Theoretical and Natural Science最新文献_第9页

Thermal history A review of human energy development 热历史人类能源发展回顾

Theoretical and Natural Science Pub Date : 2024-03-07 DOI: 10.54254/2753-8818/31/20240799

Zhiheng You

引用次数: 0

Comprehensive analysis of the COVID-19 pandemic through the SIR model 通过 SIR 模型全面分析 COVID-19 大流行病

Theoretical and Natural Science Pub Date : 2024-03-07 DOI: 10.54254/2753-8818/31/20241127

Xiaorui Bao

{"title":"Comprehensive analysis of the COVID-19 pandemic through the SIR model","authors":"Xiaorui Bao","doi":"10.54254/2753-8818/31/20241127","DOIUrl":"https://doi.org/10.54254/2753-8818/31/20241127","url":null,"abstract":"In the study of infectious disease transmission, understanding the dynamics of disease spread and the impact of population-wide preventive measures is crucial. This study is conducted with the overarching goal of investigating how a comprehensive set of protective measures affects the spread of infectious diseases, while simultaneously creating a mathematical model that can accurately describe the dynamics of disease transmission within a population. By utilizing a mathematical modeling approach, this study aim to unravel the intricate relationship between key variables, including the overall protection coefficient, the daily contact rate of infected individuals, and the size of the total population. Furthermore, the model is subjected to a rigorous refinement process to explore the conditions under which disease transmission comes to a halt. The findings of this research shed light on the paramount importance of implementing broad-scale protective measures at the population level in order to effectively control and mitigate the spread of infectious diseases. These insights not only inform the development of robust disease prevention strategies but also provide a foundation for evidence-based policymaking to safeguard public health and well-being.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"71 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dynamic planning of office building elevator scheduling 办公楼电梯调度的动态规划

Theoretical and Natural Science Pub Date : 2024-03-07 DOI: 10.54254/2753-8818/31/20240776

Jiaqi Liu

{"title":"Dynamic planning of office building elevator scheduling","authors":"Jiaqi Liu","doi":"10.54254/2753-8818/31/20240776","DOIUrl":"https://doi.org/10.54254/2753-8818/31/20240776","url":null,"abstract":"Every morning rush hour is the most crowded time for elevators in office buildings, and many office workers will be late because they can't wait for the elevator. How to reasonably call the existing elevator resources has become a problem we need to pay attention to. In this paper, we will discuss the modeling of elevator scheduling optimization problem for office buildings. In this paper, the background and significance of the research is firstly explained, and then the elevator group linkage control system is briefly understood and analyzed, and the evaluation indexes are determined according to its multi-objective and diversified characteristics, and then the group control method focusing on making the elevator run time the shortest is adopted, and the principle of the ratio of elevator running period/total running time equal to the number of passengers transported/total passengers transported by the elevator in one cycle is followed to compare several common elevator running methods, and the results are summarized in the following table. Common elevator operation methods are compared, the most effective way to arrive at, and finally use dynamic programming to solve the partition point, to establish the optimal scheme of elevator scheduling for the office building division. Since it is not possible to expand the elevator in the office building, reducing the number of stops of each elevator to shorten the time required for the elevator to carry passengers becomes the most feasible method. After comparing the common elevator operation methods, it can be found that zoning can shorten the final average arrival time of passengers more than no zoning. That is, the elevators in an office building are divided into different zones, and each zone has a designated elevator serving a designated floor segment. In order to solve the floor segment allocation problem, the shortest path algorithm is used in this paper. The paper concludes with a summary and future outlook of the resulting optimization model.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design analysis of simulated smart cars at different cases 不同情况下模拟智能汽车的设计分析

Theoretical and Natural Science Pub Date : 2024-03-07 DOI: 10.54254/2753-8818/31/20241102

Yunjing You

{"title":"Design analysis of simulated smart cars at different cases","authors":"Yunjing You","doi":"10.54254/2753-8818/31/20241102","DOIUrl":"https://doi.org/10.54254/2753-8818/31/20241102","url":null,"abstract":"This abstract provides a brief overview of the importance of force analysis in motion analysis within the context of intelligent vehicle systems. It highlights the significance of force analysis in understanding the dynamics of motion in these systems and its applications for optimizing vehicle performance and safety. Force analysis plays a crucial role in motion analysis within the field of intelligent vehicle systems. By analyzing the forces acting on a vehicle, researchers and engineers can gain insights into its acceleration, trajectory, stability, and overall performance. This analysis aids in optimizing vehicle control strategies, such as steering, braking, and acceleration, to ensure smooth and safe operation. Furthermore, force analysis helps identify critical factors that influence vehicle dynamics, such as tire-road interactions, aerodynamics, and vehicle weight distribution. By understanding these forces, engineers can design intelligent vehicle systems that enhance stability, maneuverability, and fuel efficiency. In conclusion, force analysis is instrumental in motion analysis within intelligent vehicle systems. Its applications range from optimizing vehicle control strategies to improving stability, safety, and fuel efficiency. By leveraging force analysis, researchers and engineers can contribute to the development of advanced intelligent vehicles that meet the demands of a rapidly evolving transportation landscape.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"50 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140258863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Continuous ambulatory epilepsy detection system incorporating feature engineering 结合特征工程的持续动态癫痫检测系统

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240806

A. Wu, Gaolin Liu

引用次数: 0

Current understanding of pollen allergy: Its origin, impacting factors, treatment regime, and monitoring methods 目前对花粉过敏的认识：其起源、影响因素、治疗方法和监测方法

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240875

L. J. Tong

引用次数: 0

Drug resistance and therapeutic advances in Treponema pallidum: A review 苍白螺旋体的耐药性和治疗进展：综述

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240845

Jian Zhang, Qiuping Fei

{"title":"Drug resistance and therapeutic advances in Treponema pallidum: A review","authors":"Jian Zhang, Qiuping Fei","doi":"10.54254/2753-8818/32/20240845","DOIUrl":"https://doi.org/10.54254/2753-8818/32/20240845","url":null,"abstract":"Treponema pallidum, a common pathogen in sexually transmitted diseases, has emerged as a significant public health threat in recent decades, showing a gradual increase in global prevalence. Antibiotics have been the primary method to treat Treponema pallidum infections. However, high-dose antibiotic use in clinical trials has raised concerns and unveiled a series of issues. This paper employs a literature review approach to summarize and compare scientific studies conducted in various countries and regions regarding Treponema pallidum in recent years. It aims to introduce and summarize the drug resistance of Treponema pallidum and the current progress in treatment. Studies indicate widespread resistance of Treponema pallidum to macrolides, while no resistance has been found to first-line drugs like benzathine penicillin and other alternative medications. Presently, benzathine penicillin remains pivotal in syphilis treatment. Alternatives such as ceftriaxone, second-generation tetracyclines, amoxicillin, and adjunctive immunomodulators, after clinical trials, have been used in early or late-stage syphilis treatment and prevention. The concept and research direction of syphilis vaccines are emerging and are poised to be a crucial approach in curtailing Treponema pallidum transmission. Diversified drug treatment strategies and the development of syphilis vaccines hold significant implications in safeguarding public health and ensuring global health security.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"75 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140261377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucagon-like peptide-1 analogs for Alzheimers disease -- A systematic meta-analysis 治疗阿尔茨海默病的胰高血糖素样肽-1 类似物 - 系统荟萃分析

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240813

Cindy Wang, Kailin Ye

{"title":"Glucagon-like peptide-1 analogs for Alzheimers disease -- A systematic meta-analysis","authors":"Cindy Wang, Kailin Ye","doi":"10.54254/2753-8818/32/20240813","DOIUrl":"https://doi.org/10.54254/2753-8818/32/20240813","url":null,"abstract":"Alzheimers Disease (AD) poses a serious health concern especially for the aging population above the years of 65. An estimated 6 million Americans are diagnosed with Alzheimers Disease, and there are at least 50 million Alzheimers patients in the world. AD affects the daily life of these patients, yet there is no permanent cure. Current treatments involve cholinesterase inhibitors and NMDA-receptor agonists to help alleviate the symptoms. GLP-1 is a peptide often used in the treatment of diabetes. Since there are shared pathological features between diabetes and AD, such as insulin dysfunction and glucose metabolism dysregulation, GLP-1 may be a viable study for AD treatment. To perform a meta-analysis to investigate whether GLP-1 has a beneficiary effect on biological markers and cognitive outcome in AD patients. We searched the following electronic databases: EMBASE, MEDLINE, phycINFO, CINAHL, PubMed, Cochrane CENTRAL, and ClinicalTrials.gov. We only utilized Randomized Control Trials (RCTs) and clinical trials. We also searched with the following Medical Search Headings: Alzheimers Disease, Alzheimer, Alzheimers, and GLP-1. We included 2 randomized, double-blind, and placebo controlled clinical trials into our meta-analysis. We extracted the baseline and outcomes from the clinical trials and evaluated its risks of bias. Biological markers were measured by amyloid beta (A) accumulation, and cognitive outcomes were measured by the Wechsler Memory Scale - Fourth Edition (WMS-IV) and Mini Mental State Exam (MMSE). For one study, the WMS-IV was used to measure cognitive outcome. The other study measured cognitive outcome with the MMSE. Biological markers were measured by A accumulation in one study and with [11C]PIB tracer in another. There was no significant difference between the placebo and experimental group after the treatment period.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"12 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140263354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of dopamine in regulating microglia inflammatory responses through TLR4-NFb pathway 多巴胺在通过 TLR4-NFb 通路调节小胶质细胞炎症反应中的作用

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240782

Miao Zhang

{"title":"Role of dopamine in regulating microglia inflammatory responses through TLR4-NFb pathway","authors":"Miao Zhang","doi":"10.54254/2753-8818/32/20240782","DOIUrl":"https://doi.org/10.54254/2753-8818/32/20240782","url":null,"abstract":"Parkinsons disease (PD) is a prevalent neurodegenerative disorder that affects a significant portion of the population. One of its distinguishing features is the gradual loss of dopaminergic cells in a specific region of the brain known as the substantia nigra. In recent years, researchers have uncovered that neuroinflammation facilitates the developmental process of PD. Specifically, studies have shown that the activation of microglia, the brains immune cells, is closely linked to the levels of dopamine secreted by neurons. However, the influence of dopamine on activated microglia in PD has not been fully explored. In this study, we aimed to explore the impact of dopamine on activated microglia. To establish an activated microglia model, we used BV-2 cell lines and treated them with lipopolysaccharide (LPS) at a concentration of 200 ng/ml. Two separate groups were then exposed to dopamine at concentrations of 2 M and 10 M, respectively, to simulate dopamine treatment in the brain. To assess the effects of dopamine, we performed real-time PCR to measure the relative mRNA levels of pro- and anti-inflammatory cytokines, conducted immunofluorescent staining to observe and analyze the cell morphology, carried out a phagocytosis assay to assess the cells phagocytic ability, and conducted western blotting to identify the specific pathway through which dopamine affects microglia activation. Our findings revealed that dopamine can modulate the activation state of microglia and reduce the cells inflammatory responses via the TLR4-NFB pathway. This suggests that dopamine has the potential to alleviate neuroinflammation in PD, opening up new avenues for future treatments and therapies.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"61 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the source, preparation, and application of phytosterols 植物甾醇的来源、制备和应用方面的进展

Theoretical and Natural Science Pub Date : 2024-03-06 DOI: 10.54254/2753-8818/32/20240866

Xinyue Liu

{"title":"Advances in the source, preparation, and application of phytosterols","authors":"Xinyue Liu","doi":"10.54254/2753-8818/32/20240866","DOIUrl":"https://doi.org/10.54254/2753-8818/32/20240866","url":null,"abstract":"Phytosterols, also referred to as plant sterols, represent naturally occurring compounds exclusive to the plant kingdom. This comprehensive review delves into the multifaceted realm of phytosterols, encompassing their structural characteristics and physiological functions. A keen focus is placed on elucidating their sources, with an emphasis on their abundance in unprocessed materials. The paper meticulously explores the diverse methods employed in the preparation of phytosterols, concurrently scrutinizing the detection techniques applied in their analysis. Within the medical domain, phytosterols have gained recognition for their efficacy in reducing LDL cholesterol levels, thereby proving instrumental in averting cardiovascular diseases, addressing breast cancer, and managing metabolic disorders. In the cosmetic industry, plant-based oils, enriched with polyunsaturated fatty acids, function as potent antioxidants and moisturizers, counteracting the detrimental effects of free radicals. Furthermore, in the realm of the food industry, phytosterols play a pivotal role in the construction of Nanostructured Lipid Carriers (NLCs), preserving the bioavailability of various compounds. This review article stands out for its synthesis of existing research, offering succinct summaries of each section while adeptly bridging identified research gaps. Its intrinsic value lies in its potential to serve as a crucial resource for researchers, fostering deeper investigations and streamlining research endeavors in the medical, cosmetic, and food sectors.","PeriodicalId":506830,"journal":{"name":"Theoretical and Natural Science","volume":"19 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140077862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0