发布求助
文献互助 智能选刊 最新文献

Future Science OA最新文献

筛选
英文 中文
Computational drug–drug interaction prediction mediated by CYP450 isoforms of Ilaprazole coadministered with clopidogrel 由伊拉唑与氯吡格雷联合用药的 CYP450 同工酶介导的计算药物相互作用预测
Future Science OA Pub Date : 2024-05-17 DOI: 10.2144/fsoa-2023-0277
Priyadharshini Ananthathandavan, Damodharan Narayanasamy
{"title":"Computational drug–drug interaction prediction mediated by CYP450 isoforms of Ilaprazole coadministered with clopidogrel","authors":"Priyadharshini Ananthathandavan, Damodharan Narayanasamy","doi":"10.2144/fsoa-2023-0277","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0277","url":null,"abstract":"","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin 花青素的口服毒性和安全性评估：花青素的急性和亚急性研究
Future Science OA Pub Date : 2024-05-17 DOI: 10.2144/fsoa-2023-0322
S. Suresh, Chitra Vellapandian
{"title":"Assessment of oral toxicity and safety profile of cyanidin: acute and subacute studies on anthocyanin","authors":"S. Suresh, Chitra Vellapandian","doi":"10.2144/fsoa-2023-0322","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0322","url":null,"abstract":"","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"111 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141126535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report 源于胃标志环细胞癌的膀胱转移：病例报告
Future Science OA Pub Date : 2024-02-07 DOI: 10.2144/fsoa-2023-0127
M. Moalla, Rania Hajji, S. Charfi, M. Boudabous, H. Gdoura, L. Mnif, A. Amouri, T. Boudawara, L. Chtourou, N. Tahri
{"title":"Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report","authors":"M. Moalla, Rania Hajji, S. Charfi, M. Boudabous, H. Gdoura, L. Mnif, A. Amouri, T. Boudawara, L. Chtourou, N. Tahri","doi":"10.2144/fsoa-2023-0127","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0127","url":null,"abstract":"Bladder metastasis of gastric adenocarcinoma is a rare phenomenon. Hereby, we report a case of a 52-year-old patient who presented with upper gastro-intestinal bleeding and ascites and was diagnosed with gastric signet-ring cell carcinoma. A CT scan revealed peritoneal infiltration and anterior parietal thickening of bladder wall. Cystoscopy showed three budding lesions of the anterior wall of the bladder. He had an endoscopic resection. Histology concluded that the bladder was infiltrated by a poorly differentiated carcinoma with independent cells consistent with a gastric origin. The patient was to be treated with palliative chemotherapy.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"61 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139854832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical and biological language models in molecular design: opportunities, risks and scientific reasoning 分子设计中的化学和生物语言模型：机遇、风险和科学推理
Future Science OA Pub Date : 2024-02-07 DOI: 10.2144/fsoa-2023-0318
Jürgen Bajorath
{"title":"Chemical and biological language models in molecular design: opportunities, risks and scientific reasoning","authors":"Jürgen Bajorath","doi":"10.2144/fsoa-2023-0318","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0318","url":null,"abstract":"","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"19 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139856427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report 源于胃标志环细胞癌的膀胱转移：病例报告
Future Science OA Pub Date : 2024-02-07 DOI: 10.2144/fsoa-2023-0127
M. Moalla, Rania Hajji, S. Charfi, M. Boudabous, H. Gdoura, L. Mnif, A. Amouri, T. Boudawara, L. Chtourou, N. Tahri
{"title":"Bladder metastasis originating from gastric signet-ring cell carcinoma: a case report","authors":"M. Moalla, Rania Hajji, S. Charfi, M. Boudabous, H. Gdoura, L. Mnif, A. Amouri, T. Boudawara, L. Chtourou, N. Tahri","doi":"10.2144/fsoa-2023-0127","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0127","url":null,"abstract":"Bladder metastasis of gastric adenocarcinoma is a rare phenomenon. Hereby, we report a case of a 52-year-old patient who presented with upper gastro-intestinal bleeding and ascites and was diagnosed with gastric signet-ring cell carcinoma. A CT scan revealed peritoneal infiltration and anterior parietal thickening of bladder wall. Cystoscopy showed three budding lesions of the anterior wall of the bladder. He had an endoscopic resection. Histology concluded that the bladder was infiltrated by a poorly differentiated carcinoma with independent cells consistent with a gastric origin. The patient was to be treated with palliative chemotherapy.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"105 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139794760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chemical and biological language models in molecular design: opportunities, risks and scientific reasoning 分子设计中的化学和生物语言模型：机遇、风险和科学推理
Future Science OA Pub Date : 2024-02-07 DOI: 10.2144/fsoa-2023-0318
Jürgen Bajorath
{"title":"Chemical and biological language models in molecular design: opportunities, risks and scientific reasoning","authors":"Jürgen Bajorath","doi":"10.2144/fsoa-2023-0318","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0318","url":null,"abstract":"","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"14 1‐2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139796520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required 化学方法有助于只进行 CRISPR 的人类 iPSC 生成，并最大限度地减少所需靶向基因座的数量
Future Science OA Pub Date : 2024-02-06 DOI: 10.2144/fsoa-2023-0257
Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr
{"title":"A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required","authors":"Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr","doi":"10.2144/fsoa-2023-0257","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0257","url":null,"abstract":"Aim: We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Methods: Minimal number of human-specific guide RNAs targeting a limited set of loci were used with a unique cocktail of small molecules (CRISPRa-SM). Results: iPSC clones were efficiently generated by CRISPRa-SM, expressed general and naive iPSC markers and clustered with high-quality iPSCs generated using conventional reprogramming methods. iPSCs showed genomic stability and robust pluripotent potential as assessed by in vitro and in vivo. Conclusion: CRISPRa-SM-generated human iPSCs by direct and multiplexed loci activation facilitating a unique and potentially safer cellular reprogramming process to aid potential applications in cellular therapy and regenerative medicine.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"424 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required 化学方法有助于只进行 CRISPR 的人类 iPSC 生成，并最大限度地减少所需靶向基因座的数量
Future Science OA Pub Date : 2024-02-06 DOI: 10.2144/fsoa-2023-0257
Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr
{"title":"A chemical approach facilitates CRISPRa-only human iPSC generation and minimizes the number of targeted loci required","authors":"Ramzey Abujarour, Jason Dinella, Mochtar Pribadi, Lauren K Fong, Matthew Denholtz, Alma Gutierrez, Matt Haynes, Enaaya Mahmood, Tom T Lee, Sheng Ding, Bahram Valamehr","doi":"10.2144/fsoa-2023-0257","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0257","url":null,"abstract":"Aim: We explored the generation of human induced pluripotent stem cells (iPSCs) solely through the transcriptional activation of endogenous genes by CRISPR activation (CRISPRa). Methods: Minimal number of human-specific guide RNAs targeting a limited set of loci were used with a unique cocktail of small molecules (CRISPRa-SM). Results: iPSC clones were efficiently generated by CRISPRa-SM, expressed general and naive iPSC markers and clustered with high-quality iPSCs generated using conventional reprogramming methods. iPSCs showed genomic stability and robust pluripotent potential as assessed by in vitro and in vivo. Conclusion: CRISPRa-SM-generated human iPSCs by direct and multiplexed loci activation facilitating a unique and potentially safer cellular reprogramming process to aid potential applications in cellular therapy and regenerative medicine.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"5 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139800396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico 改进新墨西哥州一家急性康复医院的快速反应系统
Future Science OA Pub Date : 2024-02-06 DOI: 10.2144/fsoa-2023-0162
Reza Ehsanian, Jimmy To, David Mork, Melissa Owens, William F Gensler, Rebecca Dutton, John Henry Sloan
{"title":"Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico","authors":"Reza Ehsanian, Jimmy To, David Mork, Melissa Owens, William F Gensler, Rebecca Dutton, John Henry Sloan","doi":"10.2144/fsoa-2023-0162","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0162","url":null,"abstract":"Aim: Enhance the Rapid Response System (RRS) in a free-standing acute rehabilitation hospital (ARH) by improving announcements, crash cart standardization and role assignments. Materials & methods: Pre-intervention (PreIQ) and post-intervention questionnaires (PostIQ), conducted in English and utilizing a Likert scale, were distributed in-person to clinical staff, yielding a 100% response rate. The questionnaire underwent no prior testing. The PreIQ were disseminated in February 2021, and PostIQ in December 2022. Results: PostIQ illustrated the improvement of audibility and improved the clarity of roles. The training positively impacted the RRS in the ARH. Conclusion: This study highlights the value of continuous RRS improvement in ARHs. Interventions led to notable enhancements, emphasizing the need for sustained efforts and future research on broader implementation.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"122 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139858966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico 改进新墨西哥州一家急性康复医院的快速反应系统
Future Science OA Pub Date : 2024-02-06 DOI: 10.2144/fsoa-2023-0162
Reza Ehsanian, Jimmy To, David Mork, Melissa Owens, William F Gensler, Rebecca Dutton, John Henry Sloan
{"title":"Improvement of the rapid response system at an acute rehabilitation hospital in New Mexico","authors":"Reza Ehsanian, Jimmy To, David Mork, Melissa Owens, William F Gensler, Rebecca Dutton, John Henry Sloan","doi":"10.2144/fsoa-2023-0162","DOIUrl":"https://doi.org/10.2144/fsoa-2023-0162","url":null,"abstract":"Aim: Enhance the Rapid Response System (RRS) in a free-standing acute rehabilitation hospital (ARH) by improving announcements, crash cart standardization and role assignments. Materials & methods: Pre-intervention (PreIQ) and post-intervention questionnaires (PostIQ), conducted in English and utilizing a Likert scale, were distributed in-person to clinical staff, yielding a 100% response rate. The questionnaire underwent no prior testing. The PreIQ were disseminated in February 2021, and PostIQ in December 2022. Results: PostIQ illustrated the improvement of audibility and improved the clarity of roles. The training positively impacted the RRS in the ARH. Conclusion: This study highlights the value of continuous RRS improvement in ARHs. Interventions led to notable enhancements, emphasizing the need for sustained efforts and future research on broader implementation.","PeriodicalId":507258,"journal":{"name":"Future Science OA","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139799172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信