CCS ChemistryPub Date : 2021-04-15DOI: 10.31635/ccschem.021.202100964
Hua Wang, Han Wu, Yu Yi, Ke-Fei Xue, Jiang‐Fei Xu, Hao Wang, Yuliang Zhao, Xi Zhang
{"title":"Self-Motivated Supramolecular Combination Chemotherapy for Overcoming Drug Resistance Based on Acid-Activated Competition of Host–Guest Interactions","authors":"Hua Wang, Han Wu, Yu Yi, Ke-Fei Xue, Jiang‐Fei Xu, Hao Wang, Yuliang Zhao, Xi Zhang","doi":"10.31635/ccschem.021.202100964","DOIUrl":"https://doi.org/10.31635/ccschem.021.202100964","url":null,"abstract":"Open AccessCCS ChemistryRESEARCH ARTICLE1 Aug 2021Self-Motivated Supramolecular Combination Chemotherapy for Overcoming Drug Resistance Based on Acid-Activated Competition of Host–Guest Interactions Hua Wang, Han Wu, Yu Yi, Ke-Fei Xue, Jiang-Fei Xu, Hao Wang, Yuliang Zhao and Xi Zhang Hua Wang Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 Google Scholar More articles by this author , Han Wu Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 Google Scholar More articles by this author , Yu Yi *Corresponding authors: E-mail Address: [email protected] E-mail Address: [email protected] E-mail Address: [email protected] CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190 Google Scholar More articles by this author , Ke-Fei Xue Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190 Google Scholar More articles by this author , Jiang-Fei Xu Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 Google Scholar More articles by this author , Hao Wang *Corresponding authors: E-mail Address: [email protected] E-mail Address: [email protected] E-mail Address: [email protected] CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190 Google Scholar More articles by this author , Yuliang Zhao CAS Center for Excellence in Nanoscience, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology (NCNST), Beijing 100190 Google Scholar More articles by this author and Xi Zhang *Corresponding authors: E-mail Address: [email protected] E-mail Address: [email protected] E-mail Address: [email protected] Key Laboratory of Organic Optoelectronics and Molecular Engineering, Department of Chemistry, Tsinghua University, Beijing 100084 Google Scholar More articles by this author https://doi.org/10.31635/ccschem.021.202100964 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail In this work, we propose a nanoparticle-based strategy of self-motivated supramolecular combination chemotherapy that carries drugs stably and releases them actively in the acidic tumor microenvironment to overcome the drug resistance of cancer cells. This self-motivated nanoparticle consists of a cucurbi","PeriodicalId":505404,"journal":{"name":"CCS Chemistry","volume":"3 8","pages":"1413-1425"},"PeriodicalIF":0.0,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
CCS ChemistryPub Date : 2021-01-13DOI: 10.31635/ccschem.021.202000501
Ruiying Guo, Yutian Zhang, Supphachok Chanmungkalakul, Haoran Guo, Yongzhou Hu, Jia Li, Xiaogang Liu, Yi Zang, Xin Li
{"title":"Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells","authors":"Ruiying Guo, Yutian Zhang, Supphachok Chanmungkalakul, Haoran Guo, Yongzhou Hu, Jia Li, Xiaogang Liu, Yi Zang, Xin Li","doi":"10.31635/ccschem.021.202000501","DOIUrl":"https://doi.org/10.31635/ccschem.021.202000501","url":null,"abstract":"Open AccessCCS ChemistryRESEARCH ARTICLE1 Oct 2021Bioinspired Design of Reversible Fluorescent Probes for Tracking Nitric Oxide Dynamics in Live Cells Rui-Ying Guo†, Yu-Tian Zhang†, Supphachok Chanmungkalakul, Hao-Ran Guo, Yongzhou Hu, Jia Li, Xiaogang Liu, Yi Zang and Xin Li Rui-Ying Guo† College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058 , Yu-Tian Zhang† State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 University of Chinese Academy of Sciences, Beijing 100049 , Supphachok Chanmungkalakul Fluorescence Research Group, Singapore University of Technology and Design, Singapore 487372 , Hao-Ran Guo State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 University of Chinese Academy of Sciences, Beijing 100049 , Yongzhou Hu College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058 , Jia Li State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 University of Chinese Academy of Sciences, Beijing 100049 Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237 , Xiaogang Liu Fluorescence Research Group, Singapore University of Technology and Design, Singapore 487372 , Yi Zang *Corresponding authors: E-mail Address: [email protected] E-mail Address: [email protected] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203 and Xin Li *Corresponding authors: E-mail Address: [email protected] E-mail Address: [email protected] College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058 https://doi.org/10.31635/ccschem.021.202000501 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked InEmail Nitric oxide (NO) participates in various pathways and revealing its dynamics is critical for resolving its pathophysiology. While there are methods available for detecting biological NO, few are capable of tracking NO dynamics. Herein, inspired by the cellular machinery of reversible thiol modification by NO, we have successfully designed a family of cysteine analogues tagged with fluorophores for visualizing cellular NO dynamics. Biocompatible probes 1a and 2a were found to be most tolerated by the cellular machinery to swiftly switch between their original fluorescent state and quenched S-nitrosated state in response to cellular NO dynamics. We showcased their applicability in various cell types and utility to track NO fluctuations in activated murine macrophages in response to an anti-inflammatory agent treatment. We expect that probes 1a and 2a will afford promising tools for studying NO pathophysiology by tracking its dynamics in health and disease. Download figure Download PowerPoint Introduc","PeriodicalId":505404,"journal":{"name":"CCS Chemistry","volume":"3 10","pages":"116-128"},"PeriodicalIF":0.0,"publicationDate":"2021-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147885172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Natural Polyphenol Inspired Polycatechols for Efficient siRNA Delivery","authors":"Wanwan Shen, Ruojun Wang, Qianqian Fan, Xiao Gao, Hui Wang, Yang Shen, Yiwen Li, Yiyun Cheng","doi":"10.31635/ccschem.020.201900084","DOIUrl":"https://doi.org/10.31635/ccschem.020.201900084","url":null,"abstract":"There is a continuing quest to rationally fabricate polymeric biomaterials with both high transfection efficiency and minimal toxicity for the emerging opportunities in small interfering RNA (siRNA...","PeriodicalId":505404,"journal":{"name":"CCS Chemistry","volume":"2 3","pages":"146-157"},"PeriodicalIF":0.0,"publicationDate":"2020-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.chinesechemsoc.org/doi/pdf/10.31635/ccschem.020.201900084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147887200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly","authors":"Hongjun Jin, Mengqi Xie, Wenkai Wang, Lingxiang Jiang, Wen-Ying Chang, Yue Sun, Limin Xu, Shihao Zang, Jianbin Huang, Yun Yan, Lei Jiang","doi":"10.31635/ccschem.020.201900088","DOIUrl":"https://doi.org/10.31635/ccschem.020.201900088","url":null,"abstract":"Open AccessCCS ChemistryRESEARCH ARTICLE1 Apr 2020Pressing-Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembly Hongjun Jin†, Mengqi Xie†, Wenkai Wang, Lingxiang Jiang, Wenying Chang, Yue Sun, Limin Xu, Shihao Zang, Jianbin Huang, Yun Yan and Lei Jiang Hongjun Jin† Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Mengqi Xie† Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Wenkai Wang Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Lingxiang Jiang College of Chemistry and Materials Science, Jinan University, Guangzhou 510632 (China) , Wenying Chang Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry, Peking University, Beijing 100871 (China) , Yue Sun Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191 (China) , Limin Xu Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Shihao Zang Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Jianbin Huang Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) , Yun Yan *Corresponding author: E-mail Address: [email protected] Beijing National Laboratory for Molecular Sciences (BNLMS), College of Chemistry and Molecular Engineering, Peking University, Beijing 100871 (China) and Lei Jiang Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education, School of Chemistry, Beihang University, Beijing 100191 (China) CAS Key Laboratory of Bio-inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190 (China) https://doi.org/10.31635/ccschem.020.201900088 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to favoritesTrack Citations ShareFacebookTwitterLinked InEmail General strategies leading to scale-span molecular self-assembly are of crucial importance in creating bulk supramolecular materials. Here, we report that under mechanical pressure, caking of the precipitated molecular self-assemblies led to bulk supramolecular films. Massive fabrication of supramolecular films became possible by employing a simple household noodle machine. The film could be endowed to acquire diversified functions by depositing various functional ingredients via coprecipitation. We expect that our current work opens up a n","PeriodicalId":505404,"journal":{"name":"CCS Chemistry","volume":"2 2","pages":"98-106"},"PeriodicalIF":0.0,"publicationDate":"2020-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.chinesechemsoc.org/doi/pdf/10.31635/ccschem.020.201900088","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
