state subjects and normal haemoglobin A (HbAA). Measurement of P-selectin level in sickle cell diesease is recommended as an indirect way of investigating and monitoring red cell haemolysis, platelet aggregation and degree of inflammation in haemoglobin-S variants subjects.","PeriodicalId":507715,"journal":{"name":"Hematology & Transfusion International Journal","volume":"51 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139187221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematology &amp; Transfusion International Journal最新文献

Hematology & Transfusion International Journal最新文献