Carbohydrate Polymer Technologies and Applications最新文献

Extraction, isolation, purification, structural characterization, and antitumor activity of polysaccharides from safflower seed residues 红花籽残多糖的提取、分离、纯化、结构表征及抗肿瘤活性研究

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-09-01 DOI: 10.1016/j.carpta.2025.100998

Md Hasan Ali, Liang Zhang, Mengwei Jia, Yanting Lu, Chao Jiang, Furong Fan, Furong Zhu, Dongsen Wu, Haipeng Yin, Jianwang Wei, Saimijiang Yaermaimaiti, Shenghui Chu, Min Liu

{"title":"Extraction, isolation, purification, structural characterization, and antitumor activity of polysaccharides from safflower seed residues","authors":"Md Hasan Ali, Liang Zhang, Mengwei Jia, Yanting Lu, Chao Jiang, Furong Fan, Furong Zhu, Dongsen Wu, Haipeng Yin, Jianwang Wei, Saimijiang Yaermaimaiti, Shenghui Chu, Min Liu","doi":"10.1016/j.carpta.2025.100998","DOIUrl":"https://doi.org/10.1016/j.carpta.2025.100998","url":null,"abstract":"Polysaccharides from safflower seed residue (SSRPs) were extracted using hot water (100°C, 2 h, liquid-to-solid ratio 10:1), ethanol-precipitated, deproteinized by the Sevag method, and purified sequentially by DEAE-52 cellulose and Sephadex G-100 chromatography. Three fractions, SSRP1–SSRP3, were obtained with yields of 10.0 ± 0.88%, 8.5 ± 0.38%, and 6.33 ± 0.13% and purities of 90.91 ± 1.07%, 88.90 ± 0.97%, and 77.78 ± 0.59%, respectively. Chemical analysis showed total sugar contents of 45.07 ± 0.26%, 32.53 ± 0.48%, and 20.99 ± 0.39%, with uronic acid levels of 9.49 ± 0.42%, 7.79 ± 0.60%, and 6.67 ± 0.26%. Zeta potentials ranged from –16.4 to –32.9 mV, suggesting strong colloidal stability. The molecular weights were 0.707, 2.033, and 3.942 kDa, and monosaccharide analysis identified fructose, glucose, and galactose as the main components. FT-IR confirmed functional groups, while 2D NMR (HSQC, HMBC, COSY) revealed backbones of 4-linked AnGalp 2-sulfate, α-1-Galp, and α-2,3-Fucp residues. SEM imaging showed porous and lamellar morphologies. Antitumor activity was assessed by CCK-8 assay on HepG2 cells, showing dose-dependent inhibition with IC 50 values of 249 ± 12.3 µg/mL (SSRP1), 276.14 ± 6.22 µg/mL (SSRP2), and 490.91 ± 8.17 µg/mL (SSRP3). These findings demonstrate that SSRPs possess distinct structural features and significant antitumor activity, highlighting their potential as natural anticancer agents and functional food ingredients.","PeriodicalId":505486,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 1","pages":"100998-100998"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147895778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic potential of a JHCF4-based fucoidan hydrogel for localized chemotherapy of hepatocellular carcinoma 基于jhcf4的岩藻糖聚糖水凝胶在肝癌局部化疗中的治疗潜力

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-09-01 DOI: 10.1016/j.carpta.2025.100999

Hongkang Xu, Zhuo Liu, Tongchuan Wu, Fei Zheng, Yunfei Huang, Tianqi Su, Jiannan Li, Yulin Dai

{"title":"Therapeutic potential of a JHCF4-based fucoidan hydrogel for localized chemotherapy of hepatocellular carcinoma","authors":"Hongkang Xu, Zhuo Liu, Tongchuan Wu, Fei Zheng, Yunfei Huang, Tianqi Su, Jiannan Li, Yulin Dai","doi":"10.1016/j.carpta.2025.100999","DOIUrl":"https://doi.org/10.1016/j.carpta.2025.100999","url":null,"abstract":"• JHCF4-based hydrogel loaded with doxorubicin (J-H-DOX): a potent source of anticancer agent. • J-H-DOX was developed and prepared for orthotopic hepatoma treatment in a mice model. • J-H-DOX mediated by an increase in cell apoptosis and decrease in tumor angiogenesis was found. Local chemotherapy based on polymeric drug delivery systems has gained increasing attention for solid tumor treatment. In this study, a fucoidan fraction (JHCF4) extracted from Sargassum fusiforme was oxidized to produce aldehyde groups and subsequently crosslinked with ε-polylysine to fabricate an injectable hydrogel (J-H). Doxorubicin (DOX) was loaded into the hydrogel to form J-H-DOX. Physicochemical characterization showed that the hydrogel possessed good injectability, self-healing ability, biodegradability, and sustained drug release properties. In vitro studies demonstrated that JHCF4 significantly inhibited the proliferation of H22 hepatoma cells, indicating its inherent anticancer potential. Based on this, J-H, an injectable hydrogel, was constructed by crosslinking oxidized JHCF4 with ε-polylysine, and subsequently loaded with DOX to form J-H-DOX. In vivo evaluation using an orthotopic hepatocellular carcinoma (HCC) mouse model showed that J-H-DOX effectively suppressed tumor growth by inducing apoptosis, reducing cell proliferation, and inhibiting angiogenesis, outperforming both J-H and free DOX treatments. These findings suggest that JHCF4 possesses inherent anticancer activity and the hydrogel-based delivery system further enhances its therapeutic potential for localized chemotherapy in HCC. Schematic illustration of preparation of JHCF4-based hydrogel co-loaded with DOX (J-H-DOX), and synergy mechanism of J-H-DOX for the treatment of orthotopic hepatoma in a mice model.","PeriodicalId":505486,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 1","pages":"100999-100999"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chitosan oligosaccharides-modified nanoliposome improve the stability, antioxidant, and anti-inflammatory activity of cordycepin 壳聚糖修饰的纳米脂质体提高了虫草素的稳定性、抗氧化和抗炎活性

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-09-01 DOI: 10.1016/j.carpta.2025.101002

Yan Jiao, Xinqi Zhao, Ying Chang, Haodong Chen

{"title":"Chitosan oligosaccharides-modified nanoliposome improve the stability, antioxidant, and anti-inflammatory activity of cordycepin","authors":"Yan Jiao, Xinqi Zhao, Ying Chang, Haodong Chen","doi":"10.1016/j.carpta.2025.101002","DOIUrl":"https://doi.org/10.1016/j.carpta.2025.101002","url":null,"abstract":"• Development of COS-modified nanoliposome for enhanced cordycepin stability. • COS-modified nanoliposome showed better encapsulation performance for cordycepin. • Targeted absorption of cordycepin with reduced release in gastric fluid. • Improved antioxidant properties of cordycepin in COS-modified nano-liposome. • Enhanced anti-inflammatory efficacy of cordycepin in COS-Cor-Lpo. Cordycepin is an important bioactive component in Cordyceps militaris and offers significant physiological benefits for human health. However, its application is limited due to its poor stability and rapid degradation, which lead to a loss of bioactivity. This study aimed to enhance the stability and anti-inflammatory efficacy of cordycepin by developing a novel Chitosan oligosaccharides (COS) modified cordycepin nano-liposome (COS-Cor-Lpo) using a reverse evaporation and surface modification technique. The COS-Cor-Lpo exhibited a spherical microstructure with a diameter of <300 nm, demonstrating a narrower size distribution, better polydispersity, and higher encapsulation efficiency of cordycepin compared to unmodified liposomes. The formation of COS-Cor-Lpo was primarily driven by electrostatic adsorption and hydrogen bonding interactions. Moreover, COS-Cor-Lpo significantly improved cordycepin's stability under various storage conditions, reduced its release in gastric fluid, and enhanced its release in intestinal fluid, promoting targeted absorption. Compared to cordycepin and its unmodified liposomes, COS-Cor-Lpo showed lower cytotoxicity, higher antioxidant activity, and a stronger protective effect against inflammatory damage in IEC-6 cells by reducing the levels of nitric oxide (NO), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6), while inhibiting the mRNA expression of TNF-α, IL-6, P38, and JNK. These results suggest that COS-Cor-Lpo represents a promising nano-embedding system for cordycepin delivery.","PeriodicalId":505486,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 1","pages":"101002-101002"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation, rheological properties, and in vitro digestibility of starch-based hydrogel beads for curcumin delivery 姜黄素淀粉基水凝胶珠的制备、流变学性质和体外消化率

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-09-01 DOI: 10.1016/j.carpta.2025.100994

Ping Shi, Siyu Liu, Hafiz Umer Javed, Jing Lu, Yuansen Liu

{"title":"Preparation, rheological properties, and in vitro digestibility of starch-based hydrogel beads for curcumin delivery","authors":"Ping Shi, Siyu Liu, Hafiz Umer Javed, Jing Lu, Yuansen Liu","doi":"10.1016/j.carpta.2025.100994","DOIUrl":"https://doi.org/10.1016/j.carpta.2025.100994","url":null,"abstract":"Curcumin (CUR) possesses notable health benefits but suffers from poor solubility, instability, and low bioavailability. To address these limitations, this study developed a novel starch-chitosan composite cross-linked with citric acid (CA). The modified starch was employed in the fabrication of emulsion and emulsion gel beads, which were systematically evaluated based on rheological properties, texture, moisture distribution, and in vitro digestibility. The starch-based emulsion exhibited higher storage modulus and loss modulus compared to the emulsion. Texture analysis revealed that the hardness and adhesiveness decreased to 1.89 ± 0.13 N and 0.66 ± 0.05 N, respectively, while cohesion, elasticity, and chewiness were increased. The LF-NMR results indicated that the CA combined CS modified starch-based emulsion beads (CA/CS-SEB) had a diminished proportion of free water and a correspondingly greater proportion of bound water compared to starch-based emulsion beads (SEB). The encapsulation efficiency of the CUR-loaded beads reached 86.50 ± 0.25 %. In simulated gastrointestinal digestion, CA combined CS modified starch-based emulsion beads loaded with curcumin (CA/CS-SEB-CUR) exhibited the slowest release ratio, which decreased from 23.20 ± 0.03 % to 17.03 ± 0.77 %. These findings provide a theoretical basis for the use of modified starch and propose a viable strategy for curcumin delivery.","PeriodicalId":505486,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"11 1","pages":"100994-100994"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Redox-sensitive targeted nanoparticles synthesized from heparin mimetics for potential glioma treatment application 由肝素模拟物合成的氧化还原敏感靶向纳米颗粒用于潜在的胶质瘤治疗应用

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-05-22 DOI: 10.1016/j.carpta.2025.100864

Yang Yang, Jie Zhang, Yue Min, Wendi Zhou, Guozhong Lv

{"title":"Redox-sensitive targeted nanoparticles synthesized from heparin mimetics for potential glioma treatment application","authors":"Yang Yang, Jie Zhang, Yue Min, Wendi Zhou, Guozhong Lv","doi":"10.1016/j.carpta.2025.100864","DOIUrl":"https://doi.org/10.1016/j.carpta.2025.100864","url":null,"abstract":"Glioblastoma (GBM) is a highly aggressive primary brain tumor with a median survival of less than 15 months following standard treatments, largely due to obstacles such as the blood–brain barrier (BBB) and tumor heterogeneity. To overcome these challenges, we developed a redox-sensitive, targeted nanocarrier loaded with temozolomide (KCA-A2/TMZ), composed of K5 polysaccharide (derived from Escherichia coli fermentation), γ-linolenic acid, and the tumor-targeting peptide Angiopep-2 (A2). In vitro studies showed that KCA-A2 displayed excellent biocompatibility with NIH 3T3 (mouse embryonic fibroblasts) and bEnd.3 (mouse brain microvascular endothelial cells), maintaining over 90% cell viability at 1 mg/mL. In contrast, it significantly inhibited the proliferation of C6 glioma cells (rat glioma) and HUVECs (human umbilical vein endothelial cells), indicating antitumor and anti-angiogenic properties. KCA-A2/TMZ further enhanced tumor cell inhibition, with an IC₅₀ of 250 μg/mL (containing 70 μg/mL TMZ) against C6 cells, more than 3-fold lower than that of free TMZ. Furthermore, a BBB in vitro model and confocal microscopy confirmed efficient brain-targeting capabilities. These findings suggest that the KCA-A2/TMZ system not only facilitates targeted TMZ delivery but also synergizes with the drug to inhibit GBM progression, offering a promising therapeutic strategy for improved glioblastoma treatment.","PeriodicalId":505486,"journal":{"name":"Carbohydrate Polymer Technologies and Applications","volume":"10 1","pages":"100864-100864"},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Unlocking the potential of Komagataeibacter europaeus FMES: A novel source of bacterial cellulose from Monascus vinegar biofilm 释放europaeus komagataebacterium FMES的潜力：红曲霉醋生物膜中细菌纤维素的新来源

Carbohydrate Polymer Technologies and Applications Pub Date : 2025-05-14 DOI: 10.1016/j.carpta.2025.100841

Siyu Liu, Jiaqi Luo, Ying Shi, Qihe Chen

引用次数: 3

Characterization and Biological Evaluation of 3D Printed Composite Ink Consisting of Collagen, Hyaluronic Acid and Calcium Phosphate for Bone Regeneration 用于骨再生的由胶原蛋白、透明质酸和磷酸钙组成的 3D 打印复合墨水的表征和生物学评估

Carbohydrate Polymer Technologies and Applications Pub Date : 2024-05-01 DOI: 10.1016/j.carpta.2024.100518

D. Van der Heide, L.P. Hatt, E. Della Bella, A. Hangartner, W.A. Lackington, H. Yuan, F. De Groot-Barrère, M.J. Stoddart, M. D'Este

引用次数: 0

Learning from hype en route to fulfill the industrial potential of nanocellulose 在发挥纳米纤维素工业潜力的道路上从炒作中学习

Carbohydrate Polymer Technologies and Applications Pub Date : 2024-05-01 DOI: 10.1016/j.carpta.2024.100512

R. Ciriminna, Giuseppe Angellotti, Rafael Luque, Matteo Formenti, Cristina Della Pina, M. Pagliaro

引用次数: 0

Cellulose gelation in aqueous hydroxide solutions by CO2(g): fact and theory 氢氧化水溶液中二氧化碳（g）对纤维素的凝胶作用：事实与理论

Carbohydrate Polymer Technologies and Applications Pub Date : 2024-05-01 DOI: 10.1016/j.carpta.2024.100514

Shirin Naserifar, N. Karna, A. M. Kozlowski, Diana Bernin, Merima Hasani

引用次数: 0

Fructooligosaccharides: Production by recombinant fructosyltransferase from Festuca arundinacea in a continuous reactor and kinetic modeling profile 果寡糖：在连续反应器中利用从旱金莲中提取的重组果糖基转移酶生产果寡糖以及动力学模型剖面图

Carbohydrate Polymer Technologies and Applications Pub Date : 2024-05-01 DOI: 10.1016/j.carpta.2024.100511

Avijeet S. Jaswal, R. Elangovan, Saroj Mishra

引用次数: 0