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Molecular Therapy - Methods & Clinical Development最新文献

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Continuous Manufacturing of Lentiviral Vectors using a Stable Producer Cell Line in a Fixed-Bed Bioreactor 利用固定床生物反应器中的稳定生产细胞系连续生产慢病毒载体
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101209
D. J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Q. Rafiq, Nigel B. Jackson, Andrea C.M. E. Rayat
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引用次数: 0
Optimization of anti-CD19 CAR T-cell production for treatment of patients with chronic lymphocytic leukemia 优化抗 CD19 CAR T 细胞的生产，用于治疗慢性淋巴细胞白血病患者
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101212
Christina Amatya, Katherine A. Weissler, Vicki Fellowes, Norris Lam, Lauren C. Cutmore, Danielle A. Natrakul, S. Highfill, J. Kochenderfer
{"title":"Optimization of anti-CD19 CAR T-cell production for treatment of patients with chronic lymphocytic leukemia","authors":"Christina Amatya, Katherine A. Weissler, Vicki Fellowes, Norris Lam, Lauren C. Cutmore, Danielle A. Natrakul, S. Highfill, J. Kochenderfer","doi":"10.1016/j.omtm.2024.101212","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101212","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"9 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139874793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rationally engineered novel AAV capsids for intra-articular gene delivery 用于关节内基因递送的合理设计的新型 AAV 胶囊
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101211
Wenjun Li, Susi Liu Feng, Lizette Herrschaft, R. Samulski, Chengwen Li
{"title":"Rationally engineered novel AAV capsids for intra-articular gene delivery","authors":"Wenjun Li, Susi Liu Feng, Lizette Herrschaft, R. Samulski, Chengwen Li","doi":"10.1016/j.omtm.2024.101211","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101211","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"5 10","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139873775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optimization of anti-CD19 CAR T-cell production for treatment of patients with chronic lymphocytic leukemia 优化抗 CD19 CAR T 细胞的生产，用于治疗慢性淋巴细胞白血病患者
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101212
Christina Amatya, Katherine A. Weissler, Vicki Fellowes, Norris Lam, Lauren C. Cutmore, Danielle A. Natrakul, S. Highfill, J. Kochenderfer
{"title":"Optimization of anti-CD19 CAR T-cell production for treatment of patients with chronic lymphocytic leukemia","authors":"Christina Amatya, Katherine A. Weissler, Vicki Fellowes, Norris Lam, Lauren C. Cutmore, Danielle A. Natrakul, S. Highfill, J. Kochenderfer","doi":"10.1016/j.omtm.2024.101212","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101212","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"95 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139815072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Continuous Manufacturing of Lentiviral Vectors using a Stable Producer Cell Line in a Fixed-Bed Bioreactor 利用固定床生物反应器中的稳定生产细胞系连续生产慢病毒载体
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101209
D. J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Q. Rafiq, Nigel B. Jackson, Andrea C.M. E. Rayat
{"title":"Continuous Manufacturing of Lentiviral Vectors using a Stable Producer Cell Line in a Fixed-Bed Bioreactor","authors":"D. J. Stibbs, Pedro Silva Couto, Yasuhiro Takeuchi, Q. Rafiq, Nigel B. Jackson, Andrea C.M. E. Rayat","doi":"10.1016/j.omtm.2024.101209","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101209","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"160 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139820141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rationally engineered novel AAV capsids for intra-articular gene delivery 用于关节内基因递送的合理设计的新型 AAV 胶囊
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-02-01 DOI: 10.1016/j.omtm.2024.101211
Wenjun Li, Susi Liu Feng, Lizette Herrschaft, R. Samulski, Chengwen Li
{"title":"Rationally engineered novel AAV capsids for intra-articular gene delivery","authors":"Wenjun Li, Susi Liu Feng, Lizette Herrschaft, R. Samulski, Chengwen Li","doi":"10.1016/j.omtm.2024.101211","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101211","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"56 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139813858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Long Term Stability of Clinical Grade Lentiviral Vectors for Cell Therapy 用于细胞疗法的临床级慢病毒载体的长期稳定性
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-01-01 DOI: 10.1016/j.omtm.2024.101186
J. Jadlowsky, R. Leskowitz, Stephen McKenna, J. Karar, Yujie Ma, Anlan Dai, G. Plesa, Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong, Wei-Ting Hwang, Olivia Farrelly, Julie Barber-Rotenberg, Shannon Christensen, Vanessa E. Gonzalez, A. Chew, J. Fraietta, Carl H June
{"title":"Long Term Stability of Clinical Grade Lentiviral Vectors for Cell Therapy","authors":"J. Jadlowsky, R. Leskowitz, Stephen McKenna, J. Karar, Yujie Ma, Anlan Dai, G. Plesa, Fang Chen, Kathleen Alexander, Jennifer Petrella, Nan Gong, Wei-Ting Hwang, Olivia Farrelly, Julie Barber-Rotenberg, Shannon Christensen, Vanessa E. Gonzalez, A. Chew, J. Fraietta, Carl H June","doi":"10.1016/j.omtm.2024.101186","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101186","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"27 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139455150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization 通过优化囊壳和表达盒改善小鼠中枢神经系统中使用 AAV 载体的细胞特异性重组
Molecular Therapy - Methods & Clinical Development Pub Date : 2024-01-01 DOI: 10.1016/j.omtm.2024.101185
Hayato Kawabata, Ayumu Konno, Y. Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, T. Horii, I. Hatada, Hirokazu Hirai
{"title":"Improving cell-specific recombination using AAV vectors in the murine CNS by capsid and expression cassette optimization","authors":"Hayato Kawabata, Ayumu Konno, Y. Matsuzaki, Yumika Sato, Mika Kawachi, Ryo Aoki, Saki Tsutsumi, Shota Togai, Ryosuke Kobayashi, T. Horii, I. Hatada, Hirokazu Hirai","doi":"10.1016/j.omtm.2024.101185","DOIUrl":"https://doi.org/10.1016/j.omtm.2024.101185","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"124 50","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139453345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Manufacture of CD22 chimeric antigen receptor T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output 经正向和负向选择制造 CD22 嵌合抗原受体 T 细胞，会产生不同的细胞因子分泌谱和γδ T 细胞产量
Molecular Therapy - Methods & Clinical Development Pub Date : 2023-12-01 DOI: 10.1016/j.omtm.2023.101171
Hannah W. Song, M. Benzaoui, Alka Dwivedi, Sarah Underwood, L. Shao, S. Achar, Vesna Posarac, V. Remley, M. Procházková, Yihua Cai, Ping Jin, R. Somerville, David F. Stroncek, G. Altan-Bonnet, Nirali N. Shah, C. D. Chien, Naomi Taylor, S. Highfill
{"title":"Manufacture of CD22 chimeric antigen receptor T cells following positive versus negative selection results in distinct cytokine secretion profiles and γδ T cell output","authors":"Hannah W. Song, M. Benzaoui, Alka Dwivedi, Sarah Underwood, L. Shao, S. Achar, Vesna Posarac, V. Remley, M. Procházková, Yihua Cai, Ping Jin, R. Somerville, David F. Stroncek, G. Altan-Bonnet, Nirali N. Shah, C. D. Chien, Naomi Taylor, S. Highfill","doi":"10.1016/j.omtm.2023.101171","DOIUrl":"https://doi.org/10.1016/j.omtm.2023.101171","url":null,"abstract":"","PeriodicalId":507212,"journal":{"name":"Molecular Therapy - Methods & Clinical Development","volume":"54 7-8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139190558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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