评估依托考昔和醋氯芬酸对骨关节炎患者的有效性和安全性的比较研究

Sreerag J. Raj, Ms. Sheethal Kuriakose
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摘要

骨关节炎(OA)被定义为一种涉及肢体运动的疾病,其特点是细胞压力和外基质恶化,引发恶性重塑反应,包括天然免疫的炎症机制。非甾体抗炎药(NSAID)是治疗的首选药物,因为它们能减轻疼痛、改善功能。因此,通过比较用于治疗 OA 的非甾体抗炎药的有效性和安全性,可以提高患者的生活质量。本研究旨在比较醋氯芬酸和依托考昔对 OA 患者的有效性和安全性,并评估受试者的生活质量(QOL)和服药依从性。这是一项观察性研究,根据各种纳入和排除标准,在班加罗尔地区 T. Dasarahalli 的选定骨科诊所进行,为期 6 个月。研究中使用的标准化问卷包括西安大略和麦克马斯特大学关节炎指数、医疗结果研究 36 项短式健康调查和莫里斯基服药依从性量表。收集到的数据被输入 Microsoft Excel,并进行了适当的描述性和推论性统计分析。在比较醋氯芬酸和依托考昔的WOMAC评分时,发现依托考昔(28.42)比醋氯芬酸(31.61)更有效,而在比较依托考昔60毫克和90毫克时,发现90毫克(26.22)更有效。在药物的安全性方面,就副作用而言,依托考昔比比醋氯芬酸更安全。在对两组受试者的 QOL 评分进行比较后发现,醋氯芬酸组受试者的总平均分最高,为 57.68 分。对研究对象用药依从性的调查显示,在 68 名受试者中,大多数人的用药依从性较低(38 人)。由于依托考昔的安全性更强,因此在治疗 ..... 时,依托考昔比醋氯芬酸更好。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparative Study to Assess the Effectiveness and Safety of Etoricoxib & Aceclofenac in Osteoarthritis Patients
Osteoarthritis (OA) is defined as a disorder that involves the movement of limbs characterized by cellular stress and a deterioration of the outer matrix that trigger malignant remodelling responses that include inflammatory mechanisms of natural immunity. Non-steroidal anti-inflammatory (NSAID) drugs are the first choice of treatment, since they reduce pain, improve functional ability. So, by comparing the effectiveness and safety of NSAID used in the treatment of OA can enhance the quality of life of patients. The goal of the study was to compare the effectiveness and safety of Aceclofenac and Etoricoxib in OA patients as well as to assess the quality of life (QOL) and medication adherence among subjects. It is an observational study conducted in the selected Orthopaedics clinics in T. Dasarahalli, Bengaluru District for a period of 6 months, based on various inclusion and exclusion criteria. Standardized questionnaire used in the study were Western Ontario and McMaster Universities Arthritis Index, Medical Outcomes Study 36-Item Short-Form Health Survey and Morisky Medication-Taking Adherence Scale. The collected data were entered in Microsoft Excel and appropriate descriptive and inferential statistical analysis was performed. On comparing Aceclofenac and Etoricoxib in terms of WOMAC score Etoricoxib (28.42) was found to be more effective than Aceclofenac (31.61) while comparing Etoricoxib 60 mg and 90mg, 90 mg (26.22) was found to be more effective. Regarding the safety of these drugs, Etoricoxib was found to be safer than Aceclofenac in terms of side effects. On associating the QOL scores in both the groups, it was found that the subjects belonging to the Aceclofenac group had the highest overall mean score 57.68. Investigation of medication adherence in the study population revealed that out of 68 subject’s majority of them had shown low adherence (n=38). Because of its enhanced safety profile, Etoricoxib is a better option than Aceclofenac for treating .....
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