Scholars Academic Journal of Pharmacy最新文献

Antidiabetic Evaluation of Zingiber zerumbet Linn Rhizome (Zingibereceae) Collected from Agulu of Anambra State, Nigeria 从尼日利亚阿南布拉州阿古鲁采集的 Zingiber zerumbet Linn Rhizome（Zingibereceae）的抗糖尿病评估

Scholars Academic Journal of Pharmacy Pub Date : 2024-04-08 DOI: 10.36347/sajp.2024.v13i04.001

Onwunyili Amaka Roseline, Eze Charity Chinasa, Ibe Chioma Ifeoma, Ifebi Hope Morris, Ikeh Obiageli Eucharia

{"title":"Antidiabetic Evaluation of Zingiber zerumbet Linn Rhizome (Zingibereceae) Collected from Agulu of Anambra State, Nigeria","authors":"Onwunyili Amaka Roseline, Eze Charity Chinasa, Ibe Chioma Ifeoma, Ifebi Hope Morris, Ikeh Obiageli Eucharia","doi":"10.36347/sajp.2024.v13i04.001","DOIUrl":"https://doi.org/10.36347/sajp.2024.v13i04.001","url":null,"abstract":"Background and objectives: In Nigeria, there are wide use of medicinal plants for different health conditions like diabetes. Zingiber zerumbet rhizome is one such plant used for health challenges. This study assessed the effectiveness of Zingiber zerumbet in a diabetic rat model. Methods: Extraction was carried out with methanol, using cold maceration. Fractionation was carried out with n-hexane, ethyl acetate and butanol. The antidiabetic studies were done using Alloxan induced diabetic rat model. Haematological parameters and liver and kidney function enzyme levels were analyzed using standard protocols. Results: The glucose levels were reduced significantly by 68.17, 67.68, 54.29, 66.81, 77.74, 64.00, 60.89, 69.12, 62.11 and 58.26 % for 100mg/kg of Glibenclamide, 100 mg/kg crude extract, 250 mg/kg crude extract, 500 mg/kg crude extract, 250 mg/kg n-hexane, 500 mg/kg n-hexane, 250 mg/kg Ethylacetate, 500 mg/kg Ethylacetate, 250 mg/kg butanol and 500 mg/kg butanol respectively. The liver and kidney function enzymes were brought to control at p<0.05 significance. The haematological parameters were also brought to control at p<0.05 significance. Conclusion: The extract and fractions of Zingiber zerumbet rhizome exhibited potential antidiabetic effect in rat model. Further studies are required to isolate, purify, characterize and structurally elucidate the particular bioactive constituent(s) responsible for the observed antidiabetic effect.","PeriodicalId":505837,"journal":{"name":"Scholars Academic Journal of Pharmacy","volume":"51 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140729914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Verifying the Safety of Microbial Contamination in Self-Injectors of Glucagon-like peptide-1 Receptor Agonists 验证胰高血糖素样肽-1 受体激动剂自我注射器中微生物污染的安全性

Scholars Academic Journal of Pharmacy Pub Date : 2024-03-11 DOI: 10.36347/sajp.2024.v13i03.001

Atsushi Ishimura, Atsushi Inose

{"title":"Verifying the Safety of Microbial Contamination in Self-Injectors of Glucagon-like peptide-1 Receptor Agonists","authors":"Atsushi Ishimura, Atsushi Inose","doi":"10.36347/sajp.2024.v13i03.001","DOIUrl":"https://doi.org/10.36347/sajp.2024.v13i03.001","url":null,"abstract":"Glucagon-like peptide-1 receptor agonists (GLP-1RAs) enhance insulin secretion in patients with type 2 diabetes mellitus in a glucose concentration-dependent manner. Many GLP-1RA formulations are administered in divided doses using a needle attached to the patient. Prior to use, the formulation is store in a cool place owing to stability. However, it is store at room temperature after use owing to problems with the injector. Therefore, the split-dose GLP-1RAs formulations contain phenolic antiseptics (phenol and cresol). Contamination of the formulation with microorganisms must be considered because patient self-injection is not performed under aseptic conditions. Therefore, this study verified the safety against microbial contamination during use based on Escherichia coli survival in split-dose GLP-1RA formulations. Unused liraglutide, exenatide, and lixisenatide were contaminated with E. coli stored at 25°C (room temperature) and cultured over time. E. coli gradually decreased immediately after suspension and E. coli did not survive after 60-90 min. The preservative of the split-dose GLP-1RAs formulation exhibited sufficient sterilizing power at 25°C, and it was inferred that room temperature is preferable for storage after use considering the formulation storage conditions, including injector failure and drug denaturation.","PeriodicalId":505837,"journal":{"name":"Scholars Academic Journal of Pharmacy","volume":"38 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140253544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study to Assess the Effectiveness and Safety of Etoricoxib & Aceclofenac in Osteoarthritis Patients 评估依托考昔和醋氯芬酸对骨关节炎患者的有效性和安全性的比较研究

Scholars Academic Journal of Pharmacy Pub Date : 2024-01-10 DOI: 10.36347/sajp.2024.v13i01.002

Sreerag J. Raj, Ms. Sheethal Kuriakose

{"title":"Comparative Study to Assess the Effectiveness and Safety of Etoricoxib & Aceclofenac in Osteoarthritis Patients","authors":"Sreerag J. Raj, Ms. Sheethal Kuriakose","doi":"10.36347/sajp.2024.v13i01.002","DOIUrl":"https://doi.org/10.36347/sajp.2024.v13i01.002","url":null,"abstract":"Osteoarthritis (OA) is defined as a disorder that involves the movement of limbs characterized by cellular stress and a deterioration of the outer matrix that trigger malignant remodelling responses that include inflammatory mechanisms of natural immunity. Non-steroidal anti-inflammatory (NSAID) drugs are the first choice of treatment, since they reduce pain, improve functional ability. So, by comparing the effectiveness and safety of NSAID used in the treatment of OA can enhance the quality of life of patients. The goal of the study was to compare the effectiveness and safety of Aceclofenac and Etoricoxib in OA patients as well as to assess the quality of life (QOL) and medication adherence among subjects. It is an observational study conducted in the selected Orthopaedics clinics in T. Dasarahalli, Bengaluru District for a period of 6 months, based on various inclusion and exclusion criteria. Standardized questionnaire used in the study were Western Ontario and McMaster Universities Arthritis Index, Medical Outcomes Study 36-Item Short-Form Health Survey and Morisky Medication-Taking Adherence Scale. The collected data were entered in Microsoft Excel and appropriate descriptive and inferential statistical analysis was performed. On comparing Aceclofenac and Etoricoxib in terms of WOMAC score Etoricoxib (28.42) was found to be more effective than Aceclofenac (31.61) while comparing Etoricoxib 60 mg and 90mg, 90 mg (26.22) was found to be more effective. Regarding the safety of these drugs, Etoricoxib was found to be safer than Aceclofenac in terms of side effects. On associating the QOL scores in both the groups, it was found that the subjects belonging to the Aceclofenac group had the highest overall mean score 57.68. Investigation of medication adherence in the study population revealed that out of 68 subject’s majority of them had shown low adherence (n=38). Because of its enhanced safety profile, Etoricoxib is a better option than Aceclofenac for treating .....","PeriodicalId":505837,"journal":{"name":"Scholars Academic Journal of Pharmacy","volume":"14 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139534317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study to Assess the Safety and Effectiveness of Methotrexate and Tofacitinib in Patients Diagnosed with Rheumatoid Arthritis 评估甲氨蝶呤和托法替尼对类风湿关节炎患者的安全性和有效性的比较研究

Scholars Academic Journal of Pharmacy Pub Date : 2024-01-04 DOI: 10.36347/sajp.2024.v13i01.001

Carol Ann Johnson, Ms. Sheethal Kuriakose

{"title":"Comparative Study to Assess the Safety and Effectiveness of Methotrexate and Tofacitinib in Patients Diagnosed with Rheumatoid Arthritis","authors":"Carol Ann Johnson, Ms. Sheethal Kuriakose","doi":"10.36347/sajp.2024.v13i01.001","DOIUrl":"https://doi.org/10.36347/sajp.2024.v13i01.001","url":null,"abstract":"Introduction: Rheumatoid Arthritis (RA) is an autoimmune disease that causes chronic inflammation of the joints resulting in pain and disability. The prevalence of RA is estimated to be 1% to 2% globally and does not have any ethnic or racial differences. Elevated C-Reactive Protein (CRP) levels in the blood indicate the presence of inflammation and can be used to detect and monitor the disease. Patients with RA tend to have a significant load in association with pain, disability and activity limitation which in turn affects the Health-Related Quality of Life. With a growing rate of RA globally there is a need to assess the safety and effectiveness of drugs and provide a suitable treatment to improve the quality of life of the patients. OBJECTIVES: The goal of the study was to compare the safety and effectiveness of Tofacitinib and Methotrexate in patients diagnosed with Rheumatoid Arthritis. The study also aimed to assess the Health-Related Quality of Life (HRQOL) of patients. Methodology: This was an observational study conducted in selected Orthopaedic clinics in T. Dasarahalli Bengaluru. All the subjects (n=40) meeting the inclusion and exclusion criteria were briefed about the purpose of the study and the informed consent was obtained. The subject’s demographic details and responses were collected. Standard questionnaires, 36-Item Short Form survey (SF-36) to assess the HRQOL and Health Assessment Questionnaire-Disease Index (HAQ-DI) to assess the effectiveness of the drugs were used in all patients. The collected data were entered in Microsoft Excel and appropriate descriptive and statistical analysis was performed. Results: A total of 40 samples were enrolled in the study based on Inclusion and Exclusion criteria. Out of which 50% of the participants were on Methotrexate (MTX) and the other 50% were on Tofacitinib. Majority of the subjects in the study were women (90%) and men (10%) with mean age 51 and 54 respectively. On comparing the effectiveness of both","PeriodicalId":505837,"journal":{"name":"Scholars Academic Journal of Pharmacy","volume":"12 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139536386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0