International Journal of Contemporary Pediatrics最新文献

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Assessment of the prevalence of meningitis in clinically suspected cases of early and late onset neonatal sepsis 评估早期和晚期新生儿败血症临床疑似病例中脑膜炎的发病率

International Journal of Contemporary Pediatrics Pub Date : 2024-01-25 DOI: 10.18203/2349-3291.ijcp20240090

C. P. Singh, Swadha Seep

{"title":"Assessment of the prevalence of meningitis in clinically suspected cases of early and late onset neonatal sepsis","authors":"C. P. Singh, Swadha Seep","doi":"10.18203/2349-3291.ijcp20240090","DOIUrl":"https://doi.org/10.18203/2349-3291.ijcp20240090","url":null,"abstract":"Background: Meningitis is more common in the neonatal period than any other time in life and is an important cause of morbidity and mortality globally. In India, rate of neonatal sepsis is reported 0.5 per 1000 live births. The major burden of neonatal sepsis and meningitis occurs in the developing world. According to WHO estimates there are approximately 5 million neonatal deaths in a year. The objective of the study is to assess the prevalence of meningitis in neonates with clinical suspicion of sepsis.\u0000Methods: The study was conducted among suspected cases of neonatal septicemia in neonatal intensive care unit (NICU), department of pediatrics, VPIMS, Lucknow. It is a prospective observational study. A total of 180 neonates were included in the study.\u0000Results: Out of 180 neonates, CSF examination of 131 (72.78%) neonates was normal, of 37 (20.56%) was suggestive of meningitis. Prevalence of meningitis in neonatal sepsis was 20.0%. It was 18.0% in early neonatal sepsis and 32.6% in late neonatal sepsis cases.\u0000Conclusions: The findings of present study suggested that there is a high risk of meningitis among neonatal sepsis cases. Cases with risk factors like twin birth, anemia, low TLC, low platelet count, acid-base imbalance and X-ray findings suggestive of pneumonitis should be kept in a high-risk category.","PeriodicalId":507602,"journal":{"name":"International Journal of Contemporary Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140495141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hemophagocytic lymphohistiocytosis-a rare life threatening association with scrub typhus: case report 嗜血细胞淋巴组织细胞增多症--一种罕见的与恙虫病相关的危及生命的疾病：病例报告

International Journal of Contemporary Pediatrics Pub Date : 2024-01-04 DOI: 10.18203/2349-3291.ijcp20240003

Arashdeep Virk, Mohit Singla, Pranay Trivedi, Prasun Bhattacharjee, Abhinav Tiwari

{"title":"Hemophagocytic lymphohistiocytosis-a rare life threatening association with scrub typhus: case report","authors":"Arashdeep Virk, Mohit Singla, Pranay Trivedi, Prasun Bhattacharjee, Abhinav Tiwari","doi":"10.18203/2349-3291.ijcp20240003","DOIUrl":"https://doi.org/10.18203/2349-3291.ijcp20240003","url":null,"abstract":"Scrub typhus is an important cause of acute febrile illness and one of the re-emerging infectious diseases in India particularly in southern Rajasthan. Hemophagocytic lympho-histiocytosis (HLH) results from an uncontrolled and ineffective hyperinflammatory response to a variety of triggers. HLH is further subdivided into primary and secondary type. We present a case of Scrub typhus which presented with multiple organ dysfunction syndrome (MODS) and secondary HLH which is a rare entity. A 9-month-old male child presented with high grade fever with encephalopathy. Examination showed hepatosplenomegaly, cervical Lymph adenopathy with eschar mark visible on abdomen. Scrub typhus was suspected on clinical grounds and further investigations were done. Serological diagnosis was strongly positive for scrub typhus. Initially, child did not respond to doxycycline, so further investigations were done to rule out HLH which fits into criteria of secondary HLH as per the revised HLH 2004 protocol. In view of secondary HLH and MODS methylprednisolone was added to treatment. Child responded to steroids and there was complete recovery. Scrub typhus patient with progressive MODS, in spite of appropriate antimicrobial therapy should raise the suspicion of secondary HLH which is rare but life-threatening condition and steroids plays an important role in the management of this condition.","PeriodicalId":507602,"journal":{"name":"International Journal of Contemporary Pediatrics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139385715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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