Drug Delivery Letters最新文献

{"title":"Formulation and Evaluation of Niosomal Loaded Transdermal Patches for\u0000the Treatment of Osteoarthritis","authors":"Kajal, D. Sharma, Vinay Pandit, M. Ashawat","doi":"10.2174/0122103031283166240619043041","DOIUrl":"https://doi.org/10.2174/0122103031283166240619043041","url":null,"abstract":"\u0000\u0000Osteoarthritis (OA) is a degenerative joint disease resulting from the\u0000breakdown of joint cartilage and underlying bone. The most common symptoms of osteoarthritis\u0000are joint pain and stiffness. The major hurdle in its treatment is that the oral administration of\u0000NSAIDs (Lornoxicam) causes side effects like GI side effects, cardiovascular problems, liver issues, or renal problems. Thus, there is a need to develop a Transdermal drug delivery system for\u0000the transport of drugs, which reduces side effects and has several benefits over oral delivery, and\u0000a Novel drug delivery system to enhance the permeation of drugs and give relief from symptoms\u0000of OA.\u0000\u0000\u0000\u0000This work deals with the formulation and evaluation of niosomal-loaded Transdermal\u0000Patches for the treatment of Osteoarthritis.\u0000\u0000\u0000\u0000The Niosomes were prepared using the thin film hydration method, and Niosomalloaded Transdermal patches were prepared using the Solvent Casting method. The preliminary\u0000evaluation and characterization studies were conducted to find the optimized formulation. The invitro release and ex-vivo permeation studies were investigated. Stability studies were also assessed.\u0000\u0000\u0000\u0000The prepared Niosomes suspension (F2) was found to have particle size 320.2 nm, Zeta\u0000potential 23.9 mV, and Drug entrapment 79 ± 0.32%. The in-vitro drug release studies of optimized formulation show 96.44 ± 0.34 % drug release for 24 hours. Then, the optimized Niosome\u0000formulation (F2) was loaded into the transdermal patches. The in-vitro permeation studies of Niosomal-loaded transdermal patch F1 (NLXTP) were performed, which showed a higher permeability than plain drug-loaded transdermal patch. F1 (NLXTP) followed Zero order release kinetic\u0000model, which shows a non-fickian controlled release diffusion mechanism. The ex-vivo drug release studies of optimized formulation F1 (NLXTP) show 2.79 ± 0.76 (µg/ml) drug permeated for\u00008 hours with a flux value of 0.35 ± 0.55, and the percentage of drug retention was found to be\u00005.67%. The stability studies showed that patches were stable over 90 days in different atmospheric conditions.\u0000\u0000\u0000\u0000The Lornoxicam-loaded Niosomal transdermal patch was found to be a promising\u0000nano-drug-delivery alternative that showed better entrapment and release with a permeation profile for the daily management of osteoarthritis.\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141687278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Conventional to Cutting-Edge: A Comprehensive Review on Drug Delivery Systems","authors":"Akash Vikal, Rashmi Maurya, Shuvadip Bhowmik, Preeti Patel, Ghanshyam Das Gupta, B. Kurmi","doi":"10.2174/0122103031304556240430161553","DOIUrl":"https://doi.org/10.2174/0122103031304556240430161553","url":null,"abstract":"\u0000\u0000The essential need for efficacious conveyance of therapeutics to specific tissues or cells, refinement of drug formulations, and the scalability of industrial production drives the pre-sent-day demand for enhanced drug delivery systems (DDS). Newly devised drugs often exhibit suboptimal biopharmaceutical properties, resulting in diminished patient adherence and adverse side effects. The paramount importance of site-specific drug delivery lies in its capacity to facili-tate the targeted administration of diverse therapeutic agents, catering to both localized ailments and systemic treatments. Alongside targeted drug delivery strategies encompassing ligand-based targeting and stimuli-responsive systems, the advent of cutting-edge nanotechnologies such as nanoparticles, liposomes, and micelles has marked a paradigm shift. Additionally, personalized medicines have emerged as a consequential facet of drug delivery, emphasizing the customization of treatment approaches. Researchers have explored an excess of methodologies in the advance-ment of these formulation technologies, including stimuli-responsive drug delivery, 3D printing, gene delivery, and various other innovative approaches. This comprehensive review aims to pro-vide a holistic understanding of the past, present, and future of drug delivery systems, offering in-sights into the transformative potential of emerging technologies.\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":" 38","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140996485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Orally Disintegrating Tablet: Properties, Formulation and Production","authors":"K. M. Yee, Najwa Mohamad, P. Kee, Yik-Ling Chew, Siew-Keah Lee, Vijayakumar Lakshminarayanan, Ching Siang Tan, K. Liew","doi":"10.2174/0122103031291909240317162755","DOIUrl":"https://doi.org/10.2174/0122103031291909240317162755","url":null,"abstract":"\u0000\u0000Healthcare practitioners, patients, and consumers widely recognize the convenience as-sociated with administering oral tablets. The emergence of orally disintegrating tablets (ODTs) represents a significant advancement in solid dosage forms, facilitating more convenient oral de-livery while maintaining medication safety, effectiveness, and quality. The ODTs market is ex-pected to experience continuous growth in the coming years despite the internal challenges faced by commercial manufacturers. This paper initiates a comprehensive discussion of the properties of ODTs, including palatability and taste, drug content, disintegration, mechanical strength, mois-ture content, safety, and efficacy. The formulation factors that affect each of these qualities are also discussed. Additionally, this review delves into the processes of the production of ODTs, en-compassing the approaches and technologies from the mixing of active ingredients and recipients to the formation and packaging of ODTs. This review provides valuable insights into the ad-vancement in ODTs technology, aiming to equip researchers with the knowledge necessary to improve quality and optimize efficiency, ultimately receiving high acceptance from patients or consumers.\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":"6 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140227356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Applying the SeDeM Expert Diagram System for Characterisation of Multiple Component Powder Mixtures for Fixed-dose Combination Matrix-type Tablet Formulations","authors":"Hannlie Hamman, J. Steenekamp, J. Hamman, Christi A. Wilkins","doi":"10.2174/0122103031284291240306071000","DOIUrl":"https://doi.org/10.2174/0122103031284291240306071000","url":null,"abstract":"\u0000\u0000The SeDeM Expert Diagram System (SeDeM EDS) is an innovative formulation tool that provides an index of compressibility, which can be used to predict a pow-der’s suitability for direct compression to produce acceptable tablets.\u0000\u0000\u0000\u0000This study investigated the application of this tool to evaluate multiple component powder formulation mixtures for direct compression of tablets. The SeDeM EDS was specifically used to characterize powder mixtures for fixed-dose combination (FDC) matrix-type tablets that contained multiple active ingredients, which has not been done previously with SeDeM EDS.\u0000\u0000\u0000\u0000The FDC matrix-type tablets contained diclofenac sodium and vitamins B1, B6 and B12 in fixed ratios, intended for the management of peripheral neuropathy. The parameters of the SeDeM EDS were determined for the multiple-component powder mixtures and the indices were calculated to predict direct compressibility. The FDC tablets were subsequently manufactured uti-lizing direct compression and subjected to pharmacotechnical test evaluations to measure the ac-curacy of the SeDeM EDS’s predictions.\u0000\u0000\u0000\u0000This study proved the versatility of the SeDeM EDS and its utility to adequately charac-terize FDC powder mixtures for matrix-type tablets manufactured by direct compression. Addi-tionally, a new calculation was suggested to determine the percentage of corrective excipients re-quired in the case when multiple incidence factor values are below the value of 5. Prediction of the correct quantity of corrective excipient to be added is important to obtain an acceptable direct compressible formulation.\u0000\u0000\u0000\u0000The results obtained confirmed that the SeDeM EDS correctly predicted the perfor-mance of all formulations\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":"39 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140229163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Drug Delivery Strategies to Design Orally Dissolving Formulations to Target Tuberculosis: A Futuristic Review","authors":"Pinky Chowrasia, Mohini Singh, Bani Kumar Jana, Pankaj Lochan Bora, Ranjit Kumar Mahato, Rikynjai Kharbithai, Niva Rani Gogoi, Tumpa Sarkar, Paulomi Pal, Bhaskar Mazumder","doi":"10.2174/0122103031267044231031044456","DOIUrl":"https://doi.org/10.2174/0122103031267044231031044456","url":null,"abstract":"\u0000\u0000All the standard anti-tubercular drugs, well established as standard therapy, are prefer-entially available in formulations compliant with the young adult population. However, their use in the paediatric and geriatric populations is confronted with issues, such as a high likelihood of incorrect dose administration due to practices like dosage form fracture and splitting. This may lead to drug resistance due to misuse and in-accurate dosage administration, the most dreaded and difficult-to-treat stage of tuberculosis.\u0000Poor patient compliance and adherence are major issues with the conventional line of therapy. This burden may be more significant in resource-constrained settings, necessitating the creation of simple formulations that are both geriatric and child-friendly. An extensive literature survey has been conducted in this study using databases of Google Scholar, PubMed, and Research Gate, with a focus on specific research works on oro-dispersible films, tablets, and wafer technology loaded with anti-tuberculosis drugs from 2022 to 2010.\u0000Mouth dissolving formulation technology is a very novel approach in the arena of tuberculosis therapy. This may pave the way for future researchers to develop different mouth dissolving for-mulations to treat both pulmonary and extra-tuberculosis. This review paper has summarized all the formulation approaches alongside the present state of the art in tuberculosis therapy using mouth dissolving formulations.\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":"5 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139812190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current Drug Delivery Strategies to Design Orally Dissolving Formulations to Target Tuberculosis: A Futuristic Review","authors":"Pinky Chowrasia, Mohini Singh, Bani Kumar Jana, Pankaj Lochan Bora, Ranjit Kumar Mahato, Rikynjai Kharbithai, Niva Rani Gogoi, Tumpa Sarkar, Paulomi Pal, Bhaskar Mazumder","doi":"10.2174/0122103031267044231031044456","DOIUrl":"https://doi.org/10.2174/0122103031267044231031044456","url":null,"abstract":"\u0000\u0000All the standard anti-tubercular drugs, well established as standard therapy, are prefer-entially available in formulations compliant with the young adult population. However, their use in the paediatric and geriatric populations is confronted with issues, such as a high likelihood of incorrect dose administration due to practices like dosage form fracture and splitting. This may lead to drug resistance due to misuse and in-accurate dosage administration, the most dreaded and difficult-to-treat stage of tuberculosis.\u0000Poor patient compliance and adherence are major issues with the conventional line of therapy. This burden may be more significant in resource-constrained settings, necessitating the creation of simple formulations that are both geriatric and child-friendly. An extensive literature survey has been conducted in this study using databases of Google Scholar, PubMed, and Research Gate, with a focus on specific research works on oro-dispersible films, tablets, and wafer technology loaded with anti-tuberculosis drugs from 2022 to 2010.\u0000Mouth dissolving formulation technology is a very novel approach in the arena of tuberculosis therapy. This may pave the way for future researchers to develop different mouth dissolving for-mulations to treat both pulmonary and extra-tuberculosis. This review paper has summarized all the formulation approaches alongside the present state of the art in tuberculosis therapy using mouth dissolving formulations.\u0000","PeriodicalId":507230,"journal":{"name":"Drug Delivery Letters","volume":"8 5-6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139872210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}