Inorganics Pub Date : 2024-06-04 DOI: 10.3390/inorganics12060160

Oana Silvana Sarău, E. Moacă, Alexandra Semenescu, Raluca Dumitru, Alex-Robert Jîjie, Marioara Poenaru, C. Dehelean, A. Chevereșan

{"title":"Physicochemical and Toxicological Screening of Silver Nanoparticle Biosynthesis from Punica granatum Peel Extract","authors":"Oana Silvana Sarău, E. Moacă, Alexandra Semenescu, Raluca Dumitru, Alex-Robert Jîjie, Marioara Poenaru, C. Dehelean, A. Chevereșan","doi":"10.3390/inorganics12060160","DOIUrl":"https://doi.org/10.3390/inorganics12060160","url":null,"abstract":"Silver nanoparticles (AgNPs) were successfully synthesized via the biological route using a 1 M silver nitrate (AgNO3) aqueous solution and an ethanolic peel extract of Punica granatum (Pg), at 60 °C. The physicochemical analysis revealed the formation of green synthesized Pg-AgNPs with a semi-spherical shape, non-uniformly distributed, and a particle size distribution between 5 and 100 nm. As regards the preliminary in vitro toxicological screening, the green synthesized Pg-AgNPs did not significantly affect the neonatal BALB/c epidermal cells’ viability (JB6 Cl 41-5a) at lower concentrations and did not produce visible changes in the morphology of the JB6 Cl 41-5a cells. In contrast, at higher concentrations (>50 μg/mL), the green Pg-AgNPs exhibited an important decrease in cell viability and confluency. In addition, the impact of Pg-AgNPs on cell membrane integrity suggests a potential cytotoxic effect. Contrary to the in vitro assays, after the evaluation of the anti-irritant effect in ovo, the lower concentration of Pg-AgNPs (10 μg/mL) produced hemorrhage and lysis when applied to the chorioallantoic membrane, while at 50 μg/mL, only slight coagulation was observed. Therefore, regarding the in ovo toxicological screening, the higher concentration of the Pg-AgNPs exhibited a better safety profile compared to the lower concentration, as indicated by the irritation score.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141266001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mononuclear Fe(III) Schiff Base Complex with Trans-FeO4N2 Chromophore of o-Aminophenol Origin: Synthesis, Characterisation, Crystal Structure, and Spin State Investigation 邻氨基苯酚来源的反式 FeO4N2 色素的单核 Fe(III) 希夫碱配合物：合成、表征、晶体结构和自旋态研究

Inorganics Pub Date : 2024-06-03 DOI: 10.3390/inorganics12060159

Dawit Tesfaye, Jonas Braun, Mamo Gebrezgiabher, J. Kuchár, J. Černák, Taju Sani, A. Gismelseed, Tim Hochdörffer, Volker Schünemann, C. Anson, Annie K. Powell, Madhu Thomas

引用次数: 0

Evaluation of DNA and BSA-Binding, Nuclease Activity, and Anticancer Properties of New Cu(II) and Ni(II) Complexes with Quinoline-Derived Sulfonamides 评估喹啉衍生磺酰胺的新 Cu(II) 和 Ni(II) 复合物的 DNA 和 BSA 结合力、核酸酶活性以及抗癌特性

Inorganics Pub Date : 2024-06-01 DOI: 10.3390/inorganics12060158

Tamara Tŏpala, Ionel Fizeșan, Andreea-Elena Petru, A. Castiñeiras, A. Bodoki, L. Oprean, Marcos Escolano, Gloria Alzuet-Piña

{"title":"Evaluation of DNA and BSA-Binding, Nuclease Activity, and Anticancer Properties of New Cu(II) and Ni(II) Complexes with Quinoline-Derived Sulfonamides","authors":"Tamara Tŏpala, Ionel Fizeșan, Andreea-Elena Petru, A. Castiñeiras, A. Bodoki, L. Oprean, Marcos Escolano, Gloria Alzuet-Piña","doi":"10.3390/inorganics12060158","DOIUrl":"https://doi.org/10.3390/inorganics12060158","url":null,"abstract":"Four complexes of essential metal ions, Cu(II) and Ni(II), with the new sulfonamide ligand N-(pyridin-2-ylmethyl)quinoline-8-sulfonamide (HQSMP) were synthesized and physicochemically and structurally characterized. Complex [Cu(QSMP)Cl]n (2) consists of a polymeric chain formed by distorted square pyramidal units. In 2, the sulfonamide ligand acts as a bridge coordinating to one Cu(II) through its three N atoms and to another metal ion via one O atom in the sulfonamido group, while the pentacoordinate complex [Cu(QSMP)(C6H5COO)] (3) presents a highly distorted square pyramidal geometry. Complex [Ni(QSMP)(C6H5COO)(CH3OH)][Ni(QSMP)(CH3COO)(CH3OH)] (4) consists of two mononuclear entities containing different anion coligands, either a benzoate or an acetate group. Both units exhibit a distorted octahedral geometry. The interaction of the complexes with CT-DNA was studied by means of UV-Vis and fluorescence spectroscopy, interestingly revealing that the Ni(II) complex presents the highest affinity towards the nucleic acid. Complexes 1 and 2 are able to cleave DNA. Both compounds show promising nuclease activity at relatively low concentrations by mediating the production of a reactive oxygen species (ROS). The interaction of the four complexes with bovine serum albumin (BSA) was also investigated, showing that the compounds can bind to serum proteins. The antitumor potential of complexes 1 and 2 was evaluated against the A549 lung adenocarcinoma cell line, revealing cytotoxic properties that were both dose- and time-dependent.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141278740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Silver(I) and Copper(I) Complexes of Dicarboxylic Acid Derivatives: Synthesis, Characterization and Thermal Studies 二羧酸衍生物的银（I）和铜（I）配合物：合成、表征和热研究

Inorganics Pub Date : 2024-05-14 DOI: 10.3390/inorganics12050140

Katharina Hankel née Reinhold, Fabian Burzlaff, B. Beele, Fabian Mohr

引用次数: 0

Supramolecular Assemblies in Mn (II) and Zn (II) Metal–Organic Compounds Involving Phenanthroline and Benzoate: Experimental and Theoretical Studies 涉及菲罗啉和苯甲酸的 Mn (II) 和 Zn (II) 金属有机化合物的超分子组装：实验和理论研究

Inorganics Pub Date : 2024-05-13 DOI: 10.3390/inorganics12050139

Mridul Boro, Subham Banik, R. Gomila, Antonio Frontera, M. Barceló-Oliver, M. Bhattacharyya

{"title":"Supramolecular Assemblies in Mn (II) and Zn (II) Metal–Organic Compounds Involving Phenanthroline and Benzoate: Experimental and Theoretical Studies","authors":"Mridul Boro, Subham Banik, R. Gomila, Antonio Frontera, M. Barceló-Oliver, M. Bhattacharyya","doi":"10.3390/inorganics12050139","DOIUrl":"https://doi.org/10.3390/inorganics12050139","url":null,"abstract":"Two new Mn(II) and Zn(II) metal–organic compounds of 1,10-phenanthroline and methyl benzoates viz. [Mn(phen)2Cl2]2-ClBzH (1) and [Zn(4-MeBz)2(2-AmPy)2] (2) (where 4-MeBz = 4-methylbenzoate, 2-AmPy = 2-aminopyridine, phen = 1,10-phenanthroline, 2-ClBzH = 2-chlorobenzoic acid) were synthesized and characterized using elemental analysis, TGA, spectroscopic (FTIR, electronic) and single crystal X-ray diffraction techniques. The crystal structure analysis of the compounds revealed the presence of various non-covalent interactions, which provides stability to the crystal structures. The crystal structure analysis of compound 1 revealed the formation of a supramolecular dimer of 2-ClBzH enclathrate within the hexameric host cavity formed by the neighboring monomeric units. Compound 2 is a mononuclear compound of Zn(II) where flexible binding topologies of 4-CH3Bz are observed with the metal center. Moreover, various non-covalent interactions, such as lp(O)-π, lp(Cl)-π, C–H∙∙∙Cl, π-stacking interactions as well as N–H∙∙∙O, C–H∙∙∙O and C–H∙∙∙π hydrogen bonding interactions, are found to be involved in plateauing the molecular self-association of the compounds. The remarkable enclathration of the H-bonded 2-ClBzH dimer into a supramolecular cavity formed by two [Mn(phen)2Cl2] complexes were further studied theoretically using density functional theory (DFT) calculations, the non-covalent interaction (NCI) plot index and quantum theory of atoms in molecules (QTAIM) computational tools. Synergistic effects were also analyzed using molecular electrostatic potential (MEP) surface analysis.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140984737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of Ferric Chloride in Yeast Growth Media, by Sugars and Aluminum 糖和铝对酵母生长培养基中氯化铁的还原作用

Inorganics Pub Date : 2024-05-10 DOI: 10.3390/inorganics12050137

K. Mažeika, V. Melvydas, Dovilė Čepukoit

引用次数: 0

Coordination Compounds of Nickel(II) with 3,5–Dibromo–Salicylaldehyde: Structure and Interaction with Biomolecules 镍（II）与 3,5-二溴水杨醛的配位化合物：结构及与生物分子的相互作用

Inorganics Pub Date : 2024-05-10 DOI: 10.3390/inorganics12050138

Georgios I. Psarras, Ariadni Zianna, A. Hatzidimitriou, G. Psomas

引用次数: 0

Highly Biocompatible Hemoglobin-Stabilized Gold Nanoparticles for an Enhanced Catalytic Reduction of 4-Nitrophenol 用于增强 4-硝基苯酚催化还原的高生物相容性血红蛋白稳定金纳米粒子

Inorganics Pub Date : 2024-05-05 DOI: 10.3390/inorganics12050136

Yanshuai Cui, Shukai Li, Ning Yu, Xiaodong Yu, Xianbing Ji, Longgang Wang

{"title":"Highly Biocompatible Hemoglobin-Stabilized Gold Nanoparticles for an Enhanced Catalytic Reduction of 4-Nitrophenol","authors":"Yanshuai Cui, Shukai Li, Ning Yu, Xiaodong Yu, Xianbing Ji, Longgang Wang","doi":"10.3390/inorganics12050136","DOIUrl":"https://doi.org/10.3390/inorganics12050136","url":null,"abstract":"4-nitrophenol (4-NP) is a frequently encountered toxic phenolic organic pollutant in water. It is important to develop a simple method to treat 4-NP. Small and monodispersed gold nanoparticles often have good catalytic performance of 4-NP. Hemoglobin (Hb) is a kind of common and important protein in organisms. Herein, highly biocompatible bovine hemoglobin-stabilized gold nanoparticles (Aun-Hb NPs) were synthesized using hemoglobin as a biological template. Then, the size, zeta potential, and composition of Aun-Hb NPs were investigated by transmission electron microscopy, dynamic light scattering, and X-ray photoelectron spectroscopy. The Aun-Hb NPs with small gold nanoparticles of about 1.4–2.4 nm had good catalytic capabilities in reducing 4-NP to form 4-aminophenol. Au20-Hb NPs demonstrated superior catalytic efficiency in the reduction of 4-NP when compared to other nanoparticles. Moreover, as-synthesized Au20-Hb NPs exhibited excellent biocompatibility through the MTT experiment. The method of preparation of gold nanoparticles offers one way to prepare metal nanoparticles for good potential catalytic applications of gold nanoparticles.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141011400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elucidating the Structural Features of Bis(arylimino)acenaphthene (Aryl-BIAN) Bismuth Complexes: A Combined Single-Crystal X-ray Diffraction and Hirshfeld Analysis Approach 阐明双(芳基亚氨基)苊(Aryl-BIAN)铋配合物的结构特征：单晶 X 射线衍射与希尔施菲尔德分析相结合的方法

Inorganics Pub Date : 2024-05-04 DOI: 10.3390/inorganics12050135

Beatriz P. Machado, Maria Celador-Garcia, Vitor Rosa, Clara S. B. Gomes

引用次数: 0

Mechanism of Anti-Trypanosoma cruzi Action of Gold(I) Compounds: A Theoretical and Experimental Approach 金（I）化合物的抗锥虫作用机制：理论与实验方法

Inorganics Pub Date : 2024-05-03 DOI: 10.3390/inorganics12050133

Javiera Órdenes-Rojas, Paola Risco, José Ortega-Campos, Germán Barriga-González, Ana Liempi, U. Kemmerling, D. Gambino, L. Otero, Claudio Olea Azar, Esteban Rodríguez-Arce

{"title":"Mechanism of Anti-Trypanosoma cruzi Action of Gold(I) Compounds: A Theoretical and Experimental Approach","authors":"Javiera Órdenes-Rojas, Paola Risco, José Ortega-Campos, Germán Barriga-González, Ana Liempi, U. Kemmerling, D. Gambino, L. Otero, Claudio Olea Azar, Esteban Rodríguez-Arce","doi":"10.3390/inorganics12050133","DOIUrl":"https://doi.org/10.3390/inorganics12050133","url":null,"abstract":"In the search for a more effective chemotherapy for the treatment of Chagas’ disease, caused by Trypanosoma cruzi parasite, the use of gold compounds may be a promising approach. In this work, four gold(I) compounds [AuCl(HL)], (HL = bioactive 5-nitrofuryl containing thiosemicarbazones) were studied. The compounds were theoretically characterized, showing identical chemical structures with the metal ion located in a linear coordination environment and the thiosemicarbazones acting as monodentate ligands. Cyclic voltammetry and Electron Spin Resonance (ESR) studies demonstrated that the complexes could generate the nitro anion radical (NO2−) by reduction of the nitro moiety. The compounds were evaluated in vitro on the trypomastigote form of T. cruzi and human cells of endothelial morphology. The gold compounds studied showed activity in the micromolar range against T. cruzi. The most active compounds (IC50 of around 10 μM) showed an enhancement of the antiparasitic activity compared with their respective bioactive ligands and moderate selectivity. To get insight into the anti-chagasic mechanism of action, the intracellular free radical production capacity of the gold compounds was assessed by ESR and fluorescence measurements. DMPO (5,5-dimethyl-1-pirroline-N-oxide) spin adducts related to the bioreduction of the complexes and redox cycling processes were characterized. The potential oxidative stress mechanism against T. cruzi was confirmed.","PeriodicalId":507601,"journal":{"name":"Inorganics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141016292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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