Molecular and Clinical Oncology最新文献_第2页

Treatment algorithm for metastatic malignancies in the lower extremities 下肢转移性恶性肿瘤的治疗算法

Molecular and Clinical Oncology Pub Date : 2024-06-04 DOI: 10.3892/mco.2024.2749

Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Ryosuke Kakinoki, Koji Goto

引用次数: 0

Diaphragmatic clear cell carcinoma with Lynch syndrome after surgery for atypical endometrial hyperplasia and ovarian endometriosis: A case report 因非典型子宫内膜增生症和卵巢子宫内膜异位症接受手术治疗后，膈透明细胞癌伴林奇综合征：病例报告

Molecular and Clinical Oncology Pub Date : 2024-05-16 DOI: 10.3892/mco.2024.2744

M. Ueda, Takafumi Watanabe, T. Momma, Y. Kanke, Asami Kato, Chikako Okabe, Tetsu Sato, Norihito Kamo, Yuta Endo, S. Furukawa, Shu Soeda, K. Fujimori

引用次数: 0

Wnt signaling and tumors (Review) Wnt 信号与肿瘤（综述）

Molecular and Clinical Oncology Pub Date : 2024-05-15 DOI: 10.3892/mco.2024.2743

Huaishi Wang, Lihai Zhang, Chao Hu, Hui Li, Mingyan Jiang

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Refractory insulin resistance and hemophagocytic lymphohistiocytosis following enfortumab vedotin treatment: A case report 恩福单抗维多汀治疗后出现难治性胰岛素抵抗和嗜血细胞淋巴组织细胞增多症：病例报告

Molecular and Clinical Oncology Pub Date : 2024-05-08 DOI: 10.3892/mco.2024.2742

Pierre Rossignon, Le Diep Nguyen, Petra Boegner, Jade Ku, Antoine Herpain

{"title":"Refractory insulin resistance and hemophagocytic lymphohistiocytosis following enfortumab vedotin treatment: A case report","authors":"Pierre Rossignon, Le Diep Nguyen, Petra Boegner, Jade Ku, Antoine Herpain","doi":"10.3892/mco.2024.2742","DOIUrl":"https://doi.org/10.3892/mco.2024.2742","url":null,"abstract":". The increasing incidence of urothelial carcinoma, coupled with advancements in its therapeutic landscape, has resulted in improved survival rates for patients. This, in turn, has led to a growing population of patients requiring special‑ ized oncological care, with Enfortumab vedotin (EV) emerging as a pivotal treatment for metastatic urothelial carcinoma. While EV is associated with hyperglycemia, ketoacidosis is exceedingly rare. To the best of our knowledge, the link between EV and hemophagocytic lymphohistiocytosis (HLH) has not yet been explored. A 56‑year‑old patient diagnosed with metastatic urothelial carcinoma underwent EV treatment as a third‑line treatment after progression following treatment with cisplatin/gemcitabine and pembrolizumab. Notably, after receiving two doses of EV, the patient exhibited refractory insulin resistance, leading to ketoacidosis. Subsequently, HLH emerged, necessitating a treatment regimen involving dexa‑ methasone and etoposide. Despite intensive efforts, the patient experienced septic shock, resulting in death. The present case report highlights refractory insulin resistance and ketoaci‑ dosis, followed by reactive HLH, in the context of EV therapy. The limited literature on these complications demonstrates the need for further research to improve the understanding of the underlying mechanisms. With growing evidence of the efficacy of EV and evolving survival rates in urothelial carcinoma, healthcare professionals must remain vigilant for potential adverse effects, ensuring early recognition and optimal patient care.","PeriodicalId":506973,"journal":{"name":"Molecular and Clinical Oncology","volume":" 37","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141000836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic patterns and treatment options for head and neck cutaneous squamous cell carcinoma (Review) 头颈部皮肤鳞状细胞癌的转移模式和治疗方案（综述）

Molecular and Clinical Oncology Pub Date : 2024-04-24 DOI: 10.3892/mco.2024.2739

D. Iancu, A. Fulga, D. Vesa, A. Zenovia, I. Fulga, M. I. Sarbu, A. Tatu

引用次数: 0

A retrospective, descriptive analysis identifying non‑small cell lung cancer molecular markers 确定非小细胞肺癌分子标记物的回顾性描述分析

Molecular and Clinical Oncology Pub Date : 2024-04-24 DOI: 10.3892/mco.2024.2738

I. Shafiq, Said Isse, Naureen Khan, Mateen Uzebeck, Zaid Zoumot, Safia Shabeer, A. Wahla

引用次数: 0

Solitary large malignant lymphoma in the head and neck region 头颈部单发巨大恶性淋巴瘤

Molecular and Clinical Oncology Pub Date : 2024-04-17 DOI: 10.3892/mco.2024.2737

Dae-Neung Lee, Dong Lee, Joo Koo, Sang Lim

引用次数: 0

Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis 肠道微生物群与胃癌之间的因果关系：双样本孟德尔随机分析

Molecular and Clinical Oncology Pub Date : 2024-04-02 DOI: 10.3892/mco.2024.2736

Jianling Zhang, Chunlu Dong, Yanyan Lin, Lifeng Shang, Junming Ma, Ruiping Hu, Hejing Wang

{"title":"Causal relationship between gut microbiota and gastric cancer: A two‑sample Mendelian randomization analysis","authors":"Jianling Zhang, Chunlu Dong, Yanyan Lin, Lifeng Shang, Junming Ma, Ruiping Hu, Hejing Wang","doi":"10.3892/mco.2024.2736","DOIUrl":"https://doi.org/10.3892/mco.2024.2736","url":null,"abstract":"The gut microbiota is associated with GC; however, the causal association between the gut microbiota and GC remains to be determined. The aim of the present study was to investigate the causal association between gut microbiota and gastric cancer (GC) from the perspective of Mendelian randomization (MR). The present study performed MR analysis using summary statistics from a genome-wide association study of the gut microbiome and GC. Inverse-variance weighted, MR-Egger and weighted median methods were used to investigate the causal relationship between gut microbiota and GC. Heterogeneity tests were performed using Cochrane's Q statistic. Horizontal polytropy was detected using Mendelian Randomization Pleiotropy RESidual Sum and Outlier were eliminated. Estimates from MR indicated that nine gut microorganism remained stable with regard to acceptance of heterogeneity and sensitivity methods. Among them, the genera Prevotella 7, Roseburia and Ruminococcaceae UCG014 were associated with an increased risk of GC; by contrast, the family Enterobacteriaceae, the genera Allisonella, Lachnospiraceae FCS020, Ruminococcaceae UCG004 and Ruminococcaceae UCG009, and the order Enterobacteriales decreased the risk of GC development. The present study demonstrated the potential importance of modulating the abundance of gut microbiota for the prevention and treatment of GC.","PeriodicalId":506973,"journal":{"name":"Molecular and Clinical Oncology","volume":"162 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140751835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Simple predictors for the completion of scheduled gemcitabine‑cisplatin regimens based on real‑world urothelial cancer data 基于真实世界尿路癌数据的吉西他滨-顺铂计划疗程完成情况简单预测指标

Molecular and Clinical Oncology Pub Date : 2024-04-01 DOI: 10.3892/mco.2024.2735

M. Shinohara, S. Hata, Toru Inoue, T. Shibuya, T. Ando, H. Mimata, Toshitaka Shin

{"title":"Simple predictors for the completion of scheduled gemcitabine‑cisplatin regimens based on real‑world urothelial cancer data","authors":"M. Shinohara, S. Hata, Toru Inoue, T. Shibuya, T. Ando, H. Mimata, Toshitaka Shin","doi":"10.3892/mco.2024.2735","DOIUrl":"https://doi.org/10.3892/mco.2024.2735","url":null,"abstract":"Gemcitabine plus cisplatin (GC) is the standard first line of chemotherapy for urothelial carcinoma. However, it is often difficult to complete scheduled GC therapy because of real-world adverse events. Therefore, the reasons behind delays, scheduled cancelations and determined predictive factors for completing scheduled GC therapy were retrospectively analyzed. Patients diagnosed with locally advanced or metastatic urothelial carcinoma from 2009 to 2020 received a 4-week GC therapy schedule in Oita University Hospital. Information was retrospectively extracted from medical records and all cycles were divided into two groups: One wherein all treatments were administered and completed on schedule and the other wherein treatment was either delayed or canceled in during the treatment schedule. Predictive factors were then statistically extracted between the two groups. In total, 70 patients received 201 cycles of a 4-week scheduled GC therapy. Of the 201 cycles, a total of 68 (33.8%) completed all scheduled treatments, while 133 (66.1%) did not complete the treatment as scheduled. In the group where administration was not completed on schedule, the factors of male, ureteral cancer, lower stage, <90% of gemcitabine and cisplatin dosage, solitary kidney, high creatinine level, low estimated glomerular filtration rate level, low platelet count and high alkaline phosphatase level at the initiation of each cycle were more significant. Additionally, the lowest anticancer drug percentage administration was on day 15. From these results, predictive factors for patients with various backgrounds who completed the scheduled 4-week GC therapy based on real-world data were identified. This information can be useful for clinical physicians when deciding the course of treatment.","PeriodicalId":506973,"journal":{"name":"Molecular and Clinical Oncology","volume":"505 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic value of preoperative serum ferritin in hepatocellular carcinoma patients undergoing transarterial chemoembolization 接受经动脉化疗栓塞术的肝细胞癌患者术前血清铁蛋白的预后价值

Molecular and Clinical Oncology Pub Date : 2024-01-24 DOI: 10.3892/mco.2024.2720

Mi Fan, Tingting Niu, B. Lin, Feng Gao, Bangxian Tan, Xiaobo Du

引用次数: 0