Journal of Drug Delivery and Therapeutics最新文献_第2页

Formulation and Evaluation of Moxifloxacin Hydrochloride Loaded Cubosomal Gel for Ocular Delivery 用于眼部给药的盐酸莫西沙星载体立方体凝胶的制备与评估

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6464

A. Bhageerathy, V. Prasanth

引用次数: 0

The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration 全面回顾：探索鼻腔给药系统在鼻腔给药方面的未来潜力

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6444

Rahul Pal, Prachi Pandey, Manju Koli, Khushi Srivastava, Vaisanavi Tiwari, Aman Kumar Gaur, Prottay Dutta

{"title":"The Comprehensive Review: Exploring Future Potential of Nasopulmonary Drug Delivery Systems for Nasal Route Drug Administration","authors":"Rahul Pal, Prachi Pandey, Manju Koli, Khushi Srivastava, Vaisanavi Tiwari, Aman Kumar Gaur, Prottay Dutta","doi":"10.22270/jddt.v14i3.6444","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6444","url":null,"abstract":"This comprehensive review aims to explore the future potential of nasopulmonary drug delivery systems for the administration of drugs through the nasal route. Nasal drug delivery has gained significant attention due to its numerous advantages, including rapid absorption, avoidance of first-pass metabolism, and non-invasive administration. This review provides an overview of the nasal anatomy and physiology, highlighting the factors influencing drug absorption and bioavailability. Additionally, it discusses the various types of nasopulmonary drug delivery systems, such as nasal sprays, powders, and gels, along with their advantages and limitations. Furthermore, the review delves into the challenges associated with nasal drug delivery, including mucociliary clearance, nasal irritation, and formulation issues. The potential applications of nasopulmonary drug delivery systems in the treatment of various diseases, such as allergies, respiratory disorders, and systemic conditions, are also discussed. Finally, the review concludes with an outlook on the future prospects of nasopulmonary drug delivery systems, emphasising the need for further research and development to optimise their efficacy and safety. \u0000Keywords: nasal pulmonary; nasal spray; nasal mucosa; gels; drops; nasal approaches; nasal route; nasal delivery.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"25 69","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Relationship between antibody titer than the Incidence of Infection After Complete Dose of COVID-19 Astrazeneca Vaccination Based on Sociodemographics 基于社会人口统计学的 COVID-19 阿斯利康疫苗全程接种后抗体滴度与感染发生率之间的关系

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6462

Stefan Lukas, Diana Laila Ramatillah, Y. Aldi, F. Wahyuni

{"title":"Relationship between antibody titer than the Incidence of Infection After Complete Dose of COVID-19 Astrazeneca Vaccination Based on Sociodemographics","authors":"Stefan Lukas, Diana Laila Ramatillah, Y. Aldi, F. Wahyuni","doi":"10.22270/jddt.v14i3.6462","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6462","url":null,"abstract":"Background: Vaccine is an essential tool to limit the health of the COVID -19 pandemic and one of the vaccines that got permitted to used is AstraZeneca Vaccine. The base of the AstraZeneca is the viral vector vaccine. This vaccine has a more advanced method that uses a modified virus to trigger antibodies to make herd immunity for people. Objective: To found correlation between antibody titer than the incidence of Covid infection after complete dose vaccination base on sociodemographics Method: Observasional prospective Cohort method was use in this study with a convenience sampling design. Inclusion criteria were all Indonesian citizens above 18 years old (n=113) who were vaccinated at UTA 45 Jakarta Vaccine Center with no history of COVID -19 before the vaccination and had filled up the informed consents. Results: there were 43 (38%) respondents infected Covid-19 after vaccinated full dosesConclusion: Base on this study, it was found that there was a correlation between sociodemographics after vaccinated full doses AstraZeneca, gender, age, comorbid, smoking, and drinking than infected Covid -19 (P-value < 0.05)). \u0000Keywords: Astrazeneca vaccine, Antibody titer, COVID-19.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"18 71","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140237118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outbreak Over Monkey Pox Virus in Human: Immediate Countermeasures from the Endemic to Non-Endemic Regions 猴痘病毒在人类中的爆发：从流行地区到非流行地区的即时应对措施

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6472

Sameeksha Jain, Megha Jha, Anjali Singh, Rashmi Haldkar, Deepak Kumar Jain

{"title":"Outbreak Over Monkey Pox Virus in Human: Immediate Countermeasures from the Endemic to Non-Endemic Regions","authors":"Sameeksha Jain, Megha Jha, Anjali Singh, Rashmi Haldkar, Deepak Kumar Jain","doi":"10.22270/jddt.v14i3.6472","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6472","url":null,"abstract":"A zoonotic orthopoxvirus called human monkeypox has symptoms that resemble smallpox. When people come into contact with diseased animals, they may unintentionally contract monkeypox. According to reports, the virus can also spread through close physical contact, such as skin-to-skin contact or sexual contact, respiratory droplets, and by household items like towels and blankets. There are numerous medical countermeasures on hand for orthopoxviruses like monkeypox. Monkeypox, which originated in western and central Africa, has lately been found in a integer of nations, counting Spain, Canada, Australia, and the United Arab Emirates. Despite its extremely low incidence rate, it nonetheless poses a serious concern that needs to be addressed as soon as possible because of the strong likelihood that it will spread to many other nations. Outside of endemic areas, the danger of monkeypox transmission in medical settings is not well known. One recorded instance of transmission was found after a quick assessment of the literature from 2000 to 2022, which also included cases outside of areas where monkeypox is endemic. It is unusual for monkeypox to recur in non-endemic nations. It is a zoonosis that can extend from animal to human and from human to human, and it has clinical characteristics comparable to smallpox. The latest outbreaks may be attributed to lowered resistance to the orthopoxviruses, movement of people from widespread to non-endemic areas, hereditary alterations in the viral genome, and diminished observation. Transmission and pathogenicity could be avoided with the use of a multifaceted strategy that includes health education, monitoring human mobility, the development of diagnostic tools, and an efficient vaccination. \u0000Keywords: Monkeypox, Outbreak, Orthopoxvirus, Epidemiology, Vaccination, Virology, Public health, Preventive measures","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"104 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of Niosomes 新生物体概述

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6450

Pardeep Kaur, Ritu Rani, A. Singh, A. Singh

{"title":"An Overview of Niosomes","authors":"Pardeep Kaur, Ritu Rani, A. Singh, A. Singh","doi":"10.22270/jddt.v14i3.6450","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6450","url":null,"abstract":"In recent times, there has been a significant shift towards developing targeted biological substances for the treatment of infectious diseases and vaccination. Non-ionic surfactant vesicles, known as niosomes, have emerged as a distinctive vesicular structure in contemporary drug delivery methods due to their biological breakdown, compatibility, chemical resistance, cost-effectiveness, ease of manufacturing and preservation, and low toxicity. The progress in nanocarrier technology has garnered attention for its safety and associated advantages, including enhanced therapeutic administration with diverse pharmacological effects, improved targeting capabilities, and reduced side effects. Niosomes serve as vesicular carriers for drugs, composed of non-ionized surfactants, cholesterol or analogs, and charged molecules that enable controlled and targeted drug delivery. They are categorized as unilamellar, oligolamellar, or multilamellar structures. This comprehensive review article provides an overview of niosomes, covering their structure, types, formulation methods, characterization, advantages and disadvantages, preparation techniques, influencing factors, evaluation criteria, applications, and currently available formulations in the market. \u0000Keywords: Niosomes, drug delivery system, methods of Preparation, Applications.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"13 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatitis Screening in Community Pharmacies as a Measure of Reducing the Rate of Infections 社区药房的肝炎筛查是降低感染率的一项措施

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6478

Pallav Dave

{"title":"Hepatitis Screening in Community Pharmacies as a Measure of Reducing the Rate of Infections","authors":"Pallav Dave","doi":"10.22270/jddt.v14i3.6478","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6478","url":null,"abstract":"The burden of dealing with HBV and HCV still remain despite the progress that has been made in screening, vaccination, and treating the infections. On average, there about 354 million cases of hepatitis globally. Hepatitis has high mortality rates. On average, 1.1 million people lose their lives to the infections each year. Addressing hepatitis requires rigorous measures one of them being increasing screening. Hepatitis infections are identified through screening. As such, screening and taking the right preventative and treatment measures can help to reduce the risk of infections. However, screening is still a challenge. The number of people who screen for hepatitis remains low despite the efforts that have been put in place to increase uptake. The uptake of screening is low because of inadequate access to screening centers. Thus, increasing screening settings can help to increase uptake. Community pharmacies can help to bridge this barrier by making screening more accessible. They are accessible and in close proximity to vulnerable populations, which makes them ideal as screening settings. This review explores the potential of community pharmacies as screening settings for HBV and HCV and whether they can help to reduce the rate of infections. \u0000Keywords: screening, hepatitis B, hepatitis C, community pharmacies","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"70 S1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of direct electric current to the corneal and conjunctival epithelia regulates the tight junctional assembly for ocular iontophoretic drug delivery 对角膜和结膜上皮施加直流电调节眼部离子透入给药的紧密连接装配

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6455

H. Sekijima, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda

{"title":"Application of direct electric current to the corneal and conjunctival epithelia regulates the tight junctional assembly for ocular iontophoretic drug delivery","authors":"H. Sekijima, Yutaro Hazama, Soichiro Kimura, Yasunori Morimoto, Hideo Ueda","doi":"10.22270/jddt.v14i3.6455","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6455","url":null,"abstract":"Objectives: In this study, we determined how iontophoresis (IP) affects tight junctions (TJs) in isolated rabbit corneas and conjunctiva. \u0000Methods: Direct electric current in the range of 0.5–2.0 and 0.5–10 mA/cm2 were applied to the cornea and conjunctiva, respectively, for 30 min. The localization and expression levels of TJ-associated proteins were assessed before and after the application of the electric currents using immunostaining and western blotting. \u0000Results: In both corneal and conjunctival epithelia, the localization of proteins, such as claudin-1, claudin-4, occludin, and ZO-1, was temporarily altered by anodal and cathodal IP; however, the protein relocalization was slower at higher currents. Additionally, in both anodal and cathodal IP, the expression levels of claudin-1 and occludin in the cornea and conjunctiva remained unchanged after the application of the electric currents compared with those before. \u0000Conclusion: Our results indicated that the application of a direct electric current temporarily regulated TJ assemblies without altering the levels of TJ-associated proteins in both the cornea and conjunctiva. This temporary weakening of the paracellular barrier by the current may be responsible for the enhanced drug transport across the cornea and conjunctiva induced by ocular IP. \u0000Keywords: ocular drug delivery, iontophoresis, electric current, cornea, conjunctiva, tight junction","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"9 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Correlation Between Stigma and Mental Health Disorders in People Living with HIV/AIDS 艾滋病毒/艾滋病感染者的耻辱感与心理健康障碍之间的相关性

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6490

Pallav Dave

引用次数: 0

Nanotechnology at Work: Hydrogel Drug Delivery Architectures 工作中的纳米技术：水凝胶给药结构

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6465

Shubhangi Aher, Dipti Solanki, Aparna Jain

{"title":"Nanotechnology at Work: Hydrogel Drug Delivery Architectures","authors":"Shubhangi Aher, Dipti Solanki, Aparna Jain","doi":"10.22270/jddt.v14i3.6465","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6465","url":null,"abstract":"Hydrogels represent three-dimensional, interconnected networks known to absorb substantial amounts of H2O but at the same time, being insoluble in the aforementioned solvent. Their exceptional hydrophilic nature, biocompatibility and diverse therapeutic potential position them as highly promising biomaterials within biological and biomedical fields. These materials, on account of their innoxious innate characteristics and safe utilization, have garnered widespread acceptance across tremendous and diverse biomedical applications ranging from traditional therapies to state-of-the-art advancements. This extensive review incorporates a spectrum of varied types of hydrogels, elaborating on both their chemical, physical aspects and also throws light on the rheological, analytical and spectroscopic tools employed for their characterization. It also continues to elaborate on the various mechanisms of gelation for facilitating a better understanding of the topic under discussion. The review also discusses the different strategies which are substantiated in recent times to expand the utilisation of hydrogels. The primary intent of this review is to render a comprehensive understanding of hydrogels as an ideal drug delivery system to undergraduates, graduates, biomedical students and researchers across the globe. It also targets to unravel the fundamental, applied and general aspects of hydrogels, offering valuable insights to help individuals associated with multidisciplinary research and application spheres. \u0000Keywords: Gelation, Biocompatibility, Cross-linking, Smart hydrogels, Polymerization, Architecture, Polymer network","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"4 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140241127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases 探索间歇性禁食的神经保护作用：间歇性禁食对神经系统疾病影响的综合评述

Journal of Drug Delivery and Therapeutics Pub Date : 2024-03-15 DOI: 10.22270/jddt.v14i3.6486

Marudhachalam Jeevitha, R. Shanmuga Sundhram, R. Sambath Kumar

{"title":"Exploring the Neuroprotective Effects of Intermittent Fasting: A Comprehensive Review on its Impact on Neurological Diseases","authors":"Marudhachalam Jeevitha, R. Shanmuga Sundhram, R. Sambath Kumar","doi":"10.22270/jddt.v14i3.6486","DOIUrl":"https://doi.org/10.22270/jddt.v14i3.6486","url":null,"abstract":"Background: Intermittent fasting has various benefits for brain health, owing to the physiological alterations occurring in the human body during intervals of fasting. Fasting induces a metabolic condition that improves neuronal bioenergetics, plasticity, and resilience, potentially counteracting a variety of neurological disorders. \u0000Objectives: In the current research, we reveal the impact of IF (Intermittent Fasting)on neurological diseases. \u0000Methodology: A literature review was conducted to create recent studies on how IF impacts neurological illnesses, including neurodegenerative diseases and Central Nervous System (CNS) disorders. \u0000Results: Fasting decreases the production of inflammatory mediators including homocysteine, IL6, and C-reactive protein which could reduce the creation of plaques that lead to atherosclerosis, which is the primary cause of stroke in individuals. IF and ketogenic diets involve significant mechanisms, including enhanced beta-hydroxybutyrate, that have been linked with improved seizure management in certain studies, as well as the induction of other systems that work together to sustain synaptic activity. IF may also improve health and QoL (Quality Of Life) for those who have relapsing-remitting Multiple Sclerosis. IF could prove to be a beneficial dietary treatment for the prevention and/or deceleration of dementia progression. \u0000Conclusion: The creation of a self-empowering, affordable, and effective treatment alternative for a range of neurological issues in a time of rising medical costs and a rise in neurological diseases. In the future, if these studies are given priority, fasting regimens will be advised in addition to medication-based strategies, leading to the development of a single metabolic strategy that can alter the course and symptoms of the most prevalent and impairing neurological disorders that currently exist. \u0000Keywords: Intermittent Fasting, Neurological disease, Brain health.","PeriodicalId":506928,"journal":{"name":"Journal of Drug Delivery and Therapeutics","volume":"64 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140238339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0