Results in Engineering最新文献

{"title":"Copper complexes mediate the in situ production of reactive oxygen species in the nucleus, enhancing the anti-tumor efficacy of PTX","authors":"Saichao Wei, Haitao Zhang, Zhou Fang, Jiawang Shi, Baoying Li, Zhenjing Liu, Yahui Song, Jiaqi Xu, Qian Yu, Min Zhang, Kehai Liu","doi":"10.1016/j.rineng.2026.109429","DOIUrl":"https://doi.org/10.1016/j.rineng.2026.109429","url":null,"abstract":"• Nuclear-targeted nanoplatform delivering PTX and copper for synergistic therapy • GSH-responsive PTX release and NLS-mediated copper nuclear translocation • In situ nuclear Fenton-like reaction amplifying PTX efficacy via enhanced ROS generation and apoptosis • Superior in vitro and in vivo anti-tumor efficacy and biosafety compared to free PTX Engineering a combination chemotherapy of PTX and copper complex has advantages. PTX treatment of tumor cells can increaseH 2 O 2 , providing a substrate for copper to trigger the decomposition of H 2 O 2 through a Fenton-like reaction and to generate ROS, thereby causing DNA damage in tumor cells. However, due to the short half-life and limited diffusion distance of ROS, the anti-tumor efficacy is reduced. This problem can be overcome by delivering copper into the nucleus to achieve in situ Fenton-like reaction induction and ROS release therein. Here, we fabricated a hierarchical delivery system where PTX was connected to polyethyleneimine by disulfide bond, and then modified with a nuclear localization signal peptide. Finally, copper loading was realized by the rich amine-mediated coordination of PEI, and the Cu/PSPN nanoplatform was obtained. The results showed that Cu/PSPN exhibited an appropriate particle size (245 nm) and zeta potential (+1.88 mV), with minimal hemolytic toxicity. Cu/PSPN achieved hierarchical transport of PTX and copper in the cytoplasm and nucleus through glutathione responsiveness and NLS-mediated delivery. Cu/PSPN induced an efficient Fenton-like reaction in the nucleus, significantly enhancing the anti-tumor efficacy of PTX by increasing ROS generation and apoptosis rates to 1.82-fold and 3.89-fold those of the PTX group, respectively. Cu/PSPN also demonstrated superior anti-tumor efficacy in vivo with tumor weight and volume being approximately 6.8% and 10.5% of the free PTX group. This study provides a robust engineering strategy for significantly improving the anti-tumor efficacy of PTX based on the in situ generation of ROS in the nucleus.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"29 1","pages":"109429-109429"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147381531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An environmentally friendly and cost-effective application of silica modification in water to prepare crude oil flow improver","authors":"Jingwen Yang, Longhao Tang, Xuyou Li, Youxu Liu, Ruoxi Yan, Jianxun Yu, Yingna Du, Gang Chen","doi":"10.1016/j.rineng.2025.107699","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.107699","url":null,"abstract":"","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"107699"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study on in-situ self-generating proppant fracturing prepad fluid system for micrometer-scale fractures in calcium-rich reservoirs","authors":"Zengbao Wang, Yibo Gan, Weian Huang, Shi Hua-qiang, Junjie Jiang","doi":"10.1016/j.rineng.2025.108243","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.108243","url":null,"abstract":"Conventional proppants effectively maintain primary and near-wellbore fracture apertures, but cannot access far-field micron-scale fractures (≤150 μm), which are prone to closure leading to reduced fracture conductivity and impaired hydrocarbon recovery efficiency. This study proposes an innovative system based on the injection of a phosphate-based prepad fluid into reservoir fractures, where it hydrothermally reacts with calcareous minerals to form hydroxyapatite (HA). This technology aims to overcome propping challenges in far-field micron-scale fractures of calcium-rich reservoirs. This study considers the design and optimization of the proppant system, evaluates the factors influencing proppant growth, and uses lab-scale experiments to assess proppant strength and performance. Reaction mechanisms were elucidated using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results showed that hydrothermal reactions between calcareous minerals and phosphate systems ((NH4)2HPO4, NH4H2PO4, NaH2PO4) achieve HA yields exceeding 90 %. Orthogonal experiments revealed that the order of significance for factors affecting self-growth performance is: reaction temperature > initial pH > phosphate concentration > reaction time. The optimal set of conditions to achieve maximum HA yield was determined to be a phosphate concentration of 5 wt%, reaction time of 48 h, reaction temperature of 120 °C, and initial pH of 2. Fracture flow conductivity experiments showed that rational optimization of the system formulation can lead to enhancements of up to 404 times in the short-term fracture flow conductivity, as well as enhancements of 80–110 times in long-term fracture flow conductivity. This significant improvement in conductivity validates the technical feasibility of this novel method.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"108243-108243"},"PeriodicalIF":0.0,"publicationDate":"2025-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adsorption performance and mechanism of hierarchical LTA zeolite for Cs⁺ in aqueous","authors":"Jing Qing, Jian Ye, Sili Chen, Xukai Li, Liang Guo, Weimin Zheng, Jinsong Wang, Yanjiao Gao","doi":"10.1016/j.rineng.2025.108200","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.108200","url":null,"abstract":"• A novel modification of highly crystalline LTA zeolite with dimethyldiallylammonium chloride significantly enhances Cs⁺ adsorption from aqueous solution. • The modified LTA zeolite achieves adsorption equilibrium within just 5 min while maintaining its original adsorption capacity. • The allyl groups in dimethyldiallylammonium chloride are identified as the key functional groups responsible for the enhanced Cs⁺ uptake. • Adsorption proceeds via a synergistic mechanism combining electrostatic attraction and ion exchange. Radioactive wastewater discharge increased continuously with the widespread utilization of nuclear energy around the world, among which 137 Cs is one of the most critical radionuclides requiring removal. Traditional Lind Type A (LTA) zeolite exhibits promising adsorption potential for ¹³⁷Cs, however its slow adsorption kinetics remains a limitation. A hierarchically porous LTA zeolite (JLTA) via modification with Dimethyl Diallyl Ammonium Chloride (DMDAAC) was developed. Mesopores of JLTA were constructed effectively via hydrophobic groups of DMDAAC while preserving its intrinsic micropores, which was confirmed by XRD, SEM-EDS, BET, and FT-IR. Optimal conditions of JLTA’s adsorption performance (pH = 6, dosage = 5 g/L, T = 298 K) was gained during systematic investigations under varying pH, dosage, contact time, initial Cs⁺ concentration, and temperature. Cs⁺ adsorption by JLTA was primarily due to ion exchange with supplementary electrostatic attraction, following monolayer adsorption, which was revealed via kinetic models, adsorption isotherms, and characterization analyses. The intra-particle diffusion-controlled process achieved equilibrium within 5 min, demonstrating remarkably accelerated kinetics. A maximum adsorption capacity of 249.390 mg/g of JLTA was exhibited.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"108200-108200"},"PeriodicalIF":0.0,"publicationDate":"2025-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-situ growth of ZIFs on cotton fabrics for enhanced gas absorption by hierarchical porous structures","authors":"Nuo Xu, Shengjun Yuan, Yixin Liu, Zhengxiao Guo, Minghua Li, Duan‐Chao Wang","doi":"10.1016/j.rineng.2025.108152","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.108152","url":null,"abstract":"• In-situ growth of ZIF-67 and ZIF-8 on cotton fabrics forms efficient dual-mode (acidic/alkaline) gas adsorption. • Micro-CT and BET analyses reveal hierarchical porosity bridging textile macrostructure and ZIF microstructures. • The composite fabrics exhibit >90% odor gas removal and 99.9% antibacterial activity while retaining excellent breathability and water absorbency. Odors from sweat and skin secretions not only cause discomfort but may also signal microbial contamination in textiles, posing health risks. To address this, we report a multifunctional composite textile prepared via in-situ growth of two zeolitic imidazolate frameworks (ZIF-67 and ZIF-8) on cotton fabrics. Cotton was chosen for its comfort, hydrophilicity, and modifiable cellulose structure, with woven and knitted variants offering complementary mechanical and elastic properties. The integration of ZIFs imparts high surface area, tunable microporosity, and intrinsic antibacterial performance. Structural characterization confirms uniform deposition of ZIFs forming a functional shell on the cotton fibers. Notably, X-ray micro-computed tomography (Micro-CT) and BET analysis jointly reveal a hierarchical porous architecture from the textile macrostructure to ZIF microdomains, enabling efficient adsorption of both alkaline (NH 3 ) and acidic (CH 3 COOH) odor molecules. The ZIFs exhibit a surface area of 1451.0 m 2 /g, retaining 89.2 m 2 /g post-integration. The resulting fabrics demonstrate >90% odor removal, excellent water absorbency and breathability, and 99.9% antibacterial activity against S. aureus and E. coli. This study offers a promising strategy for designing next-generation functional deodorizing textiles for daily hygiene applications.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"108152-108152"},"PeriodicalIF":0.0,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147330878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycidyl ether-terminated branched polysiloxane and its synergy with DOPO for the preparation of flame-retardant, high-strength, and high-toughness epoxy resin","authors":"Yang Zhang, Shangqun Xie, Xuan Wu, Yixiao Shi, Qinghua Pan, Yanjiang Song, Zhi‐Rong Qu, Hong Dong, Chuan Wu","doi":"10.1016/j.rineng.2025.108019","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.108019","url":null,"abstract":"","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"108019-108019"},"PeriodicalIF":0.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147332473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced removal of hexavalent chromium from contaminated soil using an amphoteric–anionic mixed surfactant (SDAO/SDS): Efficiency, mechanism, and environmental implications","authors":"Chunhe Zang, Jianmin Niu, Hongyan Li, Zhenghua Wang, Zhou Shi","doi":"10.1016/j.rineng.2025.107895","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.107895","url":null,"abstract":"","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"107895-107895"},"PeriodicalIF":0.0,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147333065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanistic insights into in-situ detoxification during co-extraction of lithium and beryllium from Lepidolite via potassium bisulfate roasting","authors":"Yi Guan, Dewei Li, Xiang Lei, Jietao Jiang, Jinliang Wang","doi":"10.1016/j.rineng.2025.107363","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.107363","url":null,"abstract":"","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"28 1","pages":"107363-107363"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Further research on the impacts of humic acid in the aggregation of nanoplastics: The roles of molecular weight and surface functionalization","authors":"F.-Y. Li, Gui-Yun Song, Qingxin Zhang","doi":"10.1016/j.rineng.2025.106823","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.106823","url":null,"abstract":"• The aggregation of polystyrene nanoplastics (PS NPs) depended on HA adsorption layer. • The molecular weight and mass of HA on PS NPs surfaces controlled layer thickness. • Thicker layers impeded PS-Bare/PS-COOH flocculation in NaCl. • Ca 2+ transforms PS-Bare/PS-COOH with thicker adsorption layer to larger flocs. • Small dosage of HA with low molecular weight formed larger PS-NH 2 flocs. Humic acid (HA) affects the aggregation behavior of nanoplastics. This study examines the adsorption of molecular weight (MW)-fractionated HA onto functionalized polystyrene nanoplastics (PS-Bare, PS-COOH, and PS-NH₂) in NaCl and CaCl₂, characterizes the properties of the adsorbed HA layer, and assesses their impact on nanoplastics stability. The results reveal that pristine and MW-fractionated HA form adsorbed layers with comparable functional groups and surface charge. However, the adsorbed layer thickness (ALT) exhibits a positive correlation with the adsorption mass and MW of HA. In NaCl, the maximum ALT values were 0.21∼5.93 nm for PS-Bare, 0.74∼9.43 nm for PS-COOH, and 2.23∼12.1 nm for PS-NH₂, whereas their ranges in CaCl₂ were 0.21∼7.1 nm, 1.05∼12.1 nm, and 2.61∼12.8 nm. The increased ALT elevated the critical coagulation concentration (CCC) values in NaCl from 343 to 426∼1266 mM for PS-Bare and 339 to 467∼1380 mM for PS-COOH, while the hydrodynamic diameter (D h ) of PS-NH₂ stabilized at approximately 143 nm, indicating enhanced steric repulsion and improved nanoplastics dispersion. Similar results were also observed in CaCl 2 containing low concentrations of HA. However, in CaCl₂, higher-MW HA at 10 mg C L⁻¹ can counteract steric repulsion through a bridging effect, leading to decreasing CCC to 19.2∼23.1 mM for PS-Bare and to 18.7∼21.6 mM for PS-COOH. Lower-MW HA at 5 mg C L⁻¹ promotes increasing D h of PS-NH₂ to 600∼900 nm via the synergistic effects of charge neutralization and weak steric hindrance. Additionally, HA <3kDa induces increasing D h of PS-NH₂ to 1300 nm through patch-charge attraction, irrespective of concentration.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"27 1","pages":"106823-106823"},"PeriodicalIF":0.0,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep eutectic solvent-mediated ligand engineering for stable and high-luminance perovskite quantum dots toward ultra-bright light-emitting diodes","authors":"Qun Yan, Huanxin Wang, Shiwen Xing, Baoyou Liu, Libo Zhong, Dongming Liu, Gang Yue, Yanqin Miao","doi":"10.1016/j.rineng.2025.106747","DOIUrl":"https://doi.org/10.1016/j.rineng.2025.106747","url":null,"abstract":"Organic ligands can effectively passivate surface defects of perovskite quantum dots (PQDs), thereby enhancing their optoelectronic performance. In this study, a deep eutectic solvent (DES) prepared from caprolactam and acetamide was introduced as an organic ligand to synthesize PQDs emitting at 496 nm and fabricate high-brightness light-emitting devices. Compared to PQDs without DES modification, the DES-enhanced PQDs exhibited stronger binding via a unique hydrogen-bonding network, resulting in a significant increase in fluorescence intensity from 2852 a.u. to 6675 a.u. (144% enhancement). The DES-modified PQDs retained 50% of their initial fluorescence intensity after 5 days of ambient storage. The photoluminescence quantum yield (PLQY) improved from 18.7% to 31.85%. Light-emitting devices based on these PQDs achieved a maximum luminance of 79,430 cd/m² and Commission Internationale de l'Éclairage (CIE) coordinates of (0.32, 0.65). This work demonstrates that DES-based ligand engineering is a promising strategy for enhancing the photoluminescence efficiency and optoelectronic performance of PQDs.","PeriodicalId":505830,"journal":{"name":"Results in Engineering","volume":"27 1","pages":"106747-106747"},"PeriodicalIF":0.0,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}