Gallardo Navarro Elias, Mancera Steiner Carlos, Francisco García Rodríguez
{"title":"Clear cell carcinoma of Müllerian origin","authors":"Gallardo Navarro Elias, Mancera Steiner Carlos, Francisco García Rodríguez","doi":"10.15406/htij.2023.11.00319","DOIUrl":null,"url":null,"abstract":"Clear cell carcinoma is structures of Mullerian origin, they are associated with mutations in TP53 as they are a high-grade neoplasm, however there is no immunophenotypic pattern that guides us if the origin is from the ovary, uterus, endocervix or endometrium. A 71-year-old female patient who underwent surgery for a right parauterine tumor with a pathological report that corresponded to a clear cell tumor. Subsequently, a staging and cytoreductive laparotomy was performed, performing abdominal cavity lavage, salpingo-oophorectomy of the remaining ovary (left), and pelvic and paraortic lymphadenectomy. , omentectomy and biopsies of the parietal peritoneum, all the material was negative for metastatic disease, 18 months later there was a relapse in the vaginal vault, with the presence of an ovoid tumor measuring 10 cm in diameter, treated with colpectomy, with a report of clear cell carcinoma with CK7+ / Napsin A+ / p53+ protein immunophenotype, with a satisfactory disease-free postoperative period.","PeriodicalId":507715,"journal":{"name":"Hematology & Transfusion International Journal","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Hematology & Transfusion International Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/htij.2023.11.00319","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Clear cell carcinoma is structures of Mullerian origin, they are associated with mutations in TP53 as they are a high-grade neoplasm, however there is no immunophenotypic pattern that guides us if the origin is from the ovary, uterus, endocervix or endometrium. A 71-year-old female patient who underwent surgery for a right parauterine tumor with a pathological report that corresponded to a clear cell tumor. Subsequently, a staging and cytoreductive laparotomy was performed, performing abdominal cavity lavage, salpingo-oophorectomy of the remaining ovary (left), and pelvic and paraortic lymphadenectomy. , omentectomy and biopsies of the parietal peritoneum, all the material was negative for metastatic disease, 18 months later there was a relapse in the vaginal vault, with the presence of an ovoid tumor measuring 10 cm in diameter, treated with colpectomy, with a report of clear cell carcinoma with CK7+ / Napsin A+ / p53+ protein immunophenotype, with a satisfactory disease-free postoperative period.