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Rapid Ascent of Hollow Particles in Water Induced by an Electric Field 电场诱导水中空心颗粒快速上升
Powders Pub Date : 2023-12-12 DOI: 10.3390/powders2040046
Hiroshi Kimura
{"title":"Rapid Ascent of Hollow Particles in Water Induced by an Electric Field","authors":"Hiroshi Kimura","doi":"10.3390/powders2040046","DOIUrl":"https://doi.org/10.3390/powders2040046","url":null,"abstract":"A novel method has been proposed to induce rapid upward movement of colloidal particles with a density lower than water by applying an electric field of several V/mm in water. This phenomenon, known as the Electrically Induced Rapid Sedimentation (ERS) effect, marks the first occurrence of ‘rapid upward movement of colloidal particles’ within the scope of this phenomenon. Focusing on hollow particles, an investigation of the ERS effect was conducted through transmittance measurement. The hollow particles in water showed a drastic increase in ascending velocity through the application of an electric field. The ascending velocity raised when increasing the electric field strength. Utilizing a quasi-DC electric field (an extremely low-frequency AC electric field), aggregate structures were captured for the first time.","PeriodicalId":507225,"journal":{"name":"Powders","volume":"261 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139183117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid Dispersions of Fenbendazole with Polymers and Succinic Acid Obtained via Methods of Mechanochemistry: Their Chemical Stability and Anthelmintic Efficiency 通过机械化学方法获得的苯醚甲环唑与聚合物和丁二酸的固体分散体:它们的化学稳定性和驱虫效率
Powders Pub Date : 2023-11-30 DOI: 10.3390/powders2040045
S. Khalikov, Ekaterina A. Khakina, Marat S. Khalikov, A. Varlamova
{"title":"Solid Dispersions of Fenbendazole with Polymers and Succinic Acid Obtained via Methods of Mechanochemistry: Their Chemical Stability and Anthelmintic Efficiency","authors":"S. Khalikov, Ekaterina A. Khakina, Marat S. Khalikov, A. Varlamova","doi":"10.3390/powders2040045","DOIUrl":"https://doi.org/10.3390/powders2040045","url":null,"abstract":"The substance fenbendazole is included in the composition of many anthelmintic drugs, in which the “chemical stability” parameter is one of the main characteristics when obtaining permission for the use of drugs in veterinary practice. Fenbendazole is characterized by low solubility in water and therefore the content of the substance is overestimated in its preparations, which increases the cost of the drug as well as the safety risks of pharmacotherapy. The possibilities of mechanochemical modification of fenbendazole were evaluated in order to improve the solubility index. During the mechanical processing treatment of the substance in the presence of polymeric substances, solid dispersions are formed, which have increased solubility and high anthelmintic activity. The inclusion in these dispersions of the third component, which is succinic acid, did not significantly change the solubility of fenbendazole. In all these dispersions, the substance remained unchanged both during the preparation of its solid dispersions and during their storage. When fenbendazole is modified in an organic solvent medium, the substance is partially converted into oxfendazole, which is one of its metabolites. The chemical stability of fenbendazole was confirmed via HPLC/MS and NMR spectroscopy. The anthelmintic activity of these compositions was evaluated and it was found that they have a high nematicidal activity.","PeriodicalId":507225,"journal":{"name":"Powders","volume":"219 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139203307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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