Journal of Inflammation Research最新文献

{"title":"Identification and Comparative Evaluation of Analgesic Components in Toad Venom on Inflammatory Pain","authors":"Yuting Wen, Ruixiang Li, Xialian Cui, Fang Zhang, Jiange Zhang","doi":"10.2147/jir.s591835","DOIUrl":"https://doi.org/10.2147/jir.s591835","url":null,"abstract":"Objective: Although toad venom has been utilized in traditional Chinese medicine for centuries to manage pain, a systematic evaluation of its material basis against inflammatory pain remains lacking. This study sought to rigorously assess the analgesic efficacy of toad venom extracts and their active constituents, identify the principal bioactive components, and explore their potential underlying mechanisms through the integration of network pharmacology and experimental observation, thereby providing a scientific foundation for its potential therapeutic application. Materials and Methods: Activity-guided fractionation and LC-Q-TOF-MS were employed to identify the key active compounds of toad venom. Analgesic activities of the extracts, fractions, and selected monomers were evaluated using a carrageenan-induced mouse pain model. Network pharmacology was utilized to predict potential therapeutic targets. The predicted mechanisms were subsequently validated in vitro using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages and in vivo across distinct murine inflammatory models. Finally, a preliminary toxicological evaluation was conducted to assess in vivo safety. Results: Ethyl acetate and methanol fractions were identified as the primary active extracts. Subsequent screening revealed that Cinobufagin and Resibufogenin exhibited the most prominent analgesic properties among the tested monomers. Focusing on an examined subset of the network pharmacology predictions, in vitro assays indicated that both compounds effectively downregulated the PI3K/AKT/NF-κB signaling axis. Notably, Resibufogenin demonstrated superior anti-inflammatory efficacy and significantly mitigated oxidative stress by restoring cellular antioxidant defenses (GSH and TEAC). In vivo evaluations further showed that Resibufogenin robustly attenuated carrageenan-induced paw edema, xylene-induced ear swelling, and LPS-induced systemic inflammation. Furthermore, therapeutic dosages of Resibufogenin (3 and 10 mg/kg) exhibited no detectable toxicity under the tested conditions without inducing observable pathological lesions in major organs. Conclusion: Through origin screening, bioassay-guided fractionation, and LC-Q-TOF-MS analysis, Cinobufagin and Resibufogenin were identified as the principal analgesic constituents of toad venom. Integrated bioinformatic and experimental analyses suggest that their efficacy is associated with anti-inflammatory mechanisms. Notably, Resibufogenin, exhibiting no detectable toxicity under the tested conditions and alleviated inflammatory pain, which may involve the suppression of the PI3K/AKT/NF-κB cascade and alleviating oxidative stress, highlighting its potential as a promising lead compound for novel analgesic therapeutics. Keywords: toad venom, cinobufagin, resibufogenin, inflammatory pain","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"Volume 19 1","pages":"1-24"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148861299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Vitamin K and Suicide Attempts in Patients with Depression: A Case-Control Study [Letter]","authors":"Song Wang, Xi Wang, Xiaolian Jiang","doi":"10.2147/jir.s486032","DOIUrl":"https://doi.org/10.2147/jir.s486032","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141706537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction Model for Early-Stage CKD Using the Naples Prognostic Score and Plasma Indoleamine 2,3-dioxygenase Activity","authors":"Hao Hong, Junyao Zheng, Haimin Shi, Suya Zhou, Yue Chen, Ming Li","doi":"10.2147/jir.s460643","DOIUrl":"https://doi.org/10.2147/jir.s460643","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"6 S2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141715994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Role of Inflammatory Response in Polycystic Ovary Syndrome Using Integrated RNA-Seq Analysis","authors":"Lei Liu, Shanshan Liu, Fuyan Bai, Yangxin Deng, Xinhuan Zhang, Li Wang","doi":"10.2147/jir.s460437","DOIUrl":"https://doi.org/10.2147/jir.s460437","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"191 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Protecting Role of Black Seed Oil and Its Nano-Formulation in LPS-Induced Acute Kidney Injury in Mice: Evaluation of Oxidative Stress, Biochemical & Molecular Parameters","authors":"Barakat M AlRashdi, Diaa Massoud, Hager K. Rashwan, Shahenda Mahgoub, Nermeen Z Abuelezz, Ali Nasr, Rami Kassab, Hatem K. Amin","doi":"10.2147/jir.s463369","DOIUrl":"https://doi.org/10.2147/jir.s463369","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"6 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141704150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Pan-Cancer Analysis Reveals the Oncogenic Role of MND1 and Validation of MND1’s Role in Breast Cancer","authors":"Wenwu Zhang, Yuhan Xiao, Xin Zhu, Yanxia Zhang, Qin Xiang, Shunhong Wu, Xiaoyu Song, Junxiu Zhao, Ruanfei Yuan, Qiguang Li, Bin Xiao, Linhai Li","doi":"10.2147/jir.s458832","DOIUrl":"https://doi.org/10.2147/jir.s458832","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"61 7","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141710228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting the AMPK/Nrf2 Pathway: A Novel Therapeutic Approach for Acute Lung Injury","authors":"Qianxia Huang, Yingcong Ren, Ping Yuan, Ma Huang, Guoyue Liu, Yuanzhi Shi, Guiyang Jia, Miao Chen","doi":"10.2147/jir.s467882","DOIUrl":"https://doi.org/10.2147/jir.s467882","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"85 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141714908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metformin Mitigates Sepsis-Induced Acute Lung Injury and Inflammation in Young Mice by Suppressing the S100A8/A9-NLRP3-IL-1β Signaling Pathway","authors":"Shi-Yuan Fan, Zi-Chi Zhao, Xing-Lv Liu, Ying-Gang Peng, Hui-Min Zhu, Shi-Fan Yan, Yan-Juan Liu, Qin Xie, Yu Jiang, Sai-Zhen Zeng","doi":"10.2147/jir.s460413","DOIUrl":"https://doi.org/10.2147/jir.s460413","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"177 2‐3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Significance of Nutritional-Inflammatory Index as Predictors for Total Neoadjuvant Therapy-Induced Tumor Regression in Locally Advanced Rectal Cancer Patients","authors":"Zhou Zhao, Menghua Yan, Huayang Pang, Lihui Chen, Xi Tang, Zhixiong Chen, Xiufeng Chen, Hao Sun","doi":"10.2147/jir.s462985","DOIUrl":"https://doi.org/10.2147/jir.s462985","url":null,"abstract":"","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"30 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141405062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Lung Injury and the NLRP3 Inflammasome","authors":"Wanjun Gu, Qi Zeng, Xin Wang, H. Jasem, Ling Ma","doi":"10.2147/JIR.S464838","DOIUrl":"https://doi.org/10.2147/JIR.S464838","url":null,"abstract":"Abstract Acute lung injury (ALI) manifests through harm to the capillary endothelium and alveolar epithelial cells, arising from a multitude of factors, leading to scattered interstitial alterations, pulmonary edema, and subsequent acute hypoxic respiratory insufficiency. Acute lung injury (ALI), along with its more serious counterpart, acute respiratory distress syndrome (ARDS), carry a fatality rate that hovers around 30–40%. Its principal pathological characteristic lies in the unchecked inflammatory reaction. Currently, the main strategies for treating ALI are alleviation of inflammation and prevention of respiratory failure. Concerning the etiology of ALI, NLRP3 Inflammasome is essential to the body’s innate immune response. The composition of this inflammasome complex includes NLRP3, the pyroptosis mediator ASC, and pro-caspase-1. Recent research has reported that the inflammatory response centered on NLRP3 inflammasomes plays a key part in inflammation in ALI, and may hence be a prospective candidate for therapeutic intervention. In the review, we present an overview of the ailment characteristics of acute lung injury along with the constitution and operation of the NLRP3 inflammasome within this framework. We also explore therapeutic strategies targeting the NLRP3 inflammasome to combat acute lung injury.","PeriodicalId":506013,"journal":{"name":"Journal of Inflammation Research","volume":"17 5‐6","pages":"3801 - 3813"},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141397765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}