Zeitschrift für Physikalische Chemie最新文献

{"title":"The physicochemical and DNA binding studies of ceftazidime pentahydrate and cefotaxime sodium in aqueous medium","authors":"Abbas Khan, Sher Shah Khan, Ubaid Ur Rahman, Mohamed Bououdina, Muhammad Humayun, Nasrullah Shah, Noor Rehman","doi":"10.1515/zpch-2023-0210","DOIUrl":"https://doi.org/10.1515/zpch-2023-0210","url":null,"abstract":"Abstract Ceftazidime pentahydrate (CP) and cefotaxime sodium (CS) are semisynthetic cephalosporin antibiotics and are used to treat a variety of diseases worldwide. In order to explore the efficiency of a medicinal compound, it is important to have a deep understanding of its solution and physiochemical behaviour along with its interaction with biological molecules. In this regard, the solution of two drugs i.e., ceftazidime pentahydrate (CP) and cefotaxime sodium (CS) were investigated in detail. The physicochemical properties of drugs solutions and their interaction with deoxyribonucleic acid (DNA) were studied in water under varying experimental parameters. In the present study the physicochemical properties such as density, viscosity, surface tension, and conductance of aqueous solution, having various molar concentrations, of CP and CS were traced out at different temperatures. Five various concentrations (0.05, 0.1, 0.15, 0.2, and 0.3 mol dm−3) of each drug in an aqueous medium were prepared separately, and the physicochemical properties of each solution, were studied individually at temperatures such as 293, 303, 313, 323, and 333 K respectively. Most of these parameters have shown different behaviour with varying concentration of solution and temperature of the medium. In addition, these drugs showed a spontaneous surface-active and association behaviour in aqueous solutions and drug DNA solution. The flow behaviour, surface properties, volumetric behaviour and solute–solvent interaction of this drug were prominently influenced by experimental variables. UV-Visible spectroscopy was also used to study the interaction of these drugs with DNA in aqueous media in detail. Calculated values of binding constants (K b) for all drug–DNA are positive, indicating constructive binding and interactions between the molecules. In addition the binding efficiency of ceftazidime pentahydrate was found more than that of cefotaxime sodium. The interaction of drug–DNA was not only affected by the nature of the drug but also by the drug-to-DNA ratio and nature of the medium used.","PeriodicalId":506520,"journal":{"name":"Zeitschrift für Physikalische Chemie","volume":"13 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139438868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis of AgNPs from leaves extract of Saliva Sclarea, their characterization, antibacterial activity, and catalytic reduction ability","authors":"Shahab Khan, Ihsan Ullah, Hamayun Khan, Faizan Ur Rahman, M. Rahman, Muhammad Asim Saleem, Shoaib Nazir, Arshad Ali, Arif Ullah","doi":"10.1515/zpch-2023-0363","DOIUrl":"https://doi.org/10.1515/zpch-2023-0363","url":null,"abstract":"Abstract Several technologies are employed for the synthesis of silver nanoparticles, each synthesis technique has advantages and disadvantages, and the best technique relies on the application at hand, the required qualities of the nanoparticles, and the size of the product. But in this article green synthesis were followed. In this research, AgNPs were synthesized using Salvia Sclarea leaf extract in green synthetic routes. The synthesized nanoparticles were examined using UV–vis spectroscopy, powder XRD, SEM, and FT-IR. Here three different type of silver nanoparticles were biosynthesized, AgNPs-1, AgNPs-2, and AgNPs-3 (where composition of AgNO3 and extract were 6:1, 10:1 and 14:1 respectively). The catalytic ability of AgNPs 1–3 was determine in the reduction of nitro-compounds into corresponding amines, where AgNPs-2 was found efficient reductive catalyst. Moreover, antibacterial activities were checked against both gram-positive (Bacillus Suntilis) and gram-negative bacteria (Klebsiella pneumoniae). Upon increasing Ag contents antibacterial activities were found in increasing mode. Which open new era of knowledge for further consideration.","PeriodicalId":506520,"journal":{"name":"Zeitschrift für Physikalische Chemie","volume":"11 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139439861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of bead mill dispermat system with specific surfactants on organic pigments","authors":"Nilesh Prakash Badgujar, Ravindra D. Kulkarni, S. Sonawane, Hansraj V. Patil, Karuppiah Nagaraj, Matar Alshalwi","doi":"10.1515/zpch-2023-0427","DOIUrl":"https://doi.org/10.1515/zpch-2023-0427","url":null,"abstract":"Abstract The study demonstrates the effective application of high-speed dispersion and bead mill dispermat systems in dispersing organic pigments, specifically phthalocyanine blue and green, in water with positive results. Particle size analysis reveals that formulations prepared using a bead mill with the selective surfactants such as Tween-80, SLS, Cocosulphosuccinate (CSPS) and Oleyl sulphosuccinate (OSPS) which exhibits a narrower range of particle size distribution compared to those prepared using high-speed dispersion (HSD). Phthalocyanine blue pigment concentrate formulation, the bead mill preparation using Tween-80 and CSPS surfactants resulted in a higher viscosity and color strength compared to HSD. In addition, the phthalocyanine green pigment concentrate formulation prepared using a bead mill with SLS surfactant showed higher color strength than the formulation prepared using HSD with SLS surfactant. Moreover, the comparative study reported the Nano CaCO3 pigment concentrate formulation prepared using a bead mill with SLS surfactant displayed a narrow range of particle size distribution ranging from 0.31 to 0.56 nm, with an average particle size of 0.435 nm, compared to the formulation prepared using HSD. All these findings suggested bead mill dispermat system with specific surfactants can produce pigment dispersions with a narrower particle size distribution, higher color strength, and better viscosity compared to HSD which demonstrating its potential as a more efficient and effective method for pigment dispersion.","PeriodicalId":506520,"journal":{"name":"Zeitschrift für Physikalische Chemie","volume":"5 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biofabrication of silver nanoparticles using diallyl sulphide (DAS) and comparison of cytotoxic potential of DAS-AgNPs and Kodaikanal Hill garlic in human cervical cancer","authors":"Pranjal Priya, Uma Maheswari Nallal, Muthuswamy Razia, S. Sivaramakrishnan, Kannan Prabha, Lakshminarayanan Srimathi Priya, Suresh Kumar Kabeen, Karuppaiya Durga, Manikandan Ayyar","doi":"10.1515/zpch-2023-0454","DOIUrl":"https://doi.org/10.1515/zpch-2023-0454","url":null,"abstract":"Abstract Garlic (Allium sativum) exhibit well defined therapeutic properties due to presence of distinct bioactive compounds, specifically organosulphur compounds. Spectral analysis by UV–Vis and FT-IR confirmed interaction of different functional groups and free electrons with the electromagnetic waves showed presence of different bioactive compounds formulated silver nanoparticles (AgNPs) using diallyl sulphide (DAS) also done for aqueous garlic extract. Different assays performed for confirming the presence of antibacterial and anticancer properties of DAS-AgNPs and garlic extract. The minimum inhibitory concentration required to inhibit Gram negative (Escherichia coli, V. cholera) and Gram positive (S. aureus, B. cereus) were found lesser in DAS-AgNPs followed by garlic extract. Cytotoxicity effect confirmed by DAS-AgNPs and A. sativum towards HeLa cell line by MTT assay. The IC50 values obtained for MTT assay were at 24.09 μg/ml in DAS-AgNPs and 129.22 μg/ml in garlic extract. Anticancer efficacy was found more potent in DAS-AgNPs as compared with aqueous garlic extract.","PeriodicalId":506520,"journal":{"name":"Zeitschrift für Physikalische Chemie","volume":"46 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139440943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}